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Debbie A. Lawlor
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Journal Articles

DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework

Rebecca C. Richmond, Gemma C. Sharp, Mary E. Ward, Abigail Fraser, Oliver Lyttleton, Wendy L. McArdle, Susan M. Ring, Tom R. Gaunt, Debbie A. Lawlor, George Davey Smith, Caroline L. Relton
Journal: Diabetes
Diabetes 2016;65(5):1231–1244
https://doi.org/10.2337/db15-0996
Published: 01 February 2016
View articletitled, DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework
Open the PDF for DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework in another window
Includes: Supplementary data
Journal Articles

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

Hanieh Yaghootkar, Alena Stancáková, Rachel M. Freathy, Jagadish Vangipurapu, Michael N. Weedon, Weijia Xie, Andrew R. Wood, Ele Ferrannini, Andrea Mari, Susan M. Ring, Debbie A. Lawlor, George Davey Smith, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Valgerdur Steinthorsdottir, Daniel F. Guðbjartsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew T. Hattersley, Mark Walker, Andrew D. Morris, Mark I. McCarthy, Colin N.A. Palmer, Markku Laakso, Timothy M. Frayling
Journal: Diabetes
Diabetes 2015;64(6):2279–2285
https://doi.org/10.2337/db14-1456
Published: 20 January 2015
View articletitled, Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion
Open the PDF for Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion in another window
Includes: Supplementary data
Journal Articles

Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes

Philippa J. Talmud, Jackie A. Cooper, Richard W. Morris, Frank Dudbridge, Tina Shah, Jorgen Engmann, Caroline Dale, Jon White, Stela McLachlan, Delilah Zabaneh, Andrew Wong, Ken K. Ong, Tom Gaunt, Michael V. Holmes, Debbie A. Lawlor, Marcus Richards, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Claudia Langenberg, Yoav Ben-Shlomo, S. Goya Wannamethee, Mark W.J. Strachan, Meena Kumari, John C. Whittaker, Fotios Drenos, Mika Kivimaki, Aroon D. Hingorani, Jacqueline F. Price, Steve E. Humphries
Journal: Diabetes
Diabetes 2015;64(5):1830–1840
https://doi.org/10.2337/db14-1504
Published: 04 December 2014
View articletitled, Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Hanieh Yaghootkar, Claudia Lamina, Robert A. Scott, Zari Dastani, Marie-France Hivert, Liling L. Warren, Alena Stancáková, Sarah G. Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y.Y. Cheung, James S. Pankow, Anne U. Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M. Ballantyne, Weijia Xie, Richard N. Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S. Collins, Sandra H. Dunn, Josee Dupuis, Nita G. Forouhi, Christopher Gillson, Andrew T. Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L. Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W. Knowles, Cecilia M. Lindgren, John J. Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J.F. Loos, Mark I. McCarthy, Andrew D. Morris, Ramachandran S. Vasan, Tim D. Spector, Tanya M. Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S. Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K. Semple, Alan R. Sinaiko, Colin N.A. Palmer, Mark Walker, Karen S.L. Lam, Bernhard Paulweber, Karen L. Mohlke, Cornelia van Duijn, Olli T. Raitakari, Aurelian Bidulescu, Nick J. Wareham, Markku Laakso, Dawn M. Waterworth, Debbie A. Lawlor, James B. Meigs, J. Brent Richards, Timothy M. Frayling
Journal: Diabetes
Diabetes 2013;62(10):3589–3598
https://doi.org/10.2337/db13-0128
Published: 17 September 2013
View articletitled, Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
Open the PDF for Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

N. Maneka G. De Silva, Rachel M. Freathy, Tom M. Palmer, Louise A. Donnelly, Jian'an Luan, Tom Gaunt, Claudia Langenberg, Michael N. Weedon, Beverley Shields, Beatrice A. Knight, Kirsten J. Ward, Manjinder S. Sandhu, Roger M. Harbord, Mark I. McCarthy, George Davey Smith, Shah Ebrahim, Andrew T. Hattersley, Nicholas Wareham, Debbie A. Lawlor, Andrew D. Morris, Colin N.A. Palmer, Timothy M. Frayling
Journal: Diabetes
Diabetes 2011;60(3):1008–1018
https://doi.org/10.2337/db10-1317
Published: 21 February 2011
View articletitled, Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance
Open the PDF for Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben-Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew J. Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo-Riitta Jarvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley, Timothy M. Frayling
Journal: Diabetes
Diabetes 2008;57(5):1419–1426
https://doi.org/10.2337/db07-1466
Published: 01 May 2008
View articletitled, Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
Open the PDF for Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI in another window
Includes: Supplementary data