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Decio L. Eizirik
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Meeting Abstracts

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

MARTA TESI, MARA SULEIMAN, ROBERTO SEMERARO, CARMELA DE LUCA, EMANUELE BOSI, SILVIA DEL GUERRA, ALBERTO MAGI, MIRIAM CNOP, DECIO L. EIZIRIK, LORELLA MARSELLI, PIERO MARCHETTI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1750-P
https://doi.org/10.2337/db24-1750-P
Published: 14 June 2024
View article titled, 1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity
Meeting Abstracts

1505-P: Dipeptidyl Peptidase 6–Targeted Nanobody—A Precision Medicine Tool for Noninvasive Detection of Pancreatic Islets by PET

AMINA KHALIL, ARTURO ROCA RIVADA, IRINA VELIKYAN, ATHANASIOS BITZIOS, PAOLO SERAFINI, DECIO L. EIZIRIK, OLOF ERIKSSON
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1505-P
https://doi.org/10.2337/db24-1505-P
Published: 14 June 2024
View article titled, 1505-P: Dipeptidyl Peptidase 6–Targeted Nanobody—A Precision Medicine Tool for Noninvasive Detection of Pancreatic Islets by PET
Meeting Abstracts

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

MARA SULEIMAN, CARMELA DE LUCA, ROBERTO SEMERARO, EMANUELE BOSI, ALBERTO MAGI, MARTA TESI, SILVIA DEL GUERRA, OLIVIA PAGLIAROSI, ANNAMARIA CUDINI, LEONARDO ROSSI, DECIO L. EIZIRIK, MIRIAM CNOP, PIERO MARCHETTI, LORELLA MARSELLI, ALESSANDRA FIERABRACCI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1465-P
https://doi.org/10.2337/db24-1465-P
Published: 14 June 2024
View article titled, 1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome
Journal Articles

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Journal: Diabetes
Diabetes 2024;73(5):728–742
https://doi.org/10.2337/db23-0588
Published: 22 February 2024
View article titled, CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
Open the PDF for CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets in another window
Meeting Abstracts

296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

STACI A. WEAVER, ROBERT N. BONE, DOMINIC J. ACRI, JUNGSU KIM, TATSUYOSHI KONO, RUSSELL DAHL, DECIO L. EIZIRIK, FAROOQ SYED, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):296-LB
https://doi.org/10.2337/db23-296-LB
Published: 20 June 2023
View article titled, 296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development
Meeting Abstracts

25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes

FAROOQ SYED, OLIVIA BALLEW, CHIH-CHUN LEE, JYOTI RANA, ANGELA CASTELA, STACI A. WEAVER, SOFIA THOMAIDOU, STÉPHANE DEMINE, ALEXANDRA COOMANS DE BRACHÈNE, MARIA I. ALVELOS, GARRICK CHANG, KARA ORR, KENTARO YAMADA, JING LIU, ARNAUD ZALDUMBIDE, DONALYN SCHEUNER, DECIO L. EIZIRIK, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):25-OR
https://doi.org/10.2337/db23-25-OR
Published: 20 June 2023
View article titled, 25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes
Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Journal: Diabetes
Diabetes 2023;72(1):85–96
https://doi.org/10.2337/db22-0191
Published: 06 October 2022
View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes
Open the PDF for Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes in another window
Meeting Abstracts

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, GIORGIO BASILE, LING XIAO, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):9-OR
https://doi.org/10.2337/db22-9-OR
Published: 01 June 2022
View article titled, 9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells
Journal Articles

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Wenting Wu, Farooq Syed, Edward Simpson, Chih-Chun Lee, Jing Liu, Garrick Chang, Chuanpeng Dong, Clayton Seitz, Decio L. Eizirik, Raghavendra G. Mirmira, Yunlong Liu, Carmella Evans-Molina
Journal: Diabetes
Diabetes 2022;71(1):116–127
https://doi.org/10.2337/db20-0847
Published: 25 October 2021
View article titled, Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets
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Journal Articles

CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

Marie Eliane Azoury, Fatoumata Samassa, Mijke Buitinga, Laura Nigi, Noemi Brusco, Aïsha Callebaut, Matthieu Giraud, Magali Irla, Ana Ines Lalanne, Alexia Carré, Georgia Afonso, Zhicheng Zhou, Barbara Brandao, Maikel L. Colli, Guido Sebastiani, Francesco Dotta, Maki Nakayama, Decio L. Eizirik, Sylvaine You, Sheena Pinto, Mark J. Mamula, Yann Verdier, Joelle Vinh, Soren Buus, Chantal Mathieu, Lut Overbergh, Roberto Mallone
Journal: Diabetes
Diabetes 2021;70(12):2879–2891
https://doi.org/10.2337/db21-0259
Published: 24 September 2021
View article titled, CD8<sup>+</sup> T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
Open the PDF for CD8<sup>+</sup> T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes in another window
Journal Articles

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Decio L. Eizirik, Florian Szymczak, Maria Inês Alvelos, Frank Martin
Journal: Diabetes
Diabetes 2021;70(9):1915–1925
https://doi.org/10.2337/dbi20-0046
Published: 07 September 2021
View article titled, From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
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Meeting Abstracts

287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, JIANG HU, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, CHUAN HE, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2021;70(Supplement_1):287-OR
https://doi.org/10.2337/db21-287-OR
Published: 01 June 2021
View article titled, 287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells
Journal Articles

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Marie Eliane Azoury, Mahmoud Tarayrah, Georgia Afonso, Aurore Pais, Maikel L. Colli, Claire Maillard, Cassandra Lavaud, Laure Alexandre-Heymann, Sergio Gonzalez-Duque, Yann Verdier, Joelle Vinh, Sheena Pinto, Soren Buus, Danièle Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, Graziella Bruno, Decio L. Eizirik, Sylvaine You, Roberto Mallone
Journal: Diabetes
Diabetes 2020;69(12):2678–2690
https://doi.org/10.2337/db20-0013
Published: 14 September 2020
View article titled, Peptides Derived From Insulin Granule Proteins Are Targeted by CD8<sup>+</sup> T Cells Across MHC Class I Restrictions in Humans and NOD Mice
Open the PDF for Peptides Derived From Insulin Granule Proteins Are Targeted by CD8<sup>+</sup> T Cells Across MHC Class I Restrictions in Humans and NOD Mice in another window
Meeting Abstracts

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

XIAOYAN YI, LORELLA MARSELLI, ANTHONY PIRON, MARA SULEIMAN, FLORIAN SZYMCZAK, DECIO L. EIZIRIK, PIERO MARCHETTI, MIRIAM CNOP
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2087-P
https://doi.org/10.2337/db20-2087-P
Published: 01 June 2020
View article titled, 2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes
Meeting Abstracts

81-OR: The Impact of Proinflammatory Cytokines on Human Pancreatic Islet Alternative Splicing Patterns

WENTING WU, FAROOQ SYED, EDWARD SIMPSON, CHIH-CHUN LEE, DECIO L. EIZIRIK, SR., RAGHAVENDRA MIRMIRA, YUNLONG LIU, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):81-OR
https://doi.org/10.2337/db20-81-OR
Published: 01 June 2020
View article titled, 81-OR: The Impact of Proinflammatory Cytokines on Human Pancreatic Islet Alternative Splicing Patterns
Meeting Abstracts

2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

FRANCESCA GRANO, FEDERICA CIREGIA, MAURIZIO RONCI, MARIA ROSA MAZZONI, LUTGART OVERBERGH, CARMELA DE LUCA, MARA SULEIMAN, LORELLA MARSELLI, PAOLO DE SIMONE, UGO BOGGI, CHANTAL MATHIEU, DECIO L. EIZIRIK, SR., ANTONIO LUCACCHINI, LAURA GIUSTI, PIERO MARCHETTI, MARCO BUGLIANI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2136-P
https://doi.org/10.2337/db19-2136-P
Published: 01 June 2019
View article titled, 2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis
Journal Articles

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Journal: Diabetes
Diabetes 2018;67(3):423–436
https://doi.org/10.2337/db17-0736
Published: 15 December 2017
View article titled, SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival
Open the PDF for SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival in another window
Includes: Supplementary data
Journal Articles

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity

Sara A. Litwak, Lokman Pang, Sandra Galic, Mariana Igoillo-Esteve, William J. Stanley, Jean-Valery Turatsinze, Kim Loh, Helen E. Thomas, Arpeeta Sharma, Eric Trepo, Christophe Moreno, Daniel J. Gough, Decio L. Eizirik, Judy B. de Haan, Esteban N. Gurzov
Journal: Diabetes
Diabetes 2017;66(12):2973–2986
https://doi.org/10.2337/db17-0348
Published: 19 September 2017
View article titled, JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity
Open the PDF for JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity in another window
Includes: Supplementary data
Journal Articles

Erratum. Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65: 3384–3395

Jia Cheng, Jia Song, Xiaoyu He, Meng Zhang, Shuang Hu, Shu Zhang, Qilin Yu, Ping Yang, Fei Xiong, Dao Wen Wang, Jianfeng Zhou, Qin Ning, Zhishui Chen, Decio L. Eizirik, Zhiguang Zhou, Chunxia Zhao, Cong-Yi Wang
Journal: Diabetes
Diabetes 2017;66(9):2531
https://doi.org/10.2337/db17-er09b
Published: 26 July 2017
View article titled, Erratum. Loss of <em>Mbd2</em> Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65: 3384–3395
Open the PDF for Erratum. Loss of <em>Mbd2</em> Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65: 3384–3395 in another window
Journal Articles

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
Journal: Diabetes
Diabetes 2017;66(9):2446–2458
https://doi.org/10.2337/db16-1252
Published: 30 June 2017
View article titled, MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells
Open the PDF for MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells in another window
Includes: Supplementary data