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Diva D. De León
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Journal Articles

Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations

Changhong Li, Christine A. Juliana, Yue Yuan, Ming Li, Ming Lu, Pan Chen, Kara E. Boodhansingh, Nicolai M. Doliba, Tricia R. Bhatti, N. Scott Adzick, Charles A. Stanley, Diva D. De León
Journal: Diabetes
Diabetes 2023;72(12):1809–1819
https://doi.org/10.2337/db23-0465
Published: 19 September 2023
View article titled, Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations
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Journal Articles

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato
Journal: Diabetes
Diabetes 2023;72(9):1320–1329
https://doi.org/10.2337/db22-1039
Published: 26 June 2023
View article titled, Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism
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Journal Articles

Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis

Sarah C. Nyirjesy, Amy J. Peleckis, Jack N. Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J. Flatt, Diva D. De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A. D’Alessio, Ronald C. Rubenstein, Andrea Kelly, Michael R. Rickels
Journal: Diabetes
Diabetes 2022;71(10):2153–2165
https://doi.org/10.2337/db22-0399
Published: 07 July 2022
View article titled, Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis
Open the PDF for Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis in another window
Meeting Abstracts

79-LB: Pharmacokinetics and Pharmacodynamics of Avexitide (Exendin 9-39) in Neonates and Infants with Congenital Hyperinsulinism

COLLEEN CRAIG, DIVA D. DE LEON
Journal: Diabetes
Diabetes 2021;70(Supplement_1):79-LB
https://doi.org/10.2337/db21-79-LB
Published: 01 June 2021
View article titled, 79-LB: Pharmacokinetics and Pharmacodynamics of Avexitide (Exendin 9-39) in Neonates and Infants with Congenital Hyperinsulinism
Meeting Abstracts

1783-P: Effects of DPP-4 Inhibition on the Enteroinsular Axis in Pancreatic Insufficient Cystic Fibrosis

SABA SHEIKH, ANDREA KELLY, DARKO STEFANOVSKI, AMY J. PELECKIS, SARAH NYIRJESY, JACK N. EIEL, ANIKET SIDHAYE, DIVA D. DE LEON, DENIS HADJILIADIS, RONALD C. RUBENSTEIN, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1783-P
https://doi.org/10.2337/db20-1783-P
Published: 01 June 2020
View article titled, 1783-P: Effects of DPP-4 Inhibition on the Enteroinsular Axis in Pancreatic Insufficient Cystic Fibrosis
Meeting Abstracts

1182-P: A Selective Nonpeptide Somatostatin Receptor 5 (sst5) Agonist Effectively Decreases Insulin Secretion in the KATPHI Mouse Model

CHRISTINE JULIANA, JINGHUA CHAI, ELIZABETH F. RICO-BAUTISTA, STEPHEN F. BETZ, DIVA D. DE LEON
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1182-P
https://doi.org/10.2337/db19-1182-P
Published: 01 June 2019
View article titled, 1182-P: A Selective Nonpeptide Somatostatin Receptor 5 (sst5) Agonist Effectively Decreases Insulin Secretion in the KATPHI Mouse Model
Journal Articles

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley, Diva D. De León
Journal: Diabetes
Diabetes 2017;66(7):1901–1913
https://doi.org/10.2337/db17-0029
Published: 25 April 2017
View article titled, Functional and Metabolomic Consequences of K<sub>ATP</sub> Channel Inactivation in Human Islets
Open the PDF for Functional and Metabolomic Consequences of K<sub>ATP</sub> Channel Inactivation in Human Islets in another window
Includes: Supplementary data
Journal Articles

Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance

Saba Sheikh, Lalitha Gudipaty, Diva D. De Leon, Denis Hadjiliadis, Christina Kubrak, Nora K. Rosenfeld, Sarah C. Nyirjesy, Amy J. Peleckis, Saloni Malik, Darko Stefanovski, Marina Cuchel, Ronald C. Rubenstein, Andrea Kelly, Michael R. Rickels
Journal: Diabetes
Diabetes 2017;66(1):134–144
https://doi.org/10.2337/db16-0394
Published: 05 August 2016
View article titled, Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance
Open the PDF for Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance in another window
Includes: Supplementary data
Journal Articles

GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K+ Channel

Andrew C. Calabria, Changhong Li, Paul R. Gallagher, Charles A. Stanley, Diva D. De León
Journal: Diabetes
Diabetes 2012;61(10):2585–2591
https://doi.org/10.2337/db12-0166
Published: 13 September 2012
View article titled, GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K<sup>+</sup> Channel
Open the PDF for GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K<sup>+</sup> Channel in another window
Journal Articles

A Mutation in the TMD0-L0 Region of Sulfonylurea Receptor-1 (L225P) Causes Permanent Neonatal Diabetes Mellitus (PNDM)

Ricard Masia, Diva D. De Leon, Courtney MacMullen, Heather McKnight, Charles A. Stanley, Colin G. Nichols
Journal: Diabetes
Diabetes 2007;56(5):1357–1362
https://doi.org/10.2337/db06-1746
Published: 01 May 2007
View article titled, A Mutation in the TMD0-L0 Region of Sulfonylurea Receptor-1 (L225P) Causes Permanent Neonatal Diabetes Mellitus (PNDM)
Open the PDF for A Mutation in the TMD0-L0 Region of Sulfonylurea Receptor-1 (L225P) Causes Permanent Neonatal Diabetes Mellitus (PNDM) in another window