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Eddie A. James
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Journal Articles

Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects

Anita C. Hohenstein, Joylynn Gallegos, Mylinh Dang, Jason Groegler, Hali Broncucia, Fatima Tensun, Kathleen Waugh, Fran Dong, Eddie A. James, Cate Speake, Andrea K. Steck, Marian J. Rewers, Peter A. Gottlieb, Kathryn Haskins, Thomas Delong, Rocky L. Baker
Journal: Diabetes
Diabetes db240611
https://doi.org/10.2337/db24-0611
Published: 16 January 2025
View article titled, Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects
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Journal Articles

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Journal: Diabetes
Diabetes 2024;73(5):728–742
https://doi.org/10.2337/db23-0588
Published: 22 February 2024
View article titled, CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
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Journal Articles

An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes

Aïsha Callebaut, Perrin Guyer, Rocky L. Baker, Joylynn B. Gallegos, Anita C. Hohenstein, Peter A. Gottlieb, Chantal Mathieu, Lut Overbergh, Kathryn Haskins, Eddie A. James
Journal: Diabetes
Diabetes 2024;73(5):743–750
https://doi.org/10.2337/db23-0622
Published: 31 January 2024
View article titled, An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes
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Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Journal: Diabetes
Diabetes 2023;72(1):85–96
https://doi.org/10.2337/db22-0191
Published: 06 October 2022
View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes
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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Yi Jing, Yuelin Kong, John McGinty, Gabriele Blahnik-Fagan, Thomas Lee, Stephanie Orozco-Figueroa, Matthew L. Bettini, Eddie A. James, Maria Bettini
Journal: Diabetes
Diabetes 2022;71(5):1012–1022
https://doi.org/10.2337/db21-0993
Published: 18 February 2022
View article titled, T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
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Meeting Abstracts

12-OR: Metabolic Effects of Two Oral Insulin Dosing Regimens in Individuals at High Risk for Type 1 Diabetes (T1D)

MARIA J. REDONDO, JAY SOSENKO, EMILY K. SIMS, DAVID D. CUTHBERTSON, EDDIE A. JAMES, S. ALICE LONG, WILLIAM KWOK, LIPING YU, AARON W. MICHELS, ÅKE LERNMARK, PETER GOTTLIEB
Journal: Diabetes
Diabetes 2021;70(Supplement_1):12-OR
https://doi.org/10.2337/db21-12-OR
Published: 01 June 2021
View article titled, 12-OR: Metabolic Effects of Two Oral Insulin Dosing Regimens in Individuals at High Risk for Type 1 Diabetes (T1D)
Journal Articles

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Eddie A. James, Roberto Mallone, Sally C. Kent, Teresa P. DiLorenzo
Journal: Diabetes
Diabetes 2020;69(7):1311–1335
https://doi.org/10.2337/dbi19-0022
Published: 15 June 2020
View article titled, T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
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Meeting Abstracts

287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

YI JING, YUELIN KONG, JOHN MCGINTY, GABRIELE BLAHNIK-FAGAN, MATTHEW BETTINI, EDDIE A. JAMES, MARIA BETTINI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):287-OR
https://doi.org/10.2337/db20-287-OR
Published: 01 June 2020
View article titled, 287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
Journal Articles

Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01

David Arribas-Layton, Perrin Guyer, Thomas Delong, Mylinh Dang, I-Ting Chow, Cate Speake, Carla J. Greenbaum, William W. Kwok, Rocky L. Baker, Kathryn Haskins, Eddie A. James
Journal: Diabetes
Diabetes 2020;69(7):1492–1502
https://doi.org/10.2337/db19-0620
Published: 14 April 2020
View article titled, Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
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Journal Articles

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Journal: Diabetes
Diabetes 2018;67(11):2337–2348
https://doi.org/10.2337/db18-0295
Published: 11 October 2018
View article titled, Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

Eddie A. James, Massimo Pietropaolo, Mark J. Mamula
Journal: Diabetes
Diabetes 2018;67(6):1035–1042
https://doi.org/10.2337/dbi17-0030
Published: 15 May 2018
View article titled, Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance
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Journal Articles

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes

Meghan L. Marre, John W. McGinty, I-Ting Chow, Megan E. DeNicola, Noah W. Beck, Sally C. Kent, Alvin C. Powers, Rita Bottino, David M. Harlan, Carla J. Greenbaum, William W. Kwok, Jon D. Piganelli, Eddie A. James
Journal: Diabetes
Diabetes 2018;67(7):1356–1368
https://doi.org/10.2337/db17-1166
Published: 13 April 2018
View article titled, Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4<sup>+</sup> T Cells in Patients With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Direct Analysis of Insulin-Specific T Cells Provides New Insights

Eddie A. James
Journal: Diabetes
Diabetes 2017;66(12):2940–2941
https://doi.org/10.2337/dbi17-0041
Published: 14 November 2017
View article titled, Direct Analysis of Insulin-Specific T Cells Provides New Insights
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Journal Articles

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

John W. McGinty, I-Ting Chow, Carla Greenbaum, Jared Odegard, William W. Kwok, Eddie A. James
Journal: Diabetes
Diabetes 2014;63(9):3033–3040
https://doi.org/10.2337/db13-1952
Published: 16 August 2014
View article titled, Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes

Eddie A. James, William W. Kwok
Journal: Diabetes
Diabetes 2008;57(7):1788–1789
https://doi.org/10.2337/db08-0530
Published: 01 July 2008
View article titled, Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
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