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Edward W. Kraegen
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Journal Articles

Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

Asish K. Saha, X. Julia Xu, Ebony Lawson, Rosangela Deoliveira, Amanda E. Brandon, Edward W. Kraegen, Neil B. Ruderman
Journal: Diabetes
Diabetes 2010;59(10):2426–2434
https://doi.org/10.2337/db09-1870
Published: 03 August 2010
View article titled, Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
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Includes: Supplementary data
Journal Articles

Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent: Potent Tissue-Specific Effects of Medium-Chain Fatty Acids

Nigel Turner, Krit Hariharan, Jennifer TidAng, Georgia Frangioudakis, Susan M. Beale, Lauren E. Wright, Xiao Yi Zeng, Simon J. Leslie, Jing-Ya Li, Edward W. Kraegen, Gregory J. Cooney, Ji-Ming Ye
Journal: Diabetes
Diabetes 2009;58(11):2547–2554
https://doi.org/10.2337/db09-0784
Published: 31 August 2009
View article titled, Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent: <subtitle>Potent Tissue-Specific Effects of Medium-Chain Fatty Acids</subtitle>
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Journal Articles

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance

Clinton R. Bruce, Andrew J. Hoy, Nigel Turner, Matthew J. Watt, Tamara L. Allen, Kevin Carpenter, Gregory J. Cooney, Mark A. Febbraio, Edward W. Kraegen
Journal: Diabetes
Diabetes 2009;58(3):550–558
https://doi.org/10.2337/db08-1078
Published: 01 March 2009
View article titled, Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance
Open the PDF for Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

Fat Partitioning and Insulin Sensitivity: Robbing Peter to Pay Paul?

Matthew J. Watt, Edward W. Kraegen
Journal: Diabetes
Diabetes 2009;58(1):16–17
https://doi.org/10.2337/db08-1466
Published: 01 January 2009
View article titled, Fat Partitioning and Insulin Sensitivity: <subtitle>Robbing Peter to Pay Paul?</subtitle>
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Journal Articles

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W.C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, Ji-Ming Ye
Journal: Diabetes
Diabetes 2008;57(5):1414–1418
https://doi.org/10.2337/db07-1552
Published: 01 May 2008
View article titled, Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: <subtitle>A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action</subtitle>
Open the PDF for Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: <subtitle>A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action</subtitle> in another window
Includes: Supplementary data
Journal Articles

Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

Yun S. Lee, Woo S. Kim, Kang H. Kim, Myung J. Yoon, Hye J. Cho, Yun Shen, Ji-Ming Ye, Chul H. Lee, Won K. Oh, Chul T. Kim, Cordula Hohnen-Behrens, Alison Gosby, Edward W. Kraegen, David E. James, Jae B. Kim
Journal: Diabetes
Diabetes 2006;55(8):2256–2264
https://doi.org/10.2337/db06-0006
Published: 01 August 2006
View article titled, Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Open the PDF for Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States in another window
Includes: Supplementary data
Journal Articles

Acute Bidirectional Manipulation of Muscle Glucose Uptake by In Vivo Electrotransfer of Constructs Targeting Glucose Transporter Genes

Mark E. Cleasby, Jonathan R. Davey, Tracie A. Reinten, Michael W. Graham, David E. James, Edward W. Kraegen, Gregory J. Cooney
Journal: Diabetes
Diabetes 2005;54(9):2702–2711
https://doi.org/10.2337/diabetes.54.9.2702
Published: 01 September 2005
View article titled, Acute Bidirectional Manipulation of Muscle Glucose Uptake by In Vivo Electrotransfer of Constructs Targeting Glucose Transporter Genes
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Journal Articles

Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms

Mark E. Cleasby, Nicolas Dzamko, Bronwyn D. Hegarty, Gregory J. Cooney, Edward W. Kraegen, Ji-Ming Ye
Journal: Diabetes
Diabetes 2004;53(12):3258–3266
https://doi.org/10.2337/diabetes.53.12.3258
Published: 01 December 2004
View article titled, Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms
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Journal Articles

AMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin-Resistant Rats In Vivo

Miguel A. Iglesias, Stuart M. Furler, Gregory J. Cooney, Edward W. Kraegen, Ji-Ming Ye
Journal: Diabetes
Diabetes 2004;53(7):1649–1654
https://doi.org/10.2337/diabetes.53.7.1649
Published: 01 July 2004
View article titled, AMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin-Resistant Rats In Vivo
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Journal Articles

Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

Seng Khee Gan, Katherine Samaras, Campbell H. Thompson, Edward W. Kraegen, Andrew Carr, David A. Cooper, Donald J. Chisholm
Journal: Diabetes
Diabetes 2002;51(11):3163–3169
https://doi.org/10.2337/diabetes.51.11.3163
Published: 01 November 2002
View article titled, Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy
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Journal Articles

AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

Miguel A. Iglesias, Ji-Ming Ye, Georgia Frangioudakis, Asish K. Saha, Eva Tomas, Neil B. Ruderman, Gregory J. Cooney, Edward W. Kraegen
Journal: Diabetes
Diabetes 2002;51(10):2886–2894
https://doi.org/10.2337/diabetes.51.10.2886
Published: 01 October 2002
View article titled, AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats
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Journal Articles

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats

Bronwyn D. Hegarty, Gregory J. Cooney, Edward W. Kraegen, Stuart M. Furler
Journal: Diabetes
Diabetes 2002;51(5):1477–1484
https://doi.org/10.2337/diabetes.51.5.1477
Published: 01 May 2002
View article titled, Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats
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Journal Articles

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways

Katherine Baran, Elaine Preston, Donna Wilks, Gregory J. Cooney, Edward W. Kraegen, Amanda Sainsbury
Journal: Diabetes
Diabetes 2002;51(1):152–158
https://doi.org/10.2337/diabetes.51.1.152
Published: 01 January 2002
View article titled, Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways
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Journal Articles

Alteration in Phosphorylation of P20 Is Associated With Insulin Resistance

Yu Wang, Aimin Xu, Jiming Ye, Edward W. Kraegen, Cynthia A. Tse, Garth J.S. Cooper
Journal: Diabetes
Diabetes 2001;50(8):1821–1827
https://doi.org/10.2337/diabetes.50.8.1821
Published: 01 August 2001
View article titled, Alteration in Phosphorylation of P20 Is Associated With Insulin Resistance
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Journal Articles

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats: Comparison With PPAR-γ Activation

Ji-Ming Ye, Patrick J. Doyle, Miguel A. Iglesias, David G. Watson, Gregory J. Cooney, Edward W. Kraegen
Journal: Diabetes
Diabetes 2001;50(2):411–417
https://doi.org/10.2337/diabetes.50.2.411
Published: 01 February 2001
View article titled, Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats: <subtitle>Comparison With PPAR-γ Activation</subtitle>
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Journal Articles

Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

Nicholas D Oakes, Kim S Bell, Stuart M Furler, Souad Camilleri, Asish K Saha, Neil B Ruderman, Donald J Chisholm, Edward W Kraegen
Journal: Diabetes
Diabetes 1997;46(12):2022–2028
https://doi.org/10.2337/diab.46.12.2022
Published: 01 December 1997
View article titled, Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA
Open the PDF for Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA in another window
Journal Articles

Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding

Nicholas D Oakes, Gregory J Cooney, Souad Camilleri, Donald J Chisholm, Edward W Kraegen
Journal: Diabetes
Diabetes 1997;46(11):1768–1774
https://doi.org/10.2337/diab.46.11.1768
Published: 01 November 1997
View article titled, Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding
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Journal Articles

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

Carsten Schmitz-Peiffer, Carol L Browne, Nicholas D Oakes, Allan Watkinson, Donald J Chisholm, Edward W Kraegen, Trevor J Biden
Journal: Diabetes
Diabetes 1997;46(2):169–178
https://doi.org/10.2337/diab.46.2.169
Published: 01 February 1997
View article titled, Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat
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Journal Articles

Growth Hormone–Induced Insulin Resistance and Its Relationship to Lipid Availability in the Rat

Manthinda Hettiarachchi, Allan Watkinson, Arthur B Jenkins, Vicki Theos, Ken K Y Ho, Edward W Kraegen
Journal: Diabetes
Diabetes 1996;45(4):415–421
https://doi.org/10.2337/diab.45.4.415
Published: 01 April 1996
View article titled, Growth Hormone–Induced Insulin Resistance and Its Relationship to Lipid Availability in the Rat
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Journal Articles

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

Nicholas D Oakes, Catherine J Kennedy, Arthur B Jenkins, D Ross Laybutt, Donald J Chisholm, Edward W Kraegen
Journal: Diabetes
Diabetes 1994;43(10):1203–1210
https://doi.org/10.2337/diab.43.10.1203
Published: 01 October 1994
View article titled, A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat
Open the PDF for A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat in another window