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Eiichi Araki
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Meeting Abstracts

462-P: DPP-4 Deficiency Suppresses the Progression of Atherosclerosis via Inducing M2 Macrophage Polarization

YUQI ZHOU, TAKESHI MATSUMURA, YOSHITAKA YAGI, TOMOAKI YOSHINAGA, TAKAFUMI SENOKUCHI, NORIO ISHII, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):462-P
https://doi.org/10.2337/db23-462-P
Published: 20 June 2023
View articletitled, 462-P: DPP-4 Deficiency Suppresses the Progression of Atherosclerosis via Inducing M2 Macrophage Polarization
Meeting Abstracts

721-P: Insulin-Sparing Effects of Oral Semaglutide: An Analysis of PIONEER 8

VANITA R. ARODA, MORTEN T. ABILDLUND, RIKKE AGESEN, STEWART B. HARRIS, BANAFSHEH ZAHEDI, BERNARD ZINMAN, EIICHI ARAKI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):721-P
https://doi.org/10.2337/db22-721-P
Published: 01 June 2022
View articletitled, 721-P: Insulin-Sparing Effects of Oral Semaglutide: An Analysis of PIONEER 8
Meeting Abstracts

29-OR: Regulatory Loop of IR Signaling for Adipocyte Mitochondrial Homeostasis

MASAJI SAKAGUCHI, SHOTA OKAGAWA, YUMA OKUBO, KAZUKI FUKUDA, MOTOYUKI IGATA, JUNJI KAWASHIMA, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2021;70(Supplement_1):29-OR
https://doi.org/10.2337/db21-29-OR
Published: 01 June 2021
View articletitled, 29-OR: Regulatory Loop of IR Signaling for Adipocyte Mitochondrial Homeostasis
Meeting Abstracts

1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics

MASAJI SAKAGUCHI, SHOTA OKAGAWA, YUMA OKUBO, SAYAKA KITANO, MOTOYUKI IGATA, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1714-P
https://doi.org/10.2337/db20-1714-P
Published: 01 June 2020
View articletitled, 1714-P: Regulation of Phosphorylation Status in Insulin Signaling via a4 Is Necessary for Adipocyte Maintenance and Lipid Dynamics
Meeting Abstracts

1956-P: Inhibition of Tissue Macrophage Proliferation Improves Insulin Resistance in Liver and Adipose Tissue

TOSHIAKI WADA, TAKAFUMI SENOKUCHI, SARIE YAMADA, YUTARO MORITA, HIROYUKI MOTOSHIMA, TAKESHI MATSUMURA, EIICHI ARAKI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1956-P
https://doi.org/10.2337/db20-1956-P
Published: 01 June 2020
View articletitled, 1956-P: Inhibition of Tissue Macrophage Proliferation Improves Insulin Resistance in Liver and Adipose Tissue
Meeting Abstracts

1072-P: Activation of Heat Shock Response Ameliorates Nonalcoholic Fatty Liver Disease Biomarkers

TATSUYA KONDO, SAYAKA KITANO, NOBUKAZU MIYAKAWA, TAKURO WATANABE, RIEKO GOTO, MASAJI SAKAGUCHI, MOTOYUKI IGATA, JUNJI KAWASHIMA, HIROYUKI MOTOSHIMA, TAKESHI MATSUMURA, EIICHI ARAKI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1072-P
https://doi.org/10.2337/db20-1072-P
Published: 01 June 2020
View articletitled, 1072-P: Activation of Heat Shock Response Ameliorates Nonalcoholic Fatty Liver Disease Biomarkers
Meeting Abstracts

142-OR: Unique Role of the a4 Component for S6-Kinase Activity in Metabolic Regulation and Anti-apoptotic Effect in Brown Adipose Tissue

MASAJI SAKAGUCHI, SHOTA OKAGAWA, SAYAKA KITANO, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):142-OR
https://doi.org/10.2337/db19-142-OR
Published: 01 June 2019
View articletitled, 142-OR: Unique Role of the a4 Component for S6-Kinase Activity in Metabolic Regulation and Anti-apoptotic Effect in Brown Adipose Tissue
Meeting Abstracts

985-P: Oral Semaglutide as Add-On to Insulin in T2D: PIONEER 8

BERNARD ZINMAN, VANITA R. ARODA, JOHN B. BUSE, BERTRAND CARIOU, STEWART B. HARRIS, SOREN T. HOFF, KAREN BOJE PEDERSEN, MADS JEPPE TARP-JOHANSEN, EIICHI ARAKI, FOR THE PIONEER 8 INVESTIGATORS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):985-P
https://doi.org/10.2337/db19-985-P
Published: 01 June 2019
View articletitled, 985-P: Oral Semaglutide as Add-On to Insulin in T2D: PIONEER 8
Meeting Abstracts

482-P: Linagliptin Induces M2 Macrophage Polarization and Suppresses Progression of Atherosclerosis in High-Fat-Fed ApoE-Deficient Mice

SHUHEI NISHIDA, TAKESHI MATSUMURA, TAKAFUMI SENOKUCHI, NORIO ISHII, SAIKO MURAKAMI-NISHIDA, SARIE YAMADA, YUTARO MORITA, TOSHIAKI WADA, HIROYUKI MOTOSHIMA, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):482-P
https://doi.org/10.2337/db19-482-P
Published: 01 June 2019
View articletitled, 482-P: Linagliptin Induces M2 Macrophage Polarization and Suppresses Progression of Atherosclerosis in High-Fat-Fed ApoE-Deficient Mice
Meeting Abstracts

483-P: Pioglitazone Suppresses Macrophage Proliferation in Apolipoprotein-e Deficient Mice by Activating PPARγ

SAIKO MURAKAMI-NISHIDA, TAKESHI MATSUMURA, SHUHEI NISHIDA, TAKAFUMI SENOKUCHI, NORIO ISHII, SARIE YAMADA, YUTARO MORITA, TOSHIAKI WADA, HIROYUKI MOTOSHIMA, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):483-P
https://doi.org/10.2337/db19-483-P
Published: 01 June 2019
View articletitled, 483-P: Pioglitazone Suppresses Macrophage Proliferation in Apolipoprotein-e Deficient Mice by Activating PPARγ
Meeting Abstracts

1863-P: The Hepatic Role of Heat Shock Protein 72 in the Pathogenesis of Type 2 Diabetes

TATSUYA KONDO, SAYAKA KITANO, NOBUKAZU MIYAKAWA, TAKURO WATANABE, RIEKO GOTO, KAORU ONO, MOTOYUKI IGATA, JUNJI KAWASHIMA, HIROYUKI MOTOSHIMA, TAKESHI MATSUMURA, EIICHI ARAKI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1863-P
https://doi.org/10.2337/db19-1863-P
Published: 01 June 2019
View articletitled, 1863-P: The Hepatic Role of Heat Shock Protein 72 in the Pathogenesis of Type 2 Diabetes
Meeting Abstracts

Efficacy and Safety of Dapagliflozin in Patients with Inadequately Controlled Type 1 Diabetes—DEPICT-2 Study

CHANTAL MATHIEU, PARESH DANDONA, PIETER GILLARD, PETER A. SENIOR, CHRISTOPH HASSLACHER, EIICHI ARAKI, MARCUS LIND, STEPHEN C. BAIN, SERGE JABBOUR, NIKI ARYA, FREDRIK A. THOREN, ANNA MARIA LANGKILDE, ON BEHALF OF THE DEPICT-2 INVESTIGATORS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):213-OR
https://doi.org/10.2337/db18-213-OR
Published: 01 July 2018
View articletitled, Efficacy and Safety of Dapagliflozin in Patients with Inadequately Controlled Type 1 Diabetes—DEPICT-2 Study
Meeting Abstracts

Impacts of the Kumamoto Earthquake 2016 on Glycemic Control in Diabetic Patients

TATSUYA KONDO, NOBUKAZU MIYAKAWA, HIROYUKI MOTOSHIMA, NORIO ISHII, MOTOYUKI IGATA, KAYO YOSHINAGA, DAISUKE KUKIDOME, TAKAFUMI SENOKUCHI, JUNJI KAWASHIMA, TAKESHI MATSUMURA, EIICHI ARAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1635-P
https://doi.org/10.2337/db18-1635-P
Published: 01 July 2018
View articletitled, Impacts of the Kumamoto Earthquake 2016 on Glycemic Control in Diabetic Patients
Meeting Abstracts

Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin (DAPA) in Combination with Insulin in Japanese Patients with T1D

HIROTAKA WATADA, MASANARI SHIRAMOTO, SHINYA UEDA, WEIFENG TANG, MICHIKO ASANO, FREDRIK A. THOREN, HYOSUNG KIM, TOSHITAKA YAJIMA, DAVID W. BOULTON, EIICHI ARAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1170-P
https://doi.org/10.2337/db18-1170-P
Published: 01 July 2018
View articletitled, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin (DAPA) in Combination with Insulin in Japanese Patients with T1D
Meeting Abstracts

FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism

MASAJI SAKAGUCHI, WEIKANG CAI, CHIH-HAO WANG, THIAGO M. BATISTA, EIICHI ARAKI, C. RONALD KAHN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):356-OR
https://doi.org/10.2337/db18-356-OR
Published: 01 July 2018
View articletitled, FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism
Journal Articles

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis

Tatsuya Kondo, Kazunari Sasaki, Rina Matsuyama, Saori Morino-Koga, Hironori Adachi, Mary Ann Suico, Junji Kawashima, Hiroyuki Motoshima, Noboru Furukawa, Hirofumi Kai, Eiichi Araki
Journal: Diabetes
Diabetes 2012;61(4):838–847
https://doi.org/10.2337/db11-1098
Published: 14 March 2012
View articletitled, Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
Open the PDF for Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis in another window
Includes: Supplementary data
Journal Articles

Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling

Koujiro Imoto, Daisuke Kukidome, Takeshi Nishikawa, Takako Matsuhisa, Kazuhiro Sonoda, Kazuo Fujisawa, Miyuki Yano, Hiroyuki Motoshima, Tetsuya Taguchi, Kaku Tsuruzoe, Takeshi Matsumura, Hidenori Ichijo, Eiichi Araki
Journal: Diabetes
Diabetes 2006;55(5):1197–1204
https://doi.org/10.2337/db05-1187
Published: 01 May 2006
View articletitled, Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling
Open the PDF for Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling in another window
Journal Articles

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

Daisuke Kukidome, Takeshi Nishikawa, Kazuhiro Sonoda, Koujiro Imoto, Kazuo Fujisawa, Miyuki Yano, Hiroyuki Motoshima, Tetsuya Taguchi, Takeshi Matsumura, Eiichi Araki
Journal: Diabetes
Diabetes 2006;55(1):120–127
https://doi.org/10.2337/diabetes.55.01.06.db05-0943
Published: 01 January 2006
View articletitled, Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Open the PDF for Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells in another window
Journal Articles

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda, Daisuke Kukidome, Takahumi Senokuchi, Tomoko Matsuo, Takeshi Matsumura, Hiroshi Tokunaga, Michael Brownlee, Eiichi Araki
Journal: Diabetes
Diabetes 2003;52(10):2570–2577
https://doi.org/10.2337/diabetes.52.10.2570
Published: 01 October 2003
View articletitled, Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy
Open the PDF for Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy in another window
Journal Articles

Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling

Ryohei Yoshimura, Eiichi Araki, Sachiko Ura, Mikio Todaka, Kaku Tsuruzoe, Furukawa Noboru, Hiroyuki Motoshima, Kazuaki Yoshizato, Kengo Kaneko, Kohji Matsuda, Hideki Kishikawa, Motoaki Shichiri
Journal: Diabetes
Diabetes 1997;46(6):929–936
https://doi.org/10.2337/diab.46.6.929
Published: 01 June 1997
View articletitled, Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling
Open the PDF for Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling in another window