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Eleftheria Maratos-Flier
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Meeting Abstracts

859-P: ALN-KHK, an Investigational RNA Interference Therapeutic, Successfully Targets Hepatic Ketohexokinase in a Single Ascending Dose Study of Overweight to Obese Adults

Free
ELEFTHERIA MARATOS-FLIER, TIRTHA NANDI, KATHERINE BOYLE, XINGYU LI, YUANFENG WU, LEILA NOETZLI, FARSHAD KAJBAF, GAETANO MORELLI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):859-P
https://doi.org/10.2337/db24-859-P
Published: 14 June 2024
View articletitled, 859-P: ALN-KHK, an Investigational RNA Interference Therapeutic, Successfully Targets Hepatic Ketohexokinase in a Single Ascending Dose Study of Overweight to Obese Adults
Meeting Abstracts

830-P: Preclinical Development of ALN-KHK, an Investigational RNAi Therapeutic for Type 2 Diabetes Mellitus

Free
LEILA NOETZLI, ANNA BORODOVSKY, XIEN YU CHUA, ROXANNE TYMON, JUSTIN DARCY, SABRINA BELOZEROVA, MARK KEIBLER, HO-CHOU TU, ELEFTHERIA MARATOS-FLIER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):830-P
https://doi.org/10.2337/db23-830-P
Published: 20 June 2023
View articletitled, 830-P: Preclinical Development of ALN-KHK, an Investigational RNAi Therapeutic for Type 2 Diabetes Mellitus
Journal Articles

Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism

Open Access
Nabila Aboulaich, Patricia C. Chui, John M. Asara, Jeffrey S. Flier, Eleftheria Maratos-Flier
Journal: Diabetes
Diabetes 2011;60(3):757–765
https://doi.org/10.2337/db10-0744
Published: 21 February 2011
View articletitled, Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism
Open the PDF for Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism in another window
Includes: Supplementary data
Journal Articles

Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance

Open Access
Nadege Briancon, David E. McNay, Eleftheria Maratos-Flier, Jeffrey S. Flier
Journal: Diabetes
Diabetes 2010;59(12):3074–3084
https://doi.org/10.2337/db10-0481
Published: 28 September 2010
View articletitled, Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance
Open the PDF for Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance in another window
Includes: Supplementary data
Journal Articles

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Open Access
ffolliott M. Fisher, Patricia C. Chui, Patrick J. Antonellis, Holly A. Bina, Alexei Kharitonenkov, Jeffrey S. Flier, Eleftheria Maratos-Flier
Journal: Diabetes
Diabetes 2010;59(11):2781–2789
https://doi.org/10.2337/db10-0193
Published: 03 August 2010
View articletitled, Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
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Journal Articles

Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth

Free
Pavlos Pissios, Umut Ozcan, Efi Kokkotou, Terumasa Okada, Chong Wee Liew, Siming Liu, Jennifer N. Peters, Gabriella Dahlgren, Jason Karamchandani, Yogish C. Kudva, Amarnath J. Kurpad, Robert T. Kennedy, Eleftheria Maratos-Flier, Rohit N. Kulkarni
Journal: Diabetes
Diabetes 2007;56(2):311–319
https://doi.org/10.2337/db06-0708
Published: 01 February 2007
View articletitled, Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth
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Journal Articles

MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance

Free
Justin Y. Jeon, Richard L. Bradley, Efi G. Kokkotou, Francis E. Marino, Xiaomei Wang, Pavlos Pissios, Eleftheria Maratos-Flier
Journal: Diabetes
Diabetes 2006;55(2):428–434
https://doi.org/10.2337/diabetes.55.02.06.db05-0203
Published: 01 February 2006
View articletitled, MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance
Open the PDF for MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance in another window
Journal Articles

LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin

Free
Sarah H. Bates, Trevor A. Dundon, Matthew Seifert, Michael Carlson, Eleftheria Maratos-Flier, Martin G. Myers, Jr
Journal: Diabetes
Diabetes 2004;53(12):3067–3073
https://doi.org/10.2337/diabetes.53.12.3067
Published: 01 December 2004
View articletitled, LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin
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Journal Articles

Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

Free
Susann Blüher, Stergios Moschos, John Bullen, Jr., Efi Kokkotou, Eleftheria Maratos-Flier, Stanley J. Wiegand, Mark W. Sleeman, Christos S. Mantzoros
Journal: Diabetes
Diabetes 2004;53(11):2787–2796
https://doi.org/10.2337/diabetes.53.11.2787
Published: 01 November 2004
View articletitled, Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice
Open the PDF for Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice in another window
Includes: Supplementary data
Journal Articles

Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice

Free
Susann Blüher, Mary Ziotopoulou, John W. Bullen, Jr, Stergios J. Moschos, Linda Ungsunan, Efi Kokkotou, Eleftheria Maratos-Flier, Christos S. Mantzoros
Journal: Diabetes
Diabetes 2004;53(1):82–90
https://doi.org/10.2337/diabetes.53.1.82
Published: 01 January 2004
View articletitled, Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice
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Journal Articles

Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations

Free
Christos S Mantzoros, Robert C Frederich, Daqing Qu, Bradford B Lowell, Eleftheria Maratos-Flier, Jeffrey S Flier
Journal: Diabetes
Diabetes 1998;47(2):230–238
https://doi.org/10.2337/diab.47.2.230
Published: 01 February 1998
View articletitled, Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations
Open the PDF for Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations in another window
Journal Articles

Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice

Free
Christos S Mantzoros, Robert C Frederich, Jeffrey S Flier, Daqing Qu, Vedrana S Susulic, Bradford B Lowell, Eleftheria Maratos-Flier
Journal: Diabetes
Diabetes 1996;45(7):909–914
https://doi.org/10.2337/diab.45.7.909
Published: 01 July 1996
View articletitled, Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice
Open the PDF for Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice in another window