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Meeting Abstracts

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

MARTA TESI, MARA SULEIMAN, ROBERTO SEMERARO, CARMELA DE LUCA, EMANUELE BOSI, SILVIA DEL GUERRA, ALBERTO MAGI, MIRIAM CNOP, DECIO L. EIZIRIK, LORELLA MARSELLI, PIERO MARCHETTI

Diabetes 2024;73(Supplement_1):1750-P

https://doi.org/10.2337/db24-1750-P

Published: 14 June 2024

View article titled, 1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

Meeting Abstracts

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

MARA SULEIMAN, CARMELA DE LUCA, ROBERTO SEMERARO, EMANUELE BOSI, ALBERTO MAGI, MARTA TESI, SILVIA DEL GUERRA, OLIVIA PAGLIAROSI, ANNAMARIA CUDINI, LEONARDO ROSSI, DECIO L. EIZIRIK, MIRIAM CNOP, PIERO MARCHETTI, LORELLA MARSELLI, ALESSANDRA FIERABRACCI

Diabetes 2024;73(Supplement_1):1465-P

https://doi.org/10.2337/db24-1465-P

Published: 14 June 2024

View article titled, 1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

Meeting Abstracts

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1441-P

https://doi.org/10.2337/db23-1441-P

Published: 20 June 2023

View article titled, 1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

Meeting Abstracts

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1440-P

https://doi.org/10.2337/db23-1440-P

Published: 20 June 2023

View article titled, 1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

Meeting Abstracts

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

ERNESTO MADDALONI, AMALIA GASTALDELLI, LUCA NAVARINI, ROCCO AMENDOLARA, SIMONA FENIZIA, SAMANTHA PEZZICA, MARTA TESI, LUCA D'ONOFRIO, EMANUELE BOSI, FRANCESCO DOTTA, PIERO MARCHETTI, RAFFAELLA BUZZETTI

Diabetes 2023;72(Supplement_1):227-LB

https://doi.org/10.2337/db23-227-LB

Published: 20 June 2023

View article titled, 227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

Journal Articles

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Diabetes 2021;70(12):2892–2902

https://doi.org/10.2337/db21-0091

Published: 07 October 2021

View article titled, Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

Meeting Abstracts

249-OR: A Randomized, Double-Blind Phase 2 Trial of the CXCR1/2 Inhibitor Ladarixin in Adult Patients with New-Onset Type 1 Diabetes

EMANUELE BOSI, PAOLO POZZILLI, FRANCESCO GIORGINO, EFISIO COSSU, THOMAS LINN, LUDGER ROSE, BART KEYMEULEN, SR., PIETER GILLARD, LUISA DAFFONCHIO, PIER A. RUFFINI, MARCELLO ALLEGRETTI, LORENZO PIEMONTI

Diabetes 2020;69(Supplement_1):249-OR

https://doi.org/10.2337/db20-249-OR

Published: 01 June 2020

View article titled, 249-OR: A Randomized, Double-Blind Phase 2 Trial of the CXCR1/2 Inhibitor Ladarixin in Adult Patients with New-Onset Type 1 Diabetes

Journal Articles

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA_1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Michael J. Haller, S. Alice Long, J. Lori Blanchfield, Desmond A. Schatz, Jay S. Skyler, Jeffrey P. Krischer, Brian N. Bundy, Susan M. Geyer, Megan V. Warnock, Jessica L. Miller, Mark A. Atkinson, Dorothy J. Becker, David A. Baidal, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Jennifer B. Marks, Antoinette Moran, Henry Rodriguez, William E. Russell, Darrell M. Wilson, Carla J. Greenbaum, Type 1 Diabetes TrialNet ATG-GCSF Study Group, Carla J. Greenbaum, Mark A. Atkinson, David A. Baidal, Manuela Battaglia, Dorothy Becker, Penelope Bingley, Emanuele Bosi, Jane Buckner, Mark Clements, Peter G. Colman, Linda DiMeglio, Carmella Evans-Molina, Stephen E. Gitelman, Robin Goland, Peter Gottlieb, Kevan Herold, Mikael Knip, Jeffrey P. Krischer, Ake Lernmark, Wayne Moore, Antoinette Moran, Andrew Muir, Jerry Palmer, Mark Peakman, Louis Philipson, Philip Raskin, Maria Redondo, Henry Rodriguez, William Russell, Desmond A. Schatz, Jay M. Sosenko, Lisa Spain, John Wentworth, Diane Wherrett, Darrell M. Wilson, William Winter, Anette Ziegler, Mark Anderson, Peter Antinozzi, Richard Insel, Thomas Kay, Jennifer B. Marks, Alberto Pugliese, Bart Roep, Jay S. Skyler, Jorma Toppari, Carla J. Greenbaum, Jeffrey P. Krischer, Ellen Leschek, Lisa Spain, Katarzyna Bourcier, Richard Insel, John Ridge, Jay S. Skyler, Carla J. Greenbaum, Lisa Rafkin, Jay M. Sosenko, Jay S. Skyler, Irene Santiago, Jeffrey P. Krischer, Brian Bundy, Michael Abbondondolo, Timothy Adams, Ilma Asif, Jenna Bjellquist, Matthew Boonstra, Cristina Burroughs, Mario Cleves, David Cuthbertson, Meagan DeSalvatore, Christopher Eberhard, Steve Fiske, Julie Ford, Jennifer Garmeson, Susan Geyer, Brian Hays, Courtney Henderson, Martha Henry, Kathleen Heyman, Belinda Hsiao, Christina Karges, Beata-Gabriela Koziol, Lindsay Lane, Shu Liu, Jennifer Lloyd, Kristin Maddox, Jamie Malloy, Julie Martin, Cameron McNeill, Margaret Moore, Sarah Muller, Thuy Nguyen, Jodie Nunez, Ryan O’Donnell, Melissa Parker, M.J. Pereyra, Amy Roberts, Kelly Sadler, Christine Sullivan, Roy Tamura, Elon Walker-Veras, Megan V. Warnock, Keith Wood, Rebecca Wood, Ping Xu, Vanessa Yanek, Kenneth Young, Darlene Amado, Amanda Kinderman, Ashley Leinbach, Jessica Miller, Nichole Reed, Tina Stavros, Ellen Leschek, Lisa Spain, Emily Blumberg, Sean Aas, Gerald Beck, Rose Gubitosi-Klug, Lori Laffel, Robert Vigersky, Dennis Wallace, David Brillon, Robert Veatch, Brett Loechelt, Lindsey Baden, Peter Gottlieb, Michael Green, Ellen Leschek, Adriana Weinberg, Santica Marcovina, Jerry P. Palmer, Jay Tischfield, Adriana Weinberg, William Winter, Liping Yu, Annie Shultz, Emily Batts, Arielle Pagryzinski, Mary Ramey, Meghan Tobin, Kristin Fitzpatrick, Randy Guerra, Melita Romasco, Christopher Webb, Peter Gottlieb, Maya Barr, Mary Drye, Jordan Lykens, Aaron Michels, Allison Schauwecker, Andrea Steck, Paul Wadwa, Carla J. Greenbaum, Jane Buckner, Wei Hao, Sandra Lord, Marli McCulloch-Olson, Mary Ramey, Elaine Sachter, Jenna Snavely, Meghan Tobin, Corinna Tordillos, Dana VanBuecken, Robin Goland, Analia Alvarez, Magdalena Bogun, Rachelle Gandica, Natasha Leibel, Sarah Pollak, Barney Softness, Kristen Williams, Bryce Nelson, James Amrhein, Lisa Looper, Elaine Moreland, Andrew Smith, Beth Weir, Lori Wise, Linda DiMeglio, Carmella Evans-Molina, Manasa Mantravadi, Maureen Mullen, Vanessa Patrick, Maria Spall, Stephanie Woerner, Darrell M. Wilson, Nora Arrizon-Ruiz, Tandy Aye, Laura Bachrach, Karen Barahona, Trudy Esrey, Laura Nally, Stephen E. Gitelman, Mark Anderson, Glenna Auerback, Jeanne Buchanan, Christine T. Ferrara, Karen Ko, Srinath Sanda, Christine Torok, Rebecca Wesch, Michael J. Haller, Anastasia Albanese-O'Neill, Todd Brusko, Miriam Cintron, Jennifer Hosford, Laura M. Jacobsen, Henry Rohrs, Desmond A. Schatz, Janet Silverstein, Paula Towe, David A. Baidal, Carlos Blaschke, Della Matheson, Janine Sanchez, Natalia Sanders-Branca, Jay S. Skyler, Jay M. Sosenko, Antoinette Moran, Janice Leschyshyn, Jennifer McVean, Brandon Nathan, Brittney Nelson, Beth Pappenfus, Jessica Ruedy, Anne Street, Muna Sunni, Darcy Weingartner, Dorothy Becker, Kelli DeLallo, Ana Diaz, David Groscost, Mary Beth Klein, Ingrid Libman, Karen Riley, Henry Rodriguez, Sureka Bollepalli, Rachel Brownstein, Emily Eyth, Danielle Henson, Michele Laine, Dorothy Shulman, William Russell, Faith Brendle, Anne Brown, Brenna Dixon, Justin Gregory, Dan Moore, James Thomas, Kevan Herold, Laurie Feldman, William Tamborlane

Diabetes 2019;68(6):1267–1276

https://doi.org/10.2337/db19-0057

Published: 09 April 2019

View article titled, Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Includes: Supplementary data

Meeting Abstracts

Frequency of Flash Glucose Monitoring Scans and Hemoglobin A1c in Real Life

ANDREA LAURENZI, AMELIA CARETTO, MARILUCE BARRASSO, BOLLA ANDREA MARIO, CHIARA MOLINARI, ANNA ZANARDINI, NICOLETTA C. DOZIO, ELENA MENEGHINI, EMANUELE BOSI, MARINA SCAVINI

Diabetes 2018;67(Supplement_1):898-P

https://doi.org/10.2337/db18-898-P

Published: 01 July 2018

View article titled, Frequency of Flash Glucose Monitoring Scans and Hemoglobin A1c in Real Life

Meeting Abstracts

Metabolic Markers Associated with Increased Risk for Progression from Single to Multiple Autoantibodies in Type 1 Diabetes Relatives

EMANUELE BOSI, SUSAN GEYER, JAY SOSENKO, DOROTHY J. BECKER, MANUELA BATTAGLIA, HEBA M. ISMAIL, MARK A. ATKINSON, LOUIS H. PHILIPSON, JERRY P. PALMER, CARMELLA EVANS-MOLINA

Diabetes 2018;67(Supplement_1):94-OR

https://doi.org/10.2337/db18-94-OR

Published: 01 July 2018

View article titled, Metabolic Markers Associated with Increased Risk for Progression from Single to Multiple Autoantibodies in Type 1 Diabetes Relatives

Journal Articles

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Diabetes 2013;62(6):2072–2077

https://doi.org/10.2337/db12-1345

Published: 17 May 2013

View article titled, Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

Lorenzo Piemonti, Matthew J. Everly, Paola Maffi, Marina Scavini, Francesca Poli, Rita Nano, Massimo Cardillo, Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Vito Lampasona, Alejandro Espadas de Arias, Mario Scalamogna, Emanuele Bosi, Ezio Bonifacio, Antonio Secchi, Paul I. Terasaki

Diabetes 2013;62(5):1656–1664

https://doi.org/10.2337/db12-1258

Published: 16 April 2013

View article titled, Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Defective Differentiation of Regulatory FoxP3⁺ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Ester Badami, Chiara Sorini, Margherita Coccia, Vera Usuelli, Laura Molteni, Andrea Mario Bolla, Marina Scavini, Alberto Mariani, Cecile King, Emanuele Bosi, Marika Falcone

Diabetes 2011;60(8):2120–2124

https://doi.org/10.2337/db10-1201

Published: 18 July 2011

View article titled, Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2

Claudio Tiberti, Carla Giordano, Mattia Locatelli, Emanuele Bosi, Gian Franco Bottazzo, Raffaella Buzzetti, Domenico Cucinotta, Aldo Galluzzo, Alberto Falorni, Francesco Dotta

Diabetes 2008;57(5):1276–1283

https://doi.org/10.2337/db07-0874

Published: 01 May 2008

View article titled, Identification of Tyrosine Phosphatase 2(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: <subtitle>The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2</subtitle>

Includes: Supplementary data

Journal Articles

Autoantibody Response to Islet Transplantation in Type 1 Diabetes

Emanuele Bosi, Simona Braghi, Paola Maffi, Miriam Scirpoli, Federico Bertuzzi, Guido Pozza, Antonio Secchi, Ezio Bonifacio

Diabetes 2001;50(11):2464–2471

https://doi.org/10.2337/diabetes.50.11.2464

Published: 01 November 2001

View article titled, Autoantibody Response to Islet Transplantation in Type 1 Diabetes

Journal Articles

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

Michael R Christie, Stefano Genovese, David Cassidy, Emanuele Bosi, Thomas J Brown, Manuelita Lai, Ezio Bonifacio, Gian Franco Bottazzo

Diabetes 1994;43(10):1254–1259

https://doi.org/10.2337/diab.43.10.1254

Published: 01 October 1994

View article titled, Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

Journal Articles

Lack of Immunohistological Changes in the Islets of Nondiabetic, Autoimmune, Polyendocrine Patients With β-Selective GAD-Specific Islet Cell Antibodies

Richard Wagner, Jassica M McNally, Ezio Bonifacio, Stefano Genovese, Alan Foulis, Margaret McGill, Michael R Christie, Corrado Betterle, Emanuele Bosi, Gian Franco Bottazzo

Diabetes 1994;43(7):851–856

https://doi.org/10.2337/diab.43.7.851

Published: 01 July 1994

View article titled, Lack of Immunohistological Changes in the Islets of Nondiabetic, Autoimmune, Polyendocrine Patients With β-Selective GAD-Specific Islet Cell Antibodies

Journal Articles

Progression to Type I Diabetess in Autoimmune Endocrine Patients With Islet Cell Antibodies

Emanuele Bosi, Frank Becker, Ezio Bonifacio, Richard Wagner, Peter Collins, Edwin A M Gale, Gian Franco Bottazzo

Diabetes 1991;40(8):977–984

https://doi.org/10.2337/diab.40.8.977

Published: 01 August 1991

View article titled, Progression to Type I Diabetess in Autoimmune Endocrine Patients With Islet Cell Antibodies

Journal Articles

Islet Cell Autoimmunity in Type I Diabetic Patients After HLA-Mismatched Pancreas Transplantation

Emanuele Bosi, Gian Franco Bottazzo, Antonio Secchi, Guido Pozza, Marion Shattock, Anna Saunders, Albert Gelet, Jean Louis Touraine, Jules Traeger, Jean-Michel Dubernard

Diabetes 1989;38(Supplement_1):82–84

https://doi.org/10.2337/diab.38.1.S82

Published: 01 January 1989

View article titled, Islet Cell Autoimmunity in Type I Diabetic Patients After HLA-Mismatched Pancreas Transplantation

NARROW

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes

249-OR: A Randomized, Double-Blind Phase 2 Trial of the CXCR1/2 Inhibitor Ladarixin in Adult Patients with New-Onset Type 1 Diabetes

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA_1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Frequency of Flash Glucose Monitoring Scans and Hemoglobin A1c in Real Life

Metabolic Markers Associated with Increased Risk for Progression from Single to Multiple Autoantibodies in Type 1 Diabetes Relatives

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

Defective Differentiation of Regulatory FoxP3⁺ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2

Autoantibody Response to Islet Transplantation in Type 1 Diabetes

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

Lack of Immunohistological Changes in the Islets of Nondiabetic, Autoimmune, Polyendocrine Patients With β-Selective GAD-Specific Islet Cell Antibodies

Progression to Type I Diabetess in Autoimmune Endocrine Patients With Islet Cell Antibodies

Islet Cell Autoimmunity in Type I Diabetic Patients After HLA-Mismatched Pancreas Transplantation

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