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Meeting Abstracts

195-OR: The Ubiquitin-Ligase Substrate Adaptor KCTD17 Controls β-Cell Compensation to Insulin Resistance in Type 2 Diabetes

Free
DARIO F. DE JESUS, NATALIE K. BROWN, ZIJIE ZHANG, GARRETT FOGARTY, JIANGBO WEI, JIANG HU, SEVIM KAHRAMAN, ABDELFATTAH EL OUAAMARI, ERCUMENT DIRICE, CHUAN HE, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2025;74(Supplement_1):195-OR
https://doi.org/10.2337/db25-195-OR
Published: 20 June 2025
View articletitled, 195-OR: The Ubiquitin-Ligase Substrate Adaptor KCTD17 Controls β-Cell Compensation to Insulin Resistance in Type 2 Diabetes
Meeting Abstracts

2142-LB: GPR75 Signaling Mediates Beta-Cell Regeneration

Free
MUHAMMAD ISRAR KHAN, SUMAIYA ISLAM, JAMES L. CAMPANELLA, CARLEE DEFRANCESCO, STEVEN J. YOUSSEF, TURKER BILGEN, ERCUMENT DIRICE
Journal: Diabetes
Diabetes 2025;74(Supplement_1):2142-LB
https://doi.org/10.2337/db25-2142-LB
Published: 20 June 2025
View articletitled, 2142-LB: GPR75 Signaling Mediates Beta-Cell Regeneration
Meeting Abstracts

1557-P: Increased PAHSA Hydrolysis Driven by Mutant Carboxyl Ester Lipase (CEL) Contributes to Beta-Cell Dysfunction in MODY8

Free
ANNA SANTORO, SEVIM KAHRAMAN, GIORGIO BASILE, KHADIJA EL JELLAS, JIANG HU, RYAN TARPEY, BENTE B. JOHANSSON, ERCUMENT DIRICE, ISMAIL SYED, DIONICIO SIEGEL, ANDERS MOLVEN, BARBARA B. KAHN, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1557-P
https://doi.org/10.2337/db24-1557-P
Published: 14 June 2024
View articletitled, 1557-P: Increased PAHSA Hydrolysis Driven by Mutant Carboxyl Ester Lipase (CEL) Contributes to Beta-Cell Dysfunction in MODY8
Meeting Abstracts

83-OR: Defining the Transcriptome and Epitranscriptome of the ß-Cell Compensation to Insulin Resistance

Free
DARIO F. DE JESUS, ZIJIE ZHANG, JIANGBO WEI, NATALIE K. BROWN, JIANG HU, SEVIM KAHRAMAN, ERCUMENT DIRICE, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):83-OR
https://doi.org/10.2337/db23-83-OR
Published: 20 June 2023
View articletitled, 83-OR: Defining the Transcriptome and Epitranscriptome of the ß-Cell Compensation to Insulin Resistance
Meeting Abstracts

244-LB: GPR75 Ablation Protects against Diet-Induced Obesity, Inflammation, and Insulin Resistance

Free
SAKIB HOSSAIN, ERCUMENT DIRICE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):244-LB
https://doi.org/10.2337/db22-244-LB
Published: 01 June 2022
View articletitled, 244-LB: GPR75 Ablation Protects against Diet-Induced Obesity, Inflammation, and Insulin Resistance
Journal Articles

Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

Free
Khyati Girdhar, Marion Soto, Qian Huang, Lucie Orliaguet, Carly Cederquist, Bharathi Sundaresh, Jiang Hu, Maximilian Figura, Amol Raisingani, Emanuel E. Canfora, Ercument Dirice, Shiho Fujisaka, Gijs H. Goossens, Ellen E. Blaak, Rohit N. Kulkarni, C. Ronald Kahn, Emrah Altindis
Journal: Diabetes
Diabetes 2022;71(5):945–960
https://doi.org/10.2337/db21-0382
Published: 25 February 2022
View articletitled, Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones
Open the PDF for Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones in another window
Meeting Abstracts

2119-P: Deep Profiling of Phosphorylation Dynamics in Human Islets in Response to Inflammatory Cytokines

Free
ADAM C. SWENSEN, YINYIN YE, ERCUMENT DIRICE, ROHIT KULKARNI, WEIJUN QIAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2119-P
https://doi.org/10.2337/db20-2119-P
Published: 01 June 2020
View articletitled, 2119-P: Deep Profiling of Phosphorylation Dynamics in Human Islets in Response to Inflammatory Cytokines
Meeting Abstracts

187-OR: Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

Free
EMRAH ALTINDIS, MARION SOTO, LUCIE ORLIAGUET, QIAN HUANG, CARLY CEDERQUIST, ERCUMENT DIRICE, SHIHO FUJISAKA, JIANG HU, ROHIT KULKARNI, C. RONALD KAHN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):187-OR
https://doi.org/10.2337/db19-187-OR
Published: 01 June 2019
View articletitled, 187-OR: Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones
Meeting Abstracts

Maternal and Paternal Exercise Regulates Offspring Metabolic Health and Beta-Cell Phenotype

Free
JIA ZHENG, ANA B.A. WAGNER, NOAH B. PRINCE, KAWAI SO, JORAM MUL, ERCUMENT DIRICE, MICHAEL F. HIRSHMAN, KRISTIN I. STANFORD, ROHIT KULKARNI, LAURIE J. GOODYEAR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):64-OR
https://doi.org/10.2337/db18-64-OR
Published: 01 July 2018
View articletitled, Maternal and Paternal Exercise Regulates Offspring Metabolic Health and Beta-Cell Phenotype
Meeting Abstracts

NREP Bridges TGF-ß Signaling and Lipid Metabolism in the Epigenetic Reprogramming of NAFLD in the Offspring of Insulin-Resistant Parents

Free
DARIO F. DE JESUS, KAZUKI ORIME, CHIH-HAO WANG, JIANG HU, ERCUMENT DIRICE, AMÉLIA M. SILVA, YU-HUA TSENG, JUSSI PIHLAJAMAKI, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):46-OR
https://doi.org/10.2337/db18-46-OR
Published: 01 July 2018
View articletitled, NREP Bridges TGF-ß Signaling and Lipid Metabolism in the Epigenetic Reprogramming of NAFLD in the Offspring of Insulin-Resistant Parents
Journal Articles

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

Free
Ercument Dirice, Deepika Walpita, Amedeo Vetere, Bennett C. Meier, Sevim Kahraman, Jiang Hu, Vlado Dančík, Sean M. Burns, Tamara J. Gilbert, David E. Olson, Paul A. Clemons, Rohit N. Kulkarni, Bridget K. Wagner
Journal: Diabetes
Diabetes 2016;65(6):1660–1671
https://doi.org/10.2337/db15-1127
Published: 07 March 2016
View articletitled, Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
Open the PDF for Inhibition of DYRK1A Stimulates Human β-Cell Proliferation in another window
Includes: Supplementary data
Journal Articles

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

Free
Sangeeta Dhawan, Ercument Dirice, Rohit N. Kulkarni, Anil Bhushan
Journal: Diabetes
Diabetes 2016;65(5):1208–1218
https://doi.org/10.2337/db15-1331
Published: 02 March 2016
View articletitled, Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
Open the PDF for Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication in another window
Includes: Supplementary data
Journal Articles

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation

Open Access
Ercument Dirice, Sevim Kahraman, Wenyu Jiang, Abdelfattah El Ouaamari, Dario F. De Jesus, Adrian K.K. Teo, Jiang Hu, Dan Kawamori, Jason L. Gaglia, Diane Mathis, Rohit N. Kulkarni
Journal: Diabetes
Diabetes 2014;63(1):188–202
https://doi.org/10.2337/db13-0204
Published: 13 December 2013
View articletitled, Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
Open the PDF for Soluble Factors Secreted by T Cells Promote β-Cell Proliferation in another window
Includes: Supplementary data