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Meeting Abstracts

898-P: AAV-FGF21 Gene Therapy Extends Healthspan in Old Mice

VERONICA JIMENEZ, VICTOR SACRISTAN, MIQUEL GARCIA, CLAUDIA JAMBRINA, ESTEFANIA CASANA, SERGIO A. MUÑOZ, XAVIER LEON, ALBERT RIBERA, IVET ELIAS, TURA FERRE, FATIMA BOSCH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):898-P
https://doi.org/10.2337/db24-898-P
Published: 14 June 2024
View article titled, 898-P: AAV-FGF21 Gene Therapy Extends Healthspan in Old Mice
Meeting Abstracts

883-P: Brain-Directed AAV-FGF21 Gene Therapy Reverses Type 2 Diabetes, Obesity, and Cognitive Decline

FATIMA BOSCH, VICTOR SACRISTAN, ALBERT RIBERA, SARA MARCÓ COSTA, CLAUDIA JAMBRINA, VERONICA JIMENEZ, ESTEFANIA CASANA, XAVIER LEON, GEMMA ELIAS, TURA FERRE, SYLVIE FRANCKHAUSER, IVET ELIAS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):883-P
https://doi.org/10.2337/db24-883-P
Published: 14 June 2024
View article titled, 883-P: Brain-Directed AAV-FGF21 Gene Therapy Reverses Type 2 Diabetes, Obesity, and Cognitive Decline
Meeting Abstracts

880-P: Gene Therapy for MODY3 Moving from Mice to Large Animals

ESTEFANIA CASANA, VERONICA JIMENEZ, MIQUEL GARCIA, MARIA LUISA JAÉN, ALBA CASELLAS, MERITXELL MORRÓ, ANNA PUJOL, TURA FERRE, VICTOR SACRISTAN, CLAUDIA JAMBRINA, XAVIER LEON, SYLVIE FRANCKHAUSER, FATIMA BOSCH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):880-P
https://doi.org/10.2337/db24-880-P
Published: 14 June 2024
View article titled, 880-P: Gene Therapy for MODY3 Moving from Mice to Large Animals
Meeting Abstracts

838-P: Reversion of Nonalcoholic Steatohepatitis by Skeletal-Muscle Directed FGF21 Gene Therapy

VERONICA JIMENEZ, VÍCTOR SACRISTÁN, CLAUDIA JAMBRINA, MARIA LUISA JAÉN, SERGIO A. MUNOZ, ESTEFANIA CASANA, MIQUEL GARCIA, IGNASI GRASS, XAVIER LEON, IVET ELIAS, ALBERT RIBERA, GEMMA ELIAS, VICTOR SANCHEZ, ALBA CASELLAS, TURA FERRÉ, MARIA MOLAS, FATIMA BOSCH
Journal: Diabetes
Diabetes 2023;72(Supplement_1):838-P
https://doi.org/10.2337/db23-838-P
Published: 20 June 2023
View article titled, 838-P: Reversion of Nonalcoholic Steatohepatitis by Skeletal-Muscle Directed FGF21 Gene Therapy
Meeting Abstracts

855-P: Evolution of KT-A112, an AAV-Mediated Gene Therapy for the Treatment of Type 1 Diabetes

CHARI SMITH, WILLIAM W. HARRINGTON, MICHELE STONE, UMA KARADGE, JIEWU LIU, WILLIAM J. QUINN, III, ASHLYN BASSIRI, JASON MALLORY, VERONICA JIMENEZ, FATIMA BOSCH, MELISSA RHODES
Journal: Diabetes
Diabetes 2023;72(Supplement_1):855-P
https://doi.org/10.2337/db23-855-P
Published: 20 June 2023
View article titled, 855-P: Evolution of KT-A112, an AAV-Mediated Gene Therapy for the Treatment of Type 1 Diabetes
Meeting Abstracts

826-P: Treatment of MODY3 Disease by AAV-Hnf1a-Mediated Gene Therapy

ESTEFANIA CASANA LORENTE, VERONICA JIMENEZ, MIQUEL GARCIA, ALBA CASELLAS, MERITXELL MORRÓ, ANNA PUJOL, TURA FERRÉ, VÍCTOR SACRISTÁN, CLAUDIA JAMBRINA, XAVIER LEON, SYLVIE FRANCKHAUSER, FATIMA BOSCH
Journal: Diabetes
Diabetes 2023;72(Supplement_1):826-P
https://doi.org/10.2337/db23-826-P
Published: 20 June 2023
View article titled, 826-P: Treatment of MODY3 Disease by AAV-Hnf1a-Mediated Gene Therapy
Journal Articles

Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice

Meritxell Morró, Laia Vilà, Sylvie Franckhauser, Cristina Mallol, Gemma Elias, Tura Ferré, Maria Molas, Estefanía Casana, Jordi Rodó, Anna Pujol, Noèlia Téllez, Fàtima Bosch, Alba Casellas
Journal: Diabetes
Diabetes 2020;69(5):927–939
https://doi.org/10.2337/db19-0757
Published: 21 February 2020
View article titled, Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice
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Includes: Supplementary data
Meeting Abstracts

AAV-Mediated Overexpression of BMP7 in White Adipose Tissue Induces Adipogenesis and Ameliorates Insulin Resistance

ESTEFANIA CASANA LORENTE, VERONICA JIMENEZ, VICTOR SACRISTÁN FRAILE, SERGIO A. MUÑOZ, CLAUDIA JAMBRINA PALLARÉS, JORDI RODÓ, SARA DARRIBA, CRISTINA MALLOL, MIQUEL GARCIA, XAVIER LEON, IGNASI GRASS, SYLVIE FRANCKHAUSER, FATIMA BOSCH
Journal: Diabetes
Diabetes 2018;67(Supplement_1):231-LB
https://doi.org/10.2337/db18-231-LB
Published: 01 July 2018
View article titled, AAV-Mediated Overexpression of BMP7 in White Adipose Tissue Induces Adipogenesis and Ameliorates Insulin Resistance
Journal Articles

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance

Ivet Elias, Tura Ferré, Laia Vilà, Sergio Muñoz, Alba Casellas, Miquel Garcia, Maria Molas, Judith Agudo, Carles Roca, Jesús Ruberte, Fatima Bosch, Sylvie Franckhauser
Journal: Diabetes
Diabetes 2016;65(8):2139–2150
https://doi.org/10.2337/db16-0040
Published: 03 May 2016
View article titled, ALOX5AP Overexpression in Adipose Tissue Leads to LXA<sub>4</sub> Production and Protection Against Diet-Induced Obesity and Insulin Resistance
Open the PDF for ALOX5AP Overexpression in Adipose Tissue Leads to LXA<sub>4</sub> Production and Protection Against Diet-Induced Obesity and Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice

Veronica Jimenez, Sergio Muñoz, Estefania Casana, Cristina Mallol, Ivet Elias, Claudia Jambrina, Albert Ribera, Tura Ferre, Sylvie Franckhauser, Fatima Bosch
Journal: Diabetes
Diabetes 2013;62(12):4012–4022
https://doi.org/10.2337/db13-0311
Published: 16 November 2013
View article titled, In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice
Open the PDF for In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice in another window
Includes: Supplementary data
Journal Articles

Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy

David Callejas, Christopher J. Mann, Eduard Ayuso, Ricardo Lage, Iris Grifoll, Carles Roca, Anna Andaluz, Rafael Ruiz-de Gopegui, Joel Montané, Sergio Muñoz, Tura Ferre, Virginia Haurigot, Shangzhen Zhou, Jesús Ruberte, Federico Mingozzi, Katherine A. High, Felix Garcia, Fatima Bosch
Journal: Diabetes
Diabetes 2013;62(5):1718–1729
https://doi.org/10.2337/db12-1113
Published: 16 April 2013
View article titled, Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy
Open the PDF for Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy in another window
Includes: Multimedia, Supplementary data
Journal Articles

Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice

Xavier M. Anguela, Sabrina Tafuro, Carles Roca, David Callejas, Judith Agudo, Mercè Obach, Albert Ribera, Albert Ruzo, Christopher J. Mann, Alba Casellas, Fatima Bosch
Journal: Diabetes
Diabetes 2013;62(2):551–560
https://doi.org/10.2337/db11-1776
Published: 17 January 2013
View article titled, Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
Open the PDF for Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice in another window
Includes: Supplementary data
Journal Articles

Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813

Ivet Elias, Sylvie Franckhauser, Fatima Bosch
Journal: Diabetes
Diabetes 2013;62(1):e4
https://doi.org/10.2337/db12-1274
Published: 13 December 2012
View article titled, Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813
Open the PDF for Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813 in another window
Journal Articles

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass

Judith Agudo, Eduard Ayuso, Veronica Jimenez, Alba Casellas, Cristina Mallol, Ariana Salavert, Sabrina Tafuro, Mercè Obach, Albert Ruzo, Marta Moya, Anna Pujol, Fatima Bosch
Journal: Diabetes
Diabetes 2012;61(11):2851–2861
https://doi.org/10.2337/db12-0134
Published: 16 October 2012
View article titled, Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass
Open the PDF for Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass in another window
Includes: Supplementary data
Journal Articles

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

Ivet Elias, Sylvie Franckhauser, Tura Ferré, Laia Vilà, Sabrina Tafuro, Sergio Muñoz, Carles Roca, David Ramos, Anna Pujol, Efren Riu, Jesús Ruberte, Fatima Bosch
Journal: Diabetes
Diabetes 2012;61(7):1801–1813
https://doi.org/10.2337/db11-0832
Published: 15 June 2012
View article titled, Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
Open the PDF for Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction

Anita M. Hennige, Felicia Ranta, Isabel Heinzelmann, Martina Düfer, Diana Michael, Heidi Braumüller, Stefan Z. Lutz, Reiner Lammers, Gisela Drews, Fatima Bosch, Hans-Ulrich Häring, Susanne Ullrich
Journal: Diabetes
Diabetes 2010;59(1):119–127
https://doi.org/10.2337/db09-0512
Published: 13 October 2009
View article titled, Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction
Open the PDF for Overexpression of Kinase-Negative Protein Kinase Cδ in Pancreatic β-Cells Protects Mice From Diet-Induced Glucose Intolerance and β-Cell Dysfunction in another window
Includes: Supplementary data
Journal Articles

PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic β-Cells

Claudia Miele, Gregory Alexander Raciti, Angela Cassese, Chiara Romano, Ferdinando Giacco, Francesco Oriente, Flora Paturzo, Francesco Andreozzi, Assunta Zabatta, Giancarlo Troncone, Fatima Bosch, Anna Pujol, Hervé Chneiweiss, Pietro Formisano, Francesco Beguinot
Journal: Diabetes
Diabetes 2007;56(3):622–633
https://doi.org/10.2337/db06-1260
Published: 01 March 2007
View article titled, PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic β-Cells
Open the PDF for PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic β-Cells in another window
Journal Articles

Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes

Alba Casellas, Ariana Salavert, Judith Agudo, Eduard Ayuso, Veronica Jimenez, Marta Moya, Sergio Muñoz, Sylvie Franckhauser, Fatima Bosch
Journal: Diabetes
Diabetes 2006;55(12):3246–3255
https://doi.org/10.2337/db06-0328
Published: 01 December 2006
View article titled, Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes
Open the PDF for Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes in another window
Journal Articles

Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle

Alex Mas, Joel Montané, Xavier M. Anguela, Sergio Muñoz, Anne M. Douar, Efren Riu, Pedro Otaegui, Fatima Bosch
Journal: Diabetes
Diabetes 2006;55(6):1546–1553
https://doi.org/10.2337/db05-1615
Published: 01 June 2006
View article titled, Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle
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Journal Articles

Adipose Overexpression of Phosphoenolpyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity

Sylvie Franckhauser, Sergio Muñoz, Ivet Elias, Tura Ferre, Fatima Bosch
Journal: Diabetes
Diabetes 2006;55(2):273–280
https://doi.org/10.2337/diabetes.55.02.06.db05-0482
Published: 01 February 2006
View article titled, Adipose Overexpression of Phospho<em>enol</em>pyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity
Open the PDF for Adipose Overexpression of Phospho<em>enol</em>pyruvate Carboxykinase Leads to High Susceptibility to Diet-Induced Insulin Resistance and Obesity in another window