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Fausto Machicao
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Journal Articles

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stančáková, Han Chen, Ching-Ti Liu, Jaeyoung Hong, Richard A. Jensen, Ken Rice, Andrew P. Morris, Reedik Mägi, Anke Tönjes, Inga Prokopenko, Marcus E. Kleber, Graciela Delgado, Günther Silbernagel, Anne U. Jackson, Emil V. Appel, Niels Grarup, Joshua P. Lewis, May E. Montasser, Claes Landenvall, Harald Staiger, Jian’an Luan, Timothy M. Frayling, Michael N. Weedon, Weijia Xie, Sonsoles Morcillo, María Teresa Martínez-Larrad, Mary L. Biggs, Yii-Der Ida Chen, Arturo Corbaton-Anchuelo, Kristine Færch, Juan Miguel Gómez-Zumaquero, Mark O. Goodarzi, Jorge R. Kizer, Heikki A. Koistinen, Aaron Leong, Lars Lind, Cecilia Lindgren, Fausto Machicao, Alisa K. Manning, Gracia María Martín-Núñez, Gemma Rojo-Martínez, Jerome I. Rotter, David S. Siscovick, Joseph M. Zmuda, Zhongyang Zhang, Manuel Serrano-Rios, Ulf Smith, Federico Soriguer, Torben Hansen, Torben J. Jørgensen, Allan Linnenberg, Oluf Pedersen, Mark Walker, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Leif Groop, Jeff R. O’Connell, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Winfried März, Peter Kovacs, Michael Stumvoll, Bruce M. Psaty, Johanna Kuusisto, Markku Laakso, James B. Meigs, Josée Dupuis, Erik Ingelsson, Jose C. Florez
Journal: Diabetes
Diabetes 2016;65(10):3200–3211
https://doi.org/10.2337/db16-0199
Published: 14 July 2016
View article titled, Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies <em>BCL2</em> and <em>FAM19A2</em> as Novel Insulin Sensitivity Loci
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Includes: Supplementary data
Journal Articles

The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway

Leen M. ‘t Hart, Andreas Fritsche, Giel Nijpels, Nienke van Leeuwen, Louise A. Donnelly, Jacqueline M. Dekker, Marjan Alssema, Joao Fadista, Françoise Carlotti, Anette P. Gjesing, Colin N.A. Palmer, Timon W. van Haeften, Silke A. Herzberg-Schäfer, Annemarie M.C. Simonis-Bik, Jeanine J. Houwing-Duistermaat, Quinta Helmer, Joris Deelen, Bruno Guigas, Torben Hansen, Fausto Machicao, Gonneke Willemsen, Robert J. Heine, Mark H.H. Kramer, Jens J. Holst, Eelco J.P. de Koning, Hans-Ulrich Häring, Oluf Pedersen, Leif Groop, Eco J.C. de Geus, P. Eline Slagboom, Dorret I. Boomsma, Elisabeth M.W. Eekhoff, Ewan R. Pearson, Michaela Diamant
Journal: Diabetes
Diabetes 2013;62(9):3275–3281
https://doi.org/10.2337/db13-0227
Published: 15 August 2013
View article titled, The <em>CTRB1/2</em> Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway
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Includes: Supplementary data
Journal Articles

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

Robert Wagner, Gabriele Kaiser, Felicia Gerst, Elisabeth Christiansen, Maria E. Due-Hansen, Manuel Grundmann, Fausto Machicao, Andreas Peter, Evi Kostenis, Trond Ulven, Andreas Fritsche, Hans-Ulrich Häring, Susanne Ullrich
Journal: Diabetes
Diabetes 2013;62(6):2106–2111
https://doi.org/10.2337/db12-1249
Published: 17 May 2013
View article titled, Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans
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Includes: Supplementary data
Journal Articles

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans

Andreas Peter, Konstantinos Kantartzis, Jürgen Machann, Fritz Schick, Harald Staiger, Fausto Machicao, Erwin Schleicher, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan
Journal: Diabetes
Diabetes 2010;59(12):3167–3173
https://doi.org/10.2337/db10-0179
Published: 14 September 2010
View article titled, Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
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Journal Articles

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion

Martin Heni, Caroline Ketterer, Claus Thamer, Silke A. Herzberg-Schäfer, Martina Guthoff, Norbert Stefan, Fausto Machicao, Harald Staiger, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2010;59(12):3247–3252
https://doi.org/10.2337/db10-0674
Published: 29 August 2010
View article titled, Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
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Includes: Supplementary data
Journal Articles

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes

Axel Haupt, Claus Thamer, Martin Heni, Caroline Ketterer, Jürgen Machann, Fritz Schick, Fausto Machicao, Norbert Stefan, Claus D. Claussen, Hans-Ulrich Häring, Andreas Fritsche, Harald Staiger
Journal: Diabetes
Diabetes 2010;59(3):747–750
https://doi.org/10.2337/db09-1050
Published: 22 December 2009
View article titled, Gene Variants of <em>TCF7L2</em> Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

Leen M. ‘t Hart, Annemarie M. Simonis-Bik, Giel Nijpels, Timon W. van Haeften, Silke A. Schäfer, Jeanine J. Houwing-Duistermaat, Dorret I. Boomsma, Marlous J. Groenewoud, Erwin Reiling, Els C. van Hove, Michaela Diamant, Mark H.H. Kramer, Robert J. Heine, J. Antonie Maassen, Kerstin Kirchhoff, Fausto Machicao, Hans-Ulrich Häring, P. Eline Slagboom, Gonneke Willemsen, Elisabeth M. Eekhoff, Eco J. de Geus, Jacqueline M. Dekker, Andreas Fritsche
Journal: Diabetes
Diabetes 2010;59(1):287–292
https://doi.org/10.2337/db09-0736
Published: 06 October 2009
View article titled, Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps
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Includes: Supplementary data
Journal Articles

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

Konstantinos Kantartzis, Andreas Peter, Fausto Machicao, Jürgen Machann, Silvia Wagner, Ingmar Königsrainer, Alfred Königsrainer, Fritz Schick, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan
Journal: Diabetes
Diabetes 2009;58(11):2616–2623
https://doi.org/10.2337/db09-0279
Published: 03 August 2009
View article titled, Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
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Journal Articles

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

Andreas Peter, Cora Weigert, Harald Staiger, Fausto Machicao, Fritz Schick, Jürgen Machann, Norbert Stefan, Claus Thamer, Hans-Ulrich Häring, Erwin Schleicher
Journal: Diabetes
Diabetes 2009;58(8):1757–1765
https://doi.org/10.2337/db09-0188
Published: 28 May 2009
View article titled, Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
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Journal Articles

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion

Karsten Müssig, Harald Staiger, Fausto Machicao, Kerstin Kirchhoff, Martina Guthoff, Silke A. Schäfer, Konstantinos Kantartzis, Günther Silbernagel, Norbert Stefan, Jens J. Holst, Baptist Gallwitz, Hans-Ulrich Häring, Andreas Fritsche
Journal: Diabetes
Diabetes 2009;58(7):1715–1720
https://doi.org/10.2337/db08-1589
Published: 14 April 2009
View article titled, Association of Type 2 Diabetes Candidate Polymorphisms in <em>KCNQ1</em> With Incretin and Insulin Secretion
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Includes: Supplementary data
Journal Articles

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans

Harald Staiger, Carina Haas, Jürgen Machann, Roman Werner, Melanie Weisser, Fritz Schick, Fausto Machicao, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2009;58(3):579–589
https://doi.org/10.2337/db07-1438
Published: 01 March 2009
View article titled, Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
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Includes: Supplementary data
Journal Articles

Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells

Harald Staiger, Katrin Staiger, Norbert Stefan, Hans Günther Wahl, Fausto Machicao, Monika Kellerer, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2004;53(12):3209–3216
https://doi.org/10.2337/diabetes.53.12.3209
Published: 01 December 2004
View article titled, Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells
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Journal Articles

Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism

Harald Staiger, Simone Kaltenbach, Katrin Staiger, Norbert Stefan, Andreas Fritsche, Alke Guirguis, Claudia Péterfi, Melanie Weisser, Fausto Machicao, Michael Stumvoll, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2004;53(9):2195–2201
https://doi.org/10.2337/diabetes.53.9.2195
Published: 01 September 2004
View article titled, Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism
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Journal Articles

Genetic Factors and Insulin Secretion: Gene Variants in the IGF Genes

Leen M. ’t Hart, Andreas Fritsche, Ingrid Rietveld, Jacqueline M. Dekker, Giel Nijpels, Fausto Machicao, Michael Stumvoll, Cornelia M. van Duijn, Hans U. Häring, Robert J. Heine, J. Antonie Maassen, Timon W. van Haeften
Journal: Diabetes
Diabetes 2004;53(suppl_1):S26–S30
https://doi.org/10.2337/diabetes.53.2007.S26
Published: 01 February 2004
View article titled, Genetic Factors and Insulin Secretion: <subtitle>Gene Variants in the IGF Genes</subtitle>
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Journal Articles

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Otto Tschritter, Michael Stumvoll, Fausto Machicao, Martin Holzwarth, Melanie Weisser, Elke Maerker, Anna Teigeler, Hans Häring, Andreas Fritsche
Journal: Diabetes
Diabetes 2002;51(9):2854–2860
https://doi.org/10.2337/diabetes.51.9.2854
Published: 01 September 2002
View article titled, The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia
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Journal Articles

Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures

Hans Günther Wahl, Christiana Kausch, Fausto Machicao, Kristian Rett, Michael Stumvoll, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2002;51(4):1060–1065
https://doi.org/10.2337/diabetes.51.4.1060
Published: 01 April 2002
View article titled, Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures
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Journal Articles

Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes

Michael Stumvoll, Otto Tschritter, Andreas Fritsche, Harald Staiger, Walter Renn, Melanie Weisser, Fausto Machicao, Hans Häring
Journal: Diabetes
Diabetes 2002;51(1):37–41
https://doi.org/10.2337/diabetes.51.1.37
Published: 01 January 2002
View article titled, Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: <subtitle>Interaction With Family History of Type 2 Diabetes </subtitle>
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Journal Articles

Functional Significance of the UCSNP-43 Polymorphism in the CAPN10 Gene for Proinsulin Processing and Insulin Secretion in Nondiabetic Germans

Michael Stumvoll, Andreas Fritsche, Alexander Madaus, Norbert Stefan, Melanie Weisser, Fausto Machicao, Hans Häring
Journal: Diabetes
Diabetes 2001;50(9):2161–2163
https://doi.org/10.2337/diabetes.50.9.2161
Published: 01 September 2001
View article titled, Functional Significance of the UCSNP-43 Polymorphism in the CAPN10 Gene for Proinsulin Processing and Insulin Secretion in Nondiabetic Germans
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Journal Articles

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

Michael Stumvoll, Hans Günther Wahl, Klaus Löblein, Regine Becker, Fausto Machicao, Stephan Jacob, Hans Häring
Journal: Diabetes
Diabetes 2001;50(4):876–881
https://doi.org/10.2337/diabetes.50.4.876
Published: 01 April 2001
View article titled, Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ<sub>2</sub> Gene Is Associated With Increased Antilipolytic Insulin Sensitivity
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Journal Articles

The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans

Michael Stumvoll, Andreas Fritsche, Annette Volk, Norbert Stefan, Alexander Madaus, Elke Maerker, Anna Teigeler, Matthias Koch, Fausto Machicao, Hans Häring
Journal: Diabetes
Diabetes 2001;50(4):882–885
https://doi.org/10.2337/diabetes.50.4.882
Published: 01 April 2001
View article titled, The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans
Open the PDF for The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans in another window