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Feng Liu
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Meeting Abstracts

2018-LB: ABHD17B Modulates Diet-Induced Abdominal Obesity and Chronic Inflammation

JASON HADLEY, JIYOON RYU, JULI BAI, MEIXIA PAN, HANMEI BAO, XIANLIN HAN, ELIZABETH LEADBETTER, FENG LIU, LILY Q. DONG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2018-LB
https://doi.org/10.2337/db24-2018-LB
Published: 14 June 2024
View article titled, 2018-LB: ABHD17B Modulates Diet-Induced Abdominal Obesity and Chronic Inflammation
Meeting Abstracts

1626-P: Liver-Specific Silencing of INHBE with ARO-INHBE, an siRNA Therapeutic, for Metabolic Diseases

MICHELLE NGAI, FENG LIU, XIAOKAI LI, COLE CHRISTY, HOLLY HAMILTON, TAO PEI, JAMES HAMILTON, ZHI-MING DING
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1626-P
https://doi.org/10.2337/db24-1626-P
Published: 14 June 2024
View article titled, 1626-P: Liver-Specific Silencing of INHBE with ARO-INHBE, an siRNA Therapeutic, for Metabolic Diseases
Meeting Abstracts

724-P: A First-in-Human Study of RGT-075, a Novel, Orally Bioavailable, Small-Molecule GLP-1 Receptor Agonist, in Healthy Adult Subjects

MARK A. PIRNER, JING LIN, FENG LIU, LILI YAO, MARJORIE E. ZETTLER, DAVID J. VALACER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):724-P
https://doi.org/10.2337/db22-724-P
Published: 01 June 2022
View article titled, 724-P: A First-in-Human Study of RGT-075, a Novel, Orally Bioavailable, Small-Molecule GLP-1 Receptor Agonist, in Healthy Adult Subjects
Meeting Abstracts

94-LB: A Phase 1, Double-Blind, Placebo-Controlled Multiple Escalating Dose Study of RGT-075 Novel Small-Molecule Oral GLP-1 Receptor Agonist in Adults with Type 2 Diabetes

MARK A. PIRNER, JING LIN, FENG LIU, LILI YAO, MARJORIE E. ZETTLER, DAVID J. VALACER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):94-LB
https://doi.org/10.2337/db22-94-LB
Published: 01 June 2022
View article titled, 94-LB: A Phase 1, Double-Blind, Placebo-Controlled Multiple Escalating Dose Study of RGT-075 Novel Small-Molecule Oral GLP-1 Receptor Agonist in Adults with Type 2 Diabetes
Meeting Abstracts

753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models

FENG LIU, XIANQIANG SUN, WEI HUANG, WEI GUO, JING LIN, WENGE ZHONG
Journal: Diabetes
Diabetes 2022;71(Supplement_1):753-P
https://doi.org/10.2337/db22-753-P
Published: 01 June 2022
View article titled, 753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models
Journal Articles

Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

Jiyoon Ryu, Jason T. Hadley, Zhi Li, Feng Dong, Huan Xu, Xiaoban Xin, Ye Zhang, Cang Chen, Senlin Li, Xiaoning Guo, Jared L. Zhao, Robin J. Leach, Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Amrita Kamat, Feng Liu, Lily Q. Dong
Journal: Diabetes
Diabetes 2021;70(6):1303–1316
https://doi.org/10.2337/db20-1073
Published: 18 March 2021
View article titled, Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration
Open the PDF for Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration in another window
Meeting Abstracts

2123-P: Targeted Deletion of Grb10 in Pancreatic ß-Cells Increases ß-Cell Mass via mTORC-Dependent Inhibition of Cell Dedifferentiation

JINGJING ZHANG, FENG LIU
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2123-P
https://doi.org/10.2337/db20-2123-P
Published: 01 June 2020
View article titled, 2123-P: Targeted Deletion of Grb10 in Pancreatic ß-Cells Increases ß-Cell Mass via mTORC-Dependent Inhibition of Cell Dedifferentiation
Journal Articles

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

Juli Bai, Feng Liu
Journal: Diabetes
Diabetes 2019;68(6):1099–1108
https://doi.org/10.2337/dbi18-0052
Published: 13 May 2019
View article titled, The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
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Journal Articles

Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008;57: 1246–1253

Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpisek, David Stejskal, Zhi-Guang Zhou, Feng Liu, Rachel L.C. Wong, Wing-Sun Chow, Annette W.K. Tso, Karen S.L. Lam, Aimin Xu
Journal: Diabetes
Diabetes 2019;68(1):235
https://doi.org/10.2337/db19-er01c
Published: 19 November 2018
View article titled, Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008;57: 1246–1253
Open the PDF for Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008;57: 1246–1253 in another window
Journal Articles

Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network

Linyun He, Mowei Tang, Ting Xiao, Hailan Liu, Wei Liu, Guangdi Li, Feng Zhang, Yalun Xiao, Zhiguang Zhou, Feng Liu, Fang Hu
Journal: Diabetes
Diabetes 2018;67(12):2585–2600
https://doi.org/10.2337/db18-0626
Published: 02 October 2018
View article titled, Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network
Open the PDF for Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network in another window
Includes: Supplementary data
Journal Articles

Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin–Axin2–GSK3β Signaling Pathway

Yuan-Yuan Xie, Chun-Li Mo, Yi-Huang Cai, Wen-Jie Wang, Xin-Xin Hong, Kun-Kun Zhang, Qing-Feng Liu, Yun-Jia Liu, Jing-Jing Hong, Ting He, Zhong-Zheng Zheng, Wei Mo, Bo-An Li
Journal: Diabetes
Diabetes 2018;67(12):2569–2584
https://doi.org/10.2337/db18-0311
Published: 02 October 2018
View article titled, Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin–Axin2–GSK3β Signaling Pathway
Open the PDF for Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin–Axin2–GSK3β Signaling Pathway in another window
Includes: Supplementary data
Meeting Abstracts

Pancreatic ß-Cell Specific Knockout of Grb10 Improves ß-Cell Function by Enhancing ß-Cell Differentiation and Suppressing ß-Cell Dedifferentiation

JINGJING ZHANG, ZIXIN CAI, FENG LIU
Journal: Diabetes
Diabetes 2018;67(Supplement_1):306-LB
https://doi.org/10.2337/db18-306-LB
Published: 01 July 2018
View article titled, Pancreatic ß-Cell Specific Knockout of Grb10 Improves ß-Cell Function by Enhancing ß-Cell Differentiation and Suppressing ß-Cell Dedifferentiation
Journal Articles

Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway

Wen Meng, Xiuci Liang, Hongzhi Chen, Hairong Luo, Juli Bai, Guangdi Li, Qinghai Zhang, Ting Xiao, Sijia He, Yacheng Zhang, Zhipeng Xu, Bo Xiao, Meilian Liu, Fang Hu, Feng Liu
Journal: Diabetes
Diabetes 2017;66(5):1198–1213
https://doi.org/10.2337/db16-0886
Published: 27 February 2017
View article titled, Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway
Open the PDF for Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway in another window
Includes: Supplementary data
Journal Articles

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140

Fang Hu, Min Wang, Ting Xiao, Bangqi Yin, Linyun He, Wen Meng, Meijuan Dong, Feng Liu
Journal: Diabetes
Diabetes 2015;64(6):2056–2068
https://doi.org/10.2337/db14-1117
Published: 09 January 2015
View article titled, miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140
Open the PDF for miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140 in another window
Journal Articles

Negative Regulation of DsbA-L Gene Expression by the Transcription Factor Sp1

Qichen Fang, Wenjing Yang, Huating Li, Wenxiu Hu, Lihui Chen, Shan Jiang, Kun Dong, Qianqian Song, Chen Wang, Shuo Chen, Feng Liu, Weiping Jia
Journal: Diabetes
Diabetes 2014;63(12):4165–4171
https://doi.org/10.2337/db14-0182
Published: 13 November 2014
View article titled, Negative Regulation of DsbA-L Gene Expression by the Transcription Factor Sp1
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Journal Articles

Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

Xiaocen Kong, Jing Yu, Jianhua Bi, Hanmei Qi, Wenjuan Di, Lin Wu, Long Wang, Juanmin Zha, Shan Lv, Feng Zhang, Yan Li, Fang Hu, Feng Liu, Hong Zhou, Juan Liu, Guoxian Ding
Journal: Diabetes
Diabetes 2015;64(2):393–404
https://doi.org/10.2337/db14-0395
Published: 02 September 2014
View article titled, Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
Open the PDF for Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue in another window
Includes: Supplementary data
Journal Articles

Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis

Haibo Sha, Liu Yang, Meilian Liu, Sheng Xia, Yong Liu, Feng Liu, Sander Kersten, Ling Qi
Journal: Diabetes
Diabetes 2014;63(3):867–879
https://doi.org/10.2337/db13-1067
Published: 13 February 2014
View article titled, Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis
Open the PDF for Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis in another window
Includes: Supplementary data
Journal Articles

Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis

Jingjing Zhang, Ning Zhang, Meilian Liu, Xiuling Li, Lijun Zhou, Wei Huang, Zhipeng Xu, Jing Liu, Nicolas Musi, Ralph A. DeFronzo, John M. Cunningham, Zhiguang Zhou, Xin-Yun Lu, Feng Liu
Journal: Diabetes
Diabetes 2012;61(12):3189–3198
https://doi.org/10.2337/db12-0249
Published: 15 November 2012
View article titled, Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis
Open the PDF for Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis in another window
Includes: Supplementary data
Journal Articles

Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance

Meilian Liu, Ruihua Xiang, Sarah Ann Wilk, Ning Zhang, Lauren B. Sloane, Kian Azarnoush, Lijun Zhou, Hongzhi Chen, Guangda Xiang, Christi A. Walter, Steven N. Austad, Nicolas Musi, Ralph A. DeFronzo, Reto Asmis, Philipp E. Scherer, Lily Q. Dong, Feng Liu
Journal: Diabetes
Diabetes 2012;61(11):2776–2786
https://doi.org/10.2337/db12-0169
Published: 16 October 2012
View article titled, Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance
Open the PDF for Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation

Lijun Zhou, Meilian Liu, Jingjing Zhang, Hongzhi Chen, Lily Q. Dong, Feng Liu
Journal: Diabetes
Diabetes 2010;59(11):2809–2816
https://doi.org/10.2337/db10-0412
Published: 10 August 2010
View article titled, DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation
Open the PDF for DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation in another window
Includes: Supplementary data