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Journal Articles

Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings

Caroline Frørup, Mathias Høj Jensen, Martin Haupt-Jorgensen, Karsten Buschard, Joachim Størling, Flemming Pociot, Tina Fløyel
Journal: Diabetes
Diabetes 2024;73(8):1278–1284
https://doi.org/10.2337/db23-0911
Published: 03 May 2024
View articletitled, Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings
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Journal Articles

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Tina Fløyel, Kira Meyerovich, Michala C. Prause, Simranjeet Kaur, Caroline Frørup, Henrik B. Mortensen, Lotte B. Nielsen, Flemming Pociot, Alessandra K. Cardozo, Joachim Størling
Journal: Diabetes
Diabetes 2021;70(2):464–476
https://doi.org/10.2337/db20-0092
Published: 17 November 2020
View articletitled, SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients
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Journal Articles

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Laura Marroqui, Reinaldo Sousa Dos Santos, Tina Fløyel, Fabio A. Grieco, Izortze Santin, Anne Op de beeck, Lorella Marselli, Piero Marchetti, Flemming Pociot, Decio L. Eizirik
Journal: Diabetes
Diabetes 2015;64(11):3808–3817
https://doi.org/10.2337/db15-0362
Published: 03 August 2015
View articletitled, TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes

Caroline A. Brorsson, Suna Onengut, Wei-Min Chen, Janet Wenzlau, Liping Yu, Peter Baker, Alistair J.K. Williams, Polly J. Bingley, John C. Hutton, George S. Eisenbarth, Patrick Concannon, Stephen S. Rich, Flemming Pociot, for the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2015;64(8):3017–3027
https://doi.org/10.2337/db14-1730
Published: 31 March 2015
View articletitled, Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

Joanna M.M. Howson, Jason D. Cooper, Deborah J. Smyth, Neil M. Walker, Helen Stevens, Jin-Xiong She, George S. Eisenbarth, Marian Rewers, John A. Todd, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Flemming Pociot, Stephen S. Rich, and the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2012;61(11):3012–3017
https://doi.org/10.2337/db11-1694
Published: 16 October 2012
View articletitled, Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

Regine Bergholdt, Caroline Brorsson, Albert Palleja, Lukas A. Berchtold, Tina Fløyel, Claus Heiner Bang-Berthelsen, Klaus Stensgaard Frederiksen, Lars Juhl Jensen, Joachim Størling, Flemming Pociot
Journal: Diabetes
Diabetes 2012;61(4):954–962
https://doi.org/10.2337/db11-1263
Published: 14 March 2012
View articletitled, Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
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Includes: Supplementary data
Journal Articles

Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs

Grant Morahan, Munish Mehta, Ian James, Wei-Min Chen, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Cécile Julier, Jørn Nerup, Concepcion Nierras, Flemming Pociot, John A. Todd, Stephen S. Rich, for the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2011;60(3):1030–1040
https://doi.org/10.2337/db10-1195
Published: 21 February 2011
View articletitled, Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs
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Includes: Supplementary data
Journal Articles

Genetics of Type 1 Diabetes: What's Next?

Flemming Pociot, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Concepcion R. Nierras, John A. Todd, Stephen S. Rich, Jørn Nerup
Journal: Diabetes
Diabetes 2010;59(7):1561–1571
https://doi.org/10.2337/db10-0076
Published: 01 July 2010
View articletitled, Genetics of Type 1 Diabetes: What's Next?
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Journal Articles

Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium

Patrick Concannon, Wei-Min Chen, Cécile Julier, Grant Morahan, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Jørn Nerup, Concepcion Nierras, Flemming Pociot, John A. Todd, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2009;58(4):1018–1022
https://doi.org/10.2337/db08-1551
Published: 09 January 2009
View articletitled, Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium
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Includes: Supplementary data
Journal Articles

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

Patrick Concannon, Suna Onengut-Gumuscu, John A. Todd, Deborah J. Smyth, Flemming Pociot, Regine Bergholdt, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion R. Nierras, Wei-Min Chen, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2008;57(10):2858–2861
https://doi.org/10.2337/db08-0753
Published: 01 October 2008
View articletitled, A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
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Journal Articles

PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits

Claude Chelala, Sabine Duchatelet, Marie-Line Joffret, Regine Bergholdt, Danièle Dubois-Laforgue, Pegah Ghandil, Flemming Pociot, Sophie Caillat-Zucman, José Timsit, Cécile Julier
Journal: Diabetes
Diabetes 2007;56(2):522–526
https://doi.org/10.2337/db06-0942
Published: 01 February 2007
View articletitled, PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits
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Includes: Supplementary data
Journal Articles

Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

Patrick Concannon, Henry A. Erlich, Cecile Julier, Grant Morahan, Jørn Nerup, Flemming Pociot, John A. Todd, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2005;54(10):2995–3001
https://doi.org/10.2337/diabetes.54.10.2995
Published: 01 October 2005
View articletitled, Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families
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Includes: Supplementary data
Journal Articles

OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes

L. Leigh Field, Vagn Bonnevie-Nielsen, Flemming Pociot, Shao Lu, Thomas B. Nielsen, Henning Beck-Nielsen
Journal: Diabetes
Diabetes 2005;54(5):1588–1591
https://doi.org/10.2337/diabetes.54.5.1588
Published: 01 May 2005
View articletitled, OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
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Journal Articles

Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients

Ole Peter Kristiansen, Mahdi Zamani, Jesper Johannesen, Thomas Mandrup-Poulsen, Jean-Jacques Cassiman, Jørn Nerup, Flemming Pociot, The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood
Journal: Diabetes
Diabetes 1998;47(2):281–283
https://doi.org/10.2337/diab.47.2.281
Published: 01 February 1998
View articletitled, Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients
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Journal Articles

Polymorphisms in the Interleukin-1 Gene Cluster Do Not Contribute to the Genetic Susceptibility of Diabetic Nephropathy in Caucasian Patients With IDDM

Lise Tarnow, Flemming Pociot, Pernille M Hansen, Peter Rossing, Flemming S Nielsen, Birgitte V Hansen, Hans-Henrik Parving
Journal: Diabetes
Diabetes 1997;46(6):1075–1076
https://doi.org/10.2337/diab.46.6.1075
Published: 01 June 1997
View articletitled, Polymorphisms in the Interleukin-1 Gene Cluster Do Not Contribute to the Genetic Susceptibility of Diabetic Nephropathy in Caucasian Patients With IDDM
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Journal Articles

Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo

Jesper I Reimers, Herik U Anderson, Dídac Mauricio, Flemming Pociot, Allan Karlsen, Jacob S Peterson, Thomas Mandrup-Poulsen, Jørn Nerup
Journal: Diabetes
Diabetes 1996;45(6):771–778
https://doi.org/10.2337/diab.45.6.771
Published: 01 June 1996
View articletitled, Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo
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Journal Articles

Monokine Antagonism Is Reduced in Patients With IDDM

Thomas Mandrup-Poulsen, Flemming Pociot, Jens Mølvig, Leland Shapiro, Povl Nilsson, Torkil Emdal, Michael Røder, Lisa L Kjems, Charles A Dinarello, Jørn Nerup
Journal: Diabetes
Diabetes 1994;43(10):1242–1247
https://doi.org/10.2337/diab.43.10.1242
Published: 01 October 1994
View articletitled, Monokine Antagonism Is Reduced in Patients With IDDM
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Journal Articles

Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM

Peter M Van Endert, Roland S Liblau, Salil D Patel, Lars Fugger, Theresa Lopez, Flemming Pociot, Jørn Nerup, Hugh O McDevitt
Journal: Diabetes
Diabetes 1994;43(1):110–117
https://doi.org/10.2337/diab.43.1.110
Published: 01 January 1994
View articletitled, Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM
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