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Frances M. Ashcroft
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Journal Articles

KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture

Frances M. Ashcroft
Journal: Diabetes
Diabetes 2023;72(6):693–702
https://doi.org/10.2337/dbi22-0030
Published: 19 May 2023
View article titled, K<sub>ATP</sub> Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
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Journal Articles

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2021;70(5):1145–1156
https://doi.org/10.2337/db20-0691
Published: 10 February 2021
View article titled, The <em>KCNJ11-E23K</em> Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion
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Journal Articles

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia

Maria Rohm, Dragana Savic, Vicky Ball, M. Kate Curtis, Sarah Bonham, Roman Fischer, Nathalie Legrave, James I. MacRae, Damian J. Tyler, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2018;67(6):1057–1067
https://doi.org/10.2337/db17-1195
Published: 02 April 2018
View article titled, Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia
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Includes: Supplementary data
Journal Articles

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

Tehila Dahan, Oren Ziv, Elad Horwitz, Hai Zemmour, Judith Lavi, Avital Swisa, Gil Leibowitz, Frances M. Ashcroft, Peter In’t Veld, Benjamin Glaser, Yuval Dor
Journal: Diabetes
Diabetes 2017;66(2):426–436
https://doi.org/10.2337/db16-0641
Published: 18 November 2016
View article titled, Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
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Includes: Supplementary data
Journal Articles

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55: 2153–2156

Helen C. Freeman, Alison Hugill, Neil T. Dear, Frances M. Ashcroft, Roger D. Cox
Journal: Diabetes
Diabetes 2014;63(2):815
https://doi.org/10.2337/db14-er02
Published: 16 January 2014
View article titled, Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55: 2153–2156
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Journal Articles

Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes

Peter Proks, Heidi de Wet, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2013;62(11):3909–3919
https://doi.org/10.2337/db13-0531
Published: 18 October 2013
View article titled, Molecular Mechanism of Sulphonylurea Block of K<sub>ATP</sub> Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
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Journal Articles

A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1

Kenju Shimomura, Maija Tusa, Michaela Iberl, Melissa F. Brereton, Stephan Kaizik, Peter Proks, Carolina Lahmann, Nagendra Yaluri, Shalem Modi, Hanna Huopio, Jarkko Ustinov, Timo Otonkoski, Markku Laakso, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2013;62(11):3797–3806
https://doi.org/10.2337/db12-1611
Published: 18 October 2013
View article titled, A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
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Includes: Supplementary data
Journal Articles

Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the KATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes

Roope Männikkö, Sarah E. Flanagan, Xiuli Sim, David Segal, Khalid Hussain, Sian Ellard, Andrew T. Hattersley, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2011;60(6):1813–1822
https://doi.org/10.2337/db10-1583
Published: 21 May 2011
View article titled, Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the K<sub>ATP</sub> Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
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Includes: Supplementary data
Journal Articles

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

Michelle Goldsworthy, Alison Hugill, Helen Freeman, Emma Horner, Kenju Shimomura, Debora Bogani, Guido Pieles, Vesna Mijat, Ruth Arkell, Shoumo Bhattacharya, Frances M. Ashcroft, Roger D. Cox
Journal: Diabetes
Diabetes 2008;57(8):2234–2244
https://doi.org/10.2337/db07-0337
Published: 01 August 2008
View article titled, Role of the Transcription Factor <em>Sox4</em> in Insulin Secretion and Impaired Glucose Tolerance
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Includes: Supplementary data
Journal Articles

Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy

Julian P.H. Shield, Sarah E. Flanagan, Deborah J. Mackay, Lorna W. Harries, Peter Proks, Christophe Girard, Frances M. Ashcroft, I. Karen Temple, Sian Ellard
Journal: Diabetes
Diabetes 2008;57(1):255–258
https://doi.org/10.2337/db07-0999
Published: 01 January 2008
View article titled, Mosaic Paternal Uniparental Isodisomy and an <em>ABCC8</em> Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy
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Journal Articles

A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells

Andrei I. Tarasov, Hannah J. Welters, Sabine Senkel, Gerhart U. Ryffel, Andrew T. Hattersley, Noel G. Morgan, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2006;55(11):3075–3082
https://doi.org/10.2337/db06-0637
Published: 01 November 2006
View article titled, A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells
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Journal Articles

ATP Sensitivity of the ATP-Sensitive K+ Channel in Intact and Permeabilized Pancreatic β-Cells

Andrei I. Tarasov, Christophe A.J. Girard, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2006;55(9):2446–2454
https://doi.org/10.2337/db06-0360
Published: 01 September 2006
View article titled, ATP Sensitivity of the ATP-Sensitive K<sup>+</sup> Channel in Intact and Permeabilized Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Deletion of Nicotinamide Nucleotide Transhydrogenase : A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

Helen C. Freeman, Alison Hugill, Neil T. Dear, Frances M. Ashcroft, Roger D. Cox
Journal: Diabetes
Diabetes 2006;55(7):2153–2156
https://doi.org/10.2337/db06-0358
Published: 01 July 2006
View article titled, Deletion of Nicotinamide Nucleotide Transhydrogenase : <subtitle>A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice</subtitle>
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Includes: Supplementary data
Journal Articles

Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy

Peter Proks, Christophe Girard, Halvor Bævre, Pål R. Njølstad, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2006;55(6):1731–1737
https://doi.org/10.2337/db05-1420
Published: 01 June 2006
View article titled, Functional Effects of Mutations at F35 in the NH<sub>2</sub>-terminus of Kir6.2 (<em>KCNJ11</em>), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy
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Includes: Supplementary data
Journal Articles

Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects

Kenju Shimomura, Christophe A.J. Girard, Peter Proks, Joanna Nazim, Jonathan D. Lippiat, Franco Cerutti, Renata Lorini, Sian Ellard, Andrew T. Hattersley, Fabrizio Barbetti, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2006;55(6):1705–1712
https://doi.org/10.2337/db05-1640
Published: 01 June 2006
View article titled, Mutations at the Same Residue (R50) of Kir6.2 (<em>KCNJ11</em>) That Cause Neonatal Diabetes Produce Different Functional Effects
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Journal Articles

Activating Mutations in Kir6.2 and Neonatal Diabetes : New Clinical Syndromes, New Scientific Insights, and New Therapy

Andrew T. Hattersley, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2005;54(9):2503–2513
https://doi.org/10.2337/diabetes.54.9.2503
Published: 01 September 2005
View article titled, Activating Mutations in Kir6.2 and Neonatal Diabetes : <subtitle>New Clinical Syndromes, New Scientific Insights, and New Therapy</subtitle>
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Journal Articles

Identification of a Functionally Important Negatively Charged Residue Within the Second Catalytic Site of the SUR1 Nucleotide-Binding Domains

Jeff D. Campbell, Peter Proks, Jonathan D. Lippiat, Mark S.P. Sansom, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2004;53(suppl_3):S123–S127
https://doi.org/10.2337/diabetes.53.suppl_3.S123
Published: 01 December 2004
View article titled, Identification of a Functionally Important Negatively Charged Residue Within the Second Catalytic Site of the SUR1 Nucleotide-Binding Domains
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Journal Articles

Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the KATP Channel Is Modulated by Sulfonylureas

Jonathan D. Lippiat, Sophie L. Albinson, Frances M. Ashcroft
Journal: Diabetes
Diabetes 2002;51(suppl_3):S377–S380
https://doi.org/10.2337/diabetes.51.2007.S377
Published: 01 December 2002
View article titled, Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the K<sub>ATP</sub> Channel Is Modulated by Sulfonylureas
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Journal Articles

Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

Ann Maria K. Hansen, Inge T. Christensen, John Bondo Hansen, Richard D. Carr, Frances M. Ashcroft, Philip Wahl
Journal: Diabetes
Diabetes 2002;51(9):2789–2795
https://doi.org/10.2337/diabetes.51.9.2789
Published: 01 September 2002
View article titled, Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1
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Journal Articles

The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy- 4H -1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener

Michael Dabrowski, Frances M. Ashcroft, Rebecca Ashfield, Philippe Lebrun, Bernard Pirotte, Jan Egebjerg, John Bondo Hansen, Philip Wahl
Journal: Diabetes
Diabetes 2002;51(6):1896–1906
https://doi.org/10.2337/diabetes.51.6.1896
Published: 01 June 2002
View article titled, The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy- <em>4H</em> -1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener
Open the PDF for The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy- <em>4H</em> -1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener in another window