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Journal Articles

A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes

Gabriele Sassi, Giada Licata, Giuliana Ventriglia, Amber Wouters, Pierre Lemaitre, Ruth Seurinck, Alessia Mori, Giuseppina Emanuela Grieco, Samal Bissenova, Darcy Ellis, Silvia Caluwaerts, Pieter Rottiers, Niels Vandamme, Chantal Mathieu, Francesco Dotta, Conny Gysemans, Guido Sebastiani

Diabetes 2023;72(10):1470–1482

https://doi.org/10.2337/db22-0852

Published: 26 July 2023

View article titled, A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes

Meeting Abstracts

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

ERNESTO MADDALONI, AMALIA GASTALDELLI, LUCA NAVARINI, ROCCO AMENDOLARA, SIMONA FENIZIA, SAMANTHA PEZZICA, MARTA TESI, LUCA D'ONOFRIO, EMANUELE BOSI, FRANCESCO DOTTA, PIERO MARCHETTI, RAFFAELLA BUZZETTI

Diabetes 2023;72(Supplement_1):227-LB

https://doi.org/10.2337/db23-227-LB

Published: 20 June 2023

View article titled, 227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

Journal Articles

CD8⁺ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

Diabetes 2021;70(12):2879–2891

https://doi.org/10.2337/db21-0259

Published: 24 September 2021

View article titled, CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

Meeting Abstracts

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, GIANFRANCO DI GIUSEPPE, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, FRANCESCA CINTI, CHIARA MARIA ASSUNTA CEFALO, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2021;70(Supplement_1):290-OR

https://doi.org/10.2337/db21-290-OR

Published: 01 June 2021

View article titled, 290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

Meeting Abstracts

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, GIAN PIO SORICE, GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, JR., ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2020;69(Supplement_1):1795-P

https://doi.org/10.2337/db20-1795-P

Published: 01 June 2020

View article titled, 1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

Journal Articles

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Tatiana Takiishi, Dana Paulina Cook, Hannelie Korf, Guido Sebastiani, Francesca Mancarella, João Paulo Monteiro Carvalho Mori Cunha, Clive Wasserfall, Noelia Casares, Juan José Lasarte, Lothar Steidler, Pieter Rottiers, Francesco Dotta, Conny Gysemans, Chantal Mathieu

Diabetes 2017;66(2):448–459

https://doi.org/10.2337/db15-1625

Published: 08 November 2016

View article titled, Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Includes: Supplementary data

Journal Articles

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik

Diabetes 2017;66(1):100–112

https://doi.org/10.2337/db16-0592

Published: 13 October 2016

View article titled, MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

Sofie Robert, Conny Gysemans, Tatiana Takiishi, Hannelie Korf, Isabella Spagnuolo, Guido Sebastiani, Karolien Van Huynegem, Lothar Steidler, Silvia Caluwaerts, Pieter Demetter, Clive H. Wasserfall, Mark A. Atkinson, Francesco Dotta, Pieter Rottiers, Tom L. Van Belle, Chantal Mathieu

Diabetes 2014;63(8):2876–2887

https://doi.org/10.2337/db13-1236

Published: 17 July 2014

View article titled, Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

Includes: Supplementary data

Journal Articles

Dietary Supplementation With High Doses of Regular Vitamin D₃ Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term

Tatiana Takiishi, Lei Ding, Femke Baeke, Isabella Spagnuolo, Guido Sebastiani, Jos Laureys, Annemieke Verstuyf, Geert Carmeliet, Francesco Dotta, Tom L. Van Belle, Conny A. Gysemans, Chantal Mathieu

Diabetes 2014;63(6):2026–2036

https://doi.org/10.2337/db13-1559

Published: 15 May 2014

View article titled, Dietary Supplementation With High Doses of Regular Vitamin D3 Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term

Includes: Supplementary data

Journal Articles

Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs

Francesco Dotta, Guido Sebastiani

Diabetes 2014;63(2):384–386

https://doi.org/10.2337/db13-1441

Published: 16 January 2014

View article titled, Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs

Journal Articles

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Diabetes 2013;62(6):2072–2077

https://doi.org/10.2337/db12-1345

Published: 17 May 2013

View article titled, Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871

Francesco Vendrame, Francesco Dotta

Diabetes 2011;60(2):e12

https://doi.org/10.2337/db10-1489

Published: 21 January 2011

View article titled, Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871

Journal Articles

Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2

Claudio Tiberti, Carla Giordano, Mattia Locatelli, Emanuele Bosi, Gian Franco Bottazzo, Raffaella Buzzetti, Domenico Cucinotta, Aldo Galluzzo, Alberto Falorni, Francesco Dotta

Diabetes 2008;57(5):1276–1283

https://doi.org/10.2337/db07-0874

Published: 01 May 2008

View article titled, Identification of Tyrosine Phosphatase 2(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: <subtitle>The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2</subtitle>

Includes: Supplementary data

Journal Articles

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Roberto Lupi, Francesco Dotta, Lorella Marselli, Silvia Del Guerra, Matilde Masini, Carmela Santangelo, Giovanni Patané, Ugo Boggi, Salvatore Piro, Marcello Anello, Ettore Bergamini, Franco Mosca, Umberto Di Mario, Stefano Del Prato, Piero Marchetti

Diabetes 2002;51(5):1437–1442

https://doi.org/10.2337/diabetes.51.5.1437

Published: 01 May 2002

View article titled, Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: <subtitle>Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated</subtitle>

Journal Articles

Autoimmunity to the GM2-1 Islet Ganglioside Before and at the Onset of Type I Diabetes

Francesco Dotta, Roberto Gianani, Marcello Previti, Luisa Lenti, Sabrina Dionisi, Maria D'Erme, George S Eisenbarth, Umberto Di Mario

Diabetes 1996;45(9):1193–1196

https://doi.org/10.2337/diab.45.9.1193

Published: 01 September 1996

View article titled, Autoimmunity to the GM2-1 Islet Ganglioside Before and at the Onset of Type I Diabetes

Journal Articles

Ganglioside Expression in Human Pancreatic Islets

Francesco Dotta, Peter G Colman, Daniela Lombardi, David W Scharp, Domenico Andreani, Giuseppe M Pontieri, Umberto Di Mario, Luisa Lenti, George S Eisenbarth, Ramesh C Nayak

Diabetes 1989;38(11):1478–1483

https://doi.org/10.2337/diab.38.11.1478

Published: 01 November 1989

View article titled, Ganglioside Expression in Human Pancreatic Islets

Journal Articles

Circulating Anti-Immunoglobulin Antibodies in Recent-Onset Type I Diabetic Patients

Umberto Di Mario, Francesco Dotta, Laura Crisa, Emanuela Anastasi, Domenico Andreani, Sergio A Dib, George S Eisenbarth

Diabetes 1988;37(4):462–466

https://doi.org/10.2337/diab.37.4.462

Published: 01 April 1988

View article titled, Circulating Anti-Immunoglobulin Antibodies in Recent-Onset Type I Diabetic Patients

Journal Articles

Expression of Cytoplasmic Islet Cell Antigens by Rat Pancreas

Sergio A Dib, Peter G Colman, Francesco Dotta, Maura Tautkus, Albert Rabizadeh, George S Eisenbarth

Diabetes 1987;36(8):982–985

https://doi.org/10.2337/diab.36.8.982

Published: 01 August 1987

View article titled, Expression of Cytoplasmic Islet Cell Antigens by Rat Pancreas

NARROW

A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

CD8⁺ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

Dietary Supplementation With High Doses of Regular Vitamin D₃ Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term

Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871

Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Autoimmunity to the GM2-1 Islet Ganglioside Before and at the Onset of Type I Diabetes

Ganglioside Expression in Human Pancreatic Islets

Circulating Anti-Immunoglobulin Antibodies in Recent-Onset Type I Diabetic Patients

Expression of Cytoplasmic Islet Cell Antigens by Rat Pancreas

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