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Francis C. Lynn
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Journal Articles

Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line

Samantha Mar, Ekaterina Filatov, Shugo Sasaki, Majid Mojibian, Dahai Zhang, Angela Yang, Cuilan Nian, Francis C. Lynn
Journal: Diabetes
Diabetes 2025;74(2):188–198
https://doi.org/10.2337/db24-0756
Published: 19 November 2024
View article titled, Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line
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Meeting Abstracts

1730-P: Stochastic Differentiation of α-Cell Lineage Revealed by Single-Cell RNA Sequencing in Time-Resolved Reporter System

NAOYA SHIMIZU, SHUGO SASAKI, TOMOMI TAGUCHI, MIWA HIMURO, HIROTAKA WATADA, FRANCIS C. LYNN, TAKESHI MIYATSUKA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1730-P
https://doi.org/10.2337/db23-1730-P
Published: 20 June 2023
View article titled, 1730-P: Stochastic Differentiation of α-Cell Lineage Revealed by Single-Cell RNA Sequencing in Time-Resolved Reporter System
Journal Articles

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A.J. Krentz, Søs Skovsø, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson
Journal: Diabetes
Diabetes 2022;71(12):2612–2631
https://doi.org/10.2337/db21-1065
Published: 28 September 2022
View article titled, Dynamic <em>Ins2</em> Gene Activity Defines β-Cell Maturity States
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Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL
Journal: Diabetes
Diabetes 2022;71(Supplement_1):299-OR
https://doi.org/10.2337/db22-299-OR
Published: 01 June 2022
View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism
Journal Articles

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation

Chi Kin Wong, Adam K. Wade-Vallance, Dan S. Luciani, Paul K. Brindle, Francis C. Lynn, William T. Gibson
Journal: Diabetes
Diabetes 2018;67(3):412–422
https://doi.org/10.2337/db17-0237
Published: 07 December 2017
View article titled, The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation
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Includes: Supplementary data
Journal Articles

SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a

Eric E. Xu, Shugo Sasaki, Thilo Speckmann, Cuilan Nian, Francis C. Lynn
Journal: Diabetes
Diabetes 2017;66(8):2213–2219
https://doi.org/10.2337/db16-1074
Published: 11 May 2017
View article titled, SOX4 Allows Facultative β-Cell Proliferation Through Repression of <em>Cdkn1a</em>
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Includes: Supplementary data
Journal Articles

Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes

Samuel Z. Chow, Madeleine Speck, Piriya Yoganathan, Dominika Nackiewicz, Ann Maria Hansen, Mette Ladefoged, Björn Rabe, Stefan Rose-John, Peter J. Voshol, Francis C. Lynn, Pedro L. Herrera, Werner Müller, Helga Ellingsgaard, Jan A. Ehses
Journal: Diabetes
Diabetes 2014;63(9):2984–2995
https://doi.org/10.2337/db13-1121
Published: 16 August 2014
View article titled, Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells

Paul V. Sabatini, Nicole A.J. Krentz, Bader Zarrouki, Clara Y. Westwell-Roper, Cuilan Nian, Ryan A. Uy, A.M. James Shapiro, Vincent Poitout, Francis C. Lynn
Journal: Diabetes
Diabetes 2013;62(8):2808–2820
https://doi.org/10.2337/db12-1527
Published: 17 July 2013
View article titled, Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

Marta Szabat, Francis C. Lynn, Brad G. Hoffman, Timothy J. Kieffer, Douglas W. Allan, James D. Johnson
Journal: Diabetes
Diabetes 2012;61(6):1365–1371
https://doi.org/10.2337/db11-1361
Published: 14 May 2012
View article titled, Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: <subtitle>Developmental Biology Concepts in Adult Physiology</subtitle>
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Journal Articles

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse

Francis C. Lynn, Peter Skewes-Cox, Yasuhiro Kosaka, Michael T. McManus, Brian D. Harfe, Michael S. German
Journal: Diabetes
Diabetes 2007;56(12):2938–2945
https://doi.org/10.2337/db07-0175
Published: 01 December 2007
View article titled, MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
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Includes: Supplementary data
Journal Articles

The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas

Maria E. Wilson, Katherine Y. Yang, Anna Kalousova, Janet Lau, Yasuhiro Kosaka, Francis C. Lynn, Juehu Wang, Caroline Mrejen, Vasso Episkopou, Hans C. Clevers, Michael S. German
Journal: Diabetes
Diabetes 2005;54(12):3402–3409
https://doi.org/10.2337/diabetes.54.12.3402
Published: 01 December 2005
View article titled, The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas
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Journal Articles

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

J. Andrew Pospisilik, Jennifer Martin, Timothy Doty, Jan A. Ehses, Nathalie Pamir, Francis C. Lynn, Shalea Piteau, Hans-Ulrich Demuth, Christopher H.S. McIntosh, Raymond A. Pederson
Journal: Diabetes
Diabetes 2003;52(3):741–750
https://doi.org/10.2337/diabetes.52.3.741
Published: 01 March 2003
View article titled, Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
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Journal Articles

Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats

Francis C. Lynn, Nathalie Pamir, Eddy H.C. Ng, Christopher H.S. McIntosh, Timothy J. Kieffer, Raymond A. Pederson
Journal: Diabetes
Diabetes 2001;50(5):1004–1011
https://doi.org/10.2337/diabetes.50.5.1004
Published: 01 May 2001
View article titled, Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats
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