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Fumihiko Urano
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Meeting Abstracts

1656-P: FGF-21 Receptor Variants Demonstrate Severe Insulin Resistance in a Mouse Model of Insulin Mediated Pseudoacromegaly

STEPHEN I. STONE, TRAIAN LUPU, FUMIHIKO URANO, DAVID M. ORNITZ
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1656-P
DOI: https://doi.org/10.2337/db20-1656-P
Published: 01 June 2020
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Meeting Abstracts

1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

GUIFANG DONG, XIAOCHAO WEI, LI YIN, CHU FENG, SANGEETA ADAK, ZEENAT A. SHYR, QIANG ZHANG, SHUNTARO MORIKAWA, RIE ASADA, FUMIHIKO URANO, MARIA S. REMEDI, CLAY F. SEMENKOVICH
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1789-P
DOI: https://doi.org/10.2337/db20-1789-P
Published: 01 June 2020
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Meeting Abstracts

345-LB: Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): A New Therapeutic Target for Wolfram Syndrome

SHUNTARO MORIKAWA, JANA MAHADEVAN, TAKUYA YAGI, DAMIEN ABREU, KOHSUKE KANEKURA, CRIS M. BROWN, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):345-LB
DOI: https://doi.org/10.2337/db19-345-LB
Published: 01 June 2019
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Meeting Abstracts

26-OR: Digenic FGFR1/KLB Variants Associated with Endocrine Specific FGF-21 Signaling Defects and Extreme Insulin Resistance

STEPHEN I. STONE, DANIEL J. WEGNER, JENNIFER A. WAMBACH, F. SESSIONS COLE, DAVID M. ORNITZ, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):26-OR
DOI: https://doi.org/10.2337/db19-26-OR
Published: 01 June 2019
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Meeting Abstracts

2152-P: Impaired Iron-Sulfur-Cluster Redox Regulation in Monogenic Ncb5or Diabetes

HAO ZHU, AZUSA MUTO, TRISHA HOME, WENFANG WANG, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2152-P
DOI: https://doi.org/10.2337/db19-2152-P
Published: 01 June 2019
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Meeting Abstracts

85-LB: A Phase 1b/2 Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

DAMIEN ABREU, TONI S. PEARSON, ROBERT C. BUCELLI, ASHLEY SIMPSON, CRIS M. BROWN, KELLY KRIES, HONGJIE GU, STEPHEN I. STONE, LAWRENCE TYCHSEN, GREGORY VAN STAVERN, NEIL H. WHITE, BESS A. MARSHALL, TAMARA HERSHEY, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):85-LB
DOI: https://doi.org/10.2337/db19-85-LB
Published: 01 June 2019
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Meeting Abstracts

Digenic Mutations in the FGF-21 Signaling Pathway Found in an Adolescent with Extreme Insulin Resistance

STEPHEN I. STONE, ELIZABETH A. ADESANYA, DANIEL J. WEGNER, JENNIFER A. WAMBACH, F. SESSIONS COLE, DAVID M. ORNITZ, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):269-OR
DOI: https://doi.org/10.2337/db18-269-OR
Published: 01 July 2018
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Meeting Abstracts

Targeting Cellular Calcium Homeostasis to Prevent Beta-Cell Death in Type 1 Diabetes

AMY L. CLARK, DAMIEN ABREU, CRIS M. BROWN, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2112-P
DOI: https://doi.org/10.2337/db18-2112-P
Published: 01 July 2018
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Meeting Abstracts

Functional Characterization of Wolfram Syndrome 1 Protein in ß-Cell Function and Viability

DAMIEN ABREU, ZENO LAVAGNINO, CRIS M. BROWN, DAVID W. PISTON, FUMIHIKO URANO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2114-P
DOI: https://doi.org/10.2337/db18-2114-P
Published: 01 July 2018
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Journal Articles

Dominant ER Stress–Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts

Elisa De Franco, Sarah E. Flanagan, Takuya Yagi, Damien Abreu, Jana Mahadevan, Matthew B. Johnson, Garan Jones, Fernanda Acosta, Mphele Mulaudzi, Ngee Lek, Vera Oh, Oliver Petz, Richard Caswell, Sian Ellard, Fumihiko Urano, Andrew T. Hattersley
Journal: Diabetes
Diabetes 2017;66(7):2044–2053
DOI: https://doi.org/10.2337/db16-1296
Published: 03 May 2017
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Includes: Supplementary data
Journal Articles

Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease

Fumihiko Urano
Journal: Diabetes
Diabetes 2014;63(3):844–846
DOI: https://doi.org/10.2337/db13-1809
Published: 13 February 2014
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Journal Articles

Endoplasmic Reticulum: An Interface Between the Immune System and Metabolism

Emil R. Unanue, Fumihiko Urano
Journal: Diabetes
Diabetes 2014;63(1):48–49
DOI: https://doi.org/10.2337/db13-1478
Published: 13 December 2013
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Journal Articles

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Lori L. Bonnycastle, Peter S. Chines, Takashi Hara, Jeroen R. Huyghe, Amy J. Swift, Pirkko Heikinheimo, Jana Mahadevan, Sirkku Peltonen, Hanna Huopio, Pirjo Nuutila, Narisu Narisu, Rachel L. Goldfeder, Michael L. Stitzel, Simin Lu, Michael Boehnke, Fumihiko Urano, Francis S. Collins, Markku Laakso
Journal: Diabetes
Diabetes 2013;62(11):3943–3950
DOI: https://doi.org/10.2337/db13-0571
Published: 18 October 2013
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Journal Articles

ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes

Bryan O’Sullivan-Murphy, Fumihiko Urano
Journal: Diabetes
Diabetes 2012;61(4):780–781
DOI: https://doi.org/10.2337/db12-0091
Published: 14 March 2012
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Journal Articles

The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

Kari T. Chambers, Julie A. Unverferth, Sarah M. Weber, Ronald C. Wek, Fumihiko Urano, John A. Corbett
Journal: Diabetes
Diabetes 2008;57(1):124–132
DOI: https://doi.org/10.2337/db07-0944
Published: 01 January 2008
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