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Journal Articles

Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations

Daniel B. Rosoff, Josephin Wagner, Jeesun Jung, Pal Pacher, Constantinos Christodoulides, George Davey Smith, David Ray, Falk W. Lohoff
Journal: Diabetes
Diabetes 2024;74(1):120–130
https://doi.org/10.2337/db24-0451
Published: 17 October 2024
View article titled, Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations
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Journal Articles

Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits

Nellie Y. Loh, Daniel B. Rosoff, Rebecca Richmond, Raymond Noordam, George Davey Smith, David Ray, Fredrik Karpe, Falk W. Lohoff, Constantinos Christodoulides
Journal: Diabetes
Diabetes 2024;73(12):2084–2094
https://doi.org/10.2337/db24-0168
Published: 16 September 2024
View article titled, Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits
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Meeting Abstracts

189-LB: Using Genetics to Separate Childhood from Adult BMI Shows That Higher Childhood BMI Has No Direct Effect on Reduced Insulin Secretion or Sensitivity in Later Life

GARETH HAWKES, TOM G. RICHARDSON, GRACE M. POWER, GEORGE DAVEY SMITH, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2021;70(Supplement_1):189-LB
https://doi.org/10.2337/db21-189-LB
Published: 01 June 2021
View article titled, 189-LB: Using Genetics to Separate Childhood from Adult BMI Shows That Higher Childhood BMI Has No Direct Effect on Reduced Insulin Secretion or Sensitivity in Later Life
Meeting Abstracts

Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity

ANDREW R. WOOD, SAMUEL E. JONES, REBECCA RICHMOND, SHAFQAT AHMAD, HANIEH YAGHOOTKAR, ROBERT BEAUMONT, KATHERINE S. RUTH, MARCUS TUKE, ANNA MURRAY, RACHEL M. FREATHY, GEORGE DAVEY SMITH, I-MIN LEE, NIC TIMPSON, DANIEL CHASMAN, ZOLTAN KUTALIK, MICHAEL N. WEEDON, JESSICA TYRRELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):23-OR
https://doi.org/10.2337/db18-23-OR
Published: 01 July 2018
View article titled, Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity
Journal Articles

Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

Hannah R. Elliott, Hashem A. Shihab, Gabrielle A. Lockett, John W. Holloway, Allan F. McRae, George Davey Smith, Susan M. Ring, Tom R. Gaunt, Caroline L. Relton
Journal: Diabetes
Diabetes 2017;66(6):1713–1722
https://doi.org/10.2337/db16-0874
Published: 28 February 2017
View article titled, Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor
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Includes: Supplementary data
Journal Articles

BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization

Laura J. Corbin, Rebecca C. Richmond, Kaitlin H. Wade, Stephen Burgess, Jack Bowden, George Davey Smith, Nicholas J. Timpson
Journal: Diabetes
Diabetes 2016;65(10):3002–3007
https://doi.org/10.2337/db16-0418
Published: 08 July 2016
View article titled, BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization
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Includes: Supplementary data
Journal Articles

DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework

Rebecca C. Richmond, Gemma C. Sharp, Mary E. Ward, Abigail Fraser, Oliver Lyttleton, Wendy L. McArdle, Susan M. Ring, Tom R. Gaunt, Debbie A. Lawlor, George Davey Smith, Caroline L. Relton
Journal: Diabetes
Diabetes 2016;65(5):1231–1244
https://doi.org/10.2337/db15-0996
Published: 01 February 2016
View article titled, DNA Methylation and BMI: Investigating Identified Methylation Sites at <em>HIF3A</em> in a Causal Framework
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Includes: Supplementary data
Journal Articles

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

Hanieh Yaghootkar, Alena Stancáková, Rachel M. Freathy, Jagadish Vangipurapu, Michael N. Weedon, Weijia Xie, Andrew R. Wood, Ele Ferrannini, Andrea Mari, Susan M. Ring, Debbie A. Lawlor, George Davey Smith, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Valgerdur Steinthorsdottir, Daniel F. Guðbjartsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew T. Hattersley, Mark Walker, Andrew D. Morris, Mark I. McCarthy, Colin N.A. Palmer, Markku Laakso, Timothy M. Frayling
Journal: Diabetes
Diabetes 2015;64(6):2279–2285
https://doi.org/10.2337/db14-1456
Published: 20 January 2015
View article titled, Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at <em>CCND2</em> Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion
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Includes: Supplementary data
Journal Articles

Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass

Alexandra Groom, Catherine Potter, Daniel C. Swan, Ghazaleh Fatemifar, David M. Evans, Susan M. Ring, Valerie Turcot, Mark S. Pearce, Nicholas D. Embleton, George Davey Smith, John C. Mathers, Caroline L. Relton
Journal: Diabetes
Diabetes 2012;61(2):391–400
https://doi.org/10.2337/db11-1039
Published: 17 January 2012
View article titled, Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the <em>TACSTD2</em> Gene and Childhood Fat Mass
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Includes: Supplementary data
Journal Articles

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

Adam Barker, Stephen J. Sharp, Nicholas J. Timpson, Nabila Bouatia-Naji, Nicole M. Warrington, Stavroula Kanoni, Lawrence J. Beilin, Soren Brage, Panos Deloukas, David M. Evans, Anders Grontved, Neelam Hassanali, Deborah A. Lawlor, Cecile Lecoeur, Ruth J.F. Loos, Stephen J. Lye, Mark I. McCarthy, Trevor A. Mori, Ndeye Coumba Ndiaye, John P. Newnham, Ioanna Ntalla, Craig E. Pennell, Beate St Pourcain, Inga Prokopenko, Susan M. Ring, Naveed Sattar, Sophie Visvikis-Siest, George V. Dedoussis, Lyle J. Palmer, Philippe Froguel, George Davey Smith, Ulf Ekelund, Nicholas J. Wareham, Claudia Langenberg
Journal: Diabetes
Diabetes 2011;60(6):1805–1812
https://doi.org/10.2337/db10-1575
Published: 21 May 2011
View article titled, Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: <subtitle>A Meta-Analysis of Over 6,000 Children</subtitle>
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Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

N. Maneka G. De Silva, Rachel M. Freathy, Tom M. Palmer, Louise A. Donnelly, Jian'an Luan, Tom Gaunt, Claudia Langenberg, Michael N. Weedon, Beverley Shields, Beatrice A. Knight, Kirsten J. Ward, Manjinder S. Sandhu, Roger M. Harbord, Mark I. McCarthy, George Davey Smith, Shah Ebrahim, Andrew T. Hattersley, Nicholas Wareham, Debbie A. Lawlor, Andrew D. Morris, Colin N.A. Palmer, Timothy M. Frayling
Journal: Diabetes
Diabetes 2011;60(3):1008–1018
https://doi.org/10.2337/db10-1317
Published: 21 February 2011
View article titled, Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance
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Includes: Supplementary data
Journal Articles

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

Rachel M. Freathy, Amanda J. Bennett, Susan M. Ring, Beverley Shields, Christopher J. Groves, Nicholas J. Timpson, Michael N. Weedon, Eleftheria Zeggini, Cecilia M. Lindgren, Hana Lango, John R.B. Perry, Anneli Pouta, Aimo Ruokonen, Elina Hyppönen, Chris Power, Paul Elliott, David P. Strachan, Marjo-Riitta Järvelin, George Davey Smith, Mark I. McCarthy, Timothy M. Frayling, Andrew T. Hattersley
Journal: Diabetes
Diabetes 2009;58(6):1428–1433
https://doi.org/10.2337/db08-1739
Published: 19 February 2009
View article titled, Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth
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Includes: Supplementary data
Journal Articles

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben-Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew J. Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo-Riitta Jarvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley, Timothy M. Frayling
Journal: Diabetes
Diabetes 2008;57(5):1419–1426
https://doi.org/10.2337/db07-1466
Published: 01 May 2008
View article titled, Common Variation in the <em>FTO</em> Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
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Includes: Supplementary data
Journal Articles

A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

Aline Meirhaeghe, Colin A.G. Boreham, Liam J. Murray, Florence Richard, George Davey Smith, Ian S. Young, Philippe Amouyel
Journal: Diabetes
Diabetes 2007;56(2):494–498
https://doi.org/10.2337/db06-0915
Published: 01 February 2007
View article titled, A Possible Role for the <em>PPARG</em> Pro12Ala Polymorphism in Preterm Birth
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Journal Articles

Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene

Michael N. Weedon, Timothy M. Frayling, Beverley Shields, Beatrice Knight, Tina Turner, Bradley S. Metcalf, Linda Voss, Terence J. Wilkin, Anne McCarthy, Yoav Ben-Shlomo, George Davey Smith, Sue Ring, Richard Jones, Jean Golding, ALSPAC Study Team, Liisa Byberg, Vera Mann, Tomas Axelsson, Ann-Christine Syvänen, David Leon, Andrew T. Hattersley
Journal: Diabetes
Diabetes 2005;54(2):576–581
https://doi.org/10.2337/diabetes.54.2.576
Published: 01 February 2005
View article titled, Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene
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Journal Articles

A Putative Functional Polymorphism in the IGF-I Gene: Association Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations

Timothy M. Frayling, Andrew T. Hattersley, Anne McCarthy, Jeff Holly, Simon M.S. Mitchell, Anna L. Gloyn, Katharine Owen, David Davies, George Davey Smith, Yoav Ben-Shlomo
Journal: Diabetes
Diabetes 2002;51(7):2313–2316
https://doi.org/10.2337/diabetes.51.7.2313
Published: 01 July 2002
View article titled, A Putative Functional Polymorphism in the <em>IGF-I</em> Gene: <subtitle>Association Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations </subtitle>
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