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Gerald I. Shulman
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Journal Articles

Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes

Max C. Petersen, Mihoko Yoshino, Gordon I. Smith, Rafael C. Gaspar, Mario Kahn, Dmitri Samovski, Gerald I. Shulman, Samuel Klein
Journal: Diabetes
Diabetes 2024;73(12):2055–2064
https://doi.org/10.2337/db24-0083
Published: 12 September 2024
View article titled, Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes
Open the PDF for Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes in another window
Meeting Abstracts

1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice

NATALIE SRODA, ARCHANA VIJAYAKUMAR, EISUKE MURAKAMI, STEVE WENG, GERALD I. SHULMAN, ROBERT P. MYERS, MANI SUBRAMANIAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1637-P
https://doi.org/10.2337/db24-1637-P
Published: 14 June 2024
View article titled, 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice
Meeting Abstracts

899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice

ARCHANA VIJAYAKUMAR, NATALIE SRODA, EISUKE MURAKAMI, STEVE WENG, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):899-P
https://doi.org/10.2337/db24-899-P
Published: 14 June 2024
View article titled, 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
Meeting Abstracts

1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase Pathway

JIE ZHENG, ALI NASIRI, RAFAEL C. GASPAR, BRANDON T. HUBBARD, IKKI SAKUMA, XIAOXIAN MA, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, VARMAN SAMUEL, KITT PETERSEN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1577-P
https://doi.org/10.2337/db24-1577-P
Published: 14 June 2024
View article titled, 1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase Pathway
Meeting Abstracts

1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis

IKKI SAKUMA, RAFAEL C. GASPAR, ALI NASIRI, MARIO KAHN, JIE ZHENG, MATEUS GUERRA, DEAN YIMLAMAI, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, DANIEL F. VATNER, KITT PETERSEN, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1571-P
https://doi.org/10.2337/db24-1571-P
Published: 14 June 2024
View article titled, 1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis
Meeting Abstracts

292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets

IKKI SAKUMA, RAFAEL C. GASPAR, ALI NASIRI, MARIO KAHN, MATEUS GUERRA, DEAN YIMLAMAI, SUE MURRAY, MARK PERELIS, WILLIAM BARNES, DANIEL F. VATNER, KITT PETERSEN, VARMAN SAMUEL, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):292-OR
https://doi.org/10.2337/db24-292-OR
Published: 14 June 2024
View article titled, 292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets
Meeting Abstracts

1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 Study

EDWARD GANE, RYAN S. HUSS, JANE SUR, EISUKE MURAKAMI, STEVE WENG, BRIAN J. KIRBY, AMRIK SHAH, GERALD I. SHULMAN, MANI SUBRAMANIAN, ARCHANA VIJAYAKUMAR, ROBERT P. MYERS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1886-LB
https://doi.org/10.2337/db24-1886-LB
Published: 14 June 2024
View article titled, 1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 Study
Journal Articles

MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis

Junhee Park, Catherine Hall, Brandon Hubbard, Traci LaMoia, Rafael Gaspar, Ali Nasiri, Fang Li, Hanrui Zhang, Jiyeon Kim, Rebecca A. Haeusler, Domenico Accili, Gerald I. Shulman, Hongtao Yu, Eunhee Choi
Journal: Diabetes
Diabetes 2023;72(12):1781–1794
https://doi.org/10.2337/db23-0314
Published: 19 September 2023
View article titled, MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis
Open the PDF for MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis in another window
Meeting Abstracts

222-OR: Metformin Reduces Fasting Glycemia in Well-Controlled Type 2 Diabetes by Promoting Aerobic Glycolysis Independent of Decreasing Endogenous Glucose Production

THERESIA SARABHAI, TRACI E. LAMOIA, SOPHIE FRIESL, MARC JONUSCHEIT, KITT PETERSEN, GERALD I. SHULMAN, MICHAEL RODEN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):222-OR
https://doi.org/10.2337/db23-222-OR
Published: 20 June 2023
View article titled, 222-OR: Metformin Reduces Fasting Glycemia in Well-Controlled Type 2 Diabetes by Promoting Aerobic Glycolysis Independent of Decreasing Endogenous Glucose Production
Meeting Abstracts

849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats

ARCHANA VIJAYAKUMAR, EISUKE MURAKAMI, RYAN S. HUSS, NATALIE SRODA, ATSUYUKI SHIMAZAKI, YUTO KASHIWAGI, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):849-P
https://doi.org/10.2337/db23-849-P
Published: 20 June 2023
View article titled, 849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats
Meeting Abstracts

1510-P: Lipid-Induced Renal Cortical Insulin Resistance Perturbs Gluconeogenic and Oxidative Metabolism via an sn-1,2-diacylglycerol-PKCe-Insulin Receptor Kinase Axis In Vivo

BRANDON T. HUBBARD, RAFAEL C. GASPAR, DONGYAN ZHANG, MARIO KAHN, ALI NASIRI, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1510-P
https://doi.org/10.2337/db23-1510-P
Published: 20 June 2023
View article titled, 1510-P: Lipid-Induced Renal Cortical Insulin Resistance Perturbs Gluconeogenic and Oxidative Metabolism via an sn-1,2-diacylglycerol-PKCe-Insulin Receptor Kinase Axis In Vivo
Meeting Abstracts

1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo

TRACI E. LAMOIA, BRANDON T. HUBBARD, MATEUS GUERRA, RUSSELL GOODMAN, MICHAEL H. NATHANSON, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1558-P
https://doi.org/10.2337/db23-1558-P
Published: 20 June 2023
View article titled, 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo
Meeting Abstracts

192-OR: Lipid-Induced Insulin Resistance in Brown Adipose Tissue Is Mediated by the sn-1,2 DAG-PKCe-IRKT1150 Phosphorylation Pathway

RAFAEL C. GASPAR, BRANDON T. HUBBARD, IKKI SAKUMA, TRACI E. LAMOIA, DONGYAN ZHANG, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):192-OR
https://doi.org/10.2337/db23-192-OR
Published: 20 June 2023
View article titled, 192-OR: Lipid-Induced Insulin Resistance in Brown Adipose Tissue Is Mediated by the sn-1,2 DAG-PKCe-IRKT1150 Phosphorylation Pathway
Meeting Abstracts

191-OR: Deletion of the Type 2 Diabetes Candidate Gene SLC16A11 Reduces Peripheral Insulin Sensitivity in Mice

NERMEEN N. EL-AGROUDY, TINA SCHUMANN, ANICA KURZBACH, GENCER SANCAR, LEONTINE SANDFORTH, CHRISTINE HERRMANN, GERALD I. SHULMAN, ANDREAS L. BIRKENFELD
Journal: Diabetes
Diabetes 2023;72(Supplement_1):191-OR
https://doi.org/10.2337/db23-191-OR
Published: 20 June 2023
View article titled, 191-OR: Deletion of the Type 2 Diabetes Candidate Gene SLC16A11 Reduces Peripheral Insulin Sensitivity in Mice
Meeting Abstracts

1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency

IKKI SAKUMA, RAFAEL C. GASPAR, PANU LUUKKONEN, MARIO KAHN, SUE MURRAY, VARMAN SAMUEL, KITT PETERSEN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1569-P
https://doi.org/10.2337/db23-1569-P
Published: 20 June 2023
View article titled, 1569-P: Lysophosphatidic Acid Mediates Inflammation in Liver and White Adipose Tissue in a Rat Model of 1-acyl-sn-glycerol-3-phosphate Acyltransferase 2 Deficiency
Meeting Abstracts

122-LB: Effect of Dapagliflozin on Mitochondrial Metabolism and Cardiac Function in the Failing Heart

LEIGH GOEDEKE, YINA MA, JIASHENG ZHANG, NICOLE GUERRERA, XIAOHONG WU, DONGYAN ZHANG, MARIO KAHN, XIAN-MAN ZHANG, LAWRENCE H. YOUNG, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):122-LB
https://doi.org/10.2337/db22-122-LB
Published: 01 June 2022
View article titled, 122-LB: Effect of Dapagliflozin on Mitochondrial Metabolism and Cardiac Function in the Failing Heart
Meeting Abstracts

195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia

BRANDON T. HUBBARD, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):195-OR
https://doi.org/10.2337/db22-195-OR
Published: 01 June 2022
View article titled, 195-OR: A Novel 13C5 Glutamine Tracer Method (Q Flux) Reveals a Key Role of Succinyl CoA Anaplerosis in Promoting Increased Rates of Hepatic Gluconeogenesis during Hyperglucagonemia
Meeting Abstracts

219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation

TRACI E. LAMOIA, BRANDON T. HUBBARD, MATEUS GUERRA, RUSSELL GOODMAN, MICHAEL H. NATHANSON, VAMSI MOOTHA, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):219-LB
https://doi.org/10.2337/db22-219-LB
Published: 01 June 2022
View article titled, 219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation
Meeting Abstracts

1336-P: FoxO1-ATGL-Sirt1-FoxO1 Feed Forward Signaling Mediates Effects on Hepatic Gene Expression and Glucose Homeostasis in LIRKO Mice

IN SUG O-SULLIVAN, SUMIT BHATTACHARYYA, CHONG WEE LIEW, SAM M. LEE, JOSE CORDOBA-CHACON, RACHEL J. PERRY, GERALD I. SHULMAN, TERRY UNTERMAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1336-P
https://doi.org/10.2337/db22-1336-P
Published: 01 June 2022
View article titled, 1336-P: FoxO1-ATGL-Sirt1-FoxO1 Feed Forward Signaling Mediates Effects on Hepatic Gene Expression and Glucose Homeostasis in LIRKO Mice
Meeting Abstracts

282-OR: The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Man Assessed by Positional Isotopomer NMR Tracer Analysis (PINTA)

KITT PETERSEN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2021;70(Supplement_1):282-OR
https://doi.org/10.2337/db21-282-OR
Published: 01 June 2021
View article titled, 282-OR: The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Man Assessed by Positional Isotopomer NMR Tracer Analysis (PINTA)