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Journal Articles

Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop

Carla J. Greenbaum, MD, Gerald T. Nepom, MD, PhD, Lauren K. Wood-Heickman, MD, Diane K. Wherrett, MD, Linda A. DiMeglio, MD, Kevan C. Herold, MD, Jeffrey P. Krischer, PhD

Diabetes dbi240020

https://doi.org/10.2337/dbi24-0020

Published: 21 August 2024

View article titled, Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop

Journal Articles

Uncovering Pathways to Personalized Therapies in Type 1 Diabetes

Peter S. Linsley, Carla J. Greenbaum, Gerald T. Nepom

Diabetes 2021;70(4):831–841

https://doi.org/10.2337/db20-1185

Published: 16 March 2021

View article titled, Uncovering Pathways to Personalized Therapies in Type 1 Diabetes

Meeting Abstracts

277-OR: Teplizumab Reverses the Loss of C-Peptide in Relatives at Risk for Type 1 Diabetes (T1D)

EMILY K. SIMS, BRIAN N. BUNDY, KENNETH D. STIER, ELISAVET SERTI, NOHA LIM, GERALD T. NEPOM, CARMELLA EVANS-MOLINA, KEVAN C. HEROLD

Diabetes 2020;69(Supplement_1):277-OR

https://doi.org/10.2337/db20-277-OR

Published: 01 June 2020

View article titled, 277-OR: Teplizumab Reverses the Loss of C-Peptide in Relatives at Risk for Type 1 Diabetes (T1D)

Meeting Abstracts

250-OR: Hypoproliferative CD8 Effector Memory (EM) Subsets Are Linked to Preservation of C-Peptide in Alefacept-Treated Recent-Onset Type 1 Diabetes (T1D) Subjects

ELISAVET SERTI, KIRSTEN E. DIGGINS, VIRGINIA S. MUIR, TINGTING LU, ELISA BALMAS, GERALD T. NEPOM, S. ALICE LONG, PETER LINSLEY

Diabetes 2020;69(Supplement_1):250-OR

https://doi.org/10.2337/db20-250-OR

Published: 01 June 2020

View article titled, 250-OR: Hypoproliferative CD8 Effector Memory (EM) Subsets Are Linked to Preservation of C-Peptide in Alefacept-Treated Recent-Onset Type 1 Diabetes (T1D) Subjects

Meeting Abstracts

1746-P: Differential Depletion and Expansion of Autoreactive CD8+ T Cell Subsets after Alefacept Treatment in Type 1 Diabetes (T1D)

ALICE E. WIEDEMAN, VIRGINIA S. MUIR, GERALD T. NEPOM, PETER LINSLEY, S. ALICE LONG

Diabetes 2019;68(Supplement_1):1746-P

https://doi.org/10.2337/db19-1746-P

Published: 01 June 2019

View article titled, 1746-P: Differential Depletion and Expansion of Autoreactive CD8+ T Cell Subsets after Alefacept Treatment in Type 1 Diabetes (T1D)

Journal Articles

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

Ronald G. Gill, Philippe P. Pagni, Tinalyn Kupfer, Clive H. Wasserfall, Songyan Deng, Amanda Posgai, Yulia Manenkova, Amira Bel Hani, Laura Straub, Philip Bernstein, Mark A. Atkinson, Kevan C. Herold, Matthias von Herrath, Teodora Staeva, Mario R. Ehlers, Gerald T. Nepom

Diabetes 2016;65(5):1310–1316

https://doi.org/10.2337/db15-0492

Published: 31 December 2015

View article titled, A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

Includes: Supplementary data

Journal Articles

Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes

Mike J. Mason, Cate Speake, Vivian H. Gersuk, Quynh-Anh Nguyen, Kimberly K. O’Brien, Jared M. Odegard, Jane H. Buckner, Carla J. Greenbaum, Damien Chaussabel, Gerald T. Nepom

Diabetes 2014;63(5):1789–1795

https://doi.org/10.2337/db13-1382

Published: 12 April 2014

View article titled, Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

Diabetes 2010;59(4):947–957

https://doi.org/10.2337/db09-0498

Published: 19 January 2010

View article titled, Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

Includes: Supplementary data

Journal Articles

Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes

Qin Ouyang, Nathan E. Standifer, Huilian Qin, Peter Gottlieb, C. Bruce Verchere, Gerald T. Nepom, Rusung Tan, Constadina Panagiotopoulos

Diabetes 2006;55(11):3068–3074

https://doi.org/10.2337/db06-0065

Published: 01 November 2006

View article titled, Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes

Journal Articles

Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Nathan E. Standifer, Qin Ouyang, Constadina Panagiotopoulos, C. Bruce Verchere, Rusung Tan, Carla J. Greenbaum, Catherine Pihoker, Gerald T. Nepom

Diabetes 2006;55(11):3061–3067

https://doi.org/10.2337/db06-0066

Published: 01 November 2006

View article titled, Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Journal Articles

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study

Vicki Seyfert-Margolis, Trang D. Gisler, Adam L. Asare, Richard S. Wang, H. Michael Dosch, Barbara Brooks-Worrell, George S. Eisenbarth, Jerry P. Palmer, Carla J. Greenbaum, Stephen E. Gitelman, Gerald T. Nepom, Jeffrey A. Bluestone, Kevan C. Herold

Diabetes 2006;55(9):2588–2594

https://doi.org/10.2337/db05-1378

Published: 01 September 2006

View article titled, Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: <subtitle>Results of a Blinded Controlled Study</subtitle>

Journal Articles

GAD65-Specific CD4⁺ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes

Helena Reijonen, Roberto Mallone, Anne-Kristin Heninger, Elsa M. Laughlin, Sharon A. Kochik, Ben Falk, William W. Kwok, Carla Greenbaum, Gerald T. Nepom

Diabetes 2004;53(8):1987–1994

https://doi.org/10.2337/diabetes.53.8.1987

Published: 01 August 2004

View article titled, GAD65-Specific CD4<sup>+</sup> T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes

Journal Articles

Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

Roberto Mallone, Sharon A. Kochik, Elsa M. Laughlin, Vivian H. Gersuk, Helena Reijonen, William W. Kwok, Gerald T. Nepom

Diabetes 2004;53(4):971–977

https://doi.org/10.2337/diabetes.53.4.971

Published: 01 April 2004

View article titled, Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

Journal Articles

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

Helena Reijonen, Erik J. Novak, Sharon Kochik, Anne Heninger, Andrew W. Liu, William W. Kwok, Gerald T. Nepom

Diabetes 2002;51(5):1375–1382

https://doi.org/10.2337/diabetes.51.5.1375

Published: 01 May 2002

View article titled, Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

Journal Articles

Molecular Basis for HLA-DQ Associations With IDDM

Gerald T Nepom, William W Kwok

Diabetes 1998;47(8):1177–1184

https://doi.org/10.2337/diab.47.8.1177

Published: 01 August 1998

View article titled, Molecular Basis for HLA-DQ Associations With IDDM

Journal Articles

The Prevention of IDDM: Injecting Insulin Into the Cytokine Network

Paul Gladstone, Gerald T Nepom

Diabetes 1995;44(7):859–862

https://doi.org/10.2337/diab.44.7.859

Published: 01 July 1995

View article titled, The Prevention of IDDM: Injecting Insulin Into the Cytokine Network

Journal Articles

High Genetic Risk for IDDM in the Pacific Northwest: First Report From the Washington State Diabetes Prediction Study

Rachel E Rowe, Nicola J Leech, Gerald T Nepom, David K McCulloch

Diabetes 1994;43(1):87–94

https://doi.org/10.2337/diab.43.1.87

Published: 01 January 1994

View article titled, High Genetic Risk for IDDM in the Pacific Northwest: First Report From the Washington State Diabetes Prediction Study

Journal Articles

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

Gerald T Nepom

Diabetes 1990;39(10):1153–1157

https://doi.org/10.2337/diab.39.10.1153

Published: 01 October 1990

View article titled, A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

Journal Articles

Nonprogression of Subclinical β-Cell Dysfunction Among First-Degree Relatives of IDDM Patients: 5-Yr Follow-Up of the Seattle Family Study

David K McCulloch, Leslie J Klaff, Steven E Kahn, Steven L Schoenfeld, Carla J Greenbaum, Richard S Mauseth, Edward A Benson, Gerald T Nepom, Linda Shewey, Jerry P Palmer

Diabetes 1990;39(5):549–556

https://doi.org/10.2337/diab.39.5.549

Published: 01 May 1990

View article titled, Nonprogression of Subclinical β-Cell Dysfunction Among First-Degree Relatives of IDDM Patients: 5-Yr Follow-Up of the Seattle Family Study

Journal Articles

HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM

Henry A Erlich, Teodorica L Bugawan, Stephen Scharf, Gerald T Nepom, Brian Tait, Robert L Griffith

Diabetes 1990;39(1):96–103

https://doi.org/10.2337/diacare.39.1.96

Published: 01 January 1990

View article titled, HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM

NARROW

Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop

Uncovering Pathways to Personalized Therapies in Type 1 Diabetes

277-OR: Teplizumab Reverses the Loss of C-Peptide in Relatives at Risk for Type 1 Diabetes (T1D)

250-OR: Hypoproliferative CD8 Effector Memory (EM) Subsets Are Linked to Preservation of C-Peptide in Alefacept-Treated Recent-Onset Type 1 Diabetes (T1D) Subjects

1746-P: Differential Depletion and Expansion of Autoreactive CD8+ T Cell Subsets after Alefacept Treatment in Type 1 Diabetes (T1D)

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice

Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes

Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study

GAD65-Specific CD4⁺ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes

Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

Molecular Basis for HLA-DQ Associations With IDDM

The Prevention of IDDM: Injecting Insulin Into the Cytokine Network

High Genetic Risk for IDDM in the Pacific Northwest: First Report From the Washington State Diabetes Prediction Study

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

Nonprogression of Subclinical β-Cell Dysfunction Among First-Degree Relatives of IDDM Patients: 5-Yr Follow-Up of the Seattle Family Study

HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM

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