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Meeting Abstracts

367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D

YASMINYE D. PETTWAY, CHUNHUA DAI, TIFFANY M. RICHARDSON, JOHN T. WALKER, RADHIKA ARAMANDLA, GREG POFFENBERGER, AMBER BRADLEY, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2022;71(Supplement_1):367-OR

https://doi.org/10.2337/db22-367-OR

Published: 01 June 2022

View articletitled, 367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D

Meeting Abstracts

255-LB: Defining Functional Phenotype in Human Islets across Endocrine Cell Composition, Donor Age, Sex, and Ancestry

MARCELA BRISSOVA, HEATHER H. DURAI, SHAOJUN MEI, ANASTASIA COLDREN, COREY DAVIS, CONRAD REIHSMANN, ALEXANDER L. HOPKIRK, DANNIELLE GIBSON, RADHIKA ARAMANDLA, GREG POFFENBERGER, DIANE C. SAUNDERS, ALVIN C. POWERS, JOYCE C. NILAND, CARMELLA EVANS-MOLINA

Diabetes 2022;71(Supplement_1):255-LB

https://doi.org/10.2337/db22-255-LB

Published: 01 June 2022

View articletitled, 255-LB: Defining Functional Phenotype in Human Islets across Endocrine Cell Composition, Donor Age, Sex, and Ancestry

Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN

Diabetes 2020;69(Supplement_1):255-OR

https://doi.org/10.2337/db20-255-OR

Published: 01 June 2020

View articletitled, 255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

Meeting Abstracts

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

CHUNHUA DAI, AMBER BRADLEY, KATIE C. COATE, GREG POFFENBERGER, ERICK SPEARS, JORDAN J. WRIGHT, SHRISTI SHRESTHA, DANIELLE DEAN, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):1894-P

https://doi.org/10.2337/db20-1894-P

Published: 01 June 2020

View articletitled, 1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

Meeting Abstracts

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

JOHN T. WALKER, RACHANA HALIYUR, RADHIKA ARAMANDLA, GREG POFFENBERGER, HEATHER A. NELSON, JOSEPH LUCHSINGER, PENG WANG, ADOLFO GARCIA-OCAÑA, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2019;68(Supplement_1):44-OR

https://doi.org/10.2337/db19-44-OR

Published: 01 June 2019

View articletitled, 44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

Meeting Abstracts

107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α- and ß-Cell Subpopulations

SHRISTI SHRESTHA, DIANE C. SAUNDERS, JOHN T. WALKER, RACHANA HALIYUR, GREG POFFENBERGER, RADHIKA ARAMANDLA, ANGELA JONES, NRIPESH PRASAD, SHAWN E. LEVY, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2019;68(Supplement_1):107-OR

https://doi.org/10.2337/db19-107-OR

Published: 01 June 2019

View articletitled, 107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α- and ß-Cell Subpopulations

Journal Articles

Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice

Christopher S. Wilson, Preeti Chhabra, Andrew F. Marshall, Caleigh V. Morr, Blair T. Stocks, Emilee M. Hoopes, Rachel H. Bonami, Greg Poffenberger, Kenneth L. Brayman, Daniel J. Moore

Diabetes 2018;67(11):2349–2360

https://doi.org/10.2337/db18-0456

Published: 21 August 2018

View articletitled, Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice

Includes: Supplementary data

Meeting Abstracts

Pancreatic Islets in Short Duration Type 2 Diabetes (T2D) Show Macrophage Infiltration and Increased Inflammatory Signaling

JOHN T. WALKER, SHRISTI SHRESTHA, NRIPESH PRASAD, TIFFANY RICHARDSON, RADHIKA ARAMANDLA, GREG POFFENBERGER, RITA BOTTINO, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2018;67(Supplement_1):86-OR

https://doi.org/10.2337/db18-86-OR

Published: 01 July 2018

View articletitled, Pancreatic Islets in Short Duration Type 2 Diabetes (T2D) Show Macrophage Infiltration and Increased Inflammatory Signaling

Meeting Abstracts

Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

CHUNHUA DAI, ALENA SHOSTAK, YASIR H. BOUCHI, NATHANIEL HART, GREG POFFENBERGER, DIANE C. SAUNDERS, RACHANA HALIYUR, DANIELLE DEAN, RADHIKA ARAMANDLA, MARCELA BRISSOVA, MASAKAZU SHIOTA, DALE L. GREINER, LEONARD D. SHULTZ, RITA BOTTINO, ALVIN C. POWERS

Diabetes 2018;67(Supplement_1):323-OR

https://doi.org/10.2337/db18-323-OR

Published: 01 July 2018

View articletitled, Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

Journal Articles

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Lina Sui, Nichole Danzl, Sean R. Campbell, Ryan Viola, Damian Williams, Yuan Xing, Yong Wang, Neil Phillips, Greg Poffenberger, Bjarki Johannesson, Jose Oberholzer, Alvin C. Powers, Rudolph L. Leibel, Xiaojuan Chen, Megan Sykes, Dieter Egli

Diabetes 2018;67(1):26–35

https://doi.org/10.2337/db17-0120

Published: 20 September 2017

View articletitled, β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Includes: Supplementary data

Journal Articles

Age-Dependent Decline in the Coordinated [Ca²⁺] and Insulin Secretory Dynamics in Human Pancreatic Islets

Matthew J. Westacott, Nikki L. Farnsworth, Joshua R. St. Clair, Greg Poffenberger, Audrey Heintz, Nurin W. Ludin, Nathaniel J. Hart, Alvin C. Powers, Richard K.P. Benninger

Diabetes 2017;66(9):2436–2445

https://doi.org/10.2337/db17-0137

Published: 06 June 2017

View articletitled, Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets

Includes: Supplementary data

Journal Articles

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Rachel B. Reinert, Marcela Brissova, Alena Shostak, Fong Cheng Pan, Greg Poffenberger, Qing Cai, Gregory L. Hundemer, Jeannelle Kantz, Courtney S. Thompson, Chunhua Dai, Owen P. McGuinness, Alvin C. Powers

Diabetes 2013;62(12):4154–4164

https://doi.org/10.2337/db13-0071

Published: 16 November 2013

View articletitled, Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Includes: Supplementary data

Journal Articles

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

Eric D. Berglund, Candice Y. Li, Greg Poffenberger, Julio E. Ayala, Patrick T. Fueger, Shannon E. Willis, Marybeth M. Jewell, Alvin C. Powers, David H. Wasserman

Diabetes 2008;57(7):1790–1799

https://doi.org/10.2337/db07-1615

Published: 01 July 2008

View articletitled, Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

Journal Articles

Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells

Elizabeth Tweedie, Isabella Artner, Laura Crawford, Greg Poffenberger, Bernard Thorens, Roland Stein, Alvin C. Powers, Maureen Gannon

Diabetes 2006;55(12):3264–3270

https://doi.org/10.2337/db06-0090

Published: 01 December 2006

View articletitled, Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells

Journal Articles

Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

Marcela Brissova, Alena Shostak, Masakazu Shiota, Peter O. Wiebe, Greg Poffenberger, Jeannelle Kantz, Zhongyi Chen, Chad Carr, W. Gray Jerome, Jin Chen, H. Scott Baldwin, Wendell Nicholson, David M. Bader, Thomas Jetton, Maureen Gannon, Alvin C. Powers

Diabetes 2006;55(11):2974–2985

https://doi.org/10.2337/db06-0690

Published: 01 November 2006

View articletitled, Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

Includes: Supplementary data

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367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D

255-LB: Defining Functional Phenotype in Human Islets across Endocrine Cell Composition, Donor Age, Sex, and Ancestry

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α- and ß-Cell Subpopulations

Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice

Pancreatic Islets in Short Duration Type 2 Diabetes (T2D) Show Macrophage Infiltration and Increased Inflammatory Signaling

Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

Age-Dependent Decline in the Coordinated [Ca²⁺] and Insulin Secretory Dynamics in Human Pancreatic Islets

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells

Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

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