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Meeting Abstracts

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

GUILLAUME KRAFT, MELANIE SCOTT, BEN FARMER, KALISHA YANKEY, DALE S. EDGERTON, HARITH RAJAGOPALAN, EMILY COZZI, KATHERINE GIBSON-CORLEY, CHARLES R. FLYNN, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1597-P

https://doi.org/10.2337/db24-1597-P

Published: 14 June 2024

View article titled, 1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

Meeting Abstracts

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

DALE S. EDGERTON, GUILLAUME KRAFT, HANNAH L. WATERMAN, BEN FARMER, KALISHA YANKEY, MARTA S. SMITH, JON R. HASTINGS, MELANIE SCOTT, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1563-P

https://doi.org/10.2337/db24-1563-P

Published: 14 June 2024

View article titled, 1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

Meeting Abstracts

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

HANNAH L. WATERMAN, MARTA S. SMITH, BEN FARMER, GUILLAUME KRAFT, MELANIE SCOTT, DALE S. EDGERTON, ALAN D. CHERRINGTON, MARY C. MOORE

Diabetes 2023;72(Supplement_1):1600-P

https://doi.org/10.2337/db23-1600-P

Published: 20 June 2023

View article titled, 1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

Meeting Abstracts

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

GUILLAUME KRAFT, MELANIE SCOTT, MARTA S. SMITH, BEN FARMER, DALE S. EDGERTON, ALAN D. CHERRINGTON

Diabetes 2023;72(Supplement_1):1560-P

https://doi.org/10.2337/db23-1560-P

Published: 20 June 2023

View article titled, 1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Journal Articles

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2023;72(2):196–209

https://doi.org/10.2337/db22-0471

Published: 24 October 2022

View article titled, Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Meeting Abstracts

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

DALE S. EDGERTON, GUILLAUME KRAFT, KATIE C. COATE, BEN FARMER, MARTA S. SMITH, MELANIE SCOTT, JON R. HASTINGS, MARY C. MOORE, ALAN D. CHERRINGTON

Diabetes 2022;71(Supplement_1):1341-P

https://doi.org/10.2337/db22-1341-P

Published: 01 June 2022

View article titled, 1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

Journal Articles

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2021;70(6):1292–1302

https://doi.org/10.2337/db20-1271

Published: 23 March 2021

View article titled, The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Meeting Abstracts

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MELANIE SCOTT, MARTA S. SMITH, ALAN D. CHERRINGTON

Diabetes 2020;69(Supplement_1):367-OR

https://doi.org/10.2337/db20-367-OR

Published: 01 June 2020

View article titled, 367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

Meeting Abstracts

1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

GUILLAUME KRAFT, L. MERKLE MOORE, BEN FARMER, MELANIE F. SCOTT, DALE S. EDGERTON, PHILLIP E. WILLIAMS, BOBAK AZAMIAN, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1801-P

https://doi.org/10.2337/db19-1801-P

Published: 01 June 2019

View article titled, 1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

Meeting Abstracts

1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MARTA S. SMITH, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1848-P

https://doi.org/10.2337/db19-1848-P

Published: 01 June 2019

View article titled, 1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

Meeting Abstracts

1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MARTA S. SMITH, PHILLIP E. WILLIAMS, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1849-P

https://doi.org/10.2337/db19-1849-P

Published: 01 June 2019

View article titled, 1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

Journal Articles

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Guillaume Kraft, Anthony Vrba, Melanie Scott, Eric Allen, Dale S. Edgerton, Phil E. Williams, Scott B. Vafai, Bobak R. Azamian, Alan D. Cherrington

Diabetes 2019;68(6):1143–1155

https://doi.org/10.2337/db18-1209

Published: 01 April 2019

View article titled, Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Meeting Abstracts

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

DALE S. EDGERTON, GUILLAUME KRAFT, MARTA S. SMITH, L. MERKLE MOORE, BEN FARMER, HEATHER SARA, MELANIE SCOTT, MARY MOORE, MICHAEL A. NAUCK, ALAN D. CHERRINGTON

Diabetes 2018;67(Supplement_1):1961-P

https://doi.org/10.2337/db18-1961-P

Published: 01 July 2018

View article titled, Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Journal Articles

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Mary Courtney Moore, Marta S. Smith, Ben Farmer, Katie C. Coate, Guillaume Kraft, Masakazu Shiota, Phillip E. Williams, Alan D. Cherrington

Diabetes 2018;67(7):1237–1245

https://doi.org/10.2337/db17-0979

Published: 17 April 2018

View article titled, Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Journal Articles

Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day

Mary Courtney Moore, Marta S. Smith, Ben Farmer, Guillaume Kraft, Masakazu Shiota, Phillip E. Williams, Alan D. Cherrington

Diabetes 2017;66(5):1136–1145

https://doi.org/10.2337/db16-1308

Published: 07 February 2017

View article titled, Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day

Journal Articles

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

Justin M. Gregory, Guillaume Kraft, Melanie F. Scott, Doss W. Neal, Ben Farmer, Marta S. Smith, Jon R. Hastings, Eric J. Allen, E. Patrick Donahue, Noelia Rivera, Jason J. Winnick, Dale S. Edgerton, Erica Nishimura, Christian Fledelius, Christian L. Brand, Alan D. Cherrington

Diabetes 2015;64(10):3439–3451

https://doi.org/10.2337/db15-0071

Published: 17 June 2015

View article titled, Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

Journal Articles

Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs

Katie C. Coate, Guillaume Kraft, Jose M. Irimia, Marta S. Smith, Ben Farmer, Doss W. Neal, Peter J. Roach, Masakazu Shiota, Alan D. Cherrington

Diabetes 2013;62(2):392–400

https://doi.org/10.2337/db12-0417

Published: 17 January 2013

View article titled, Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs

Includes: Supplementary data

Journal Articles

Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion

Jason J. Winnick, Zhibo An, Guillaume Kraft, Christopher J. Ramnanan, Jose M. Irimia, Marta Smith, Margaret Lautz, Peter J. Roach, Alan D. Cherrington

Diabetes 2013;62(1):96–101

https://doi.org/10.2337/db11-1773

Published: 13 December 2012

View article titled, Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion

Journal Articles

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog

Christopher J. Ramnanan, Guillaume Kraft, Marta S. Smith, Ben Farmer, Doss Neal, Phillip E. Williams, Margaret Lautz, Tiffany Farmer, E. Patrick Donahue, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2013;62(1):74–84

https://doi.org/10.2337/db12-0148

Published: 13 December 2012

View article titled, Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog

Includes: Supplementary data

NARROW

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs

Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog

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