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Meeting Abstracts

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SUDEEP K. AGRAWAL, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):121-OR

https://doi.org/10.2337/db24-121-OR

Published: 14 June 2024

View articletitled, 121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

Meeting Abstracts

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):116-OR

https://doi.org/10.2337/db24-116-OR

Published: 14 June 2024

View articletitled, 116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

Journal Articles

Glucose Regulation of β-Cell K_ATP Channels: Is a New Model Needed?

Guy A. Rutter, Ian R. Sweet

Diabetes 2024;73(6):849–855

https://doi.org/10.2337/dbi23-0031

Published: 19 April 2024

View articletitled, Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?

Meeting Abstracts

374-OR: Exercise Training Decreases ß-Cell Senescence in Mice and Humans

PRISCILA CARAPETO, JIHO KAHNG, ANA BARBARA T. ALVES WAGNER, ROELAND J.W. MIDDELBEEK, MICHAEL F. HIRSHMAN, GUY A. RUTTER, LAURIE GOODYEAR, CRISTINA AGUAYO-MAZZUCATO

Diabetes 2023;72(Supplement_1):374-OR

https://doi.org/10.2337/db23-374-OR

Published: 20 June 2023

View articletitled, 374-OR: Exercise Training Decreases ß-Cell Senescence in Mice and Humans

Meeting Abstracts

1750-P: Differential Impacts of Two Novel HNF1A Variants Associated with Familial Young-Onset Diabetes on Protein Function and Insulin Secretion In Vitro

INES CHERKAOUI, QIAN DU, CAMILLE DION, HARRY LEITCH, PAULINE L. CHABOSSEAU, DIETRICH M. EGLI, DILSHAD SACHEDINA, JULES WASTIN, SHIVANI MISRA, GUY A. RUTTER

Diabetes 2023;72(Supplement_1):1750-P

https://doi.org/10.2337/db23-1750-P

Published: 20 June 2023

View articletitled, 1750-P: Differential Impacts of Two Novel HNF1A Variants Associated with Familial Young-Onset Diabetes on Protein Function and Insulin Secretion In Vitro

Meeting Abstracts

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SATISH T. PANCHAL, SUDEEP K. AGRAWAL, BERNARD JANDRAIN, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2023;72(Supplement_1):766-P

https://doi.org/10.2337/db23-766-P

Published: 20 June 2023

View articletitled, 766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

Meeting Abstracts

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Diabetes 2023;72(Supplement_1):765-P

https://doi.org/10.2337/db23-765-P

Published: 20 June 2023

View articletitled, 765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Meeting Abstracts

364-OR: Unsupervised Approach Systematically Analyzes the Multiomics Profiles Associated with T2D Insulin Insensitivity—An IMI-RHAPSODY Study

SHIYING LI, MARK IBBERSON, GUY A. RUTTER, EWAN PEARSON, RODERICK SLIEKER, JOLINE BEULENS, MICHAEL K. HANSEN, DMITRY KUZNETSOV, MATHIAS J. GERL, IULIAN J. DRAGAN, KAI SIMONS, LOUISE A. DONNELLY, VAN DU T. TRAN, FLORENCE MEHL, LEEN M. 'T HART

Diabetes 2023;72(Supplement_1):364-OR

https://doi.org/10.2337/db23-364-OR

Published: 20 June 2023

View articletitled, 364-OR: Unsupervised Approach Systematically Analyzes the Multiomics Profiles Associated with T2D Insulin Insensitivity—An IMI-RHAPSODY Study

Meeting Abstracts

1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

LUIS F. DELGADILLO SILVA, GUY A. RUTTER, PAULINE L. CHABOSSEAU, AUDREY PROVENCHER-GIRARD, ALEXANDRE PRAT, LIVIA LOPEZ NORIEGA

Diabetes 2023;72(Supplement_1):1767-P

https://doi.org/10.2337/db23-1767-P

Published: 20 June 2023

View articletitled, 1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

Journal Articles

Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

Elina Akalestou, Livia Lopez-Noriega, Iain R. Tough, Ming Hu, Isabelle Leclerc, Helen M. Cox, Guy A. Rutter

Diabetes 2022;71(8):1623–1635

https://doi.org/10.2337/db21-0768

Published: 21 August 2022

View articletitled, Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

Meeting Abstracts

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

PAULINE L. CHABOSSEAU, SU WERN FIONA YONG, LIVIA LOPEZ, ISABELLE LECLERC, YUSUF ALI, AIDA MARTINEZ-SANCHEZ, GUY A. RUTTER

Diabetes 2022;71(Supplement_1):1454-P

https://doi.org/10.2337/db22-1454-P

Published: 01 June 2022

View articletitled, 1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

Meeting Abstracts

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2022;71(Supplement_1):744-P

https://doi.org/10.2337/db22-744-P

Published: 01 June 2022

View articletitled, 744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

Meeting Abstracts

362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion

KINGA SUBA, YATEEN S. PATEL, ANNA ROBERTS, JED V. SHREWSBURY, SHIQIAN CHEN, RACHEL KWOK, VASILIKI KALOGIANNI, XIAOXUAN LIU, GUY A. RUTTER, BEN JONES, TRICIA M. TAN, BRYN OWEN, DANIEL J. DRUCKER, STEPHEN BLOOM, KEVIN MURPHY, VICTORIA SALEM

Diabetes 2022;71(Supplement_1):362-OR

https://doi.org/10.2337/db22-362-OR

Published: 01 June 2022

View articletitled, 362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion

Journal Articles

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Diabetes 2022;71(7):1525–1545

https://doi.org/10.2337/db21-0803

Published: 27 April 2022

View articletitled, Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Journal Articles

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Diabetes 2022;71(7):1472–1489

https://doi.org/10.2337/db21-0800

Published: 26 April 2022

View articletitled, Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Journal Articles

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Diabetes 2021;70(11):2683–2693

https://doi.org/10.2337/db20-1281

Published: 10 August 2021

View articletitled, Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Meeting Abstracts

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

STAVROULA BITSI, KINGA SUBA, NIMCO MOHAMED, ISABELLE LECLERC, GUY A. RUTTER, VICTORIA SALEM, BEN JONES, ALEJANDRA TOMAS

Diabetes 2021;70(Supplement_1):228-LB

https://doi.org/10.2337/db21-228-LB

Published: 01 June 2021

View articletitled, 228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

Meeting Abstracts

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2021;70(Supplement_1):638-P

https://doi.org/10.2337/db21-638-P

Published: 01 June 2021

View articletitled, 638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

Meeting Abstracts

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

ELENI GEORGIADOU, CHARANYA MURALIDHARAN, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, THEODOROS STYLIANIDES, CRISTINA LEGIDO-QUIGLEY, NOUR ALSABEEH, CÉLINE CRUCIANI-GUGLIELMACCI, CHRISTOPHE MAGNAN, MARK IBBERSON, ISABELLE LECLERC, AMELIA K. LINNEMANN, YUSUF ALI, TRISTAN RODRIGUEZ, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):38-OR

https://doi.org/10.2337/db21-38-OR

Published: 01 June 2021

View articletitled, 38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

Meeting Abstracts

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

YUSMAN MANCHANDA, BEN JONES, GAELLE CARRAT, ZENOUSKA RAMCHUNDER, PIERO MARCHETTI, ISABELLE LECLERC, RAJAMANNAR THENNATI, VINOD S. BURADE, ALEJANDRA TOMAS, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):87-LB

https://doi.org/10.2337/db21-87-LB

Published: 01 June 2021

View articletitled, 87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

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121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

Glucose Regulation of β-Cell K_ATP Channels: Is a New Model Needed?

374-OR: Exercise Training Decreases ß-Cell Senescence in Mice and Humans

1750-P: Differential Impacts of Two Novel HNF1A Variants Associated with Familial Young-Onset Diabetes on Protein Function and Insulin Secretion In Vitro

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

364-OR: Unsupervised Approach Systematically Analyzes the Multiomics Profiles Associated with T2D Insulin Insensitivity—An IMI-RHAPSODY Study

1767-P: “Leader” ß-Cells within the Pancreatic Islet Are a Functionally Stable Subpopulation In Vitro and In Vivo

Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

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