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Hanieh Yaghootkar
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Journal Articles

Identifying four obesity axes through integrative multi-omics and imaging analysis

Free
Chiemela S. Odoemelam, Afreen Naz, Marjola Thanaj, Elena P Sorokin, Brandon Whitcher, Naveed Sattar, Jimmy D Bell, E Louise Thomas, Madeleine Cule, Hanieh Yaghootkar
Journal: Diabetes
Diabetes db241103
https://doi.org/10.2337/db24-1103
Published: 24 April 2025
View articletitled, Identifying four obesity axes through integrative multi-omics and imaging analysis
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Journal Articles

Genetic Evidence for Distinct Biological Mechanisms That Link Adiposity to Type 2 Diabetes: Toward Precision Medicine

Free
Angela Abraham, Madeleine Cule, Marjola Thanaj, Nicolas Basty, M. Amin Hashemloo, Elena P. Sorokin, Brandon Whitcher, Stephen Burgess, Jimmy D. Bell, Naveed Sattar, E. Louise Thomas, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2024;73(6):1012–1025
https://doi.org/10.2337/db23-1005
Published: 26 March 2024
View articletitled, Genetic Evidence for Distinct Biological Mechanisms That Link Adiposity to Type 2 Diabetes: Toward Precision Medicine
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Meeting Abstracts

190-LB: Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects

Free
SUSAN MARTIN, JESSICA TYRRELL, ELIZABETH L. THOMAS, MATTHEW BOWN, JAMES T. ELDER, CHRISTOPHER KABRHEL, NIKOS PAPADIMITRIOU, MARC GUNTER, EMMA E. VINCENT, JIMMY D. BELL, TIMOTHY M. FRAYLING, HANIEH YAGHOOTKAR
Journal: Diabetes
Diabetes 2021;70(Supplement_1):190-LB
https://doi.org/10.2337/db21-190-LB
Published: 01 June 2021
View articletitled, 190-LB: Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects
Journal Articles

Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease

Free
Susan Martin, Madeleine Cule, Nicolas Basty, Jessica Tyrrell, Robin N. Beaumont, Andrew R. Wood, Timothy M. Frayling, Elena Sorokin, Brandon Whitcher, Yi Liu, Jimmy D. Bell, E. Louise Thomas, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2021;70(8):1843–1856
https://doi.org/10.2337/db21-0129
Published: 12 May 2021
View articletitled, Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease
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Journal Articles

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Free
Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen
Journal: Diabetes
Diabetes 2020;69(12):2806–2818
https://doi.org/10.2337/db20-0070
Published: 11 September 2020
View articletitled, Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
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Journal Articles

A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function

Free
Francesco Casanova, Andrew R. Wood, Hanieh Yaghootkar, Robert N. Beaumont, Samuel E. Jones, Kim M. Gooding, Kunihiko Aizawa, W. David Strain, Andrew T. Hattersley, Faisel Khan, Angela C. Shore, Timothy M. Frayling, Jessica Tyrrell
Journal: Diabetes
Diabetes 2020;69(5):1072–1082
https://doi.org/10.2337/db19-0862
Published: 08 January 2020
View articletitled, A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Open the PDF for A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function in another window
Includes: Supplementary data
Journal Articles

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Free
Yingjie Ji, Andrianos M. Yiorkas, Francesca Frau, Dennis Mook-Kanamori, Harald Staiger, E. Louise Thomas, Naeimeh Atabaki-Pasdar, Archie Campbell, Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont, Andrew R. Wood, Marcus A. Tuke, Katherine S. Ruth, Anubha Mahajan, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Andrew T. Hattersley, Caroline Hayward, Jürgen Machann, Hans-Ulrich Häring, Paul Franks, Renée de Mutsert, Ewan Pearson, Norbert Stefan, Timothy M. Frayling, Karla V. Allebrandt, Jimmy D. Bell, Alexandra I. Blakemore, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2019;68(1):207–219
https://doi.org/10.2337/db18-0708
Published: 23 October 2018
View articletitled, Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Open the PDF for Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension in another window
Includes: Supplementary data
Meeting Abstracts

Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity

Free
ANDREW R. WOOD, SAMUEL E. JONES, REBECCA RICHMOND, SHAFQAT AHMAD, HANIEH YAGHOOTKAR, ROBERT BEAUMONT, KATHERINE S. RUTH, MARCUS TUKE, ANNA MURRAY, RACHEL M. FREATHY, GEORGE DAVEY SMITH, I-MIN LEE, NIC TIMPSON, DANIEL CHASMAN, ZOLTAN KUTALIK, MICHAEL N. WEEDON, JESSICA TYRRELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):23-OR
https://doi.org/10.2337/db18-23-OR
Published: 01 July 2018
View articletitled, Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity
Meeting Abstracts

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes

Free
HANIEH YAGHOOTKAR, YINGJIE JI, ANDRIANOS M. YIORKAS, FRANCESCA FRAU, DENNIS MOOK-KANAMORI, RENÉE DE MUTSERT, JESSICA TYRRELL, SAMUEL E. JONES, ROBERT BEAUMONT, ANDREW R. WOOD, LOUISE THOMAS, KARLA V. ALLEBRANDT, NORBERT STEFAN, HARALD STAIGER, EWAN PEARSON, ALEX I. BLAKEMORE, JIMMY D. BELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):20-OR
https://doi.org/10.2337/db18-20-OR
Published: 01 July 2018
View articletitled, Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes
Journal Articles

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

Free
Hanieh Yaghootkar, Luca A. Lotta, Jessica Tyrrell, Roelof A.J. Smit, Sam E. Jones, Louise Donnelly, Robin Beaumont, Archie Campbell, Marcus A. Tuke, Caroline Hayward, Katherine S. Ruth, Sandosh Padmanabhan, J. Wouter Jukema, Colin C. Palmer, Andrew Hattersley, Rachel M. Freathy, Claudia Langenberg, Nicholas J. Wareham, Andrew R. Wood, Anna Murray, Michael N. Weedon, Naveed Sattar, Ewan Pearson, Robert A. Scott, Timothy M. Frayling
Journal: Diabetes
Diabetes 2016;65(8):2448–2460
https://doi.org/10.2337/db15-1671
Published: 26 April 2016
View articletitled, Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Open the PDF for Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease in another window
Includes: Supplementary data
Journal Articles

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

Free
Tove Fall, Weijia Xie, Wenny Poon, Hanieh Yaghootkar, Reedik Mägi, the GENESIS Consortium, Joshua W. Knowles, Valeriya Lyssenko, Michael Weedon, Timothy M. Frayling, Erik Ingelsson
Journal: Diabetes
Diabetes 2015;64(7):2676–2684
https://doi.org/10.2337/db14-1710
Published: 06 May 2015
View articletitled, Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes
Open the PDF for Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

Free
Hanieh Yaghootkar, Alena Stancáková, Rachel M. Freathy, Jagadish Vangipurapu, Michael N. Weedon, Weijia Xie, Andrew R. Wood, Ele Ferrannini, Andrea Mari, Susan M. Ring, Debbie A. Lawlor, George Davey Smith, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Valgerdur Steinthorsdottir, Daniel F. Guðbjartsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew T. Hattersley, Mark Walker, Andrew D. Morris, Mark I. McCarthy, Colin N.A. Palmer, Markku Laakso, Timothy M. Frayling
Journal: Diabetes
Diabetes 2015;64(6):2279–2285
https://doi.org/10.2337/db14-1456
Published: 20 January 2015
View articletitled, Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion
Open the PDF for Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion in another window
Includes: Supplementary data
Journal Articles

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

Free
Hanieh Yaghootkar, Robert A. Scott, Charles C. White, Weihua Zhang, Elizabeth Speliotes, Patricia B. Munroe, Georg B. Ehret, Joshua C. Bis, Caroline S. Fox, Mark Walker, Ingrid B. Borecki, Joshua W. Knowles, Laura Yerges-Armstrong, Claes Ohlsson, John R.B. Perry, John C. Chambers, Jaspal S. Kooner, Nora Franceschini, Claudia Langenberg, Marie-France Hivert, Zari Dastani, J. Brent Richards, Robert K. Semple, Timothy M. Frayling
Journal: Diabetes
Diabetes 2014;63(12):4369–4377
https://doi.org/10.2337/db14-0318
Published: 13 November 2014
View articletitled, Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
Open the PDF for Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

Free
Robert A. Scott, Tove Fall, Dorota Pasko, Adam Barker, Stephen J. Sharp, Larraitz Arriola, Beverley Balkau, Aurelio Barricarte, Inês Barroso, Heiner Boeing, Françoise Clavel-Chapelon, Francesca L. Crowe, Jacqueline M. Dekker, Guy Fagherazzi, Ele Ferrannini, Nita G. Forouhi, Paul W. Franks, Diana Gavrila, Vilmantas Giedraitis, Sara Grioni, Leif C. Groop, Rudolf Kaaks, Timothy J. Key, Tilman Kühn, Luca A. Lotta, Peter M. Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J. Ramón Quirós, Olov Rolandsson, Nina Roswall, Carlotta Sacerdote, Núria Sala, María-José Sánchez, Matthias B. Schulze, Afshan Siddiq, Nadia Slimani, Ivonne Sluijs, Annemieke M.W. Spijkerman, Anne Tjonneland, Rosario Tumino, Daphne L. van der A, Hanieh Yaghootkar, The RISC Study Group, The EPIC-InterAct Consortium, Mark I. McCarthy, Robert K. Semple, Elio Riboli, Mark Walker, Erik Ingelsson, Tim M. Frayling, David B. Savage, Claudia Langenberg, Nicholas J. Wareham
Journal: Diabetes
Diabetes 2014;63(12):4378–4387
https://doi.org/10.2337/db14-0319
Published: 13 November 2014
View articletitled, Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
Open the PDF for Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity in another window
Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Open Access
Hanieh Yaghootkar, Claudia Lamina, Robert A. Scott, Zari Dastani, Marie-France Hivert, Liling L. Warren, Alena Stancáková, Sarah G. Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y.Y. Cheung, James S. Pankow, Anne U. Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M. Ballantyne, Weijia Xie, Richard N. Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S. Collins, Sandra H. Dunn, Josee Dupuis, Nita G. Forouhi, Christopher Gillson, Andrew T. Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L. Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W. Knowles, Cecilia M. Lindgren, John J. Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J.F. Loos, Mark I. McCarthy, Andrew D. Morris, Ramachandran S. Vasan, Tim D. Spector, Tanya M. Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S. Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K. Semple, Alan R. Sinaiko, Colin N.A. Palmer, Mark Walker, Karen S.L. Lam, Bernhard Paulweber, Karen L. Mohlke, Cornelia van Duijn, Olli T. Raitakari, Aurelian Bidulescu, Nick J. Wareham, Markku Laakso, Dawn M. Waterworth, Debbie A. Lawlor, James B. Meigs, J. Brent Richards, Timothy M. Frayling
Journal: Diabetes
Diabetes 2013;62(10):3589–3598
https://doi.org/10.2337/db13-0128
Published: 17 September 2013
View articletitled, Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
Open the PDF for Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes in another window
Includes: Supplementary data