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Meeting Abstracts

2043-LB: hERG Potassium Channels as Novel Targets for GLP-1 and GIP Secretagogue Therapies in Diabetes and Obesity

Free
YING-CHAO YUAN, HAO WANG, JIN-KUI YANG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2043-LB
https://doi.org/10.2337/db24-2043-LB
Published: 14 June 2024
View articletitled, 2043-LB: hERG Potassium Channels as Novel Targets for GLP-1 and GIP Secretagogue Therapies in Diabetes and Obesity
Meeting Abstracts

1511-P: Fas Apoptosis Inhibitory Molecule (FAIM) Regulates Adipose Browning, Glucose Homeostasis, and Thermogenesis

Free
LLOYD NORIEGA, CHIH-HAO WANG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1511-P
https://doi.org/10.2337/db24-1511-P
Published: 14 June 2024
View articletitled, 1511-P: Fas Apoptosis Inhibitory Molecule (FAIM) Regulates Adipose Browning, Glucose Homeostasis, and Thermogenesis
Meeting Abstracts

1656-P: Glucagon-Like peptide-1 (GLP-1) Secretion from Intestinal L-Cells Is Mediated by hERG Potassium Channels

Free
JIN-KUI YANG, CHANG LIU, HAO WANG, YINGCHAO YUAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1656-P
https://doi.org/10.2337/db23-1656-P
Published: 20 June 2023
View articletitled, 1656-P: Glucagon-Like peptide-1 (GLP-1) Secretion from Intestinal L-Cells Is Mediated by hERG Potassium Channels
Meeting Abstracts

1746-P: The Role of Cell–Cell Junction Associated Mediator in Glucose-Stimulated Insulin Secretion of Pancreatic Islets

Free
HAO WANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1746-P
https://doi.org/10.2337/db23-1746-P
Published: 20 June 2023
View articletitled, 1746-P: The Role of Cell–Cell Junction Associated Mediator in Glucose-Stimulated Insulin Secretion of Pancreatic Islets
Journal Articles

Erratum. TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model. Diabetes 2011;60:2963–2974

Free
Yun Ti, Guo-lu Xie, Zhi-hao Wang, Xiao-lei Bi, Wen-yuan Ding, Jia Wang, Gui-hua Jiang, Pei-li Bu, Yun Zhang, Ming Zhong, Wei Zhang
Journal: Diabetes
Diabetes 2023;72(6):820
https://doi.org/10.2337/db23-er06a
Published: 18 April 2023
View articletitled, Erratum. TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model. Diabetes 2011;60:2963–2974
Open the PDF for Erratum. TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model. Diabetes 2011;60:2963–2974 in another window
Meeting Abstracts

310-OR: Histone Variant H2A.Z-Mediated Chromatin Organization Regulates Brown Adipocyte Thermogenic Function

Free
YANG ZHANG, RONGBIN ZHENG, CHIH-HAO WANG, JUSTIN DARCY, KAIFU CHEN, YU-HUA TSENG
Journal: Diabetes
Diabetes 2022;71(Supplement_1):310-OR
https://doi.org/10.2337/db22-310-OR
Published: 01 June 2022
View articletitled, 310-OR: Histone Variant H2A.Z-Mediated Chromatin Organization Regulates Brown Adipocyte Thermogenic Function
Journal Articles

Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance

Free
Hao Wang, Yongyan Song, Yuxin Wu, Virender Kumar, Ram I. Mahato, Qiaozhu Su
Journal: Diabetes
Diabetes 2021;70(3):710–719
https://doi.org/10.2337/db20-0181
Published: 07 January 2021
View articletitled, Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance
Open the PDF for Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance in another window
Journal Articles

Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane

Free
Hao Wang, Kouichi Mizuno, Noriko Takahashi, Eri Kobayashi, Jun Shirakawa, Yasuo Terauchi, Haruo Kasai, Katsuhide Okunishi, Tetsuro Izumi
Journal: Diabetes
Diabetes 2020;69(12):2655–2666
https://doi.org/10.2337/db20-0069
Published: 29 November 2020
View articletitled, Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane
Open the PDF for Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane in another window
Meeting Abstracts

1701-P: The Role of UGT1a in Regulating Brown Adipose Tissue and Thermogenic Function

Free
SEAN KODANI, MATTHEW LYNES, FARNAZ SHAMSI, CHIH-HAO WANG, SATORU SUGIMOTO, RUIDAN XUE, TIAN LIAN HUANG, ANDREW P. WHITE, AARON M. CYPESS, YU-HUA TSENG
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1701-P
https://doi.org/10.2337/db20-1701-P
Published: 01 June 2020
View articletitled, 1701-P: The Role of UGT1a in Regulating Brown Adipose Tissue and Thermogenic Function
Meeting Abstracts

1937-P: ALK-7: A Validated Target for the Treatment of Obesity

Free
YUN BU, MIN ZHAO, MAUREEN FREDERICKS, MARISHKA CANNELL, YOSSI DAGON, CONNOR A. EMDIN, KATSUHIDE OKUNISHI, HAO WANG, DIANNE SAKO, ROSELYNE CASTONGUAY, RAJASEKHAR N.V. SURAGANI, SEKAR KATHIRESAN, ASYA GRINBERG, JOHN KNOPF, ROBERT S. PEARSALL, RAVINDRA KUMAR, TETSURO IZUMI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1937-P
https://doi.org/10.2337/db20-1937-P
Published: 01 June 2020
View articletitled, 1937-P: ALK-7: A Validated Target for the Treatment of Obesity
Journal Articles

Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults

Free
Wei Gan, Fiona Bragg, Robin G. Walters, Iona Y. Millwood, Kuang Lin, Yiping Chen, Yu Guo, Julien Vaucher, Zheng Bian, Derrick Bennett, Jun Lv, Canqing Yu, Anubha Mahajan, Robert J. Clarke, Liming Li, Michael V. Holmes, Mark I. McCarthy, Zhengming Chen, China Kadoorie Biobank Collaborative Group, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Yu Guo, Liming Li, Jun Lv, Richard Peto, Robin Walters, Daniel Avery, Derrick Bennett, Ruth Boxall, Fiona Bragg, Yumei Chang, Yiping Chen, Huaidong Du, Simon Gilbert, Alex Hacker, Michael Holmes, Andri Iona, Christiana Kartsonaki, Rene Kerosi, Om Kurmi, Sarah Lewington, Garry Lancaster, Kuang Lin, John McDonnell, Iona Millwood, Qunhua Nie, Jayakrishnan Radhakrishnan, Paul Ryder, Sam Sansome, Dan Schmidt, Paul Sherliker, Rajani Sohoni, Becky Stevens, Iain Turnbull, Jenny Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Zheng Bian, Ge Chen, Xiao Han, Can Hou, Pei Pei, Shuzhen Qu, Yunlong Tan, Canqing Yu, Zengchang Pang, Ruqin Gao, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Silu Lv, Junzheng Wang, Wei Hou, Jiyuan Yin, Ge Jiang, Xue Zhou, Liqiu Yang, Hui He, Bo Yu, Yanjie Li, Huaiyi Mu, Qinai Xu, Meiling Dou, Jiaojiao Ren, Shanqing Wang, Ximin Hu, Hongmei Wang, Jinyan Chen, Yan Fu, Zhenwang Fu, Xiaohuan Wang, Min Weng, Xiangyang Zheng, Yilei Li, Huimei Li, Yanjun Wang, Ming Wu, Jinyi Zhou, Ran Tao, Jie Yang, Chuanming Ni, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jingchao Liu, Zhenzhu Tang, Naying Chen, Ying Huang, Mingqiang Li, Jinhuai Meng, Rong Pan, Qilian Jiang, Weiyuan Zhang, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Hairong Guan, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xuefeng Tang, Guojin Luo, Jianguo Li, Xunfu Zhong, Jiaqiu Liu, Qiang Sun, Pengfei Ge, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Ding Zhang, Gang Zhou, Shixian Feng, Liang Chang, Lei Fan, Yulian Gao, Tianyou He, Huarong Sun, Pan He, Chen Hu, Qiannan Lv, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Yijian Qian, Chunmei Wang, Kaixue Xie, Lingli Chen, Yidan Zhang, Dongxia Pan, Yuelong Huang, Biyun Chen, Li Yin, Donghui Jin, Huilin Liu, Zhongxi Fu, Qiaohua Xu, Xin Xu, Hao Zhang, Youping Xiong, Huajun Long, Xianzhi Li, Libo Zhang, Zhe Qiu
Journal: Diabetes
Diabetes 2019;68(11):2155–2164
https://doi.org/10.2337/db19-0224
Published: 09 August 2019
View articletitled, Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults
Open the PDF for Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults in another window
Includes: Supplementary data
Meeting Abstracts

597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity

Free
HISASHI YOKOMIZO, KYOUNGMIN PARK, ALLEN CLERMONT, YASUTAKA MAEDA, WARD FICKWEILER, ATSUSHI ISHIKADO, QIAN LI, CHIH-HAO WANG, DAVID M. POBER, I-HSIEN WU, HILLARY A. KEENAN, LLOYD P. AIELLO, JENNIFER K. SUN, GEORGE L. KING
Journal: Diabetes
Diabetes 2019;68(Supplement_1):597-P
https://doi.org/10.2337/db19-597-P
Published: 01 June 2019
View articletitled, 597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity
Meeting Abstracts

1999-P: Cysteine-Rich Protein 2 (CRIP2) Is a Novel Transcriptional Regulator of Uncoupling Protein 1

Free
JUSTIN DARCY, CHIH-HAO WANG, MORTEN LUNDH, FARNAZ SHAMSI, MATTHEW LYNES, THOMAS D'APRIGNY, BRICE EMANUELLI, YU-HUA TSENG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1999-P
https://doi.org/10.2337/db19-1999-P
Published: 01 June 2019
View articletitled, 1999-P: Cysteine-Rich Protein 2 (CRIP2) Is a Novel Transcriptional Regulator of Uncoupling Protein 1
Meeting Abstracts

NREP Bridges TGF-ß Signaling and Lipid Metabolism in the Epigenetic Reprogramming of NAFLD in the Offspring of Insulin-Resistant Parents

Free
DARIO F. DE JESUS, KAZUKI ORIME, CHIH-HAO WANG, JIANG HU, ERCUMENT DIRICE, AMÉLIA M. SILVA, YU-HUA TSENG, JUSSI PIHLAJAMAKI, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):46-OR
https://doi.org/10.2337/db18-46-OR
Published: 01 July 2018
View articletitled, NREP Bridges TGF-ß Signaling and Lipid Metabolism in the Epigenetic Reprogramming of NAFLD in the Offspring of Insulin-Resistant Parents
Meeting Abstracts

CRISPR-Engineered Human Brown-Like Adipocytes Promotes Metabolic Homeostasis through Activation of Endogenous Brown Fat

Free
CHIH-HAO WANG, MORTEN LUNDH, ROKUS KRISZT, TIAN LIAN HUANG, LUIZ O. LEIRIA, FARNAZ SHAMSI, MATT LYNES, JUSTIN DARCY, BRICE EMANUELLI, MICHAEL KIEBISH, YU-HUA TSENG
Journal: Diabetes
Diabetes 2018;67(Supplement_1):273-OR
https://doi.org/10.2337/db18-273-OR
Published: 01 July 2018
View articletitled, CRISPR-Engineered Human Brown-Like Adipocytes Promotes Metabolic Homeostasis through Activation of Endogenous Brown Fat
Meeting Abstracts

FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism

Free
MASAJI SAKAGUCHI, WEIKANG CAI, CHIH-HAO WANG, THIAGO M. BATISTA, EIICHI ARAKI, C. RONALD KAHN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):356-OR
https://doi.org/10.2337/db18-356-OR
Published: 01 July 2018
View articletitled, FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism
Meeting Abstracts

Identification of Novel Transcriptional Regulators of Uncoupling Protein 1 Using a Modified CRISPR-Cas9 Methodology

Free
JUSTIN DARCY, CHIH-HAO WANG, MORTEN LUNDH, FARNAZ SHAMSI, MATT LYNES, BRICE EMANUELLI, YU-HUA TSENG
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2022-P
https://doi.org/10.2337/db18-2022-P
Published: 01 July 2018
View articletitled, Identification of Novel Transcriptional Regulators of Uncoupling Protein 1 Using a Modified CRISPR-Cas9 Methodology
Journal Articles

Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress

Open Access
Stanley M.H. Chan, Ruo-Qiong Sun, Xiao-Yi Zeng, Zi-Heng Choong, Hao Wang, Matthew J. Watt, Ji-Ming Ye
Journal: Diabetes
Diabetes 2013;62(6):2095–2105
https://doi.org/10.2337/db12-1397
Published: 17 May 2013
View articletitled, Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress
Open the PDF for Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress in another window
Includes: Supplementary data
Journal Articles

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE−/−/LDL Receptor−/− Mice

Open Access
Zhi-hao Wang, Yuan-yuan Shang, Shun Zhang, Ming Zhong, Xu-ping Wang, Jing-ti Deng, Jie Pan, Yun Zhang, Wei Zhang
Journal: Diabetes
Diabetes 2012;61(2):463–473
https://doi.org/10.2337/db11-0518
Published: 17 January 2012
View articletitled, Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE−/−/LDL Receptor−/− Mice
Open the PDF for Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE−/−/LDL Receptor−/− Mice in another window
Includes: Supplementary data
Journal Articles

TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model

Open Access
Yun Ti, Guo-lu Xie, Zhi-hao Wang, Xiao-lei Bi, Wen-yuan Ding, Jia Wang, Gui-hua Jiang, Pei-li Bu, Yun Zhang, Ming Zhong, Wei Zhang
Journal: Diabetes
Diabetes 2011;60(11):2963–2974
https://doi.org/10.2337/db11-0549
Published: 17 October 2011
View articletitled, TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model
Open the PDF for TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model in another window
Includes: Supplementary data