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Harald Staiger
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Journal Articles

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

Anne-Sofie Graae, Niels Grarup, Rasmus Ribel-Madsen, Sara H. Lystbæk, Trine Boesgaard, Harald Staiger, Andreas Fritsche, Niels Wellner, Karolina Sulek, Mads Kjolby, Marie Balslev Backe, Sabina Chubanava, Clara Prats, Annette K. Serup, Jesper B. Birk, Johanne Dubail, Linn Gillberg, Sara G. Vienberg, Anders Nykjær, Bente Kiens, Jørgen F.P. Wojtaszewski, Steen Larsen, Suneel S. Apte, Hans-Ulrich Häring, Allan Vaag, Björn Zethelius, Oluf Pedersen, Jonas T. Treebak, Torben Hansen, Birgitte Holst
Journal: Diabetes
Diabetes 2019;68(3):502–514
https://doi.org/10.2337/db18-0418
Published: 09 January 2019
View article titled, ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations
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Includes: Supplementary data
Journal Articles

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Yingjie Ji, Andrianos M. Yiorkas, Francesca Frau, Dennis Mook-Kanamori, Harald Staiger, E. Louise Thomas, Naeimeh Atabaki-Pasdar, Archie Campbell, Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont, Andrew R. Wood, Marcus A. Tuke, Katherine S. Ruth, Anubha Mahajan, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Andrew T. Hattersley, Caroline Hayward, Jürgen Machann, Hans-Ulrich Häring, Paul Franks, Renée de Mutsert, Ewan Pearson, Norbert Stefan, Timothy M. Frayling, Karla V. Allebrandt, Jimmy D. Bell, Alexandra I. Blakemore, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2019;68(1):207–219
https://doi.org/10.2337/db18-0708
Published: 23 October 2018
View article titled, Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Open the PDF for Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension in another window
Includes: Supplementary data
Meeting Abstracts

SNP x SNP Interactions Elucidate TCF7L2’s Physiology Conveying Incretin Action

BENJAMIN JAGHUTRIZ, MARTIN HENI, STEFAN Z. LUTZ, HARALD STAIGER, ANDREAS PETER, HANS-ULRICH HAERING, ANDREAS FRITSCHE, ROBERT WAGNER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1717-P
https://doi.org/10.2337/db18-1717-P
Published: 01 July 2018
View article titled, SNP x SNP Interactions Elucidate TCF7L2’s Physiology Conveying Incretin Action
Meeting Abstracts

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes

HANIEH YAGHOOTKAR, YINGJIE JI, ANDRIANOS M. YIORKAS, FRANCESCA FRAU, DENNIS MOOK-KANAMORI, RENÉE DE MUTSERT, JESSICA TYRRELL, SAMUEL E. JONES, ROBERT BEAUMONT, ANDREW R. WOOD, LOUISE THOMAS, KARLA V. ALLEBRANDT, NORBERT STEFAN, HARALD STAIGER, EWAN PEARSON, ALEX I. BLAKEMORE, JIMMY D. BELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):20-OR
https://doi.org/10.2337/db18-20-OR
Published: 01 July 2018
View article titled, Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes
Journal Articles

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stančáková, Han Chen, Ching-Ti Liu, Jaeyoung Hong, Richard A. Jensen, Ken Rice, Andrew P. Morris, Reedik Mägi, Anke Tönjes, Inga Prokopenko, Marcus E. Kleber, Graciela Delgado, Günther Silbernagel, Anne U. Jackson, Emil V. Appel, Niels Grarup, Joshua P. Lewis, May E. Montasser, Claes Landenvall, Harald Staiger, Jian’an Luan, Timothy M. Frayling, Michael N. Weedon, Weijia Xie, Sonsoles Morcillo, María Teresa Martínez-Larrad, Mary L. Biggs, Yii-Der Ida Chen, Arturo Corbaton-Anchuelo, Kristine Færch, Juan Miguel Gómez-Zumaquero, Mark O. Goodarzi, Jorge R. Kizer, Heikki A. Koistinen, Aaron Leong, Lars Lind, Cecilia Lindgren, Fausto Machicao, Alisa K. Manning, Gracia María Martín-Núñez, Gemma Rojo-Martínez, Jerome I. Rotter, David S. Siscovick, Joseph M. Zmuda, Zhongyang Zhang, Manuel Serrano-Rios, Ulf Smith, Federico Soriguer, Torben Hansen, Torben J. Jørgensen, Allan Linnenberg, Oluf Pedersen, Mark Walker, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Leif Groop, Jeff R. O’Connell, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Winfried März, Peter Kovacs, Michael Stumvoll, Bruce M. Psaty, Johanna Kuusisto, Markku Laakso, James B. Meigs, Josée Dupuis, Erik Ingelsson, Jose C. Florez
Journal: Diabetes
Diabetes 2016;65(10):3200–3211
https://doi.org/10.2337/db16-0199
Published: 14 July 2016
View article titled, Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies <em>BCL2</em> and <em>FAM19A2</em> as Novel Insulin Sensitivity Loci
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Includes: Supplementary data
Journal Articles

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

Anja Böhm, Christoph Hoffmann, Martin Irmler, Patrick Schneeweiss, Günter Schnauder, Corinna Sailer, Vera Schmid, Jens Hudemann, Jürgen Machann, Fritz Schick, Johannes Beckers, Martin Hrabě de Angelis, Harald Staiger, Andreas Fritsche, Norbert Stefan, Andreas M. Nieß, Hans-Ulrich Häring, Cora Weigert
Journal: Diabetes
Diabetes 2016;65(10):2849–2861
https://doi.org/10.2337/db15-1723
Published: 29 June 2016
View article titled, TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle
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Includes: Supplementary data
Journal Articles

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans

Andreas Peter, Konstantinos Kantartzis, Jürgen Machann, Fritz Schick, Harald Staiger, Fausto Machicao, Erwin Schleicher, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan
Journal: Diabetes
Diabetes 2010;59(12):3167–3173
https://doi.org/10.2337/db10-0179
Published: 14 September 2010
View article titled, Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
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Journal Articles

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion

Martin Heni, Caroline Ketterer, Claus Thamer, Silke A. Herzberg-Schäfer, Martina Guthoff, Norbert Stefan, Fausto Machicao, Harald Staiger, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2010;59(12):3247–3252
https://doi.org/10.2337/db10-0674
Published: 29 August 2010
View article titled, Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion
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Includes: Supplementary data
Journal Articles

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes

Axel Haupt, Claus Thamer, Martin Heni, Caroline Ketterer, Jürgen Machann, Fritz Schick, Fausto Machicao, Norbert Stefan, Claus D. Claussen, Hans-Ulrich Häring, Andreas Fritsche, Harald Staiger
Journal: Diabetes
Diabetes 2010;59(3):747–750
https://doi.org/10.2337/db09-1050
Published: 22 December 2009
View article titled, Gene Variants of <em>TCF7L2</em> Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
Open the PDF for Gene Variants of <em>TCF7L2</em> Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

Andreas Peter, Cora Weigert, Harald Staiger, Fausto Machicao, Fritz Schick, Jürgen Machann, Norbert Stefan, Claus Thamer, Hans-Ulrich Häring, Erwin Schleicher
Journal: Diabetes
Diabetes 2009;58(8):1757–1765
https://doi.org/10.2337/db09-0188
Published: 28 May 2009
View article titled, Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
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Journal Articles

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion

Karsten Müssig, Harald Staiger, Fausto Machicao, Kerstin Kirchhoff, Martina Guthoff, Silke A. Schäfer, Konstantinos Kantartzis, Günther Silbernagel, Norbert Stefan, Jens J. Holst, Baptist Gallwitz, Hans-Ulrich Häring, Andreas Fritsche
Journal: Diabetes
Diabetes 2009;58(7):1715–1720
https://doi.org/10.2337/db08-1589
Published: 14 April 2009
View article titled, Association of Type 2 Diabetes Candidate Polymorphisms in <em>KCNQ1</em> With Incretin and Insulin Secretion
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Includes: Supplementary data
Journal Articles

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans

Harald Staiger, Carina Haas, Jürgen Machann, Roman Werner, Melanie Weisser, Fritz Schick, Fausto Machicao, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2009;58(3):579–589
https://doi.org/10.2337/db07-1438
Published: 01 March 2009
View article titled, Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
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Includes: Supplementary data
Journal Articles

A Candidate Type 2 Diabetes Polymorphism Near the HHEX Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations : Results from the EUGENE2 study

Harald Staiger, Alena Stančáková, Jone Zilinskaite, Markku Vänttinen, Torben Hansen, Maria Adelaide Marini, Ann Hammarstedt, Per-Anders Jansson, Giorgio Sesti, Ulf Smith, Oluf Pedersen, Markku Laakso, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2008;57(2):514–517
https://doi.org/10.2337/db07-1254
Published: 01 February 2008
View article titled, A Candidate Type 2 Diabetes Polymorphism Near the <em>HHEX</em> Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations : <subtitle>Results from the EUGENE2 study</subtitle>
Open the PDF for A Candidate Type 2 Diabetes Polymorphism Near the <em>HHEX</em> Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations : <subtitle>Results from the EUGENE2 study</subtitle> in another window
Includes: Supplementary data
Journal Articles

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation

Katrin Staiger, Harald Staiger, Cora Weigert, Carina Haas, Hans-Ulrich Häring, Monika Kellerer
Journal: Diabetes
Diabetes 2006;55(11):3121–3126
https://doi.org/10.2337/db06-0188
Published: 01 November 2006
View article titled, Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-κB Activation
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Journal Articles

Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells

Harald Staiger, Katrin Staiger, Norbert Stefan, Hans Günther Wahl, Fausto Machicao, Monika Kellerer, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2004;53(12):3209–3216
https://doi.org/10.2337/diabetes.53.12.3209
Published: 01 December 2004
View article titled, Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells
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Journal Articles

Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism

Harald Staiger, Simone Kaltenbach, Katrin Staiger, Norbert Stefan, Andreas Fritsche, Alke Guirguis, Claudia Péterfi, Melanie Weisser, Fausto Machicao, Michael Stumvoll, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2004;53(9):2195–2201
https://doi.org/10.2337/diabetes.53.9.2195
Published: 01 September 2004
View article titled, Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism
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Journal Articles

Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells

Katrin Eitel, Harald Staiger, Johannes Rieger, Harald Mischak, Heide Brandhorst, Mathias D. Brendel, Reinhard G. Bretzel, Hans-Ulrich Häring, Monika Kellerer
Journal: Diabetes
Diabetes 2003;52(4):991–997
https://doi.org/10.2337/diabetes.52.4.991
Published: 01 April 2003
View article titled, Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells
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Journal Articles

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

Otto Tschritter, Andreas Fritsche, Claus Thamer, Michael Haap, Fatemeh Shirkavand, Stefanie Rahe, Harald Staiger, Elke Maerker, Hans Häring, Michael Stumvoll
Journal: Diabetes
Diabetes 2003;52(2):239–243
https://doi.org/10.2337/diabetes.52.2.239
Published: 01 February 2003
View article titled, Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
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Journal Articles

Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes

Michael Stumvoll, Otto Tschritter, Andreas Fritsche, Harald Staiger, Walter Renn, Melanie Weisser, Fausto Machicao, Hans Häring
Journal: Diabetes
Diabetes 2002;51(1):37–41
https://doi.org/10.2337/diabetes.51.1.37
Published: 01 January 2002
View article titled, Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: <subtitle>Interaction With Family History of Type 2 Diabetes </subtitle>
Open the PDF for Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: <subtitle>Interaction With Family History of Type 2 Diabetes </subtitle> in another window