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Herbert Y. Gaisano
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Journal Articles

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2017;66(7):1890–1900
https://doi.org/10.2337/db16-1170
Published: 15 June 2017
View article titled, Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction
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Includes: Supplementary data
Journal Articles

The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1

Sarah E. Wheeler, Holly M. Stacey, Yasaman Nahaei, Stephen J. Hale, Alexandre B. Hardy, Frank Reimann, Fiona M. Gribble, Pierre Larraufie, Herbert Y. Gaisano, Patricia L. Brubaker
Journal: Diabetes
Diabetes 2017;66(9):2327–2338
https://doi.org/10.2337/db16-1403
Published: 08 June 2017
View article titled, The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1
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Journal Articles

Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis

Dan Zhu, Li Xie, Youhou Kang, Subhankar Dolai, Jakob Bondo Hansen, Tairan Qin, Huanli Xie, Tao Liang, Deborah C. Rubin, Lucy Osborne, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2017;66(4):948–959
https://doi.org/10.2337/db16-0636
Published: 23 January 2017
View article titled, Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
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Includes: Supplementary data
Journal Articles

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells

Subhankar Dolai, Li Xie, Dan Zhu, Tao Liang, Tairan Qin, Huanli Xie, Youhou Kang, Edwin R. Chapman, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2016;65(7):1962–1976
https://doi.org/10.2337/db15-1436
Published: 26 April 2016
View article titled, Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
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Includes: Supplementary data
Journal Articles

PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance

Linyuan Wang, Cynthia T. Luk, Erica P. Cai, Stephanie A. Schroer, Emma M. Allister, Sally Y. Shi, Michael B. Wheeler, Herbert Y. Gaisano, Minna Woo
Journal: Diabetes
Diabetes 2015;64(1):147–157
https://doi.org/10.2337/db13-1715
Published: 04 August 2014
View article titled, PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
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Includes: Supplementary data
Journal Articles

Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

Negar Karimian, Tairan Qin, Tao Liang, Mayowa Osundiji, Yachi Huang, Trevor Teich, Michael C. Riddell, Mark S. Cattral, David H. Coy, Mladen Vranic, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2013;62(8):2968–2977
https://doi.org/10.2337/db13-0164
Published: 17 July 2013
View article titled, Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats
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Journal Articles

Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells

Patrick P.L. Lam, Mitsuyo Ohno, Subhankar Dolai, Yu He, Tairan Qin, Tao Liang, Dan Zhu, Youhou Kang, Yunfeng Liu, Maria Kauppi, Li Xie, Wilson C.Y. Wan, Na-Rhum Bin, Shuzo Sugita, Vesa M. Olkkonen, Noriko Takahashi, Haruo Kasai, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2013;62(7):2416–2428
https://doi.org/10.2337/db12-1380
Published: 14 June 2013
View article titled, Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells
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Includes: Multimedia, Supplementary data
Journal Articles

UCP2 Regulates the Glucagon Response to Fasting and Starvation

Emma M. Allister, Christine A. Robson-Doucette, Kacey J. Prentice, Alexandre B. Hardy, Sobia Sultan, Herbert Y. Gaisano, Dong Kong, Patrick Gilon, Pedro L. Herrera, Bradford B. Lowell, Michael B. Wheeler
Journal: Diabetes
Diabetes 2013;62(5):1623–1633
https://doi.org/10.2337/db12-0981
Published: 16 April 2013
View article titled, UCP2 Regulates the Glucagon Response to Fasting and Starvation
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Includes: Supplementary data
Journal Articles

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

Ya-Chi Huang, Marjan S. Rupnik, Negar Karimian, Pedro L. Herrera, Patrick Gilon, Zhong-Ping Feng, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2013;62(2):519–530
https://doi.org/10.2337/db11-0786
Published: 17 January 2013
View article titled, In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion
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Journal Articles

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Erica P. Cai, Marina Casimir, Stephanie A. Schroer, Cynthia T. Luk, Sally Yu Shi, Diana Choi, Xiao Qing Dai, Catherine Hajmrle, Aliya F. Spigelman, Dan Zhu, Herbert Y. Gaisano, Patrick E. MacDonald, Minna Woo
Journal: Diabetes
Diabetes 2012;61(7):1708–1718
https://doi.org/10.2337/db11-1344
Published: 15 June 2012
View article titled, In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking
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Journal Articles

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Xiao-Qing Dai, Greg Plummer, Marina Casimir, Youhou Kang, Catherine Hajmrle, Herbert Y. Gaisano, Jocelyn E. Manning Fox, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2011;60(3):838–847
https://doi.org/10.2337/db10-0440
Published: 21 February 2011
View article titled, SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
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Journal Articles

Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells

Edwin P. Kwan, Li Xie, Laura Sheu, Toshihisa Ohtsuka, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2007;56(10):2579–2588
https://doi.org/10.2337/db06-1207
Published: 01 October 2007
View article titled, Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

Nicole Liadis, Leonardo Salmena, Edwin Kwan, Panteha Tajmir, Stephanie A. Schroer, Anna Radziszewska, Xie Li, Laura Sheu, Mohamed Eweida, Shilong Xu, Herbert Y. Gaisano, Razqallah Hakem, Minna Woo
Journal: Diabetes
Diabetes 2007;56(9):2302–2311
https://doi.org/10.2337/db06-1771
Published: 01 September 2007
View article titled, Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models
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Journal Articles

The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1

Betty Ng, Youhou Kang, Chadwick L. Elias, Yan He, Huanli Xie, John B. Hansen, Philip Wahl, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2007;56(8):2124–2134
https://doi.org/10.2337/db07-0030
Published: 01 August 2007
View article titled, The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K<sup>+</sup> Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1
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Includes: Supplementary data
Journal Articles

Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance

Edwin P. Kwan, Li Xie, Laura Sheu, Christopher J. Nolan, Marc Prentki, Andrea Betz, Nils Brose, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2006;55(5):1421–1429
https://doi.org/10.2337/db05-1263
Published: 01 May 2006
View article titled, Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance
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Journal Articles

Transgenic Mouse Overexpressing Syntaxin-1A as a Diabetes Model

Patrick P.L. Lam, Yuk-Man Leung, Laura Sheu, James Ellis, Robert G. Tsushima, Lucy R. Osborne, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2005;54(9):2744–2754
https://doi.org/10.2337/diabetes.54.9.2744
Published: 01 September 2005
View article titled, Transgenic Mouse Overexpressing Syntaxin-1A as a Diabetes Model
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Journal Articles

Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet β-Cells

Edwin P. Kwan, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2005;54(9):2734–2743
https://doi.org/10.2337/diabetes.54.9.2734
Published: 01 September 2005
View article titled, Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet β-Cells
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Includes: Multimedia, Supplementary data
Journal Articles

Modulation of L-Type Ca2+ Channels by Distinct Domains Within SNAP-25

Junzhi Ji, Shao-Nian Yang, Xiaohang Huang, Xidan Li, Laura Sheu, Nicholas Diamant, Per-Olof Berggren, Herbert Y. Gaisano
Journal: Diabetes
Diabetes 2002;51(5):1425–1436
https://doi.org/10.2337/diabetes.51.5.1425
Published: 01 May 2002
View article titled, Modulation of L-Type Ca<sup>2+</sup> Channels by Distinct Domains Within SNAP-25
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