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Meeting Abstracts

748-P: GLP-1 Receptor Agonists Dulaglutide and Semaglutide in Japanese Patients with Type 2 Diabetes—Randomized, Parallel-Group, Multicenter, Open-Label Trial

TOMOHIKO KIMURA, YUKINO KATAKURA, MASASHI SHIMODA, FUMIKO KAWASAKI, MIZUHO YAMABE, FUMINORI TATSUMI, MICHIHIRO MATSUKI, YUICHIRO IWAMOTO, TAKATOSHI ANNO, YOSHIRO FUSHIMI, SHINJI KAMEI, YUKIKO KIMURA, JUNPEI SANADA, YURIE HIRATA, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2023;72(Supplement_1):748-P

https://doi.org/10.2337/db23-748-P

Published: 20 June 2023

View article titled, 748-P: GLP-1 Receptor Agonists Dulaglutide and Semaglutide in Japanese Patients with Type 2 Diabetes—Randomized, Parallel-Group, Multicenter, Open-Label Trial

Meeting Abstracts

1604-P: DPP-4 Inhibitor and SGLT2 Inhibitor Additively Ameliorate Hepatic Steatosis in NAFLD Model Mice through Different Action Mechanisms

YUICHIRO IWAMOTO, TOMOHIKO KIMURA, HIDEYUKI IWAMOTO, YOSHIRO FUSHIMI, JUNPEI SANADA, YUKINO KATAKURA, MASASHI SHIMODA, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2023;72(Supplement_1):1604-P

https://doi.org/10.2337/db23-1604-P

Published: 20 June 2023

View article titled, 1604-P: DPP-4 Inhibitor and SGLT2 Inhibitor Additively Ameliorate Hepatic Steatosis in NAFLD Model Mice through Different Action Mechanisms

Meeting Abstracts

886-P: Protective Effects of DPP-4 Inhibitor and SGLT2 Inhibitor on Pancreatic ß-Cell Function—Randomized, Parallel-Group, Multicenter, Open-Label Study (SECRETE-I)

MASASHI SHIMODA, YUKINO KATAKURA, MASAHIRO IWAMOTO, YUKIKO KIMURA, TAKATOSHI ANNO, HAYATO ISOBE, YUICHIRO IWAMOTO, YOSHIRO FUSHIMI, JUNPEI SANADA, ATSUSHI OBATA, TOMOHIKO KIMURA, FUMIKO KAWASAKI, FUMINORI TATSUMI, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2023;72(Supplement_1):886-P

https://doi.org/10.2337/db23-886-P

Published: 20 June 2023

View article titled, 886-P: Protective Effects of DPP-4 Inhibitor and SGLT2 Inhibitor on Pancreatic ß-Cell Function—Randomized, Parallel-Group, Multicenter, Open-Label Study (SECRETE-I)

Meeting Abstracts

2054-P: Combination of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor and Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitor Substantially Protects Pancreatic ß-Cells Especially in Early Phase of Diabetes Rather than Advanced Phase

YOSHIRO FUSHIMI, ATSUSHI OBATA, JUNPEI SANADA, YUKA NOGAMI, TOMOKO IKEDA, YOSHIYUKI OBATA, MASASHI SHIMODA, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2020;69(Supplement_1):2054-P

https://doi.org/10.2337/db20-2054-P

Published: 01 June 2020

View article titled, 2054-P: Combination of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor and Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitor Substantially Protects Pancreatic ß-Cells Especially in Early Phase of Diabetes Rather than Advanced Phase

Meeting Abstracts

1435-P: Dulaglutide Exerts More Beneficial Antiatherosclerotic Effects in Early Phase of Diabetes than in Late Phase in ApoE Knockout Mice with Diabetes

JUNPEI SANADA, ATSUSHI OBATA, YOSHIYUKI OBATA, YOSHIRO FUSHIMI, TOMOKO IKEDA, YUKA NOGAMI, MASASHI SHIMODA, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2020;69(Supplement_1):1435-P

https://doi.org/10.2337/db20-1435-P

Published: 01 June 2020

View article titled, 1435-P: Dulaglutide Exerts More Beneficial Antiatherosclerotic Effects in Early Phase of Diabetes than in Late Phase in ApoE Knockout Mice with Diabetes

Meeting Abstracts

1032-P: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed-Ratio Combination vs. Insulin Glargine in Japanese Patients with T2DM

HIDEAKI KANETO, AKANE TAKAMI, ROBERT SPRANGER, ATSUSHI AMANO, DAISUKE WATANABE, ELISABETH NIEMOELLER

Diabetes 2019;68(Supplement_1):1032-P

https://doi.org/10.2337/db19-1032-P

Published: 01 June 2019

View article titled, 1032-P: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed-Ratio Combination vs. Insulin Glargine in Japanese Patients with T2DM

Meeting Abstracts

Protective Effects of SGLT2 Inhibitor Luseogliflozin on Pancreatic Beta Cells in Obese Diabetic db/db Mice—"The Earlier and Longer, the Better”

TOMOHIKO KIMURA, MASASHI SHIMODA, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2018;67(Supplement_1):2111-P

https://doi.org/10.2337/db18-2111-P

Published: 01 July 2018

View article titled, Protective Effects of SGLT2 Inhibitor Luseogliflozin on Pancreatic Beta Cells in Obese Diabetic db/db Mice—"The Earlier and Longer, the Better”

Meeting Abstracts

Effects of Different Types of Oral Glucose-Lowering Drugs on Hepatic Fat Accumulation and Liver Function in Japanese Subjects with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease—A Randomized, Open-Label, 3-Arm Active-Control Study

TOMOE KINOSHITA, MASASHI SHIMODA, SHUHEI NAKANISHI, TOMOATSU MUNE, KOHEI KAKU, HIDEAKI KANETO

Diabetes 2018;67(Supplement_1):2050-P

https://doi.org/10.2337/db18-2050-P

Published: 01 July 2018

View article titled, Effects of Different Types of Oral Glucose-Lowering Drugs on Hepatic Fat Accumulation and Liver Function in Japanese Subjects with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease—A Randomized, Open-Label, 3-Arm Active-Control Study

Journal Articles

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Taka-aki Matsuoka, Satoshi Kawashima, Takeshi Miyatsuka, Shugo Sasaki, Naoki Shimo, Naoto Katakami, Dan Kawamori, Satomi Takebe, Pedro L. Herrera, Hideaki Kaneto, Roland Stein, Iichiro Shimomura

Diabetes 2017;66(5):1293–1300

https://doi.org/10.2337/db16-0887

Published: 21 February 2017

View article titled, Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Includes: Supplementary data

Journal Articles

Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

Taka-aki Matsuoka, Hideaki Kaneto, Takeshi Miyatsuka, Tsunehiko Yamamoto, Kaoru Yamamoto, Ken Kato, Iichiro Shimomura, Roland Stein, Munehide Matsuhisa

Diabetes 2010;59(7):1709–1720

https://doi.org/10.2337/db08-0693

Published: 27 April 2010

View article titled, Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

Includes: Supplementary data

Journal Articles

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes

Gang Xu, Hideaki Kaneto, D. Ross Laybutt, Valerie F. Duvivier-Kali, Nitin Trivedi, Kiyoshi Suzuma, George L. King, Gordon C. Weir, Susan Bonner-Weir

Diabetes 2007;56(6):1551–1558

https://doi.org/10.2337/db06-1033

Published: 01 June 2007

View article titled, Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: <subtitle>Possible Contribution to Impaired Incretin Effects in Diabetes</subtitle>

Journal Articles

PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance

Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Taka-aki Matsuoka, Munehide Matsuhisa, Masatsugu Hori, Yoshimitsu Yamasaki

Diabetes 2005;54(4):1009–1022

https://doi.org/10.2337/diabetes.54.4.1009

Published: 01 April 2005

View article titled, PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance

Journal Articles

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase

Dan Kawamori, Yoshitaka Kajimoto, Hideaki Kaneto, Yutaka Umayahara, Yoshio Fujitani, Takeshi Miyatsuka, Hirotaka Watada, Ingo B. Leibiger, Yoshimitsu Yamasaki, Masatsugu Hori

Diabetes 2003;52(12):2896–2904

https://doi.org/10.2337/diabetes.52.12.2896

Published: 01 December 2003

View article titled, Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

Journal Articles

PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells

Hirofumi Noguchi, Hideaki Kaneto, Gordon C. Weir, Susan Bonner-Weir

Diabetes 2003;52(7):1732–1737

https://doi.org/10.2337/diabetes.52.7.1732

Published: 01 July 2003

View article titled, PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells

Journal Articles

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

D. Ross Laybutt, Gordon C. Weir, Hideaki Kaneto, Judith Lebet, Richard D. Palmiter, Arun Sharma, Susan Bonner-Weir

Diabetes 2002;51(6):1793–1804

https://doi.org/10.2337/diabetes.51.6.1793

Published: 01 June 2002

View article titled, Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

Journal Articles

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

D. Ross Laybutt, Hideaki Kaneto, Wendy Hasenkamp, Shane Grey, Jean-Christophe Jonas, Dennis C. Sgroi, Adam Groff, Christiane Ferran, Susan Bonner-Weir, Arun Sharma, Gordon C. Weir

Diabetes 2002;51(2):413–423

https://doi.org/10.2337/diabetes.51.2.413

Published: 01 February 2002

View article titled, Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

Journal Articles

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

Hirotaka Watada, Yoshitaka Kajimoto, Yutaka Umayahara, Taka-aki Matsuoka, Hideaki Kaneto, Yoshi Fujitani, Takenobu Kamada, Ryuzo Kawamori, Yoshimitsu Yamasaki

Diabetes 1996;45(11):1478–1488

https://doi.org/10.2337/diab.45.11.1478

Published: 01 November 1996

View article titled, The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

Journal Articles

Involvement of Glycation and Oxidative Stress in Diabetic Macroangiopathy

Naoyuki Taniguchi, Hideaki Kaneto, Michio Asahi, Motoko Takahashi, Che Wenyi, Shigeki Higashiyama, Junichi Fujii, Keiichiro Suzuki, Yoshiro Kayanoki

Diabetes 1996;45(Supplement_3):S81–S83

https://doi.org/10.2337/diab.45.3.S81

Published: 01 July 1996

View article titled, Involvement of Glycation and Oxidative Stress in Diabetic Macroangiopathy

Journal Articles

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

Hideaki Kaneto, Junichi Fujii, Han Geuk Seo, Keiichiro Suzuki, Taka-aki Matsuko, Nakamura Masahiro, Haruyuki Tatsumi, Yoshimitsu Yamasaki, Takenobu Kamada, Naoyuki Taniguchi

Diabetes 1995;44(7):733–738

https://doi.org/10.2337/diab.44.7.733

Published: 01 July 1995

View article titled, Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

NARROW

748-P: GLP-1 Receptor Agonists Dulaglutide and Semaglutide in Japanese Patients with Type 2 Diabetes—Randomized, Parallel-Group, Multicenter, Open-Label Trial

1604-P: DPP-4 Inhibitor and SGLT2 Inhibitor Additively Ameliorate Hepatic Steatosis in NAFLD Model Mice through Different Action Mechanisms

886-P: Protective Effects of DPP-4 Inhibitor and SGLT2 Inhibitor on Pancreatic ß-Cell Function—Randomized, Parallel-Group, Multicenter, Open-Label Study (SECRETE-I)

2054-P: Combination of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor and Sodium–Glucose Cotransporter 2 (SGLT2) Inhibitor Substantially Protects Pancreatic ß-Cells Especially in Early Phase of Diabetes Rather than Advanced Phase

1435-P: Dulaglutide Exerts More Beneficial Antiatherosclerotic Effects in Early Phase of Diabetes than in Late Phase in ApoE Knockout Mice with Diabetes

1032-P: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed-Ratio Combination vs. Insulin Glargine in Japanese Patients with T2DM

Protective Effects of SGLT2 Inhibitor Luseogliflozin on Pancreatic Beta Cells in Obese Diabetic db/db Mice—"The Earlier and Longer, the Better”

Effects of Different Types of Oral Glucose-Lowering Drugs on Hepatic Fat Accumulation and Liver Function in Japanese Subjects with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease—A Randomized, Open-Label, 3-Arm Active-Control Study

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes

PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase

PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

Involvement of Glycation and Oxidative Stress in Diabetic Macroangiopathy

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

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