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Meeting Abstracts

1757-P: Imeglimin Enhances Glucose-Induced Insulin Secretion with Activating Mitochondrial Function

MAMI TAKIGUCHI, HITOSHI IIDA, HIROTSUGU UZAWA, AKIKO KANAI, KYOSEI UEKI, KOKI IKEDA, SAORI KAKEHI, HIDENORI HARUNA, NORIYUKI TAKUBO, YUYA NISHIDA, TOSHIAKI SHIMIZU, HIROTAKA WATADA

Diabetes 2024;73(Supplement_1):1757-P

https://doi.org/10.2337/db24-1757-P

Published: 14 June 2024

View articletitled, 1757-P: Imeglimin Enhances Glucose-Induced Insulin Secretion with Activating Mitochondrial Function

Meeting Abstracts

1747-P: Glucolipotoxicity Inhibits Proinsulin Processing through Disrupting V-ATPase Function Leading to Impaired Acidification within Secretory Granules

HITOSHI IIDA, MAMI TAKIGUCHI, YUYA NISHIDA, HIROTAKA WATADA

Diabetes 2024;73(Supplement_1):1747-P

https://doi.org/10.2337/db24-1747-P

Published: 14 June 2024

View articletitled, 1747-P: Glucolipotoxicity Inhibits Proinsulin Processing through Disrupting V-ATPase Function Leading to Impaired Acidification within Secretory Granules

Meeting Abstracts

886-P: Response to Imeglimin for Japanese Patients with Type 2 Diabetes—Response Distribution Analysis of Individual Participant in Randomized Placebo-Controlled Trials

KATSUHIKO HAGI, KENJI KOCHI, HIROTAKA WATADA, KOHEI KAKU, KOHJIRO UEKI

Diabetes 2024;73(Supplement_1):886-P

https://doi.org/10.2337/db24-886-P

Published: 14 June 2024

View articletitled, 886-P: Response to Imeglimin for Japanese Patients with Type 2 Diabetes—Response Distribution Analysis of Individual Participant in Randomized Placebo-Controlled Trials

Journal Articles

Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery

Kyosei Ueki, Yuya Nishida, Shuhei Aoyama, Hirotsugu Uzawa, Akiko Kanai, Minami Ito, Koki Ikeda, Hitoshi Iida, Takeshi Miyatsuka, Hirotaka Watada

Diabetes 2023;72(11):1609–1620

https://doi.org/10.2337/db23-0445

Published: 25 August 2023

View articletitled, Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery

Meeting Abstracts

1715-P: Osteopenic Obesity Is Associated with Small Vessel Disease in Old Adults—The Bunkyo Health Study

NAOAKI ITO, III, YOSHIFUMI TAMURA, HIDEYOSHI KAGA, YUKI SOMEYA, HIROKI TABATA, SAORI KAKEHI, MAI KIYA, TSUBASA TAJIMA, HITOSHI NAITO, YASUYO YOSHIZAWA, HIROTAKA WATADA

Diabetes 2023;72(Supplement_1):1715-P

https://doi.org/10.2337/db23-1715-P

Published: 20 June 2023

View articletitled, 1715-P: Osteopenic Obesity Is Associated with Small Vessel Disease in Old Adults—The Bunkyo Health Study

Meeting Abstracts

1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

HITOSHI NAITO, HIDEYOSHI KAGA, YUKI SOMEYA, HIROKI TABATA, SAORI KAKEHI, YASUYO YOSHIZAWA, MAI KIYA, TSUBASA TAJIMA, NAOAKI ITO, MOTONORI SATO, SATOSHI KADOWAKI, TAKASHI FUNAYAMA, HIROTAKA WATADA, YOSHIFUMI TAMURA

Diabetes 2023;72(Supplement_1):1216-P

https://doi.org/10.2337/db23-1216-P

Published: 20 June 2023

View articletitled, 1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

Meeting Abstracts

1730-P: Stochastic Differentiation of α-Cell Lineage Revealed by Single-Cell RNA Sequencing in Time-Resolved Reporter System

NAOYA SHIMIZU, SHUGO SASAKI, TOMOMI TAGUCHI, MIWA HIMURO, HIROTAKA WATADA, FRANCIS C. LYNN, TAKESHI MIYATSUKA

Diabetes 2023;72(Supplement_1):1730-P

https://doi.org/10.2337/db23-1730-P

Published: 20 June 2023

View articletitled, 1730-P: Stochastic Differentiation of α-Cell Lineage Revealed by Single-Cell RNA Sequencing in Time-Resolved Reporter System

Meeting Abstracts

1534-P: Nasal-Insulin–Induced Change of Functional MRI Signal at the Level of Hypothalamic Nuclei in the Patients with Type 2 Diabetes Mellitus

MAI KIYA, HIDEYOSHI KAGA, NAOAKI ITO, TSUBASA TAJIMA, HITOSHI NAITO, MOTONORI SATO, SATOSHI KADOWAKI, SAORI KAKEHI, HIROTAKA WATADA, YOSHIFUMI TAMURA

Diabetes 2023;72(Supplement_1):1534-P

https://doi.org/10.2337/db23-1534-P

Published: 20 June 2023

View articletitled, 1534-P: Nasal-Insulin–Induced Change of Functional MRI Signal at the Level of Hypothalamic Nuclei in the Patients with Type 2 Diabetes Mellitus

Meeting Abstracts

850-P: The Efficacy of Imeglimin in Diabetes Subgroups Stratified by Data-Driven Cluster Analysis—A Post Hoc Analysis of Imeglimin Clinical Trial Data

KATSUHIKO HAGI, KENJI KOCHI, HIROTAKA WATADA, KOHEI KAKU, KOHJIRO UEKI

Diabetes 2023;72(Supplement_1):850-P

https://doi.org/10.2337/db23-850-P

Published: 20 June 2023

View articletitled, 850-P: The Efficacy of Imeglimin in Diabetes Subgroups Stratified by Data-Driven Cluster Analysis—A Post Hoc Analysis of Imeglimin Clinical Trial Data

Meeting Abstracts

324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

SUZANNE V. ARNOLD, FENGMING TANG, ANDREW COOPER, HUNGTA CHEN, MARILIA B. GOMES, WOLFGANG RATHMANN, IICHIRO SHIMOMURA, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD

Diabetes 2021;70(Supplement_1):324-OR

https://doi.org/10.2337/db21-324-OR

Published: 01 June 2021

View articletitled, 324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

Meeting Abstracts

1861-P: Short-Term Overfeeding with Dairy Fat Impairs Insulin Sensitivity in Muscle and Liver but Increases Adipose Tissue Insulin Sensitivity and Suppresses Postprandial Glucose Rise in Healthy Nonobese Men

DAISUKE SUGIMOTO, YOSHIFUMI TAMURA, SATOSHI KADOWAKI, YUKI SOMEYA, HIDEYOSHI KAGA, RURIKO SUZUKI, SAORI KAKEHI, NOZOMU YAMASAKI, MOTONORI SATO, AKIO KANAZAWA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1861-P

https://doi.org/10.2337/db20-1861-P

Published: 01 June 2020

View articletitled, 1861-P: Short-Term Overfeeding with Dairy Fat Impairs Insulin Sensitivity in Muscle and Liver but Increases Adipose Tissue Insulin Sensitivity and Suppresses Postprandial Glucose Rise in Healthy Nonobese Men

Meeting Abstracts

649-P: The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction

MIKA KURITA, HIROAKI SATOH, SATOSHI KADOWAKI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):649-P

https://doi.org/10.2337/db20-649-P

Published: 01 June 2020

View articletitled, 649-P: The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction

Meeting Abstracts

1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men

SATOSHI KADOWAKI, YOSHIFUMI TAMURA, DAISUKE SUGIMOTO, YUKI SOMEYA, HIDEYOSHI KAGA, RURIKO SUZUKI, SAORI KAKEHI, NOZOMU YAMASAKI, MOTONORI SATO, AKIO KANAZAWA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1864-P

https://doi.org/10.2337/db20-1864-P

Published: 01 June 2020

View articletitled, 1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men

Meeting Abstracts

225-OR: The Impact of Visualizing Macronutrient Content via Food-Log App "Calomeal" on Glycemic Control and QoL in People with Type 2 Diabetes

ASAKO TSUNEMI, JUNKO SATO, MARI ENOMOTO, YUKO IWAGAKI, SAKAE SUGIMOTO, YUKI SOMEYA, MAI KIYA, EIKO MATSUHASHI, YUKA WAKABAYASHI, TAKASHI FUNAYAMA, TOYOYOSHI UCHIDA, TAKESHI MIYATSUKA, KOSUKE AZUMA, TOMOAKI SHIMIZU, HIROAKI SATOH, AKIO KANAZAWA, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):225-OR

https://doi.org/10.2337/db20-225-OR

Published: 01 June 2020

View articletitled, 225-OR: The Impact of Visualizing Macronutrient Content via Food-Log App "Calomeal" on Glycemic Control and QoL in People with Type 2 Diabetes

Meeting Abstracts

175-LB: The Impact of Glucose Metabolism Abnormality on the Reduced Muscle Strength Is Higher in Elderly Women than Men: The Bunkyo Health Study

HIDEYOSHI KAGA, YOSHIFUMI TAMURA, YUKI SOMEYA, SATOSHI KADOWAKI, DAISUKE SUGIMOTO, RURIKO SUZUKI, MOTONORI SATO, NOZOMU YAMASAKI, MAI KIYA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):175-LB

https://doi.org/10.2337/db20-175-LB

Published: 01 June 2020

View articletitled, 175-LB: The Impact of Glucose Metabolism Abnormality on the Reduced Muscle Strength Is Higher in Elderly Women than Men: The Bunkyo Health Study

Meeting Abstracts

1704-P: Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnormality Due to Muscle Insulin Resistance in Nonobese Japanese Men

MAI KIYA, YOSHIFUMI TAMURA, KAGEUMI TAKENO, YUKI SOMEYA, SAORI KAKEHI, MOTONORI SATO, NOZOMU YAMASAKI, SATOSHI KADOWAKI, RURIKO SUZUKI, YASUHIKO FURUKAWA, DAISUKE SUGIMOTO, HIDEYOSHI KAGA, TAKASHI FUNAYAMA, HIROAKI SATOH, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1704-P

https://doi.org/10.2337/db20-1704-P

Published: 01 June 2020

View articletitled, 1704-P: Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnormality Due to Muscle Insulin Resistance in Nonobese Japanese Men

Meeting Abstracts

40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

ANTONIO NICOLUCCI, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD, PAUL LEIGH, LARISA RAMIREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, SUZANNE V. ARNOLD

Diabetes 2020;69(Supplement_1):40-OR

https://doi.org/10.2337/db20-40-OR

Published: 01 June 2020

View articletitled, 40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

Meeting Abstracts

1590-P: Effects of Second-Line Metformin Combination Therapies on Weight, HbA1c, and Risk of Hypoglycemia over 3 Years: The DISCOVER Study

KAMLESH KHUNTI, BERNARD CHARBONNEL, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, PAUL LEIGH, ANTONIO NICOLUCCI, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, AFRAH SIDDIQUI, FENGMING TANG, HIROTAKA WATADA, HUNGTA CHEN

Diabetes 2020;69(Supplement_1):1590-P

https://doi.org/10.2337/db20-1590-P

Published: 01 June 2020

View articletitled, 1590-P: Effects of Second-Line Metformin Combination Therapies on Weight, HbA1c, and Risk of Hypoglycemia over 3 Years: The DISCOVER Study

Meeting Abstracts

1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

FABRICE BONNET, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, PAUL LEIGH, LARISA RAMIREZ GUTIERREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI

Diabetes 2020;69(Supplement_1):1598-P

https://doi.org/10.2337/db20-1598-P

Published: 01 June 2020

View articletitled, 1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

Meeting Abstracts

1585-P: Reduced Insulin Sensitivity and Muscle Strength Are Independent Risk Factors for Silent Lacunar Infarcts and Synergistically Increase the Risk among Japanese Elderly People: The Bunkyo Health Study

YUKI SOMEYA, YOSHIFUMI TAMURA, HIDEYOSHI KAGA, DAISUKE SUGIMOTO, SATOSHI KADOWAKI, RURIKO SUZUKI, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1585-P

https://doi.org/10.2337/db20-1585-P

Published: 01 June 2020

View articletitled, 1585-P: Reduced Insulin Sensitivity and Muscle Strength Are Independent Risk Factors for Silent Lacunar Infarcts and Synergistically Increase the Risk among Japanese Elderly People: The Bunkyo Health Study

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1757-P: Imeglimin Enhances Glucose-Induced Insulin Secretion with Activating Mitochondrial Function

1747-P: Glucolipotoxicity Inhibits Proinsulin Processing through Disrupting V-ATPase Function Leading to Impaired Acidification within Secretory Granules

886-P: Response to Imeglimin for Japanese Patients with Type 2 Diabetes—Response Distribution Analysis of Individual Participant in Randomized Placebo-Controlled Trials

Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery

1715-P: Osteopenic Obesity Is Associated with Small Vessel Disease in Old Adults—The Bunkyo Health Study

1216-P: Effects of Aging after Age 65 on Glucose Tolerance, Insulin Sensitivity, and ß-Cell Function in Japanese—The Bunkyo Health Study

1730-P: Stochastic Differentiation of α-Cell Lineage Revealed by Single-Cell RNA Sequencing in Time-Resolved Reporter System

1534-P: Nasal-Insulin–Induced Change of Functional MRI Signal at the Level of Hypothalamic Nuclei in the Patients with Type 2 Diabetes Mellitus

850-P: The Efficacy of Imeglimin in Diabetes Subgroups Stratified by Data-Driven Cluster Analysis—A Post Hoc Analysis of Imeglimin Clinical Trial Data

324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

1861-P: Short-Term Overfeeding with Dairy Fat Impairs Insulin Sensitivity in Muscle and Liver but Increases Adipose Tissue Insulin Sensitivity and Suppresses Postprandial Glucose Rise in Healthy Nonobese Men

649-P: The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction

1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men

225-OR: The Impact of Visualizing Macronutrient Content via Food-Log App "Calomeal" on Glycemic Control and QoL in People with Type 2 Diabetes

175-LB: The Impact of Glucose Metabolism Abnormality on the Reduced Muscle Strength Is Higher in Elderly Women than Men: The Bunkyo Health Study

1704-P: Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnormality Due to Muscle Insulin Resistance in Nonobese Japanese Men

40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

1590-P: Effects of Second-Line Metformin Combination Therapies on Weight, HbA1c, and Risk of Hypoglycemia over 3 Years: The DISCOVER Study

1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

1585-P: Reduced Insulin Sensitivity and Muscle Strength Are Independent Risk Factors for Silent Lacunar Infarcts and Synergistically Increase the Risk among Japanese Elderly People: The Bunkyo Health Study

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