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Meeting Abstracts

324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

SUZANNE V. ARNOLD, FENGMING TANG, ANDREW COOPER, HUNGTA CHEN, MARILIA B. GOMES, WOLFGANG RATHMANN, IICHIRO SHIMOMURA, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD

Diabetes 2021;70(Supplement_1):324-OR

DOI: https://doi.org/10.2337/db21-324-OR

Published: 01 June 2021

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Meeting Abstracts

175-LB: The Impact of Glucose Metabolism Abnormality on the Reduced Muscle Strength Is Higher in Elderly Women than Men: The Bunkyo Health Study

HIDEYOSHI KAGA, YOSHIFUMI TAMURA, YUKI SOMEYA, SATOSHI KADOWAKI, DAISUKE SUGIMOTO, RURIKO SUZUKI, MOTONORI SATO, NOZOMU YAMASAKI, MAI KIYA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):175-LB

DOI: https://doi.org/10.2337/db20-175-LB

Published: 01 June 2020

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Meeting Abstracts

1704-P: Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnormality Due to Muscle Insulin Resistance in Nonobese Japanese Men

MAI KIYA, YOSHIFUMI TAMURA, KAGEUMI TAKENO, YUKI SOMEYA, SAORI KAKEHI, MOTONORI SATO, NOZOMU YAMASAKI, SATOSHI KADOWAKI, RURIKO SUZUKI, YASUHIKO FURUKAWA, DAISUKE SUGIMOTO, HIDEYOSHI KAGA, TAKASHI FUNAYAMA, HIROAKI SATOH, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1704-P

DOI: https://doi.org/10.2337/db20-1704-P

Published: 01 June 2020

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Meeting Abstracts

1116-P: Effect of Tofogliflozin on Carotid Intima-Media Thickness in Patients with Type 2 Diabetes: Results from the Prospective, Randomized, Open-Label, Parallel-Group Comparative UTOPIA Trial

NAOTO KATAKAMI, TOMOYA MITA, HIROTAKA WATADA, IICHIRO SHIMOMURA, UTOPIA STUDY INVESTIGATORS

Diabetes 2020;69(Supplement_1):1116-P

DOI: https://doi.org/10.2337/db20-1116-P

Published: 01 June 2020

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Meeting Abstracts

1135-P: Acute Increase in Endogenous Glucose Production by a Single Administration of Tofogliflozin Is Disappeared by Suppressing Its Glucose Lowering Effect in the Patients with Type 2 Diabetes Mellitus

NOZOMU YAMASAKI, SR., YOSHIFUMI TAMURA, HIDEYOSHI KAGA, MOTONORI SATO, MAI KIYA, SATOSHI KADOWAKI, RURIKO SUZUKI, YASUHIKO FURUKAWA, DAISUKE SUGIMOTO, TAKASHI FUNAYAMA, YUKI SOMEYA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1135-P

DOI: https://doi.org/10.2337/db20-1135-P

Published: 01 June 2020

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Meeting Abstracts

40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

ANTONIO NICOLUCCI, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD, PAUL LEIGH, LARISA RAMIREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, SUZANNE V. ARNOLD

Diabetes 2020;69(Supplement_1):40-OR

DOI: https://doi.org/10.2337/db20-40-OR

Published: 01 June 2020

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Meeting Abstracts

1861-P: Short-Term Overfeeding with Dairy Fat Impairs Insulin Sensitivity in Muscle and Liver but Increases Adipose Tissue Insulin Sensitivity and Suppresses Postprandial Glucose Rise in Healthy Nonobese Men

DAISUKE SUGIMOTO, YOSHIFUMI TAMURA, SATOSHI KADOWAKI, YUKI SOMEYA, HIDEYOSHI KAGA, RURIKO SUZUKI, SAORI KAKEHI, NOZOMU YAMASAKI, MOTONORI SATO, AKIO KANAZAWA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1861-P

DOI: https://doi.org/10.2337/db20-1861-P

Published: 01 June 2020

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Meeting Abstracts

649-P: The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction

MIKA KURITA, HIROAKI SATOH, SATOSHI KADOWAKI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):649-P

DOI: https://doi.org/10.2337/db20-649-P

Published: 01 June 2020

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Meeting Abstracts

225-OR: The Impact of Visualizing Macronutrient Content via Food-Log App "Calomeal" on Glycemic Control and QoL in People with Type 2 Diabetes

ASAKO TSUNEMI, JUNKO SATO, MARI ENOMOTO, YUKO IWAGAKI, SAKAE SUGIMOTO, YUKI SOMEYA, MAI KIYA, EIKO MATSUHASHI, YUKA WAKABAYASHI, TAKASHI FUNAYAMA, TOYOYOSHI UCHIDA, TAKESHI MIYATSUKA, KOSUKE AZUMA, TOMOAKI SHIMIZU, HIROAKI SATOH, AKIO KANAZAWA, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):225-OR

DOI: https://doi.org/10.2337/db20-225-OR

Published: 01 June 2020

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Meeting Abstracts

1143-P: A Single and Chronic SGLT2 Inhibitor Administration Did Not Alter Insulin Clearance in Type 2 Diabetes

MOTONORI SATO, YOSHIFUMI TAMURA, HIDEYOSHI KAGA, NOZOMU YAMASAKI, MAI KIYA, RURIKO SUZUKI, DAISUKE SUGIMOTO, SATOSHI KADOWAKI, YASUHIKO FURUKAWA, TAKASHI FUNAYAMA, YUKI SOMEYA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1143-P

DOI: https://doi.org/10.2337/db20-1143-P

Published: 01 June 2020

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Meeting Abstracts

1590-P: Effects of Second-Line Metformin Combination Therapies on Weight, HbA1c, and Risk of Hypoglycemia over 3 Years: The DISCOVER Study

KAMLESH KHUNTI, BERNARD CHARBONNEL, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, PAUL LEIGH, ANTONIO NICOLUCCI, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, AFRAH SIDDIQUI, FENGMING TANG, HIROTAKA WATADA, HUNGTA CHEN

Diabetes 2020;69(Supplement_1):1590-P

DOI: https://doi.org/10.2337/db20-1590-P

Published: 01 June 2020

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Meeting Abstracts

1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

FABRICE BONNET, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, PAUL LEIGH, LARISA RAMIREZ GUTIERREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI

Diabetes 2020;69(Supplement_1):1598-P

DOI: https://doi.org/10.2337/db20-1598-P

Published: 01 June 2020

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Meeting Abstracts

1585-P: Reduced Insulin Sensitivity and Muscle Strength Are Independent Risk Factors for Silent Lacunar Infarcts and Synergistically Increase the Risk among Japanese Elderly People: The Bunkyo Health Study

YUKI SOMEYA, YOSHIFUMI TAMURA, HIDEYOSHI KAGA, DAISUKE SUGIMOTO, SATOSHI KADOWAKI, RURIKO SUZUKI, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1585-P

DOI: https://doi.org/10.2337/db20-1585-P

Published: 01 June 2020

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Meeting Abstracts

1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men

SATOSHI KADOWAKI, YOSHIFUMI TAMURA, DAISUKE SUGIMOTO, YUKI SOMEYA, HIDEYOSHI KAGA, RURIKO SUZUKI, SAORI KAKEHI, NOZOMU YAMASAKI, MOTONORI SATO, AKIO KANAZAWA, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2020;69(Supplement_1):1864-P

DOI: https://doi.org/10.2337/db20-1864-P

Published: 01 June 2020

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Meeting Abstracts

420-P: Micro- and Macrovascular Events in Patients with T2D—Results from the Global DISCOVER Study

SUZANNE V. ARNOLD, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, KAMLESH KHUNTI, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, ANTONIO NICOLUCCI, STUART POCOCK, SHAUKAT M. SADIKOT, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, MIKHAIL N. KOSIBOROD

Diabetes 2019;68(Supplement_1):420-P

DOI: https://doi.org/10.2337/db19-420-P

Published: 01 June 2019

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Meeting Abstracts

293-LB: The Suppression of Xanthine Oxidoreductase (XOR) Improves Skeletal Muscle Insulin Resistance

CHIHIRO TSUKAGOSHI MORIYA, HIROAKI SATOH, SAORI KAKEHI, HIROTAKA WATADA

Diabetes 2019;68(Supplement_1):293-LB

DOI: https://doi.org/10.2337/db19-293-LB

Published: 01 June 2019

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Meeting Abstracts

1628-P: Changes in HbA_1c and Treatment in the Second Year following Initiation of Second-Line Therapy in People with T2D—The Global DISCOVER Study

BERNARD CHARBONNEL, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, ANTONIO NICOLUCCI, STUART POCOCK, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, SHAUKAT M. SADIKOT, FILIP SURMONT, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI

Diabetes 2019;68(Supplement_1):1628-P

DOI: https://doi.org/10.2337/db19-1628-P

Published: 01 June 2019

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Meeting Abstracts

1279-P: Socioeconomic Factors Associated with Poor Glycemic Control in People with Type 2 Diabetes: The DISCOVER Study

MARILIA B. GOMES, FENGMING TANG, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, KAMLESH KHUNTI, STUART POCOCK, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, FILIP SURMONT, HIROTAKA WATADA, JESUS MEDINA, SHAUKAT M. SADIKOT, IICHIRO SHIMOMURA, GABRIELA LUPORINI SARAIVA, ANTONIO NICOLUCCI

Diabetes 2019;68(Supplement_1):1279-P

DOI: https://doi.org/10.2337/db19-1279-P

Published: 01 June 2019

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Meeting Abstracts

1941-P: The Relationship among Intramyocellular Lipid, Peak Oxygen Consumption, and Insulin Resistance in Nonobese Japanese Men

NOZOMU YAMASAKI, YOSHIFUMI TAMURA, KAGEUMI TAKENO, SAORI KAKEHI, YUKI SOMEYA, TAKASHI FUNAYAMA, YASUHIKO FURUKAWA, HIDEYOSHI KAGA, RURIKO SUZUKI, DAISUKE SUGIMOTO, SATOSHI KADOWAKI, MOTONORI SATO, RYUZO KAWAMORI, HIROTAKA WATADA

Diabetes 2019;68(Supplement_1):1941-P

DOI: https://doi.org/10.2337/db19-1941-P

Published: 01 June 2019

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Meeting Abstracts

148-OR: IDegLira Improves Glycemic Control in Japanese Patients with Type 2 Diabetes (T2D) Uncontrolled on Premixed Insulin Therapy

HIROTAKA WATADA, BUE F. AGNER, ANKUR DOSHI, RANDI GRØN, MATTIS F. RANTHE, LIANA K. BILLINGS

Diabetes 2019;68(Supplement_1):148-OR

DOI: https://doi.org/10.2337/db19-148-OR

Published: 01 June 2019

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NARROW

324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

175-LB: The Impact of Glucose Metabolism Abnormality on the Reduced Muscle Strength Is Higher in Elderly Women than Men: The Bunkyo Health Study

1704-P: Coexistence of Hypoadiponectinemia and Impaired Adipose Tissue Insulin Sensitivity Increases the Risk of Metabolic Abnormality Due to Muscle Insulin Resistance in Nonobese Japanese Men

1116-P: Effect of Tofogliflozin on Carotid Intima-Media Thickness in Patients with Type 2 Diabetes: Results from the Prospective, Randomized, Open-Label, Parallel-Group Comparative UTOPIA Trial

1135-P: Acute Increase in Endogenous Glucose Production by a Single Administration of Tofogliflozin Is Disappeared by Suppressing Its Glucose Lowering Effect in the Patients with Type 2 Diabetes Mellitus

40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

1861-P: Short-Term Overfeeding with Dairy Fat Impairs Insulin Sensitivity in Muscle and Liver but Increases Adipose Tissue Insulin Sensitivity and Suppresses Postprandial Glucose Rise in Healthy Nonobese Men

649-P: The 7-Day Diabetes Education Hospitalization Program Improves Quality of Life and Treatment Satisfaction

225-OR: The Impact of Visualizing Macronutrient Content via Food-Log App "Calomeal" on Glycemic Control and QoL in People with Type 2 Diabetes

1143-P: A Single and Chronic SGLT2 Inhibitor Administration Did Not Alter Insulin Clearance in Type 2 Diabetes

1590-P: Effects of Second-Line Metformin Combination Therapies on Weight, HbA1c, and Risk of Hypoglycemia over 3 Years: The DISCOVER Study

1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

1585-P: Reduced Insulin Sensitivity and Muscle Strength Are Independent Risk Factors for Silent Lacunar Infarcts and Synergistically Increase the Risk among Japanese Elderly People: The Bunkyo Health Study

1864-P: Higher Relative Abundance of Bacteroidetes in Gut Microbiota Is Associated with Decreased Insulin Clearance and Insulin Sensitivity after a Short-Term High-Calorie, High-Fat Diet in Healthy Men

420-P: Micro- and Macrovascular Events in Patients with T2D—Results from the Global DISCOVER Study

293-LB: The Suppression of Xanthine Oxidoreductase (XOR) Improves Skeletal Muscle Insulin Resistance

1628-P: Changes in HbA_1c and Treatment in the Second Year following Initiation of Second-Line Therapy in People with T2D—The Global DISCOVER Study

1279-P: Socioeconomic Factors Associated with Poor Glycemic Control in People with Type 2 Diabetes: The DISCOVER Study

1941-P: The Relationship among Intramyocellular Lipid, Peak Oxygen Consumption, and Insulin Resistance in Nonobese Japanese Men

148-OR: IDegLira Improves Glycemic Control in Japanese Patients with Type 2 Diabetes (T2D) Uncontrolled on Premixed Insulin Therapy

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