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Meeting Abstracts

24-OR: Podocyte Targeted Pyruvate Kinase M2 (PKM2) Activation Normalized Glomerular VEGF Expression, Mitochondrial Function, Fuel Metabolism, and Diabetic Nephropathy

JIALIN FU, TAKANORI SHINJO, QIAN LI, KYOUNGMIN PARK, MARC GREGORY YU, HISASHI YOKOMIZO, QIAN HUANG, I-HSIEN WU, GEORGE L. KING

Diabetes 2022;71(Supplement_1):24-OR

DOI: https://doi.org/10.2337/db22-24-OR

Published: 01 June 2022

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Meeting Abstracts

183-OR: Pyruvate Kinase M2 (PKM2) Enzymatic Activity Is Necessary to Improve Podocyte Mitochondrial Function and Glomerular Fuel Metabolism and Diabetic Nephropathy

JIALIN FU, TAKANORI SHINJO, QIAN LI, RONALD ST-LOUIS, KYOUNGMIN PARK, HISASHI YOKOMIZO, MARC GREGORY YU, HETAL SHAH, I-HSIEN WU, GEORGE L. KING

Diabetes 2021;70(Supplement_1):183-OR

DOI: https://doi.org/10.2337/db21-183-OR

Published: 01 June 2021

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Meeting Abstracts

307-OR: Activation of Mitochondrial Activities by Pyruvate Kinase M2 (PKM2) in Podocytes Improved Glomerular Metabolism and Diabetic Nephropathy

JIALIN FU, TAKANORI SHINJO, RONALD ST-LOUIS, QIAN LI, KYOUNGMIN PARK, HISASHI YOKOMIZO, YUMI ZAITSU, MARC GREGORY YU, I-HSIEN WU, HETAL SHAH, GEORGE L. KING

Diabetes 2020;69(Supplement_1):307-OR

DOI: https://doi.org/10.2337/db20-307-OR

Published: 01 June 2020

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Meeting Abstracts

309-OR: IGF-1 Receptors, Not Insulin Receptors, on Mesangial Cells Are Accelerating Mesangial Expansion and Albuminuria in Streptozotocin-Induced Diabetic Mice

ATSUSHI ISHIKADO, TAKANORI SHINJO, HISASHI YOKOMIZO, YASUTAKA MAEDA, KYOUNGMIN PARK, WEIER QI, RONALD ST-LOUIS, QIAN LI, GEORGE L. KING

Diabetes 2020;69(Supplement_1):309-OR

DOI: https://doi.org/10.2337/db20-309-OR

Published: 01 June 2020

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Meeting Abstracts

327-OR: Association of Retinol Binding Protein 3 with Retinal Neural Structure and Clinical Parameters in Diabetic Retinopathy

WARD FICKWEILER, KYOUNGMIN PARK, EMILY WOLFSON, HYUNSEOK PARK, HISASHI YOKOMIZO, I-HSIEN WU, DANIEL GORDIN, VALMA HARJUTSALO, PER-HENRIK GROOP, LLOYD P. AIELLO, JENNIFER SUN, GEORGE L. KING

Diabetes 2020;69(Supplement_1):327-OR

DOI: https://doi.org/10.2337/db20-327-OR

Published: 01 June 2020

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Meeting Abstracts

436-P: Characterization of Autoimmunity in the Acceleration of Atherosclerosis in Type 1 Diabetes

KYOUNGMIN PARK, QIAN LI, HYUNSEOK PARK, RONALD ST-LOUIS, JIALIN FU, CHRISTIAN RASK-MADSEN, ERNESTO MADDALONI, HISASHI YOKOMIZO, STEPHAN KISSLER, ANDREW H. LICHTMAN, GEORGE L. KING

Diabetes 2020;69(Supplement_1):436-P

DOI: https://doi.org/10.2337/db20-436-P

Published: 01 June 2020

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Meeting Abstracts

480-P: Reversal of Diabetic Nephropathy in T2D db/db Mouse Model by Systemic Pyruvate Kinase M2 (PKM2) Activation

RONALD ST-LOUIS, JIALIN FU, KYOUNGMIN PARK, TAKANORI SHINJO, JOHANNA LUDEKE, HISASHI YOKOMIZO, QIAN LI, EMILY WOLFSON, GEORGE L. KING

Diabetes 2020;69(Supplement_1):480-P

DOI: https://doi.org/10.2337/db20-480-P

Published: 01 June 2020

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Meeting Abstracts

1867-P: White and Brown Rice Supplementation Changes High-Fat Diet–Induced Dysbiosis of Gut Microbiome and Improves Energy and Glucose Metabolism

HISASHI YOKOMIZO, ATSUSHI ISHIKADO, TAKANORI SHINJO, KYOUNGMIN PARK, YASUTAKA MAEDA, QIAN LI, I-HSIEN WU, MOTONOBU MATSUMOTO, SUZANNE DEVKOTA, ALEKSANDAR KOSTIC, GEORGE L. KING

Diabetes 2020;69(Supplement_1):1867-P

DOI: https://doi.org/10.2337/db20-1867-P

Published: 01 June 2020

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Meeting Abstracts

478-P: Accelerating Atherosclerosis by Autoimmune Process in Nonobese Diabetic Mice Made ApoE Deficient by CRISPR/Cas9 Gene Editing

KYOUNGMIN PARK, QIAN LI, HAIYAN WANG, RONALD ST-LOUIS, HISASHI YOKOMIZO, ERNESTO MADDALONI, TAKANORI SHINJO, JIALIN FU, I-HSIEN WU, STEPHAN KISSLER, GEORGE L. KING

Diabetes 2019;68(Supplement_1):478-P

DOI: https://doi.org/10.2337/db19-478-P

Published: 01 June 2019

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Meeting Abstracts

231-OR: ADA Presidents' Select Abstract: Pyruvate Kinase M2 Overexpression in Podocytes Ameliorates Nephropathy in Diabetic Mice

TAKANORI SHINJO, RONALD ST-LOUIS, JIALIN FU, KYOUNGMIN PARK, QIAN LI, HISASHI YOKOMIZO, MARC GREGORY YU, HAIYAN WANG, AIMO KANNT, THORSTEN SADOWSKI, GEORGE L. KING

Diabetes 2019;68(Supplement_1):231-OR

DOI: https://doi.org/10.2337/db19-231-OR

Published: 01 June 2019

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Meeting Abstracts

597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity

HISASHI YOKOMIZO, KYOUNGMIN PARK, ALLEN CLERMONT, YASUTAKA MAEDA, WARD FICKWEILER, ATSUSHI ISHIKADO, QIAN LI, CHIH-HAO WANG, DAVID M. POBER, I-HSIEN WU, HILLARY A. KEENAN, LLOYD P. AIELLO, JENNIFER K. SUN, GEORGE L. KING

Diabetes 2019;68(Supplement_1):597-P

DOI: https://doi.org/10.2337/db19-597-P

Published: 01 June 2019

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Meeting Abstracts

628-P: Insulin's Regulation of CXCL1 Expression Is Critical for Neutrophil Recruitments and the Development of Periodontitis and Poor Wound Healing in Diabetes

TAKANORI SHINJO, QIAN LI, ATSUSHI ISHIKADO, KYOUNGMIN PARK, RONALD ST-LOUIS, HISASHI YOKOMIZO, JIALIN FU, MARC GREGORY YU, HAIYAN WANG, HATICE HASTURK, THOMAS E. VAN DYKE, GEORGE L. KING

Diabetes 2019;68(Supplement_1):628-P

DOI: https://doi.org/10.2337/db19-628-P

Published: 01 June 2019

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Meeting Abstracts

586-P: Vitreous and Serum Measurements of Retinol Binding Protein 3 in the Clinical Evaluation of Diabetic Retinopathy

WARD FICKWEILER, HISASHI YOKOMIZO, KYOUNGMIN PARK, SAMANTHA M. PANIAGUA, I-HSIEN WU, DAVID M. POBER, VANESSA BAHNAM, ALLEN CLERMONT, LLOYD P. AIELLO, JENNIFER K. SUN, GEORGE L. KING

Diabetes 2019;68(Supplement_1):586-P

DOI: https://doi.org/10.2337/db19-586-P

Published: 01 June 2019

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Meeting Abstracts

Diabetic Retinopathy Reversed by Intravitreous Application of Retinol Binding Protein 3

HISASHI YOKOMIZO, KYOUNGMIN PARK, ALLEN CLERMONT, YASUTAKA MAEDA, WARD FICKWEILER, ATSUSHI ISHIKADO, QIAN LI, LIANE J. TINSLEY, DAVID M. POBER, I-HSIEN WU, LLOYD P. AIELLO, HILLARY A. KEENAN, JENNIFER SUN, GEORGE L. KING

Diabetes 2018;67(Supplement_1):245-OR

DOI: https://doi.org/10.2337/db18-245-OR

Published: 01 July 2018

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Meeting Abstracts

White- and Brown-Rice Supplementation Improves Insulin Tolerance, Brown Fat Activation, Energy Expenditure, and Changes the Gut Microflora in Diet-Induced Obesity

HISASHI YOKOMIZO, ATSUSHI ISHIKADO, TAKANORI SHINJO, KYOUNGMIN PARK, YASUTAKA MAEDA, I-HSIEN WU, DAVID M. POBER, SUZANNE DEVKOTA, MOTONOBU MATSUMOTO, ALEKSANDAR KOSTIC, GEORGE L. KING

Diabetes 2018;67(Supplement_1):1897-P

DOI: https://doi.org/10.2337/db18-1897-P

Published: 01 July 2018

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Meeting Abstracts

Endothelial/Nitric Oxide Regulation of Brown Adipose Tissue Activating Lipokine, 12, 13-diHOME and Its Antiatherogenic Actions

KYOUNGMIN PARK, QIAN LI, MATT LYNES, HISASHI YOKOMIZO, TAKANORI SHINJO, RONALD ST-LOUIS, JIALIN FU, CHRISTIAN RASK-MADSEN, YU-HUA TSENG, GEORGE L. KING

Diabetes 2018;67(Supplement_1):286-OR

DOI: https://doi.org/10.2337/db18-286-OR

Published: 01 July 2018

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Journal Articles

Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance

Sayaka Katagiri, Kyoungmin Park, Yasutaka Maeda, Tata Nageswara Rao, Mogher Khamaisi, Qian Li, Hisashi Yokomizo, Akira Mima, Luca Lancerotto, Amy Wagers, Dennis P. Orgill, George L. King

Diabetes 2016;65(9):2760–2771

DOI: https://doi.org/10.2337/db15-1721

Published: 23 May 2016

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Includes: Supplementary data

NARROW

24-OR: Podocyte Targeted Pyruvate Kinase M2 (PKM2) Activation Normalized Glomerular VEGF Expression, Mitochondrial Function, Fuel Metabolism, and Diabetic Nephropathy

183-OR: Pyruvate Kinase M2 (PKM2) Enzymatic Activity Is Necessary to Improve Podocyte Mitochondrial Function and Glomerular Fuel Metabolism and Diabetic Nephropathy

307-OR: Activation of Mitochondrial Activities by Pyruvate Kinase M2 (PKM2) in Podocytes Improved Glomerular Metabolism and Diabetic Nephropathy

309-OR: IGF-1 Receptors, Not Insulin Receptors, on Mesangial Cells Are Accelerating Mesangial Expansion and Albuminuria in Streptozotocin-Induced Diabetic Mice

327-OR: Association of Retinol Binding Protein 3 with Retinal Neural Structure and Clinical Parameters in Diabetic Retinopathy

436-P: Characterization of Autoimmunity in the Acceleration of Atherosclerosis in Type 1 Diabetes

480-P: Reversal of Diabetic Nephropathy in T2D db/db Mouse Model by Systemic Pyruvate Kinase M2 (PKM2) Activation

1867-P: White and Brown Rice Supplementation Changes High-Fat Diet–Induced Dysbiosis of Gut Microbiome and Improves Energy and Glucose Metabolism

478-P: Accelerating Atherosclerosis by Autoimmune Process in Nonobese Diabetic Mice Made ApoE Deficient by CRISPR/Cas9 Gene Editing

231-OR: ADA Presidents' Select Abstract: Pyruvate Kinase M2 Overexpression in Podocytes Ameliorates Nephropathy in Diabetic Mice

597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity

628-P: Insulin's Regulation of CXCL1 Expression Is Critical for Neutrophil Recruitments and the Development of Periodontitis and Poor Wound Healing in Diabetes

586-P: Vitreous and Serum Measurements of Retinol Binding Protein 3 in the Clinical Evaluation of Diabetic Retinopathy

Diabetic Retinopathy Reversed by Intravitreous Application of Retinol Binding Protein 3

White- and Brown-Rice Supplementation Improves Insulin Tolerance, Brown Fat Activation, Energy Expenditure, and Changes the Gut Microflora in Diet-Induced Obesity

Endothelial/Nitric Oxide Regulation of Brown Adipose Tissue Activating Lipokine, 12, 13-diHOME and Its Antiatherogenic Actions

Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance

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