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Hubert Vidal
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Journal Articles

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

Emily Tubbs, Stéphanie Chanon, Maud Robert, Nadia Bendridi, Gabriel Bidaux, Marie-Agnès Chauvin, Jingwei Ji-Cao, Christine Durand, Daphné Gauvrit-Ramette, Hubert Vidal, Etienne Lefai, Jennifer Rieusset
Journal: Diabetes
Diabetes 2018;67(4):636–650
https://doi.org/10.2337/db17-0316
Published: 11 January 2018
View article titled, Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans
Open the PDF for Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans in another window
Includes: Supplementary data
Journal Articles

Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

Assia Eljaafari, Maud Robert, Marwa Chehimi, Stephanie Chanon, Christine Durand, Guillaume Vial, Nadia Bendridi, Anne-Marie Madec, Emmanuel Disse, Martine Laville, Jennifer Rieusset, Etienne Lefai, Hubert Vidal, Luciano Pirola
Journal: Diabetes
Diabetes 2015;64(7):2477–2488
https://doi.org/10.2337/db15-0162
Published: 12 March 2015
View article titled, Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation
Open the PDF for Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation in another window
Includes: Supplementary data
Journal Articles

Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Guillaume Vial, Marie-Agnès Chauvin, Nadia Bendridi, Annie Durand, Emmanuelle Meugnier, Anne-Marie Madec, Nathalie Bernoud-Hubac, Jean-Paul Pais de Barros, Éric Fontaine, Cécile Acquaviva, Sophie Hallakou-Bozec, Sébastien Bolze, Hubert Vidal, Jennifer Rieusset
Journal: Diabetes
Diabetes 2015;64(6):2254–2264
https://doi.org/10.2337/db14-1220
Published: 31 December 2014
View article titled, Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model
Open the PDF for Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model in another window
Includes: Supplementary data
Journal Articles

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

Emily Tubbs, Pierre Theurey, Guillaume Vial, Nadia Bendridi, Amélie Bravard, Marie-Agnès Chauvin, Jingwei Ji-Cao, Fabien Zoulim, Birke Bartosch, Michel Ovize, Hubert Vidal, Jennifer Rieusset
Journal: Diabetes
Diabetes 2014;63(10):3279–3294
https://doi.org/10.2337/db13-1751
Published: 15 September 2014
View article titled, Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance
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Includes: Supplementary data
Journal Articles

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Stefania Carobbio, Rachel M. Hagen, Christopher J. Lelliott, Marc Slawik, Gema Medina-Gomez, Chong-Yew Tan, Audrey Sicard, Helen J. Atherton, Nuria Barbarroja, Mikael Bjursell, Mohammad Bohlooly-Y, Sam Virtue, Antoinette Tuthill, Etienne Lefai, Martine Laville, Tingting Wu, Robert V. Considine, Hubert Vidal, Dominique Langin, Matej Oresic, Francisco J. Tinahones, Jose Manuel Fernandez-Real, Julian L. Griffin, Jaswinder K. Sethi, Miguel López, Antonio Vidal-Puig
Journal: Diabetes
Diabetes 2013;62(11):3697–3708
https://doi.org/10.2337/db12-1748
Published: 18 October 2013
View article titled, Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
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Includes: Supplementary data
Journal Articles

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

Amélie Bravard, Etienne Lefai, Emmanuelle Meugnier, Sandra Pesenti, Emmanuel Disse, Julien Vouillarmet, Nöel Peretti, Rémi Rabasa-Lhoret, Martine Laville, Hubert Vidal, Jennifer Rieusset
Journal: Diabetes
Diabetes 2011;60(1):258–268
https://doi.org/10.2337/db10-0281
Published: 13 October 2010
View article titled, FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
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Includes: Supplementary data
Journal Articles

Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis

Jennifer Jager, Thierry Grémeaux, Teresa Gonzalez, Stéphanie Bonnafous, Cyrille Debard, Martine Laville, Hubert Vidal, Albert Tran, Philippe Gual, Yannick Le Marchand-Brustel, Mireille Cormont, Jean-François Tanti
Journal: Diabetes
Diabetes 2010;59(1):61–70
https://doi.org/10.2337/db09-0470
Published: 06 October 2009
View article titled, Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis
Open the PDF for Tpl2 Kinase Is Upregulated in Adipose Tissue in Obesity and May Mediate Interleukin-1β and Tumor Necrosis Factor-α Effects on Extracellular Signal–Regulated Kinase Activation and Lipolysis in another window
Includes: Supplementary data
Journal Articles

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

Aurélie Granjon, Marie-Paule Gustin, Jennifer Rieusset, Etienne Lefai, Emmanuelle Meugnier, Isabelle Güller, Catherine Cerutti, Christian Paultre, Emmanuel Disse, Rémi Rabasa-Lhoret, Martine Laville, Hubert Vidal, Sophie Rome
Journal: Diabetes
Diabetes 2009;58(11):2555–2564
https://doi.org/10.2337/db09-0165
Published: 31 August 2009
View article titled, The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway
Open the PDF for The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway in another window
Includes: Supplementary data
Journal Articles

Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects

Emmanuelle Meugnier, May Faraj, Sophie Rome, Geneviève Beauregard, Angélique Michaut, Véronique Pelloux, Jean-Louis Chiasson, Martine Laville, Karine Clement, Hubert Vidal, Rémi Rabasa-Lhoret
Journal: Diabetes
Diabetes 2007;56(4):992–999
https://doi.org/10.2337/db06-1242
Published: 01 April 2007
View article titled, Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects
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Includes: Supplementary data
Journal Articles

Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle : Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6

Daniel Bach, Deborah Naon, Sara Pich, Francesc X. Soriano, Nathalie Vega, Jennifer Rieusset, Martine Laville, Christelle Guillet, Yves Boirie, Harriet Wallberg-Henriksson, Melania Manco, Menotti Calvani, Marco Castagneto, Manuel Palacín, Geltrude Mingrone, Juleen R. Zierath, Hubert Vidal, Antonio Zorzano
Journal: Diabetes
Diabetes 2005;54(9):2685–2693
https://doi.org/10.2337/diabetes.54.9.2685
Published: 01 September 2005
View article titled, Expression of <em>Mfn2</em>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle : <subtitle>Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6</subtitle>
Open the PDF for Expression of <em>Mfn2</em>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle : <subtitle>Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6</subtitle> in another window
Journal Articles

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

Jennifer Rieusset, Karim Bouzakri, Emmanuel Chevillotte, Nadège Ricard, Delphine Jacquet, Jean-Philippe Bastard, Martine Laville, Hubert Vidal
Journal: Diabetes
Diabetes 2004;53(9):2232–2241
https://doi.org/10.2337/diabetes.53.9.2232
Published: 01 September 2004
View article titled, Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients
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Journal Articles

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Yvan Gosmain, Etienne Lefai, Stephan Ryser, Marina Roques, Hubert Vidal
Journal: Diabetes
Diabetes 2004;53(2):321–329
https://doi.org/10.2337/diabetes.53.2.321
Published: 01 February 2004
View article titled, Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells
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Journal Articles

Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes

Karim Bouzakri, Marina Roques, Philippe Gual, Sophie Espinosa, Fitsum Guebre-Egziabher, Jean-Paul Riou, Martine Laville, Yannick Le Marchand-Brustel, Jean-François Tanti, Hubert Vidal
Journal: Diabetes
Diabetes 2003;52(6):1319–1325
https://doi.org/10.2337/diabetes.52.6.1319
Published: 01 June 2003
View article titled, Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes
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Journal Articles

The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression

Patrick Schrauwen, Dorien P.C. van Aggel-Leijssen, Gabby Hul, Anton J.M. Wagenmakers, Hubert Vidal, Wim H.M. Saris, Marleen A. van Baak
Journal: Diabetes
Diabetes 2002;51(7):2220–2226
https://doi.org/10.2337/diabetes.51.7.2220
Published: 01 July 2002
View article titled, The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression
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Journal Articles

Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes

Pierre-Henri Ducluzeau, Noël Perretti, Martine Laville, Fabrizio Andreelli, Nathalie Vega, Jean-Paul Riou, Hubert Vidal
Journal: Diabetes
Diabetes 2001;50(5):1134–1142
https://doi.org/10.2337/diabetes.50.5.1134
Published: 01 May 2001
View article titled, Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: <subtitle>Evidence for Specific Defects in Type 2 Diabetes</subtitle>
Open the PDF for Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: <subtitle>Evidence for Specific Defects in Type 2 Diabetes</subtitle> in another window
Journal Articles

Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects

Anne-Marie Lefebvre, Martine Laville, Nathalie Vega, Jean Paul Riou, Luc van Gaal, Johan Auwerx, Hubert Vidal
Journal: Diabetes
Diabetes 1998;47(1):98–103
https://doi.org/10.2337/diab.47.1.98
Published: 01 January 1998
View article titled, Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects
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Journal Articles

Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

Didier Auboeuf, Jennifer Rieusset, Lluis Fajas, Paulette Vallier, Vincent Frering, Jean Paul Riou, Bart Staels, Johan Auwerx, Martine Laville, Hubert Vidal
Journal: Diabetes
Diabetes 1997;46(8):1319–1327
https://doi.org/10.2337/diab.46.8.1319
Published: 01 August 1997
View article titled, Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients
Open the PDF for Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients in another window
Journal Articles

Glucose-6-Phosphatase mRNA and Activity Are Increased to the Same Extent in Kidney and Liver of Diabetic Rats

Gilles Mithieux, Hubert Vidal, Carine Zitoun, Nathalie Bruni, Nathalie Daniele, Carol Minassian
Journal: Diabetes
Diabetes 1996;45(7):891–896
https://doi.org/10.2337/diab.45.7.891
Published: 01 July 1996
View article titled, Glucose-6-Phosphatase mRNA and Activity Are Increased to the Same Extent in Kidney and Liver of Diabetic Rats
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Journal Articles

Regulation of Insulin Receptor mRNA Splicing in Rat Tissues: Effect of Fasting, Aging, and Diabetes

Hubert Vidal, Didier Auboeuf, Michel Beylot, Jean Paul Riou
Journal: Diabetes
Diabetes 1995;44(10):1196–1201
https://doi.org/10.2337/diab.44.10.1196
Published: 01 October 1995
View article titled, Regulation of Insulin Receptor mRNA Splicing in Rat Tissues: Effect of Fasting, Aging, and Diabetes
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Journal Articles

Importance of Substrate Changes in the Decrease of Hepatic Glucose Cycling During Insulin Infusion and Declining Glycemia in the Depancreatized Dog

Z Shi Qing, Adria Giacca, Simon Fisher, Hubert Vidal, Gerald Van De Werve, Mladen Vranic
Journal: Diabetes
Diabetes 1994;43(11):1284–1290
https://doi.org/10.2337/diab.43.11.1284
Published: 01 November 1994
View article titled, Importance of Substrate Changes in the Decrease of Hepatic Glucose Cycling During Insulin Infusion and Declining Glycemia in the Depancreatized Dog
Open the PDF for Importance of Substrate Changes in the Decrease of Hepatic Glucose Cycling During Insulin Infusion and Declining Glycemia in the Depancreatized Dog in another window