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Iichiro Shimomura
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Journal Articles

Interrelationships Among Accumulations of Intra- and Periorgan Fats, Visceral Fat, and Subcutaneous Fat

Kento Mitsushio, Megu Y. Baden, Takuya Kagisaki, Sarasa Kato, Akiko Niki, Risa Takayama, Tomomi Horii, Harutoshi Ozawa, Chisaki Ishibashi, Yoshiya Hosokawa, Yukari Fujita, Junji Kozawa, Iichiro Shimomura
Journal: Diabetes
Diabetes 2024;73(7):1122–1126
https://doi.org/10.2337/db24-0035
Published: 24 April 2024
View article titled, Interrelationships Among Accumulations of Intra- and Periorgan Fats, Visceral Fat, and Subcutaneous Fat
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Journal Articles

Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients

Satoshi Kawata, Junji Kozawa, Sho Yoneda, Yukari Fujita, Risa Kashiwagi-Takayama, Takekazu Kimura, Yoshiya Hosokawa, Megu Y. Baden, Sae Uno, Rikako Uenaka, Kazuyuki Namai, Yoko Koh, Yoshito Tomimaru, Haruhiko Hirata, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Hidetoshi Eguchi, Akihisa Imagawa, Iichiro Shimomura
Journal: Diabetes
Diabetes 2023;72(4):511–519
https://doi.org/10.2337/db22-0557
Published: 19 January 2023
View article titled, Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients
Open the PDF for Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients in another window
Journal Articles

Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Jihoon Shin, Shinichiro Toyoda, Shigeki Nishitani, Atsunori Fukuhara, Shunbun Kita, Michio Otsuki, Iichiro Shimomura
Journal: Diabetes
Diabetes 2021;70(12):2745–2755
https://doi.org/10.2337/db20-1094
Published: 22 October 2021
View article titled, Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
Open the PDF for Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19 in another window
Meeting Abstracts

324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER

SUZANNE V. ARNOLD, FENGMING TANG, ANDREW COOPER, HUNGTA CHEN, MARILIA B. GOMES, WOLFGANG RATHMANN, IICHIRO SHIMOMURA, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD
Journal: Diabetes
Diabetes 2021;70(Supplement_1):324-OR
https://doi.org/10.2337/db21-324-OR
Published: 01 June 2021
View article titled, 324-OR: Global Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes: Results from DISCOVER
Meeting Abstracts

82-OR: Effect of Semaglutide 2.4 mg on Glucose Metabolism and Body Weight in Adults with Overweight/Obesity and Type 2 Diabetes in the STEP 2 Trial

LEIGH PERREAULT, MELANIE J. DAVIES, LOUISE FÆRCH, OLE JEPPESEN, ARASH PAKSERESHT, SUE PEDERSEN, JULIO ROSENSTOCK, IICHIRO SHIMOMURA, ADIE VILJOEN, THOMAS A. WADDEN, ILDIKO LINGVAY
Journal: Diabetes
Diabetes 2021;70(Supplement_1):82-OR
https://doi.org/10.2337/db21-82-OR
Published: 01 June 2021
View article titled, 82-OR: Effect of Semaglutide 2.4 mg on Glucose Metabolism and Body Weight in Adults with Overweight/Obesity and Type 2 Diabetes in the STEP 2 Trial
Meeting Abstracts

40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER

ANTONIO NICOLUCCI, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD, PAUL LEIGH, LARISA RAMIREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, SUZANNE V. ARNOLD
Journal: Diabetes
Diabetes 2020;69(Supplement_1):40-OR
https://doi.org/10.2337/db20-40-OR
Published: 01 June 2020
View article titled, 40-OR: Quality of Life in People with Type 2 Diabetes following Initiation of Second-Line Therapy: DISCOVER
Meeting Abstracts

1598-P: HbA1c <7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study

FABRICE BONNET, HUNGTA CHEN, ANDREW COOPER, MARILIA B. GOMES, LINONG JI, PAUL LEIGH, LARISA RAMIREZ GUTIERREZ, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, AFRAH SIDDIQUI, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1598-P
https://doi.org/10.2337/db20-1598-P
Published: 01 June 2020
View article titled, 1598-P: HbA1c &lt;7.0% 6 Months after Initiation of Second-Line Therapy in Patients with Uncontrolled Type 2 Diabetes Is Associated with Good Glycemic Control at 3 Years: The DISCOVER Study
Meeting Abstracts

1116-P: Effect of Tofogliflozin on Carotid Intima-Media Thickness in Patients with Type 2 Diabetes: Results from the Prospective, Randomized, Open-Label, Parallel-Group Comparative UTOPIA Trial

NAOTO KATAKAMI, TOMOYA MITA, HIROTAKA WATADA, IICHIRO SHIMOMURA, UTOPIA STUDY INVESTIGATORS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1116-P
https://doi.org/10.2337/db20-1116-P
Published: 01 June 2020
View article titled, 1116-P: Effect of Tofogliflozin on Carotid Intima-Media Thickness in Patients with Type 2 Diabetes: Results from the Prospective, Randomized, Open-Label, Parallel-Group Comparative UTOPIA Trial
Meeting Abstracts

1628-P: Changes in HbA1c and Treatment in the Second Year following Initiation of Second-Line Therapy in People with T2D—The Global DISCOVER Study

BERNARD CHARBONNEL, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, ANTONIO NICOLUCCI, STUART POCOCK, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, SHAUKAT M. SADIKOT, FILIP SURMONT, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, KAMLESH KHUNTI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1628-P
https://doi.org/10.2337/db19-1628-P
Published: 01 June 2019
View article titled, 1628-P: Changes in HbA<sub>1c</sub> and Treatment in the Second Year following Initiation of Second-Line Therapy in People with T2D—The Global DISCOVER Study
Meeting Abstracts

420-P: Micro- and Macrovascular Events in Patients with T2D—Results from the Global DISCOVER Study

SUZANNE V. ARNOLD, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, KAMLESH KHUNTI, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, ANTONIO NICOLUCCI, STUART POCOCK, SHAUKAT M. SADIKOT, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, MIKHAIL N. KOSIBOROD
Journal: Diabetes
Diabetes 2019;68(Supplement_1):420-P
https://doi.org/10.2337/db19-420-P
Published: 01 June 2019
View article titled, 420-P: Micro- and Macrovascular Events in Patients with T2D—Results from the Global DISCOVER Study
Meeting Abstracts

1279-P: Socioeconomic Factors Associated with Poor Glycemic Control in People with Type 2 Diabetes: The DISCOVER Study

MARILIA B. GOMES, FENGMING TANG, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, KAMLESH KHUNTI, STUART POCOCK, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, FILIP SURMONT, HIROTAKA WATADA, JESUS MEDINA, SHAUKAT M. SADIKOT, IICHIRO SHIMOMURA, GABRIELA LUPORINI SARAIVA, ANTONIO NICOLUCCI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1279-P
https://doi.org/10.2337/db19-1279-P
Published: 01 June 2019
View article titled, 1279-P: Socioeconomic Factors Associated with Poor Glycemic Control in People with Type 2 Diabetes: The DISCOVER Study
Meeting Abstracts

207-LB: Type 2 Diabetes and Heart Failure: Insights from the DISCOVER Study

SUZANNE V. ARNOLD, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, KAMLESH KHUNTI, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, STUART POCOCK, SHAUKAT M. SADIKOT, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, JITEN VORA, HIROTAKA WATADA, LINONG JI, BERNARD CHARBONNEL, FABRICE BONNET, MIKHAIL N. KOSIBOROD
Journal: Diabetes
Diabetes 2019;68(Supplement_1):207-LB
https://doi.org/10.2337/db19-207-LB
Published: 01 June 2019
View article titled, 207-LB: Type 2 Diabetes and Heart Failure: Insights from the DISCOVER Study
Meeting Abstracts

1448-P: Potential Overtreatment of Older Patients with T2D: The Global DISCOVER Study

BRENDA BONGAERTS, SUZANNE V. ARNOLD, BERNARD CHARBONNEL, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, LINONG JI, KAMLESH KHUNTI, MIKHAIL N. KOSIBOROD, GABRIELA LUPORINI SARAIVA, JESUS MEDINA, ANTONIO NICOLUCCI, STUART POCOCK, SHAUKAT M. SADIKOT, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, HIROTAKA WATADA, WOLFGANG RATHMANN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1448-P
https://doi.org/10.2337/db19-1448-P
Published: 01 June 2019
View article titled, 1448-P: Potential Overtreatment of Older Patients with T2D: The Global DISCOVER Study
Meeting Abstracts

Twelve-Month Changes in HbA1c, Fasting Plasma Glucose, and Weight among Patients with Type 2 Diabetes in 37 Countries—DISCOVER

BERNARD CHARBONNEL, FABRICE BONNET, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, NIKLAS HAMMAR, LINONG JI, KEVIN KENNEDY, MIKHAIL KOSIBOROD, STUART POCOCK, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, KAMLESH KHUNTI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1615-P
https://doi.org/10.2337/db18-1615-P
Published: 01 July 2018
View article titled, Twelve-Month Changes in HbA1c, Fasting Plasma Glucose, and Weight among Patients with Type 2 Diabetes in 37 Countries—DISCOVER
Meeting Abstracts

Temporal Trends in the Use of Sodium-Glucose Cotransporter 2 Inhibitors—The Global DISCOVER Study

MIKHAIL KOSIBOROD, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, NIKLAS HAMMAR, KAMLESH KHUNTI, STUART POCOCK, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, LINONG JI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1141-P
https://doi.org/10.2337/db18-1141-P
Published: 01 July 2018
View article titled, Temporal Trends in the Use of Sodium-Glucose Cotransporter 2 Inhibitors—The Global DISCOVER Study
Meeting Abstracts

Individualized HbA1c Targets in People with Type 2 Diabetes Initiating Second-Line Therapy—The Global DISCOVER Study

KAMLESH KHUNTI, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, NIKLAS HAMMAR, KEVIN KENNEDY, MIKHAIL KOSIBOROD, STUART POCOCK, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, LINONG JI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1629-P
https://doi.org/10.2337/db18-1629-P
Published: 01 July 2018
View article titled, Individualized HbA1c Targets in People with Type 2 Diabetes Initiating Second-Line Therapy—The Global DISCOVER Study
Meeting Abstracts

Vascular Events in Patients with Type 2 Diabetes in the Year following Initiation of Second-Line Therapy-The DISCOVER Study

MIKHAIL KOSIBOROD, HUNGTA CHEN, JAVIER CID-RUZAFA, PETER FENICI, MARILIA B. GOMES, KAMLESH KHUNTI, STUART POCOCK, WOLFGANG RATHMANN, MARINA V. SHESTAKOVA, IICHIRO SHIMOMURA, FILIP SURMONT, FENGMING TANG, HIROTAKA WATADA, LINONG JI, NIKLAS HAMMAR
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1562-P
https://doi.org/10.2337/db18-1562-P
Published: 01 July 2018
View article titled, Vascular Events in Patients with Type 2 Diabetes in the Year following Initiation of Second-Line Therapy-The DISCOVER Study
Meeting Abstracts

Identification and Analysis of a Novel Glucose Toxicity–Sensitive Gene in Pancreatic ß Cell

NAOKI SHIMO, TAKAAKI MATSUOKA, DAN KAWAMORI, SATOMI TAKEBE, TAKESHI MIYATSUKA, IICHIRO SHIMOMURA
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2144-P
https://doi.org/10.2337/db18-2144-P
Published: 01 July 2018
View article titled, Identification and Analysis of a Novel Glucose Toxicity–Sensitive Gene in Pancreatic ß Cell
Journal Articles

Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway

Yosuke Okuno, Atsunori Fukuhara, Erika Hashimoto, Hironori Kobayashi, Sachiko Kobayashi, Michio Otsuki, Iichiro Shimomura
Journal: Diabetes
Diabetes 2018;67(6):1113–1127
https://doi.org/10.2337/db17-1032
Published: 04 April 2018
View article titled, Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway
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Includes: Supplementary data
Journal Articles

SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes

Jihoon Shin, Atsunori Fukuhara, Toshiharu Onodera, Shunbun Kita, Chieko Yokoyama, Michio Otsuki, Iichiro Shimomura
Journal: Diabetes
Diabetes 2018;67(6):1068–1078
https://doi.org/10.2337/db17-0706
Published: 26 March 2018
View article titled, SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes
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Includes: Supplementary data