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In-Kyu Lee
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Meeting Abstracts

2022-LB: Diabetes Primes Neutrophils for Neutrophil Extracellular Trap by Metabolic Reprogramming

JAE-HAN JEON, MI-KYUNG KIM, IN-KYU LEE
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2022-LB
https://doi.org/10.2337/db24-2022-LB
Published: 14 June 2024
View article titled, 2022-LB: Diabetes Primes Neutrophils for Neutrophil Extracellular Trap by Metabolic Reprogramming
Meeting Abstracts

1800-LB: Reprogramming of Macrophage Metabolism by Pyruvate Dehydrogenase Attenuates Atherosclerosis through Mitigation of iNOS-Induced Foam Cell Formation

JAE-HAN JEON, MI-KYUNG KIM, IN-KYU LEE
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1800-LB
https://doi.org/10.2337/db24-1800-LB
Published: 14 June 2024
View article titled, 1800-LB: Reprogramming of Macrophage Metabolism by Pyruvate Dehydrogenase Attenuates Atherosclerosis through Mitigation of iNOS-Induced Foam Cell Formation
Journal Articles

Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance

Soyoung Park, Hye-Na Cha, Min-Gyeong Shin, Sanghee Park, Yeongmin Kim, Min-Seob Kim, Kyung-Hoon Shin, Themis Thoudam, Eun Ju Lee, Robert R. Wolfe, Jinmyoung Dan, Jin-Ho Koh, Il-Young Kim, Inho Choi, In-Kyu Lee, Hoon-Ki Sung, So-Young Park
Journal: Diabetes
Diabetes 2024;73(7):1084–1098
https://doi.org/10.2337/db23-0432
Published: 24 April 2024
View article titled, Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance
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Meeting Abstracts

821-P: Randomized Clinical Trial on the Renoprotective Effect of CU01-10in Patients with Diabetic Kidney Disease (DKD)

JUN SUNG MOON, KYU CHANG WON, MIN-JI KIM, IN-KYU LEE, SO HEE KWON, JUNG-IN PYO, JI-HYE KANG, YOUNG-GUEN KWON, HEEWON SEO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):821-P
https://doi.org/10.2337/db22-821-P
Published: 01 June 2022
View article titled, 821-P: Randomized Clinical Trial on the Renoprotective Effect of CU01-10in Patients with Diabetic Kidney Disease (DKD)
Meeting Abstracts

511-P: The Renoprotective Effect of Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, in a Mouse Model of Renal Fibrosis

NAYOUNG KIM, IN-KYU LEE, SUNG DON PARK, MIN-JI KIM, JUNG-GUK KIM, YEON-KYUNG CHOI, KEUN-GYU PARK, MI-JIN KIM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):511-P
https://doi.org/10.2337/db19-511-P
Published: 01 June 2019
View article titled, 511-P: The Renoprotective Effect of Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, in a Mouse Model of Renal Fibrosis
Meeting Abstracts

508-P: Gemigliptin Ameliorates Renal Fibrosis by Attenuating NLRP3-Mediated Inflammation in a Murine Model

GWONSOO JUNG, YEON-KYUNG CHOI, JUNG BEOM SEO, SUNG DON PARK, NAYOUNG KIM, MIN-JI KIM, JUNG-GUK KIM, IN-KYU LEE, KEUN-GYU PARK
Journal: Diabetes
Diabetes 2019;68(Supplement_1):508-P
https://doi.org/10.2337/db19-508-P
Published: 01 June 2019
View article titled, 508-P: Gemigliptin Ameliorates Renal Fibrosis by Attenuating NLRP3-Mediated Inflammation in a Murine Model
Journal Articles

PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee
Journal: Diabetes
Diabetes 2019;68(3):571–586
https://doi.org/10.2337/db18-0363
Published: 06 December 2018
View article titled, PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
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Includes: Supplementary data
Journal Articles

PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels

Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
Journal: Diabetes
Diabetes 2018;67(10):2054–2068
https://doi.org/10.2337/db17-1529
Published: 31 July 2018
View article titled, PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
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Includes: Supplementary data
Journal Articles

Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence

Yu-Mi Lee, Chae-Myeong Ha, Se-A Kim, Themis Thoudam, Young-Ran Yoon, Dae-Jung Kim, Hyeon-Chang Kim, Hyo-Bang Moon, Sungmi Park, In-Kyu Lee, Duk-Hee Lee
Journal: Diabetes
Diabetes 2017;66(10):2669–2680
https://doi.org/10.2337/db17-0188
Published: 18 July 2017
View article titled, Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence
Open the PDF for Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence in another window
Includes: Supplementary data
Journal Articles

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Younghoon Go, Ji Yun Jeong, Nam Ho Jeoung, Jae-Han Jeon, Bo-Yoon Park, Hyeon-Ji Kang, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Hye Jin Ham, Byung-Gyu Kim, Keun-Gyu Park, So Young Park, Chul-Ho Lee, Cheol Soo Choi, Tae-Sik Park, W.N. Paul Lee, Robert A. Harris, In-Kyu Lee
Journal: Diabetes
Diabetes 2016;65(10):2876–2887
https://doi.org/10.2337/db16-0223
Published: 06 July 2016
View article titled, Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis
Open the PDF for Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis in another window
Includes: Supplementary data
Journal Articles

O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis

Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2016;65(10):2835–2848
https://doi.org/10.2337/db15-1523
Published: 22 June 2016
View article titled, O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis
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Includes: Supplementary data
Journal Articles

Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis

Don-Kyu Kim, Gil-Tae Gang, Dongryeol Ryu, Minseob Koh, Yo-Na Kim, Su Sung Kim, Jinyoung Park, Yong-Hoon Kim, Taebo Sim, In-Kyu Lee, Cheol Soo Choi, Seung Bum Park, Chul-Ho Lee, Seung-Hoi Koo, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2013;62(9):3093–3102
https://doi.org/10.2337/db12-0946
Published: 15 August 2013
View article titled, Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis
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Includes: Supplementary data
Journal Articles

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner

Yong Deuk Kim, Yong-Hoon Kim, Surendar Tadi, Ji Hoon Yu, Yong-Hyeon Yim, Nam Ho Jeoung, Minho Shong, Lothar Hennighausen, Robert A. Harris, In-Kyu Lee, Chul-Ho Lee, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2012;61(10):2484–2494
https://doi.org/10.2337/db11-1665
Published: 13 September 2012
View article titled, Metformin Inhibits Growth Hormone–Mediated Hepatic <em>PDK4</em> Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner
Open the PDF for Metformin Inhibits Growth Hormone–Mediated Hepatic <em>PDK4</em> Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner in another window
Includes: Supplementary data
Journal Articles

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women

Soo Heon Kwak, Sung-Hoon Kim, Young Min Cho, Min Jin Go, Yoon Shin Cho, Sung Hee Choi, Min Kyong Moon, Hye Seung Jung, Hyoung Doo Shin, Hyun Min Kang, Nam H. Cho, In Kyu Lee, Seong Yeon Kim, Bok-Ghee Han, Hak C. Jang, Kyong Soo Park
Journal: Diabetes
Diabetes 2012;61(2):531–541
https://doi.org/10.2337/db11-1034
Published: 17 January 2012
View article titled, A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
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Includes: Supplementary data
Journal Articles

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Yong Deuk Kim, Keun-Gyu Park, Yong-Soo Lee, Yun-Yong Park, Don-Kyu Kim, Balachandar Nedumaran, Won Gu Jang, Won-Jea Cho, Joohun Ha, In-Kyu Lee, Chul-Ho Lee, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2008;57(2):306–314
https://doi.org/10.2337/db07-0381
Published: 01 February 2008
View article titled, Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP
Open the PDF for Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP in another window
Includes: Supplementary data
Journal Articles

Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells

Sung Sik Choe, A Hyun Choi, Joo-Won Lee, Kang Ho Kim, Jun-Jae Chung, Jiyoung Park, Kyeong-Min Lee, Keun-Gyu Park, In-Kyu Lee, Jae Bum Kim
Journal: Diabetes
Diabetes 2007;56(6):1534–1543
https://doi.org/10.2337/db06-1059
Published: 01 June 2007
View article titled, Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis: <subtitle>Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells</subtitle>
Open the PDF for Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis: <subtitle>Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells</subtitle> in another window
Includes: Supplementary data
Journal Articles

Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner

Keun-Gyu Park, Kyeong-Min Lee, Hye-Young Seo, Ji-Ho Suh, Hye-Soon Kim, Li Wang, Kyu-Chang Won, Hyoung-Woo Lee, Joong-Yeol Park, Ki-Up Lee, Jung-Guk Kim, Bo-Wan Kim, Hueng-Sik Choi, In-Kyu Lee
Journal: Diabetes
Diabetes 2007;56(2):431–437
https://doi.org/10.2337/db06-0753
Published: 01 February 2007
View article titled, Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner
Open the PDF for Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner in another window
Includes: Supplementary data