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Journal Articles

Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

Elina Akalestou, Livia Lopez-Noriega, Iain R. Tough, Ming Hu, Isabelle Leclerc, Helen M. Cox, Guy A. Rutter

Diabetes 2022;71(8):1623–1635

https://doi.org/10.2337/db21-0768

Published: 21 August 2022

View articletitled, Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

Meeting Abstracts

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

PAULINE L. CHABOSSEAU, SU WERN FIONA YONG, LIVIA LOPEZ, ISABELLE LECLERC, YUSUF ALI, AIDA MARTINEZ-SANCHEZ, GUY A. RUTTER

Diabetes 2022;71(Supplement_1):1454-P

https://doi.org/10.2337/db22-1454-P

Published: 01 June 2022

View articletitled, 1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

Journal Articles

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Diabetes 2022;71(7):1525–1545

https://doi.org/10.2337/db21-0803

Published: 27 April 2022

View articletitled, Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Journal Articles

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Diabetes 2022;71(7):1472–1489

https://doi.org/10.2337/db21-0800

Published: 26 April 2022

View articletitled, Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Meeting Abstracts

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

STAVROULA BITSI, KINGA SUBA, NIMCO MOHAMED, ISABELLE LECLERC, GUY A. RUTTER, VICTORIA SALEM, BEN JONES, ALEJANDRA TOMAS

Diabetes 2021;70(Supplement_1):228-LB

https://doi.org/10.2337/db21-228-LB

Published: 01 June 2021

View articletitled, 228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

Meeting Abstracts

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

ELENI GEORGIADOU, CHARANYA MURALIDHARAN, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, THEODOROS STYLIANIDES, CRISTINA LEGIDO-QUIGLEY, NOUR ALSABEEH, CÉLINE CRUCIANI-GUGLIELMACCI, CHRISTOPHE MAGNAN, MARK IBBERSON, ISABELLE LECLERC, AMELIA K. LINNEMANN, YUSUF ALI, TRISTAN RODRIGUEZ, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):38-OR

https://doi.org/10.2337/db21-38-OR

Published: 01 June 2021

View articletitled, 38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

Meeting Abstracts

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

YUSMAN MANCHANDA, BEN JONES, GAELLE CARRAT, ZENOUSKA RAMCHUNDER, PIERO MARCHETTI, ISABELLE LECLERC, RAJAMANNAR THENNATI, VINOD S. BURADE, ALEJANDRA TOMAS, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):87-LB

https://doi.org/10.2337/db21-87-LB

Published: 01 June 2021

View articletitled, 87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

Meeting Abstracts

124-OR: Repetitive Ca2+ Waves Emanate from a Stable Leader Cell in Mouse Islets

PAULINE L. CHABOSSEAU, AIDA MARTINEZ-SANCHEZ, ISABELLE LECLERC, VICTORIA SALEM, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):124-OR

https://doi.org/10.2337/db21-124-OR

Published: 01 June 2021

View articletitled, 124-OR: Repetitive Ca2+ Waves Emanate from a Stable Leader Cell in Mouse Islets

Meeting Abstracts

1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

VICTORIA SALEM, USAMA ALI, KINGA SUBA, STAVROULA BITSI, TATIANA LOPES, ALDARA MARTIN ALONSO, YATEEN S. PATEL, ISABELLE LECLERC, BRYN OWEN, GUY A. RUTTER, STEPHEN M. ROTHERY, ALEJANDRA TOMAS

Diabetes 2020;69(Supplement_1):1683-P

https://doi.org/10.2337/db20-1683-P

Published: 01 June 2020

View articletitled, 1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

Meeting Abstracts

320-OR: Bariatric Surgery Improves Ca2+ Dynamics across Pancreatic Islets In Vivo

ELINA AKALESTOU, KINGA SUBA, LIVIA LOPEZ NORIEGA, PAULINE L. CHABOSSEAU, ISABELLE LECLERC, VICTORIA SALEM, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):320-OR

https://doi.org/10.2337/db20-320-OR

Published: 01 June 2020

View articletitled, 320-OR: Bariatric Surgery Improves Ca2+ Dynamics across Pancreatic Islets In Vivo

Meeting Abstracts

2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

ELENI GEORGIADOU, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):2072-P

https://doi.org/10.2337/db20-2072-P

Published: 01 June 2020

View articletitled, 2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

Meeting Abstracts

2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

GAELLE CARRAT, MARIE-SOPHIE NGUYEN-TU, ISABELLE LECLERC, RAJAMANNAR THENNATI, BEN JONES, ALEJANDRA TOMAS, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):2100-P

https://doi.org/10.2337/db20-2100-P

Published: 01 June 2020

View articletitled, 2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

Meeting Abstracts

1798-P: Chronic Administration of a Long-Acting Glucagon Analogue Results in Enhanced Insulin Secretory Activity in a Directly-Observed Murine Model

KINGA SUBA, YATEEN S. PATEL, ALDARA MARTIN ALONSO, REBECCA SCOTT, JAMES S. MINNION, ISABELLE LECLERC, BRYN OWEN, WALTER DISTASO, TRICIA M. TAN, KEVIN MURPHY, STEPHEN BLOOM, GUY A. RUTTER, VICTORIA SALEM

Diabetes 2020;69(Supplement_1):1798-P

https://doi.org/10.2337/db20-1798-P

Published: 01 June 2020

View articletitled, 1798-P: Chronic Administration of a Long-Acting Glucagon Analogue Results in Enhanced Insulin Secretory Activity in a Directly-Observed Murine Model

Meeting Abstracts

1912-P: Bariatric Surgery Downregulates Glucocorticoid Signaling in Mice

ELINA AKALESTOU, LIVIA LOPEZ NORIEGA, IOANNIS CHRISTAKIS, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):1912-P

https://doi.org/10.2337/db20-1912-P

Published: 01 June 2020

View articletitled, 1912-P: Bariatric Surgery Downregulates Glucocorticoid Signaling in Mice

Meeting Abstracts

343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

GAELLE CARRAT, ELIZABETH HAYTHORNE, LEENA HAATAJA, PETER ARVAN, ALEJANDRA TOMAS, ALEXANDRA PIUNTI, TIMOTHY J. PULLEN, ELENI GEORGIADOU, THEODOROS STYLIANIDES, VICTORIA SALEM, WALTER DISTASO, ANDREW CAKEBREAD, DAVID HODSON, ANNIE C. FUNG, RICHARD B. SESSIONS, FABIEN ALPY, ALICE P. KONG, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2019;68(Supplement_1):343-LB

https://doi.org/10.2337/db19-343-LB

Published: 01 June 2019

View articletitled, 343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

Meeting Abstracts

161-LB: Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice

ELINA AKALESTOU, LIVIA LOPEZ NORIEGA, PAULINE L. CHABOSSEAU, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2019;68(Supplement_1):161-LB

https://doi.org/10.2337/db19-161-LB

Published: 01 June 2019

View articletitled, 161-LB: Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice

Meeting Abstracts

42-OR: Hub Cells Orchestrate 3-Dimensional Pancreatic Beta-Cell Ca2⁺ Dynamics In Vivo

VICTORIA SALEM, LUIS F. DELGADILLO SILVA, KINGA SUBA, ALDARA MARTIN ALONSO, WHEI-CHANG KIM, VASILIKI KALOGIANNI, NADEEM AKHTAR, NEDA MOUSAVY GHARAVY, ELENI GEORGIADOU, ISABELLE LECLERC, LINFORD BRIANT, DAVID HODSON, WALTER DISTASO, NIKOLAY N. NINOV, GUY A. RUTTER

Diabetes 2019;68(Supplement_1):42-OR

https://doi.org/10.2337/db19-42-OR

Published: 01 June 2019

View articletitled, 42-OR: Hub Cells Orchestrate 3-Dimensional Pancreatic Beta-Cell Ca2+ Dynamics In Vivo

Meeting Abstracts

2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs ß-Cell Function

REBECCA CHEUNG, GRAZIA PIZZA, DELPHINE M. ROLANDO, PAULINE L. CHABOSSEAU, MARIE-SOPHIE NGUYEN-TU, ISABELLE LECLERC, GUY A. RUTTER, AIDA MARTINEZ-SANCHEZ

Diabetes 2019;68(Supplement_1):2183-P

https://doi.org/10.2337/db19-2183-P

Published: 01 June 2019

View articletitled, 2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs ß-Cell Function

Meeting Abstracts

2173-P: Effects of AMP-Activated Protein Kinase Activation on Insulin Secretion in Mice

MARIE-SOPHIE NGUYEN-TU, JOSEPH P. HARRIS, AIDA MARTINEZ-SANCHEZ, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2019;68(Supplement_1):2173-P

https://doi.org/10.2337/db19-2173-P

Published: 01 June 2019

View articletitled, 2173-P: Effects of AMP-Activated Protein Kinase Activation on Insulin Secretion in Mice

Meeting Abstracts

Real-Time In Vivo Imaging of Whole Islet Ca²⁺Dynamics Reveals Glucose-Induced Changes in Beta-Cell Connectivity in Mouse and Human Islets

VICTORIA SALEM, KINGA SUBA, ALDARA MARTIN ALONSO, PAULINE L. CHABOSSEAU, ELENI GEORGIADOU, THEODOROS STYLIANIDES, LINFORD BRIANT, DAVID HODSON, GAELLE CARRAT, ISABELLE LECLERC, DAVID C. GABORIAU, STEPHEN M. ROTHERY, GUY A. RUTTER

Diabetes 2018;67(Supplement_1):249-LB

https://doi.org/10.2337/db18-249-LB

Published: 01 July 2018

View articletitled, Real-Time In Vivo Imaging of Whole Islet Ca2+ Dynamics Reveals Glucose-Induced Changes in Beta-Cell Connectivity in Mouse and Human Islets

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Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney

1454-P: A Transcriptomic Signature of Pancreatic Islet Leader Beta Cells

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

124-OR: Repetitive Ca2+ Waves Emanate from a Stable Leader Cell in Mouse Islets

1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

320-OR: Bariatric Surgery Improves Ca2+ Dynamics across Pancreatic Islets In Vivo

2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

1798-P: Chronic Administration of a Long-Acting Glucagon Analogue Results in Enhanced Insulin Secretory Activity in a Directly-Observed Murine Model

1912-P: Bariatric Surgery Downregulates Glucocorticoid Signaling in Mice

343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

161-LB: Inhibition of Kidney SGLT2 Expression following Bariatric Surgery in Mice

42-OR: Hub Cells Orchestrate 3-Dimensional Pancreatic Beta-Cell Ca2⁺ Dynamics In Vivo

2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs ß-Cell Function

2173-P: Effects of AMP-Activated Protein Kinase Activation on Insulin Secretion in Mice

Real-Time In Vivo Imaging of Whole Islet Ca²⁺Dynamics Reveals Glucose-Induced Changes in Beta-Cell Connectivity in Mouse and Human Islets

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