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Jørn Nerup
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Journal Articles

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

Joanna M.M. Howson, Jason D. Cooper, Deborah J. Smyth, Neil M. Walker, Helen Stevens, Jin-Xiong She, George S. Eisenbarth, Marian Rewers, John A. Todd, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Flemming Pociot, Stephen S. Rich, and the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2012;61(11):3012–3017
https://doi.org/10.2337/db11-1694
Published: 16 October 2012
View article titled, Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs

Grant Morahan, Munish Mehta, Ian James, Wei-Min Chen, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Cécile Julier, Jørn Nerup, Concepcion Nierras, Flemming Pociot, John A. Todd, Stephen S. Rich, for the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2011;60(3):1030–1040
https://doi.org/10.2337/db10-1195
Published: 21 February 2011
View article titled, Tests for Genetic Interactions in Type 1 Diabetes: <subtitle>Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs</subtitle>
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Includes: Supplementary data
Journal Articles

Genetics of Type 1 Diabetes: What's Next?

Flemming Pociot, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Concepcion R. Nierras, John A. Todd, Stephen S. Rich, Jørn Nerup
Journal: Diabetes
Diabetes 2010;59(7):1561–1571
https://doi.org/10.2337/db10-0076
Published: 01 July 2010
View article titled, Genetics of Type 1 Diabetes: What's Next?
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Journal Articles

Associations Between Features of Glucose Exposure and A1C: The A1C-Derived Average Glucose (ADAG) Study

Rikke Borg, Judith C. Kuenen, Bendix Carstensen, Hui Zheng, David M. Nathan, Robert J. Heine, Jorn Nerup, Knut Borch-Johnsen, Daniel R. Witte, on behalf of the ADAG Study Group
Journal: Diabetes
Diabetes 2010;59(7):1585–1590
https://doi.org/10.2337/db09-1774
Published: 27 April 2010
View article titled, Associations Between Features of Glucose Exposure and A1C: <subtitle>The A1C-Derived Average Glucose (ADAG) Study</subtitle>
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Includes: Supplementary data
Journal Articles

Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium

Patrick Concannon, Wei-Min Chen, Cécile Julier, Grant Morahan, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Jørn Nerup, Concepcion Nierras, Flemming Pociot, John A. Todd, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2009;58(4):1018–1022
https://doi.org/10.2337/db08-1551
Published: 09 January 2009
View article titled, Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium
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Includes: Supplementary data
Journal Articles

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

Patrick Concannon, Suna Onengut-Gumuscu, John A. Todd, Deborah J. Smyth, Flemming Pociot, Regine Bergholdt, Beena Akolkar, Henry A. Erlich, Joan E. Hilner, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion R. Nierras, Wei-Min Chen, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2008;57(10):2858–2861
https://doi.org/10.2337/db08-0753
Published: 01 October 2008
View article titled, A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
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Journal Articles

Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

Patrick Concannon, Henry A. Erlich, Cecile Julier, Grant Morahan, Jørn Nerup, Flemming Pociot, John A. Todd, Stephen S. Rich, the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2005;54(10):2995–3001
https://doi.org/10.2337/diabetes.54.10.2995
Published: 01 October 2005
View article titled, Type 1 Diabetes: <subtitle>Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families</subtitle>
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Includes: Supplementary data
Journal Articles

Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 With Several Autoimmune Diseases

Tony R. Merriman, Heather J. Cordell, Iain A. Eaves, Patrick A. Danoy, Francesca Coraddu, Rachael Barber, Francesco Cucca, Simon Broadley, Stephen Sawcer, Alastair Compston, Paul Wordsworth, Jane Shatford, Steve Laval, Johan Jirholt, Rikard Holmdahl, Argyrios N. Theofilopoulos, Dwight H. Kono, Jaakko Tuomilehto, Eva Tuomilehto-Wolf, Raffaella Buzzetti, Maria Giovanna Marrosu, Dag E. Undlien, Kjersti S. Rønningen, C. Ionesco-Tirgoviste, Julian P. Shield, Fleming Pociot, Jorn Nerup, Chaim O. Jacob, Constantin Polychronakos, Steve C. Bain, John A. Todd
Journal: Diabetes
Diabetes 2001;50(1):184–194
https://doi.org/10.2337/diabetes.50.1.184
Published: 01 January 2001
View article titled, Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 With Several Autoimmune Diseases
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Journal Articles

Linkage and Association Between a CD4 Gene Polymorphism and IDDM in Danish IDDM Patients

Ole Peter Kristiansen, Mahdi Zamani, Jesper Johannesen, Thomas Mandrup-Poulsen, Jean-Jacques Cassiman, Jørn Nerup, Flemming Pociot, The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood
Journal: Diabetes
Diabetes 1998;47(2):281–283
https://doi.org/10.2337/diab.47.2.281
Published: 01 February 1998
View article titled, Linkage and Association Between a <em>CD4</em> Gene Polymorphism and IDDM in Danish IDDM Patients
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Journal Articles

Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo

Jesper I Reimers, Herik U Anderson, Dídac Mauricio, Flemming Pociot, Allan Karlsen, Jacob S Peterson, Thomas Mandrup-Poulsen, Jørn Nerup
Journal: Diabetes
Diabetes 1996;45(6):771–778
https://doi.org/10.2337/diab.45.6.771
Published: 01 June 1996
View article titled, Strain-Dependent Differences in Sensitivity of Rat β-Cells to Interleukin 1β In Vitro and In Vivo
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Journal Articles

Localization of MODY3 to a 5-cM Region of Human Chromosome 12

Stephan Menzel, Kazuya Yamagata, Jeffrey B Trabb, Jørn Nerup, M Alan Permutt, Stefan S Fajans, Ruth Menzel, Naoko Iwasaki, Yasue Omori, Nancy J Cox, Graeme I Bell
Journal: Diabetes
Diabetes 1995;44(12):1408–1413
https://doi.org/10.2337/diab.44.12.1408
Published: 01 December 1995
View article titled, Localization of <em>MODY3</em> to a 5-cM Region of Human Chromosome 12
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Journal Articles

Cloning and Expression of Cytokine-Inducible Nitric Oxide Synthase cDNA From Rat Islets of Langerhans

Allan E Karlsen, Henrik U Andersen, Henrik Vissing, Peter Mose Larsen, Stephen J Fey, Beatriz Cuartero, Ole D Madsen, Jacob S Petersen, Steen B Mortensen, Thomas Mandrup-Poulsen, Esper Boel, Jørn Nerup
Journal: Diabetes
Diabetes 1995;44(7):753–758
https://doi.org/10.2337/diab.44.7.753
Published: 01 July 1995
View article titled, Cloning and Expression of Cytokine-Inducible Nitric Oxide Synthase cDNA From Rat Islets of Langerhans
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Journal Articles

Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1β-Induced Changes in Protein Expression are Reduced by L-Arginine Depletion and Nicotinamide

Henrik U Andersen, Peter Mose Larsen, Stephen J Fey, Allan E Karlsen, Thomas Mandrup-Poulsen, Jørn Nerup
Journal: Diabetes
Diabetes 1995;44(4):400–407
https://doi.org/10.2337/diab.44.4.400
Published: 01 April 1995
View article titled, Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1β-Induced Changes in Protein Expression are Reduced by <sc>L</sc>-Arginine Depletion and Nicotinamide
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Journal Articles

Glutamic Acid Decarboxylase (GAD65) Autoantibodies in Prediction of β-Cell Function and Remission in Recent-Onset IDDM After Cyclosporin Treatment

Jacob Sten Petersen, Thomas Dyrberg, Allan E Karlsen, Jens Mølvig, Birgitte Michelsen, Jørn Nerup, Thomas Mandrup-Poulsen, Canadian-European Randomized Control Trial Group
Journal: Diabetes
Diabetes 1994;43(11):1291–1296
https://doi.org/10.2337/diab.43.11.1291
Published: 01 November 1994
View article titled, Glutamic Acid Decarboxylase (GAD<sub>65</sub>) Autoantibodies in Prediction of β-Cell Function and Remission in Recent-Onset IDDM After Cyclosporin Treatment
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Journal Articles

Monokine Antagonism Is Reduced in Patients With IDDM

Thomas Mandrup-Poulsen, Flemming Pociot, Jens Mølvig, Leland Shapiro, Povl Nilsson, Torkil Emdal, Michael Røder, Lisa L Kjems, Charles A Dinarello, Jørn Nerup
Journal: Diabetes
Diabetes 1994;43(10):1242–1247
https://doi.org/10.2337/diab.43.10.1242
Published: 01 October 1994
View article titled, Monokine Antagonism Is Reduced in Patients With IDDM
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Journal Articles

Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans

Henrik U Andersen, Klavs H Jørgensen, Jørn Egeberg, Thomas Mandrup-Poulsen, Jørn Nerup
Journal: Diabetes
Diabetes 1994;43(6):770–777
https://doi.org/10.2337/diab.43.6.770
Published: 01 June 1994
View article titled, Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans
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Journal Articles

Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM

Peter M Van Endert, Roland S Liblau, Salil D Patel, Lars Fugger, Theresa Lopez, Flemming Pociot, Jørn Nerup, Hugh O McDevitt
Journal: Diabetes
Diabetes 1994;43(1):110–117
https://doi.org/10.2337/diab.43.1.110
Published: 01 January 1994
View article titled, Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM
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Journal Articles

Linkage Analysis of Maturity-Onset Diabetes of the Young With Microsatellite Polymorphisms: No Linkage to ADA or GLUT2 Genes in Two Families

Pushpa Patel, Y -M Dennis Lo, Andrew Hattersley, Graeme I Bell, Anne Tybjaerg-Hansen, Jorn Nerup, Robert C Turner, James S Wainscoat
Journal: Diabetes
Diabetes 1992;41(8):962–967
https://doi.org/10.2337/diab.41.8.962
Published: 01 August 1992
View article titled, Linkage Analysis of Maturity-Onset Diabetes of the Young With Microsatellite Polymorphisms: No Linkage to ADA or GLUT2 Genes in Two Families
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Journal Articles

Interaction of β-Cell Activity and IL-1 Concentration and Exposure Time in Isolated Rat Islets of Langerhans

Jerry P Palmer, Steffen Helqvist, Giatgen A Spinas, Jens Mølvig, Thomas Mandrup-Poulsen, Henrik U Andersen, Jørn Nerup
Journal: Diabetes
Diabetes 1989;38(10):1211–1216
https://doi.org/10.2337/diab.38.10.1211
Published: 01 October 1989
View article titled, Interaction of β-Cell Activity and IL-1 Concentration and Exposure Time in Isolated Rat Islets of Langerhans
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Journal Articles

Islet Cytotoxicity of Interleukin 1: Influence of Culture Conditions and Islet Donor Characteristics

Thomas Mandrup-Poulsen, Giatgen A Spinas, Stephen J Prowse, Birgit S Hansen, Dorte W Jørgensen, Klaus Bendtzen, Jens Høiriis Nielsen, Jørn Nerup
Journal: Diabetes
Diabetes 1987;36(5):641–647
https://doi.org/10.2337/diab.36.5.641
Published: 01 May 1987
View article titled, Islet Cytotoxicity of Interleukin 1: Influence of Culture Conditions and Islet Donor Characteristics
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