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Meeting Abstracts

1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population

JUDY Z. LOUIE, DOV SHIFFMAN, JAMES B. MEIGS, MICHAEL J. MCPHAUL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1286-P
https://doi.org/10.2337/db23-1286-P
Published: 20 June 2023
View article titled, 1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population
Meeting Abstracts

1469-P: Gene-Level Gene–Mediterranean Diet Interaction Detection Influencing Inflammatory and Glycemic Biomarkers in 137,000 UK Biobank Participants

KENNETH E. WESTERMAN, JAMES B. MEIGS, ALISA MANNING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1469-P
https://doi.org/10.2337/db23-1469-P
Published: 20 June 2023
View article titled, 1469-P: Gene-Level Gene–Mediterranean Diet Interaction Detection Influencing Inflammatory and Glycemic Biomarkers in 137,000 UK Biobank Participants
Meeting Abstracts

188-OR: Circulating Metabolites and Type 2 Diabetes (T2D) Risk—An Integrated Metabolomics and Genetics Study of ~23,000 Adults

JUN LI, JIE HU, LIMING LIANG, MARTA GUASCH, JORDI MERINO, MIGUEL RUIZ-CANELA, KAI LUO, CASEY REBHOLZ, BIANCA PORNEALA, JOSEE DUPUIS, ELIZABETH SELVIN, SHILPA BHUPATHIRAJU, JENNIFER A. BRODY, YONGMEI LIU, A. HEATHER ELIASSEN, JOANN E. MANSON, CLARY B. CLISH, ROZENN N. LEMAITRE, KATHERINE L. TUCKER, JEROME I. ROTTER, MIGUEL A. MARTINEZ-GONZALEZ, KATHRYN M. REXRODE, JAMES B. MEIGS, ERIC BOERWINKLE, ROBERT KAPLAN, FRANK HU, BING YU, QIBIN QI, THE NHLBI TOPMED METABOLOMICS AND PROTEOMICS WORKING GROUP
Journal: Diabetes
Diabetes 2023;72(Supplement_1):188-OR
https://doi.org/10.2337/db23-188-OR
Published: 20 June 2023
View article titled, 188-OR: Circulating Metabolites and Type 2 Diabetes (T2D) Risk—An Integrated Metabolomics and Genetics Study of ~23,000 Adults
Meeting Abstracts

70-OR: Identification of 489 Type 2 Diabetes Shared and Tissue-Specific Effector Genes by Integrating eQTL Data with a Multiancestry GWAS of 2.5 Million Individuals

RAVI MANDLA, KIMBERLY LORENZ, XIANYONG YIN, LORRAINE SOUTHAM, KEN SUZUKI, KONSTANTINOS HATZIKOTOULAS, HENRY J. TAYLOR, ALICIA HUERTA, NIGEL W. RAYNER, DIAMANTE CONSORTIUM, VA MILLION VETERAN PROGRAM, JAMES B. MEIGS, MARK I. MCCARTHY, ANUBHA MAHAJAN, CASSANDRA SPRACKLEN, MICHAEL BOEHNKE, MARIJANA VUJKOVIC, JEROME I. ROTTER, BENJAMIN F. VOIGHT, ELEFTHERIA ZEGGINI, ANDREW MORRIS, JOSEP M. MERCADER, TYPE 2 DIABETES GLOBAL GENOMICS INITIATIVE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):70-OR
https://doi.org/10.2337/db23-70-OR
Published: 20 June 2023
View article titled, 70-OR: Identification of 489 Type 2 Diabetes Shared and Tissue-Specific Effector Genes by Integrating eQTL Data with a Multiancestry GWAS of 2.5 Million Individuals
Meeting Abstracts

69-OR: Multiancestry Genome-Wide Association Study Reveals Distinct Biological Pathways and Cell Types Driving Type 2 Diabetes Risk with Heterogeneous Effects across Diverse Populations

KEN SUZUKI, KONSTANTINOS HATZIKOTOULAS, LORRAINE SOUTHAM, XIANYONG YIN, KIMBERLY LORENZ, RAVI MANDLA, HENRY J. TAYLOR, ALICIA HUERTA, NIGEL W. RAYNER, DIAMANTE CONSORTIUM, VA MILLION VETERAN PROGRAM, JAMES B. MEIGS, MARK I. MCCARTHY, ANUBHA MAHAJAN, JOSEP M. MERCADER, CASSANDRA SPRACKLEN, MICHAEL BOEHNKE, MARIJANA VUJKOVIC, JEROME I. ROTTER, BENJAMIN F. VOIGHT, ELEFTHERIA ZEGGINI, ANDREW MORRIS, TYPE 2 DIABETES GLOBAL GENOMICS INITIATIVE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):69-OR
https://doi.org/10.2337/db23-69-OR
Published: 20 June 2023
View article titled, 69-OR: Multiancestry Genome-Wide Association Study Reveals Distinct Biological Pathways and Cell Types Driving Type 2 Diabetes Risk with Heterogeneous Effects across Diverse Populations
Journal Articles

Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits

Kenneth E. Westerman, Maura E. Walker, Sheila M. Gaynor, Jennifer Wessel, Daniel DiCorpo, Jiantao Ma, Alvaro Alonso, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Mary L. Biggs, Jennifer A. Brody, Yii-Der Ida Chen, Joseé Dupuis, Mark O. Goodarzi, Xiuqing Guo, Natalie R. Hasbani, Adam Heath, Bertha Hidalgo, Marguerite R. Irvin, W. Craig Johnson, Rita R. Kalyani, Leslie Lange, Rozenn N. Lemaitre, Ching-Ti Liu, Simin Liu, Jee-Young Moon, Rami Nassir, James S. Pankow, Mary Pettinger, Laura M. Raffield, Laura J. Rasmussen-Torvik, Elizabeth Selvin, Mackenzie K. Senn, Aladdin H. Shadyab, Albert V. Smith, Nicholas L. Smith, Lyn Steffen, Sameera Talegakwar, Kent D. Taylor, Paul S. de Vries, James G. Wilson, Alexis C. Wood, Lisa R. Yanek, Jie Yao, Yinan Zheng, Eric Boerwinkle, Alanna C. Morrison, Miriam Fornage, Tracy P. Russell, Bruce M. Psaty, Daniel Levy, Nancy L. Heard-Costa, Vasan S. Ramachandran, Rasika A. Mathias, Donna K. Arnett, Robert Kaplan, Kari E. North, Adolfo Correa, April Carson, Jerome I. Rotter, Stephen S. Rich, JoAnn E. Manson, Alexander P. Reiner, Charles Kooperberg, Jose C. Florez, James B. Meigs, Jordi Merino, Deirdre K. Tobias, Han Chen, Alisa K. Manning
Journal: Diabetes
Diabetes 2023;72(5):653–665
https://doi.org/10.2337/db22-0851
Published: 15 February 2023
View article titled, Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits
Open the PDF for Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits in another window
Journal Articles

Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans

Zsu-Zsu Chen, Julian Avila Pacheco, Yan Gao, Shuliang Deng, Bennet Peterson, Xu Shi, Shuning Zheng, Usman A. Tahir, Daniel H. Katz, Daniel E. Cruz, Debby Ngo, Mark D. Benson, Jeremy M. Robbins, Xiuqing Guo, Magdalena del Rocio Sevilla Gonzalez, Alisa Manning, Adolfo Correa, James B. Meigs, Kent D. Taylor, Stephen S. Rich, Mark O. Goodarzi, Jerome I. Rotter, James G. Wilson, Clary B. Clish, Robert E. Gerszten
Journal: Diabetes
Diabetes 2022;71(11):2426–2437
https://doi.org/10.2337/db22-0033
Published: 23 August 2022
View article titled, Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
Open the PDF for Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans in another window
Meeting Abstracts

1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes

YALING TANG, MARIE PIGEYRE, XIUQIN SUN, MARIO LUCA MORIERI, HETAL SHAH, GUILLAUME PARE, HERTZEL C. GERSTEIN, KENT TAYLOR, VASAN S. RAMACHANDRAN, JEROME I. ROTTER, STEPHEN S. RICH, JAMES B. MEIGS, ALISA MANNING, JOSYF MYCHALECKYJ, ALESSANDRO DORIA, CONSORTIUM NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED)
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1276-P
https://doi.org/10.2337/db22-1276-P
Published: 01 June 2022
View article titled, 1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes
Meeting Abstracts

1199-P: Racial/Ethnic and Socioeconomic Disparities in the Look AHEAD Trial

SARA JANE CROMER, JAMES B. MEIGS, DEBORAH J. WEXLER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1199-P
https://doi.org/10.2337/db22-1199-P
Published: 01 June 2022
View article titled, 1199-P: Racial/Ethnic and Socioeconomic Disparities in the Look AHEAD Trial
Meeting Abstracts

109-OR: Physiologic Subtypes of Gestational Glucose Intolerance and Risk of Future Prediabetes

DARYL J. SELEN, TANAYOTT THAWEETHAI, CHU YU, SARAH HSU, KAITLYN JAMES, JEFFREY L. ECKER, JAMES B. MEIGS, CAMILLE E. POWE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):109-OR
https://doi.org/10.2337/db22-109-OR
Published: 01 June 2022
View article titled, 109-OR: Physiologic Subtypes of Gestational Glucose Intolerance and Risk of Future Prediabetes
Meeting Abstracts

137-OR: A Genetic Approach to Detangling the Heterogeneity of Fasting Insulin Levels

MAGDALENA SEVILLA, MARK O. GOODARZI, DANIEL A. DICORPO, JEROME I. ROTTER, JAMES B. MEIGS, MIRIAM UDLER, ALISA MANNING
Journal: Diabetes
Diabetes 2022;71(Supplement_1):137-OR
https://doi.org/10.2337/db22-137-OR
Published: 01 June 2022
View article titled, 137-OR: A Genetic Approach to Detangling the Heterogeneity of Fasting Insulin Levels
Meeting Abstracts

24-OR: Time-to-Event GWAS for Incident Cardiovascular Disease in Type 2 Diabetes Patients

SOO HEON KWAK, PEITAO WU, JAMES B. MEIGS, ON BEHALF OF THE CHARGE DIABETES WORKING GROUP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):24-OR
https://doi.org/10.2337/db21-24-OR
Published: 01 June 2021
View article titled, 24-OR: Time-to-Event GWAS for Incident Cardiovascular Disease in Type 2 Diabetes Patients
Meeting Abstracts

1100-P: A Four-Humanitarian Agency Survey of Diabetes Care in 83 Humanitarian Settings

SYLVIA KEHLENBRINK, OMAR MAHBOOB, SARA A. AL-ZUBI, PHILIPPA BOULLE, SIGIRIYA AEBISCHER PERONE, LILIAN KIAPI, AHMAD H. ALANI, HEIKO HERING, MICHAEL WOODMAN, STEPHANIE KAYDEN, KAREN DONELAN, BIANCA PORNEALA, JAMES B. MEIGS
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1100-P
https://doi.org/10.2337/db21-1100-P
Published: 01 June 2021
View article titled, 1100-P: A Four-Humanitarian Agency Survey of Diabetes Care in 83 Humanitarian Settings
Meeting Abstracts

98-OR: Gestational Glucose Intolerance without Gestational Diabetes Is a Risk Factor for Type 2 Diabetes

DARYL J. SELEN, TANAYOTT THAWEETHAI, SARAH HSU, KAITLYN JAMES, ANJALI KAIMAL, JAMES B. MEIGS, CAMILLE E. POWE
Journal: Diabetes
Diabetes 2021;70(Supplement_1):98-OR
https://doi.org/10.2337/db21-98-OR
Published: 01 June 2021
View article titled, 98-OR: Gestational Glucose Intolerance without Gestational Diabetes Is a Risk Factor for Type 2 Diabetes
Meeting Abstracts

73-OR: Clonal Hematopoiesis of Indeterminate Potential (CHIP), Glycemic Traits, and Type 2 Diabetes (T2D) Risk

DEIRDRE K. TOBIAS, ALISA MANNING, JENNIFER WESSEL, KENNETH E. WESTERMAN, SRIDHARAN RAGHAVAN, LAURA RAFFIELD, JOSEE DUPUIS, ALEXANDER BICK, PEITAO WU, DANIEL A. DICORPO, BRUCE M. PSATY, ALANNA C. MORRISON, VASAN S. RAMACHANDRAN, L. ADRIENNE CUPPLES, LESLIE LANGE, ADOLFO CORREA, CHARLES L. KOOPERBERG, LESLEY F. TINKER, BARBARA V. HOWARD, ALEX REINER, JEROME I. ROTTER, JASON M. COLLINS, JAMES B. MEIGS, JOANN E. MANSON
Journal: Diabetes
Diabetes 2021;70(Supplement_1):73-OR
https://doi.org/10.2337/db21-73-OR
Published: 01 June 2021
View article titled, 73-OR: Clonal Hematopoiesis of Indeterminate Potential (CHIP), Glycemic Traits, and Type 2 Diabetes (T2D) Risk
Journal Articles

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen
Journal: Diabetes
Diabetes 2020;69(12):2806–2818
https://doi.org/10.2337/db20-0070
Published: 11 September 2020
View article titled, Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
Open the PDF for Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity in another window
Meeting Abstracts

1649-P: Effect of Fasting Insulin-Derived Gene Variant Clusters on Cardiometabolic Traits

MAGDALENA SEVILLA, MIRIAM UDLER, HYUNKYUNG KIM, SARAH HSU, JAMES B. MEIGS, ALISA MANNING
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1649-P
https://doi.org/10.2337/db20-1649-P
Published: 01 June 2020
View article titled, 1649-P: Effect of Fasting Insulin-Derived Gene Variant Clusters on Cardiometabolic Traits
Meeting Abstracts

1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients

SOO HEON KWAK, JOSEP M. MERCADER, AARON LEONG, BIANCA PORNEALA, PEITAO WU, JOANNE B. COLE, JORDI MERINO, KYONG SOO PARK, NAM H. CHO, JOSEE DUPUIS, JOSE C. FLOREZ, JAMES B. MEIGS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1655-P
https://doi.org/10.2337/db20-1655-P
Published: 01 June 2020
View article titled, 1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients
Meeting Abstracts

240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank

JOSEP M. MERCADER, JOSE C. FLOREZ, AARON LEONG, VARINDERPAL KAUR, MIRIAM UDLER, JAMES B. MEIGS, BIANCA PORNEALA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):240-OR
https://doi.org/10.2337/db20-240-OR
Published: 01 June 2020
View article titled, 240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank
Meeting Abstracts

239-OR: Genome-Wide Association Study (GWAS) of Hypoglycemia in the Million Veteran Program (MVP)

SRIDHARAN RAGHAVAN, ZEYUAN WANG, ADRIANA M. HUNG, BRIAN R. CHAREST, LAUREN COSTA, ELIZABETH M. LITKOWSKI, AARON LEONG, JAMES B. MEIGS, PETER W. WILSON, PETER REAVEN, MARY K. RHEE, YAN V. SUN, LAWRENCE S. PHILLIPS, MILLION VETERAN PROGRAM
Journal: Diabetes
Diabetes 2020;69(Supplement_1):239-OR
https://doi.org/10.2337/db20-239-OR
Published: 01 June 2020
View article titled, 239-OR: Genome-Wide Association Study (GWAS) of Hypoglycemia in the Million Veteran Program (MVP)