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James D. Johnson
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Journal Articles

Response to Comment on Mittendorfer et al. Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia. Diabetes 2024;73:837–843

Bettina Mittendorfer, James D. Johnson, Giovanni Solinas, Per-Anders Jansson
Journal: Diabetes
Diabetes 2024;73(11):e12
https://doi.org/10.2337/dbi24-0039
Published: 21 October 2024
View article titled, Response to Comment on Mittendorfer et al. Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia. Diabetes 2024;73:837–843
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Meeting Abstracts

1483-P: Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning

CHRISTOPHER EMFINGER, ELYSE FREIBERGER, MARY RABAGLIA, JELENA KOLIC, SHANE SIMONETT, MICHAEL SHORTREED, LAUREN CLARK, DONNIE STAPLETON, KATHRYN SCHUELER, KELLY MITOK, TARA R. PRICE, JOSHUA J. COON, LLOYD SMITH, MATTHEW J. MERRINS, JAMES D. JOHNSON, MARK KELLER, ALAN D. ATTIE
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1483-P
https://doi.org/10.2337/db24-1483-P
Published: 14 June 2024
View article titled, 1483-P: Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning
Journal Articles

Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia

Bettina Mittendorfer, James D. Johnson, Giovanni Solinas, Per-Anders Jansson
Journal: Diabetes
Diabetes 2024;73(6):837–843
https://doi.org/10.2337/dbi23-0035
Published: 20 May 2024
View article titled, Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia
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Journal Articles

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A.J. Krentz, Søs Skovsø, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson
Journal: Diabetes
Diabetes 2022;71(12):2612–2631
https://doi.org/10.2337/db21-1065
Published: 28 September 2022
View article titled, Dynamic <em>Ins2</em> Gene Activity Defines β-Cell Maturity States
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Journal Articles

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D. Johnson, Timothy J. Kieffer, Bahira Hussein, Brian Rodrigues
Journal: Diabetes
Diabetes 2017;66(1):45–57
https://doi.org/10.2337/db16-0761
Published: 07 October 2016
View article titled, Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes
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Includes: Supplementary data
Journal Articles

Bcl-2 and Bcl-xL Suppress Glucose Signaling in Pancreatic β-Cells

Dan S. Luciani, Sarah A. White, Scott B. Widenmaier, Varun V. Saran, Farnaz Taghizadeh, Xiaoke Hu, Michael F. Allard, James D. Johnson
Journal: Diabetes
Diabetes 2013;62(1):170–182
https://doi.org/10.2337/db11-1464
Published: 13 December 2012
View article titled, Bcl-2 and Bcl-x<sub>L</sub> Suppress Glucose Signaling in Pancreatic β-Cells
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Journal Articles

Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

Marta Szabat, Francis C. Lynn, Brad G. Hoffman, Timothy J. Kieffer, Douglas W. Allan, James D. Johnson
Journal: Diabetes
Diabetes 2012;61(6):1365–1371
https://doi.org/10.2337/db11-1361
Published: 14 May 2012
View article titled, Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas: <subtitle>Developmental Biology Concepts in Adult Physiology</subtitle>
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Journal Articles

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function

Janine K. Kruit, Nadeeja Wijesekara, Clara Westwell-Roper, Tim Vanmierlo, Willeke de Haan, Alpana Bhattacharjee, Renmei Tang, Cheryl L. Wellington, Dieter LütJohann, James D. Johnson, Liam R. Brunham, C. Bruce Verchere, Michael R. Hayden
Journal: Diabetes
Diabetes 2012;61(3):659–664
https://doi.org/10.2337/db11-1341
Published: 13 February 2012
View article titled, Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function
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Journal Articles

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Janine K. Kruit, Nadeeja Wijesekara, Jocelyn E. Manning Fox, Xiao-Qing Dai, Liam R. Brunham, Gavin J. Searle, Garry P. Morgan, Adam J. Costin, Renmei Tang, Alpana Bhattacharjee, James D. Johnson, Peter E. Light, Brad J. Marsh, Patrick E. MacDonald, C. Bruce Verchere, Michael R. Hayden
Journal: Diabetes
Diabetes 2011;60(12):3186–3196
https://doi.org/10.2337/db11-0081
Published: 13 November 2011
View article titled, Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
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Includes: Supplementary data
Journal Articles

Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death

Dan S. Luciani, Kamila S. Gwiazda, Ting-Lin B. Yang, Tatyana B. Kalynyak, Yaryna Bychkivska, Matthew H.Z. Frey, Kristin D. Jeffrey, Arthur V. Sampaio, T. Michael Underhill, James D. Johnson
Journal: Diabetes
Diabetes 2009;58(2):422–432
https://doi.org/10.2337/db07-1762
Published: 01 February 2009
View article titled, Roles of IP<sub>3</sub>R and RyR Ca<sup>2+</sup> Channels in Endoplasmic Reticulum Stress and β-Cell Death
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Journal Articles

Suppressed Insulin Signaling and Increased Apoptosis in Cd38-Null Islets

James D. Johnson, Eric L. Ford, Ernesto Bernal-Mizrachi, Kim L. Kusser, Dan S. Luciani, Zhiqiang Han, Hung Tran, Troy D. Randall, Frances E. Lund, Kenneth S. Polonsky
Journal: Diabetes
Diabetes 2006;55(10):2737–2746
https://doi.org/10.2337/db05-1455
Published: 01 October 2006
View article titled, Suppressed Insulin Signaling and Increased Apoptosis in <em>Cd38</em>-Null Islets
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