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James L. Kirkland
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Journal Articles

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Free
Abraham S. Meijnikman, Casper C. van Olden, Ömrüm Aydin, Hilde Herrema, Dorota Kaminska, Dimitra Lappa, Ville Männistö, Valentina Tremaroli, Louise E. Olofsson, Maurits de Brauw, Arnold van de Laar, Joanne Verheij, Victor E.A. Gerdes, Thue W. Schwartz, Jens Nielsen, Fredrik Bäckhed, Päivi Pajukanta, Jussi Pihlajamäki, Tamar Tchkonia, James L. Kirkland, Folkert Kuipers, Max Nieuwdorp, Albert K. Groen
Journal: Diabetes
Diabetes 2022;71(9):1929–1936
https://doi.org/10.2337/db21-1076
Published: 17 June 2022
View articletitled, Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
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Journal Articles

Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair

Free
LaTonya J. Hickson, Alfonso Eirin, Sabena M. Conley, Timucin Taner, Xiaohui Bian, Ahmed Saad, Sandra M. Herrmann, Ramila A. Mehta, Travis J. McKenzie, Todd A. Kellogg, James L. Kirkland, Tamar Tchkonia, Ishran M. Saadiq, Hui Tang, Kyra L. Jordan, Xiangyang Zhu, Mathew D. Griffin, Andrew D. Rule, Andre J. van Wijnen, Stephen C. Textor, Lilach O. Lerman
Journal: Diabetes
Diabetes 2021;70(7):1561–1574
https://doi.org/10.2337/db19-1268
Published: 15 April 2021
View articletitled, Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair
Open the PDF for Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair in another window
Journal Articles

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Open Access
Marissa J. Schafer, Thomas A. White, Glenda Evans, Jason M. Tonne, Grace C. Verzosa, Michael B. Stout, Daniel L. Mazula, Allyson K. Palmer, Darren J. Baker, Michael D. Jensen, Michael S. Torbenson, Jordan D. Miller, Yasuhiro Ikeda, Tamara Tchkonia, Jan M. van Deursen, James L. Kirkland, Nathan K. LeBrasseur
Journal: Diabetes
Diabetes 2016;65(6):1606–1615
https://doi.org/10.2337/db15-0291
Published: 16 March 2016
View articletitled, Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
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Includes: Supplementary data
Journal Articles

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Free
Allyson K. Palmer, Tamara Tchkonia, Nathan K. LeBrasseur, Eduardo N. Chini, Ming Xu, James L. Kirkland
Journal: Diabetes
Diabetes 2015;64(7):2289–2298
https://doi.org/10.2337/db14-1820
Published: 17 June 2015
View articletitled, Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
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Journal Articles

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

Free
Carlos Escande, Veronica Nin, Tamar Pirtskhalava, Claudia C.S. Chini, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini
Journal: Diabetes
Diabetes 2015;64(1):12–22
https://doi.org/10.2337/db14-0192
Published: 22 July 2014
View articletitled, Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
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Includes: Supplementary data
Journal Articles

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

Open Access
Aurélie Villaret, Jean Galitzky, Pauline Decaunes, David Estève, Marie-Adeline Marques, Coralie Sengenès, Patrick Chiotasso, Tamara Tchkonia, Max Lafontan, James L. Kirkland, Anne Bouloumié
Journal: Diabetes
Diabetes 2010;59(11):2755–2763
https://doi.org/10.2337/db10-0398
Published: 16 August 2010
View articletitled, Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence
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Includes: Supplementary data
Journal Articles

Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors

Open Access
Laure-Emmanuelle Zaragosi, Brigitte Wdziekonski, Phi Villageois, Mayoura Keophiphath, Marie Maumus, Tamara Tchkonia, Virginie Bourlier, Tala Mohsen-Kanson, Annie Ladoux, Christian Elabd, Marcel Scheideler, Zlatko Trajanoski, Yasuhiro Takashima, Ez-Zoubir Amri, Daniele Lacasa, Coralie Sengenes, Gérard Ailhaud, Karine Clément, Anne Bouloumie, James L. Kirkland, Christian Dani
Journal: Diabetes
Diabetes 2010;59(10):2513–2521
https://doi.org/10.2337/db10-0013
Published: 08 June 2010
View articletitled, Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
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Includes: Supplementary data
Journal Articles

Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes

Free
Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Thomas Thomou, Matthew DePonte, Ada Koo, R. Armour Forse, Dharmaraj Chinnappan, Carmen Martin-Ruiz, Thomas von Zglinicki, James L. Kirkland
Journal: Diabetes
Diabetes 2006;55(9):2571–2578
https://doi.org/10.2337/db06-0540
Published: 01 September 2006
View articletitled, Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
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Includes: Supplementary data