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Meeting Abstracts

1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing

VICTOR G. HOWARD, CHRISTOPHER D. CHURCH, STEPHANIE OLDHAM, DAVID C. HORNIGOLD, JAMES TREVASKIS, DAVID BAKER, CHRISTOPHER J. RHODES, ALESSANDRA ROSSI, JACQUELINE NAYLOR, JATINDER DHILLON, ANDREW BUCHANAN, LIHUAN LIANG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1086-P
https://doi.org/10.2337/db19-1086-P
Published: 01 June 2019
View article titled, 1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing
Meeting Abstracts

1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis

RHIANNA C. LAKER, MICHELLE BOLAND, ARKADIUSZ NAWROCKI, KARLY M. MATHER, LUTZ JERMUTUS, MARTIN R. LARSEN, JAMES TREVASKIS, CHRISTOPHER J. RHODES
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1883-P
https://doi.org/10.2337/db19-1883-P
Published: 01 June 2019
View article titled, 1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis
Meeting Abstracts

2020-P: Comparable Disease Progression in GAN and AMLN Diet-Induced Obese Mouse Models of Biopsy-Confirmed Nonalcoholic Steatohepatitis

BRANDON B. BOLAND, HENRIK H. HANSEN, MICHELLE BOLAND, DENISE ORÓ, KIRSTINE SLOTH TØLBØL, SANNE VEIDAL, MICHAEL FEIGH, JACOB JELSING, NIELS VRANG, JAMES TREVASKIS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2020-P
https://doi.org/10.2337/db19-2020-P
Published: 01 June 2019
View article titled, 2020-P: Comparable Disease Progression in GAN and AMLN Diet-Induced Obese Mouse Models of Biopsy-Confirmed Nonalcoholic Steatohepatitis
Journal Articles

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Brandon B. Boland, Charles Brown, Jr., Michelle L. Boland, Jennifer Cann, Michal Sulikowski, Gitte Hansen, Rikke V. Grønlund, Wanda King, Cristina Rondinone, James Trevaskis, Christopher J. Rhodes, Joseph S. Grimsby
Journal: Diabetes
Diabetes 2019;68(1):131–140
https://doi.org/10.2337/db18-0304
Published: 10 October 2018
View article titled, Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
Open the PDF for Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes in another window
Includes: Supplementary data
Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Enhances Leptin-Mediated pSTAT3 Induction in Key Neuronal Regions That Regulate Metabolism

HANI JOUIHAN, PERNILLE BARKHOLT, RIKKE GRÔNLUND, JAMES TREVASKIS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1788-P
https://doi.org/10.2337/db18-1788-P
Published: 01 July 2018
View article titled, MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Enhances Leptin-Mediated pSTAT3 Induction in Key Neuronal Regions That Regulate Metabolism
Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Acutely Inhibits Food Intake in Leptin-Deficient ob/ob Mice and Leptin Receptor–Deficient fa/fa Rats

VICTOR G. HOWARD, STEPHANIE OLDHAM, ANISH KONKAR, JAMES TREVASKIS, SARAH WILL
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1891-P
https://doi.org/10.2337/db18-1891-P
Published: 01 July 2018
View article titled, MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Acutely Inhibits Food Intake in Leptin-Deficient ob/ob Mice and Leptin Receptor–Deficient fa/fa Rats
Meeting Abstracts

Evaluating the Sub-chronic Effects of MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, on Weight Loss in Male ob/ob Mice

STEPHANIE OLDHAM, CHRISTOPHER D. CHURCH, SARAH WILL, ANISH KONKAR, JAMES TREVASKIS, GRAEME R. DAVIES
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1890-P
https://doi.org/10.2337/db18-1890-P
Published: 01 July 2018
View article titled, Evaluating the Sub-chronic Effects of MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, on Weight Loss in Male ob/ob Mice
Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Shows Differential Brain Activation vs. Liraglutide in Mice

LUKE K. BURKE, LEE BROWN, JEAN-MARTIN LAPOINTE, MICHAL GRZEGORZ SULIKOWSKI, ARTHUR R. LEWIS, JAMES TREVASKIS, DAVID BAKER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1789-P
https://doi.org/10.2337/db18-1789-P
Published: 01 July 2018
View article titled, MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Shows Differential Brain Activation vs. Liraglutide in Mice
Meeting Abstracts

Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission

BRANDON BOLAND, VICTOR G. HOWARD, MICHELLE BEATON, SARAH WILL, STEPHANIE OLDHAM, JAMES TREVASKIS, CHRISTOPHER J. RHODES, JOE GRIMSBY
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1909-P
https://doi.org/10.2337/db18-1909-P
Published: 01 July 2018
View article titled, Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission
Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH

MICHELLE BEATON, SILVIA GUIONAUD, JAMES P. CONWAY, JOE GRIMSBY, CHRISTOPHER J. RHODES, LUTZ JERMUTUS, JAMES TREVASKIS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1841-P
https://doi.org/10.2337/db18-1841-P
Published: 01 July 2018
View article titled, MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH
Journal Articles

Tanis: A Link Between Type 2 Diabetes and Inflammation?

Ken Walder, Lakshmi Kantham, Janine S. McMillan, James Trevaskis, Lyndal Kerr, Andrea de Silva, Terry Sunderland, Nathan Godde, Yuan Gao, Natalie Bishara, Kelly Windmill, Janette Tenne-Brown, Guy Augert, Paul Z. Zimmet, Greg R. Collier
Journal: Diabetes
Diabetes 2002;51(6):1859–1866
https://doi.org/10.2337/diabetes.51.6.1859
Published: 01 June 2002
View article titled, Tanis: A Link Between Type 2 Diabetes and Inflammation?
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