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Meeting Abstracts

293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver

RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, ALLISON M. KIM, LAUREN H. KIM, NATALIE M. BAEZ TORRES, LAUREN A. TAUER, XIAODI HU, JASON K. KIM

Diabetes 2023;72(Supplement_1):293-OR

https://doi.org/10.2337/db23-293-OR

Published: 20 June 2023

View article titled, 293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver

Meeting Abstracts

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

BUKYUNG KIM, LAUREN A. TAUER, XIAODI HU, JASON K. KIM

Diabetes 2023;72(Supplement_1):130-OR

https://doi.org/10.2337/db23-130-OR

Published: 20 June 2023

View article titled, 130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

Meeting Abstracts

270-OR: Loss of Myeloid IFNgamma Signaling Prevents Hepatic Inflammation and NASH in Obesity

RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, HYE LIM NOH, ALLISON M. KIM, LAUREN H. KIM, DORIS X.T. ZHENG, GLENNA SWINAND, ANNIKA BEAVERSON, XIAODI HU, LAUREN A. TAUER, WERNER MULLER, JASON K. KIM

Diabetes 2022;71(Supplement_1):270-OR

https://doi.org/10.2337/db22-270-OR

Published: 01 June 2022

View article titled, 270-OR: Loss of Myeloid IFNgamma Signaling Prevents Hepatic Inflammation and NASH in Obesity

Journal Articles

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Weikang Cai, Xuemei Zhang, Thiago M. Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K. Ramirez, Masahiro Konishi, Brian T. O’Neill, Jong Hun Kim, Jason K. Kim, C. Ronald Kahn

Diabetes 2021;70(8):1857–1873

https://doi.org/10.2337/db20-1119

Published: 24 May 2021

View article titled, Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Journal Articles

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Guoxiao Wang, Yingying Yu, Weikang Cai, Thiago M. Batista, Sujin Suk, Hye Lim Noh, Michael Hirshman, Pasquale Nigro, Mengyao Ella Li, Samir Softic, Laurie Goodyear, Jason K. Kim, C. Ronald Kahn

Diabetes 2020;69(11):2294–2309

https://doi.org/10.2337/db20-0439

Published: 31 August 2020

View article titled, Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Meeting Abstracts

1727-P: Mice Deficient in Myeloid Cell-Derived Interleukin-1a Are Protected from Diet-Induced Obesity and Insulin Resistance

SUJIN SUK, RANDALL H. FRIEDLINE, HYE LIM NOH, XIAODI HU, DUY A. TRAN, LAUREN A. TAUER, ALLISON M. KIM, LAUREN H. KIM, JASON K. KIM

Diabetes 2020;69(Supplement_1):1727-P

https://doi.org/10.2337/db20-1727-P

Published: 01 June 2020

View article titled, 1727-P: Mice Deficient in Myeloid Cell-Derived Interleukin-1a Are Protected from Diet-Induced Obesity and Insulin Resistance

Meeting Abstracts

1726-P: Male Mice Lacking Estrogen Receptor Beta Develop Obesity but Are Protected from Diet-Induced Insulin Resistance in Skeletal Muscle

RANDALL H. FRIEDLINE, HYE LIM NOH, SUJIN SUK, CEREN GORAL, KAREN A. DUNPHY, AMY L. ROBERTS, DUY A. TRAN, LAUREN A. TAUER, XIAODI HU, LAUREN H. KIM, ALLISON M. KIM, D. JOSEPH JERRY, JASON K. KIM

Diabetes 2020;69(Supplement_1):1726-P

https://doi.org/10.2337/db20-1726-P

Published: 01 June 2020

View article titled, 1726-P: Male Mice Lacking Estrogen Receptor Beta Develop Obesity but Are Protected from Diet-Induced Insulin Resistance in Skeletal Muscle

Meeting Abstracts

1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission

WEIKANG CAI, THIAGO M. BATISTA, RUBEN GARCIA MARTIN, ALFRED RAMIREZ, MASAHIRO KONISHI, O'NEILL BRIAN T., JASON K. KIM, C. RONALD KAHN

Diabetes 2019;68(Supplement_1):1805-P

https://doi.org/10.2337/db19-1805-P

Published: 01 June 2019

View article titled, 1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission

Meeting Abstracts

1991-P: Mammary Tumors Increase Diet-Induced Obesity and Insulin Resistance in Female MMTV-PyMT Mice

HYE LIM NOH, HEE JOON KANG, JOSE MERCADO-MATOS, RANDALL H. FRIEDLINE, SUJIN SUK, XIAODI HU, DUY A. TRAN, LAUREN A. TAUER, MIN-JI KO, JUNGEUN CHOI, THAVANVOTEY LUONG, YURAN TSUCHIDA, LESLIE M. SHAW, JASON K. KIM

Diabetes 2019;68(Supplement_1):1991-P

https://doi.org/10.2337/db19-1991-P

Published: 01 June 2019

View article titled, 1991-P: Mammary Tumors Increase Diet-Induced Obesity and Insulin Resistance in Female MMTV-PyMT Mice

Meeting Abstracts

1992-P: Early and Chronic Exposure to Penicillin Increases Obesity and Insulin Resistance in High-Fat Diet-Fed Mice

HYE LIM NOH, SUJIN SUK, RANDALL H. FRIEDLINE, XIAODI HU, DUY A. TRAN, LAUREN A. TAUER, JUNGEUN CHOI, MIN-JI KO, BRANDON KIM, TANUJ SURAPANENI, MARTIN J. BLASER, JASON K. KIM

Diabetes 2019;68(Supplement_1):1992-P

https://doi.org/10.2337/db19-1992-P

Published: 01 June 2019

View article titled, 1992-P: Early and Chronic Exposure to Penicillin Increases Obesity and Insulin Resistance in High-Fat Diet-Fed Mice

Journal Articles

Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

Camille Allard, Jamie J. Morford, Beibei Xu, Benjamin Salwen, Weiwei Xu, Lucie Desmoulins, Andrea Zsombok, Jason K. Kim, Ellis R. Levin, Franck Mauvais-Jarvis

Diabetes 2019;68(3):490–501

https://doi.org/10.2337/db18-0293

Published: 10 October 2018

View article titled, Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

Includes: Supplementary data

Meeting Abstracts

Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission

WEIKANG CAI, ALFRED RAMIREZ, JONATHAN DREYFUSS, THIAGO M. BATISTA, RUBEN GARCIA MARTIN, HUI PAN, MENGYAO E. LI, BRIAN T. O'NEILL, JASON K. KIM, C. RONALD KAHN

Diabetes 2018;67(Supplement_1):1792-P

https://doi.org/10.2337/db18-1792-P

Published: 01 July 2018

View article titled, Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission

Meeting Abstracts

Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions

THIAGO M. BATISTA, RUBEN GARCIA MARTIN, WEIKANG CAI, SUJIN SUK, HYE LIM NOH, JASON K. KIM, C. RONALD KAHN

Diabetes 2018;67(Supplement_1):1785-P

https://doi.org/10.2337/db18-1785-P

Published: 01 July 2018

View article titled, Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions

Meeting Abstracts

IMG-1 Reduces Blood Glucose Levels in Type 1 Diabetic Animal Models

JONATHAN B. POLLETT, HYE LIM NOH, JASON K. KIM, NGOC THAI

Diabetes 2018;67(Supplement_1):1215-P

https://doi.org/10.2337/db18-1215-P

Published: 01 July 2018

View article titled, IMG-1 Reduces Blood Glucose Levels in Type 1 Diabetic Animal Models

Meeting Abstracts

IMG-1 Lowers Insulin Resistance by Decreasing Hepatic Glucose Production in a DIO Mouse Clamp Test

JONATHAN B. POLLETT, HYE LIM NOH, JASON K. KIM, NGOC THAI

Diabetes 2018;67(Supplement_1):1214-P

https://doi.org/10.2337/db18-1214-P

Published: 01 July 2018

View article titled, IMG-1 Lowers Insulin Resistance by Decreasing Hepatic Glucose Production in a DIO Mouse Clamp Test

Meeting Abstracts

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

HYE LIM NOH, SUJIN SUK, RANDALL H. FRIEDLINE, KUNIKAZU INASHIMA, DUY A. TRAN, ALLISON M. KIM, SOOYOUNG KIM, SANGEUN JEONG, CECILIA UONG, BERK A. OZKAN, VISHAL KASINA, KATHERINE P. KNOWLES, GUILLERMO PEREZ-PEREZ, KI WON LEE, MARTIN J. BLASER, JASON K. KIM

Diabetes 2018;67(Supplement_1):1999-P

https://doi.org/10.2337/db18-1999-P

Published: 01 July 2018

View article titled, Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Meeting Abstracts

DNA Repair Enzyme Ogg1 Regulates Hepatic Insulin Resistance in High-Fat Diet-Fed Obese Mice

LARYSA YUZEFOVYCH, MICHELE SCHULER, HYE LIM NOH, SUJIN SUK, JASON K. KIM, LYUDMILA RACHEK

Diabetes 2018;67(Supplement_1):235-LB

https://doi.org/10.2337/db18-235-LB

Published: 01 July 2018

View article titled, DNA Repair Enzyme Ogg1 Regulates Hepatic Insulin Resistance in High-Fat Diet-Fed Obese Mice

Meeting Abstracts

Grp78 Is Critical for Beta-Cell Maturation and Survival

ROHIT B. SHARMA, XIAOYING ZHENG, BRIAN GABLASKI, JASON K. KIM, AMY S. LEE, LAURA C. ALONSO

Diabetes 2018;67(Supplement_1):85-OR

https://doi.org/10.2337/db18-85-OR

Published: 01 July 2018

View article titled, Grp78 Is Critical for Beta-Cell Maturation and Survival

Journal Articles

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Asma Ejaz, Laura Martinez-Guino, Allison B. Goldfine, Francesc Ribas-Aulinas, Valeria De Nigris, Sílvia Ribó, Alba Gonzalez-Franquesa, Pablo M. Garcia-Roves, Elizabeth Li, Jonathan M. Dreyfuss, Walt Gall, Jason K. Kim, Teodoro Bottiglieri, Francesc Villarroya, Robert E. Gerszten, Mary-Elizabeth Patti, Carles Lerin

Diabetes 2016;65(4):902–912

https://doi.org/10.2337/db15-1094

Published: 08 February 2016

View article titled, Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Includes: Supplementary data

Journal Articles

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

Qusai Y. Al-Share, Anthony M. DeAngelis, Sumona Ghosh Lester, Thomas A. Bowman, Sadeesh K. Ramakrishnan, Simon L. Abdallah, Lucia Russo, Payal R. Patel, Meenakshi K. Kaw, Christian K. Raphael, Andrea Jung Kim, Garrett Heinrich, Abraham D. Lee, Jason K. Kim, Rohit N. Kulkarni, William M. Philbrick, Sonia M. Najjar

Diabetes 2015;64(8):2780–2790

https://doi.org/10.2337/db14-1772

Published: 13 May 2015

View article titled, Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

Includes: Supplementary data

NARROW

293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

270-OR: Loss of Myeloid IFNgamma Signaling Prevents Hepatic Inflammation and NASH in Obesity

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

1727-P: Mice Deficient in Myeloid Cell-Derived Interleukin-1a Are Protected from Diet-Induced Obesity and Insulin Resistance

1726-P: Male Mice Lacking Estrogen Receptor Beta Develop Obesity but Are Protected from Diet-Induced Insulin Resistance in Skeletal Muscle

1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission

1991-P: Mammary Tumors Increase Diet-Induced Obesity and Insulin Resistance in Female MMTV-PyMT Mice

1992-P: Early and Chronic Exposure to Penicillin Increases Obesity and Insulin Resistance in High-Fat Diet-Fed Mice

Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission

Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions

IMG-1 Reduces Blood Glucose Levels in Type 1 Diabetic Animal Models

IMG-1 Lowers Insulin Resistance by Decreasing Hepatic Glucose Production in a DIO Mouse Clamp Test

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

DNA Repair Enzyme Ogg1 Regulates Hepatic Insulin Resistance in High-Fat Diet-Fed Obese Mice

Grp78 Is Critical for Beta-Cell Maturation and Survival

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

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