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Jay M. Sosenko
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Journal Articles

The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes

Heba M Ismail, David Cuthbertson, Alfonso Galderisi, Ingrid Libman, Laura Jacobsen, Antoinette Moran, Alessandra Petrelli, Mark Atkinson, Maria J. Redondo, Tamara Hannon, Kieren J Mather, Jay M. Sosenko
Journal: Diabetes
Diabetes db241000
https://doi.org/10.2337/db24-1000
Published: 02 April 2025
View articletitled, The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Open the PDF for The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes in another window
Journal Articles

The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes

Emily K. Sims, David Cuthbertson, Kevan C. Herold, Jay M. Sosenko
Journal: Diabetes
Diabetes 2021;70(12):2922–2931
https://doi.org/10.2337/db21-0519
Published: 22 September 2021
View articletitled, The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes
Open the PDF for The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes in another window
Journal Articles

Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials

Jay M. Sosenko, Jay S. Skyler, Kevan C. Herold, Desmond A. Schatz, Michael J. Haller, Alberto Pugliese, Mario Cleves, Susan Geyer, Lisa E. Rafkin, Della Matheson, Jerry P. Palmer
Journal: Diabetes
Diabetes 2020;69(8):1827–1832
https://doi.org/10.2337/db20-0166
Published: 21 May 2020
View articletitled, Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials
Open the PDF for Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials in another window
Meeting Abstracts

1469-P: Associations between Heart Rate, Glycemia, and A1c Levels

SARAH CASAGRANDE, CATHERINE C. COWIE, JAY M. SOSENKO, KARA R. MIZOKAMI-STOUT, ANDREW J. BOULTON, RODICA POP-BUSUI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1469-P
https://doi.org/10.2337/db19-1469-P
Published: 01 June 2019
View articletitled, 1469-P: Associations between Heart Rate, Glycemia, and A1c Levels
Meeting Abstracts

1689-P: Assessments of Alternative C-Peptide (C-P) Endpoints for New-Onset Type 1 Diabetes (T1D) Clinical Trials

HEBA M. ISMAIL, BRIAN N. BUNDY, MARK A. ATKINSON, WAYNE V. MOORE, MICHAEL J. HALLER, WILLIAM E. RUSSELL, STEPHEN E. GITELMAN, KEVAN C. HEROLD, MARIA JOSE REDONDO, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1689-P
https://doi.org/10.2337/db19-1689-P
Published: 01 June 2019
View articletitled, 1689-P: Assessments of Alternative C-Peptide (C-P) Endpoints for New-Onset Type 1 Diabetes (T1D) Clinical Trials
Meeting Abstracts

1678-P: Comparisons of Combined C-Peptide and Glucose Intermediate Endpoints for Identifying Individuals at Very High Risk for Type 1 Diabetes

LAURA M. JACOBSEN, MARK A. CLEMENTS, MARIA JOSE REDONDO, BRANDON M. NATHAN, DESMOND SCHATZ, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1678-P
https://doi.org/10.2337/db19-1678-P
Published: 01 June 2019
View articletitled, 1678-P: Comparisons of Combined C-Peptide and Glucose Intermediate Endpoints for Identifying Individuals at Very High Risk for Type 1 Diabetes
Meeting Abstracts

1671-P: Comorbid Autoimmune Disease in Participants at Risk for Type 1 Diabetes

KIMBER SIMMONS, SUSAN GEYER, DIANE K. WHERRETT, HEBA M. ISMAIL, MARKUS LUNDGREN, LAURA E. BOCCHINO, JAY M. SOSENKO, CARLA GREENBAUM, ANDREA STECK
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1671-P
https://doi.org/10.2337/db19-1671-P
Published: 01 June 2019
View articletitled, 1671-P: Comorbid Autoimmune Disease in Participants at Risk for Type 1 Diabetes
Meeting Abstracts

1684-P: Using Index60 to Detect Heterogeneity and Identify Subpopulations with Characteristic Type 1 Diabetes (T1D) Profiles among Individuals with Normal Two-Hour Glucose Levels

BRANDON M. NATHAN, SUSAN GEYER, LAURA E. BOCCHINO, JERRY P. PALMER, LAURA M. JACOBSEN, MARIA JOSE REDONDO, EMILY K. SIMS, JAY S. SKYLER, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1684-P
https://doi.org/10.2337/db19-1684-P
Published: 01 June 2019
View articletitled, 1684-P: Using Index60 to Detect Heterogeneity and Identify Subpopulations with Characteristic Type 1 Diabetes (T1D) Profiles among Individuals with Normal Two-Hour Glucose Levels
Meeting Abstracts

85-OR: Modifiers of C-Peptide Change during the Progression to Type 1 Diabetes (T1D) in the TrialNet Pathway to Prevention Study

HEBA M. ISMAIL, MARIO A. CLEVES, STEPHEN E. GITELMAN, JAY S. SKYLER, ANDREA STECK, HENRY RODRIGUEZ, MARK A. ATKINSON, BRANDON M. NATHAN, MARIA JOSE REDONDO, KEVAN C. HEROLD, JERRY P. PALMER, CARMELLA EVANS-MOLINA, LINDA DIMEGLIO, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):85-OR
https://doi.org/10.2337/db19-85-OR
Published: 01 June 2019
View articletitled, 85-OR: Modifiers of C-Peptide Change during the Progression to Type 1 Diabetes (T1D) in the TrialNet Pathway to Prevention Study
Meeting Abstracts

1343-P: A Comparison of C-Peptide and Glucose Responses between Children and Adolescents Who Progress to Type 1 Diabetes (T1D)

HEBA M. ISMAIL, BRANDON M. NATHAN, JERRY P. PALMER, LINDA DIMEGLIO, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1343-P
https://doi.org/10.2337/db19-1343-P
Published: 01 June 2019
View articletitled, 1343-P: A Comparison of C-Peptide and Glucose Responses between Children and Adolescents Who Progress to Type 1 Diabetes (T1D)
Meeting Abstracts

1344-P: Persistent ß-Cell Responsiveness in Children at High Risk for Type 1 Diabetes (T1D) Is Associated with Decreased Progression to T1D in the Diabetes Prevention Trial-Type 1 (DPT-1)

EMILY K. SIMS, HEBA M. ISMAIL, BRANDON M. NATHAN, JAY M. SOSENKO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1344-P
https://doi.org/10.2337/db19-1344-P
Published: 01 June 2019
View articletitled, 1344-P: Persistent ß-Cell Responsiveness in Children at High Risk for Type 1 Diabetes (T1D) Is Associated with Decreased Progression to T1D in the Diabetes Prevention Trial-Type 1 (DPT-1)
Meeting Abstracts

187-LB: Glucose Response Curve (GRC) Shapes in Mixed Meal Tolerance Tests (MMTTs) and Prediction of Response to Intervention in the TrialNet New-Onset Clinical Trials

NOURAH NAJI ALMUTLAQ, MARIO A. CLEVES, STEPHEN E. GITELMAN, LINDA DIMEGLIO, JAY M. SOSENKO, HEBA M. ISMAIL
Journal: Diabetes
Diabetes 2019;68(Supplement_1):187-LB
https://doi.org/10.2337/db19-187-LB
Published: 01 June 2019
View articletitled, 187-LB: Glucose Response Curve (GRC) Shapes in Mixed Meal Tolerance Tests (MMTTs) and Prediction of Response to Intervention in the TrialNet New-Onset Clinical Trials
Journal Articles

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Michael J. Haller, S. Alice Long, J. Lori Blanchfield, Desmond A. Schatz, Jay S. Skyler, Jeffrey P. Krischer, Brian N. Bundy, Susan M. Geyer, Megan V. Warnock, Jessica L. Miller, Mark A. Atkinson, Dorothy J. Becker, David A. Baidal, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Jennifer B. Marks, Antoinette Moran, Henry Rodriguez, William E. Russell, Darrell M. Wilson, Carla J. Greenbaum, Type 1 Diabetes TrialNet ATG-GCSF Study Group, Carla J. Greenbaum, Mark A. Atkinson, David A. Baidal, Manuela Battaglia, Dorothy Becker, Penelope Bingley, Emanuele Bosi, Jane Buckner, Mark Clements, Peter G. Colman, Linda DiMeglio, Carmella Evans-Molina, Stephen E. Gitelman, Robin Goland, Peter Gottlieb, Kevan Herold, Mikael Knip, Jeffrey P. Krischer, Ake Lernmark, Wayne Moore, Antoinette Moran, Andrew Muir, Jerry Palmer, Mark Peakman, Louis Philipson, Philip Raskin, Maria Redondo, Henry Rodriguez, William Russell, Desmond A. Schatz, Jay M. Sosenko, Lisa Spain, John Wentworth, Diane Wherrett, Darrell M. Wilson, William Winter, Anette Ziegler, Mark Anderson, Peter Antinozzi, Richard Insel, Thomas Kay, Jennifer B. Marks, Alberto Pugliese, Bart Roep, Jay S. Skyler, Jorma Toppari, Carla J. Greenbaum, Jeffrey P. Krischer, Ellen Leschek, Lisa Spain, Katarzyna Bourcier, Richard Insel, John Ridge, Jay S. Skyler, Carla J. Greenbaum, Lisa Rafkin, Jay M. Sosenko, Jay S. Skyler, Irene Santiago, Jeffrey P. Krischer, Brian Bundy, Michael Abbondondolo, Timothy Adams, Ilma Asif, Jenna Bjellquist, Matthew Boonstra, Cristina Burroughs, Mario Cleves, David Cuthbertson, Meagan DeSalvatore, Christopher Eberhard, Steve Fiske, Julie Ford, Jennifer Garmeson, Susan Geyer, Brian Hays, Courtney Henderson, Martha Henry, Kathleen Heyman, Belinda Hsiao, Christina Karges, Beata-Gabriela Koziol, Lindsay Lane, Shu Liu, Jennifer Lloyd, Kristin Maddox, Jamie Malloy, Julie Martin, Cameron McNeill, Margaret Moore, Sarah Muller, Thuy Nguyen, Jodie Nunez, Ryan O’Donnell, Melissa Parker, M.J. Pereyra, Amy Roberts, Kelly Sadler, Christine Sullivan, Roy Tamura, Elon Walker-Veras, Megan V. Warnock, Keith Wood, Rebecca Wood, Ping Xu, Vanessa Yanek, Kenneth Young, Darlene Amado, Amanda Kinderman, Ashley Leinbach, Jessica Miller, Nichole Reed, Tina Stavros, Ellen Leschek, Lisa Spain, Emily Blumberg, Sean Aas, Gerald Beck, Rose Gubitosi-Klug, Lori Laffel, Robert Vigersky, Dennis Wallace, David Brillon, Robert Veatch, Brett Loechelt, Lindsey Baden, Peter Gottlieb, Michael Green, Ellen Leschek, Adriana Weinberg, Santica Marcovina, Jerry P. Palmer, Jay Tischfield, Adriana Weinberg, William Winter, Liping Yu, Annie Shultz, Emily Batts, Arielle Pagryzinski, Mary Ramey, Meghan Tobin, Kristin Fitzpatrick, Randy Guerra, Melita Romasco, Christopher Webb, Peter Gottlieb, Maya Barr, Mary Drye, Jordan Lykens, Aaron Michels, Allison Schauwecker, Andrea Steck, Paul Wadwa, Carla J. Greenbaum, Jane Buckner, Wei Hao, Sandra Lord, Marli McCulloch-Olson, Mary Ramey, Elaine Sachter, Jenna Snavely, Meghan Tobin, Corinna Tordillos, Dana VanBuecken, Robin Goland, Analia Alvarez, Magdalena Bogun, Rachelle Gandica, Natasha Leibel, Sarah Pollak, Barney Softness, Kristen Williams, Bryce Nelson, James Amrhein, Lisa Looper, Elaine Moreland, Andrew Smith, Beth Weir, Lori Wise, Linda DiMeglio, Carmella Evans-Molina, Manasa Mantravadi, Maureen Mullen, Vanessa Patrick, Maria Spall, Stephanie Woerner, Darrell M. Wilson, Nora Arrizon-Ruiz, Tandy Aye, Laura Bachrach, Karen Barahona, Trudy Esrey, Laura Nally, Stephen E. Gitelman, Mark Anderson, Glenna Auerback, Jeanne Buchanan, Christine T. Ferrara, Karen Ko, Srinath Sanda, Christine Torok, Rebecca Wesch, Michael J. Haller, Anastasia Albanese-O'Neill, Todd Brusko, Miriam Cintron, Jennifer Hosford, Laura M. Jacobsen, Henry Rohrs, Desmond A. Schatz, Janet Silverstein, Paula Towe, David A. Baidal, Carlos Blaschke, Della Matheson, Janine Sanchez, Natalia Sanders-Branca, Jay S. Skyler, Jay M. Sosenko, Antoinette Moran, Janice Leschyshyn, Jennifer McVean, Brandon Nathan, Brittney Nelson, Beth Pappenfus, Jessica Ruedy, Anne Street, Muna Sunni, Darcy Weingartner, Dorothy Becker, Kelli DeLallo, Ana Diaz, David Groscost, Mary Beth Klein, Ingrid Libman, Karen Riley, Henry Rodriguez, Sureka Bollepalli, Rachel Brownstein, Emily Eyth, Danielle Henson, Michele Laine, Dorothy Shulman, William Russell, Faith Brendle, Anne Brown, Brenna Dixon, Justin Gregory, Dan Moore, James Thomas, Kevan Herold, Laurie Feldman, William Tamborlane
Journal: Diabetes
Diabetes 2019;68(6):1267–1276
https://doi.org/10.2337/db19-0057
Published: 09 April 2019
View articletitled, Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
Open the PDF for Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data in another window
Includes: Supplementary data
Journal Articles

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

Jay S. Skyler, George L. Bakris, Ezio Bonifacio, Tamara Darsow, Robert H. Eckel, Leif Groop, Per-Henrik Groop, Yehuda Handelsman, Richard A. Insel, Chantal Mathieu, Allison T. McElvaine, Jerry P. Palmer, Alberto Pugliese, Desmond A. Schatz, Jay M. Sosenko, John P.H. Wilding, Robert E. Ratner
Journal: Diabetes
Diabetes 2017;66(2):241–255
https://doi.org/10.2337/db16-0806
Published: 15 December 2016
View articletitled, Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
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Includes: Supplementary data
Journal Articles

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression

Alberto Pugliese, David Boulware, Liping Yu, Sunanda Babu, Andrea K. Steck, Dorothy Becker, Henry Rodriguez, Linda DiMeglio, Carmella Evans-Molina, Leonard C. Harrison, Desmond Schatz, Jerry P. Palmer, Carla Greenbaum, George S. Eisenbarth, Jay M. Sosenko, the Type 1 Diabetes TrialNet Study Group
Journal: Diabetes
Diabetes 2016;65(4):1109–1119
https://doi.org/10.2337/db15-1105
Published: 28 January 2016
View articletitled, HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression
Open the PDF for HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression in another window
Includes: Supplementary data
Journal Articles

Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants

Jay M. Sosenko, Jay S. Skyler, Craig A. Beam, Jeffrey P. Krischer, Carla J. Greenbaum, Jeffrey Mahon, Lisa E. Rafkin, Della Matheson, Kevan C. Herold, Jerry P. Palmer, and the Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Journal: Diabetes
Diabetes 2013;62(12):4179–4183
https://doi.org/10.2337/db13-0656
Published: 16 November 2013
View articletitled, Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants
Open the PDF for Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants in another window
Includes: Supplementary data
Journal Articles

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

Carla J. Greenbaum, Craig A. Beam, David Boulware, Stephen E. Gitelman, Peter A. Gottlieb, Kevan C. Herold, John M. Lachin, Paula McGee, Jerry P. Palmer, Mark D. Pescovitz, Heidi Krause-Steinrauf, Jay S. Skyler, Jay M. Sosenko, on behalf of the Type 1 Diabetes TrialNet Study Group
Journal: Diabetes
Diabetes 2012;61(8):2066–2073
https://doi.org/10.2337/db11-1538
Published: 17 July 2012
View articletitled, Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data
Open the PDF for Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data in another window
Includes: Supplementary data
Journal Articles

The Metabolic Progression to Type 1 Diabetes as Indicated by Serial Oral Glucose Tolerance Testing in the Diabetes Prevention Trial–Type 1

Jay M. Sosenko, Jay S. Skyler, Kevan C. Herold, Jerry P. Palmer, the Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Journal: Diabetes
Diabetes 2012;61(6):1331–1337
https://doi.org/10.2337/db11-1660
Published: 14 May 2012
View articletitled, The Metabolic Progression to Type 1 Diabetes as Indicated by Serial Oral Glucose Tolerance Testing in the Diabetes Prevention Trial–Type 1
Open the PDF for The Metabolic Progression to Type 1 Diabetes as Indicated by Serial Oral Glucose Tolerance Testing in the Diabetes Prevention Trial–Type 1 in another window
Includes: Supplementary data
Journal Articles

Glucose Excursions Between States of Glycemia With Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1)

Jay M. Sosenko, Jay S. Skyler, Jeffrey P. Krischer, Carla J. Greenbaum, Jeffrey Mahon, Lisa E. Rafkin, David Cuthbertson, Catherine Cowie, Kevan Herold, George Eisenbarth, Jerry P. Palmer, the Diabetes Prevention Trial–Type 1 Study Group
Journal: Diabetes
Diabetes 2010;59(10):2386–2389
https://doi.org/10.2337/db10-0534
Published: 03 August 2010
View articletitled, Glucose Excursions Between States of Glycemia With Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1)
Open the PDF for Glucose Excursions Between States of Glycemia With Progression to Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) in another window
Includes: Supplementary data
Journal Articles

Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset

Ele Ferrannini, Andrea Mari, Valentina Nofrate, Jay M. Sosenko, Jay S. Skyler, for the DPT-1 Study Group
Journal: Diabetes
Diabetes 2010;59(3):679–685
https://doi.org/10.2337/db09-1378
Published: 22 December 2009
View articletitled, Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset
Open the PDF for Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset in another window
Includes: Supplementary data