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Jens J. Holst
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Journal Articles

The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

Morten Hindsø, Nora Hedbäck, Maria S. Svane, Andreas Møller, Christoffer Martinussen, Nils B. Jørgensen, Carsten Dirksen, Lærke S. Gasbjerg, Viggo B. Kristiansen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller
Journal: Diabetes
Diabetes 2023;72(3):336–347
DOI: https://doi.org/10.2337/db22-0568
Published: 07 December 2022
View article titled, The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery
Click here to open pdf in another window PDF for The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery
Journal Articles

Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes

Signe Stensen, Lærke S. Gasbjerg, Mette M. Rosenkilde, Tina Vilsbøll, Jens J. Holst, Bolette Hartmann, Mikkel B. Christensen, Filip K. Knop
Journal: Diabetes
Diabetes 2022;71(10):2209–2221
DOI: https://doi.org/10.2337/db22-0059
Published: 07 July 2022
View article titled, Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes
Click here to open pdf in another window PDF for Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes
Journal Articles

The Liver–α-Cell Axis in Health and in Disease

Michael M. Richter, Katrine D. Galsgaard, Emilie Elmelund, Filip K. Knop, Malte P. Suppli, Jens J. Holst, Marie Winther-Sørensen, Sasha A.S. Kjeldsen, Nicolai J. Wewer Albrechtsen
Journal: Diabetes
Diabetes 2022;71(9):1852–1861
DOI: https://doi.org/10.2337/dbi22-0004
Published: 03 June 2022
View article titled, The Liver–α-Cell Axis in Health and in Disease
Click here to open pdf in another window PDF for The Liver–α-Cell Axis in Health and in Disease
Meeting Abstracts

1332-P: Increased and Decreased Glucagon Receptor Signaling Respectively Enhances and Impairs Triglyceride Metabolism Acutely and Chronically

KATRINE D. GALSGAARD, EMILIE E. CHRISTENSEN, ANNA B. BOMHOLT, JENNA HUNT, THOMAS KRUSE, JESPER F. LAU, CHRISTINA CHRISTOFFERSEN, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1332-P
DOI: https://doi.org/10.2337/db22-1332-P
Published: 01 June 2022
View article titled, 1332-P: Increased and Decreased Glucagon Receptor Signaling Respectively Enhances and Impairs Triglyceride Metabolism Acutely and Chronically
Meeting Abstracts

1385-P: Impact of Preanalytical and Analytical Factors on Glucagon and GLP-1 Levels in Humans

CHRISTINE RASMUSSEN, SASHA KJELDSEN, NICOLE J. JENSEN, NIKLAS HEINZ, BOLETTE HARTMANN, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1385-P
DOI: https://doi.org/10.2337/db22-1385-P
Published: 01 June 2022
View article titled, 1385-P: Impact of Preanalytical and Analytical Factors on Glucagon and GLP-1 Levels in Humans
Meeting Abstracts

230-LB: Amino Acid–Induced Glucagon Secretion and Glucagon Enhancement of Amino Acid Catabolism Is Independent of Glucose

KATHARINA MARUSZCZAK, CHRISTINE RASMUSSEN, FREDERIK R. CEUTZ, ANNE ØRGAARD, EMILIE E. CHRISTENSEN, MICHAEL M. RICHTER, JENS J. HOLST, MARIE WINTHER-SOERENSEN, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):230-LB
DOI: https://doi.org/10.2337/db22-230-LB
Published: 01 June 2022
View article titled, 230-LB: Amino Acid–Induced Glucagon Secretion and Glucagon Enhancement of Amino Acid Catabolism Is Independent of Glucose
Meeting Abstracts

1425-P: Effect of Ghrelin on Glucose Tolerance after Sleeve Gastrectomy

NORA HEDBÄCK, MARIE-LOUISE DICHMAN, CARSTEN DIRKSEN, KIRSTINE N. BOJSEN-MOLLER, NILS B. JØRGENSEN, MORTEN G. HINDSØ, VIGGO B. KRISTIANSEN, JENS J. HOLST, MARIA S. SVANE, STEN MADSBAD, SR.
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1425-P
DOI: https://doi.org/10.2337/db22-1425-P
Published: 01 June 2022
View article titled, 1425-P: Effect of Ghrelin on Glucose Tolerance after Sleeve Gastrectomy
Meeting Abstracts

876-P: Empagliflozin-Induced Metabolic Changes and Cardiac Function in Patients with Type 2 Diabetes: A Randomized Crossover MRI Study with Insulin as Comparator

ROOPAMEERA THIRUMATHYAM, JENS PETER GOETZE, JENS J. HOLST, NIELS VEJLSTRUP, STEN MADSBAD, SR., PER L. MADSEN, NILS B. JØRGENSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):876-P
DOI: https://doi.org/10.2337/db22-876-P
Published: 01 June 2022
View article titled, 876-P: Empagliflozin-Induced Metabolic Changes and Cardiac Function in Patients with Type 2 Diabetes: A Randomized Crossover MRI Study with Insulin as Comparator
Meeting Abstracts

271-OR: Hepatic Glucagon Resistance in Mice with Nonalcoholic Fatty Liver Disease

FREDERIK R. CEUTZ, EMILIE E. CHRISTENSEN, MARIE WINTHER-SOERENSEN, HENDRIK VILSTRUP, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):271-OR
DOI: https://doi.org/10.2337/db22-271-OR
Published: 01 June 2022
View article titled, 271-OR: Hepatic Glucagon Resistance in Mice with Nonalcoholic Fatty Liver Disease
Meeting Abstracts

235-OR: Sustained QTc Prolongation during Recovery from Hypoglycemia in Patients with Type 1 Diabetes

CHRISTINE R. ANDREASEN, ANDREAS ANDERSEN, PER G. HAGELQVIST, JULIUS V. LAURITSEN, SUSANNE ENGBERG, JENS J. HOLST, ULRIK PEDERSEN-BJERGAARD, FILIP K. KNOP, TINA VILSBØLL
Journal: Diabetes
Diabetes 2022;71(Supplement_1):235-OR
DOI: https://doi.org/10.2337/db22-235-OR
Published: 01 June 2022
View article titled, 235-OR: Sustained QTc Prolongation during Recovery from Hypoglycemia in Patients with Type 1 Diabetes
Meeting Abstracts

1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes

LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, LIVA S.L. KROGH, ALEXANDER H. SPARRE-ULRICH, BOLETTE HARTMANN, TINA VILSBØLL, MIKKEL B. CHRISTENSEN, JENS J. HOLST, CHRISTINA CHRISTOFFERSEN, FILIP K. KNOP, METTE M. ROSENKILDE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1362-P
DOI: https://doi.org/10.2337/db22-1362-P
Published: 01 June 2022
View article titled, 1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes
Meeting Abstracts

321-OR: Empagliflozin Improves Beta-Cell Function Independently of Glucose Toxicity in Patients with Type 2 Diabetes

ROOPAMEERA THIRUMATHYAM, ERIK A. RICHTER, JENS PETER GOETZE, PER L. MADSEN, JENS J. HOLST, STEN MADSBAD, SR., NILS B. JØRGENSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):321-OR
DOI: https://doi.org/10.2337/db22-321-OR
Published: 01 June 2022
View article titled, 321-OR: Empagliflozin Improves Beta-Cell Function Independently of Glucose Toxicity in Patients with Type 2 Diabetes
Meeting Abstracts

1343-P: The Acute Effects of Glucagon on Glucose Dynamics Are Not Impaired in Individuals with Nonalcoholic Fatty Liver Disease

SASHA KJELDSEN, NICOLE J. JENSEN, MALIN NILSSON, NIKLAS HEINZ, JANUS D. NYBING, FREDERIK H. LINDEN, ERIK HØGH-SCHMIDT, MIKAEL P. BOESEN, STEN MADSBAD, HENDRIK VILSTRUP, SR., FRANK V. SCHIØDT, ANDREAS MØLLER, ELIAS B. RASHU, LISE GLUUD, STEEN B. HAUGAARD, JENS J. HOLST, JOERGEN RUNGBY, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1343-P
DOI: https://doi.org/10.2337/db22-1343-P
Published: 01 June 2022
View article titled, 1343-P: The Acute Effects of Glucagon on Glucose Dynamics Are Not Impaired in Individuals with Nonalcoholic Fatty Liver Disease
Meeting Abstracts

357-OR: Improved Glycemic Control in Persons with Type 2 Diabetes Improves Beta-Cell Actions of Endogenous Glucose-Dependent Insulinotropic Polypeptide

BJØRN HOE, MADS B. LYNGGAARD, LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, BOLETTE HARTMANN, JENS J. HOLST, MIKKEL B. CHRISTENSEN, TINA VILSBØLL, FILIP K. KNOP
Journal: Diabetes
Diabetes 2022;71(Supplement_1):357-OR
DOI: https://doi.org/10.2337/db22-357-OR
Published: 01 June 2022
View article titled, 357-OR: Improved Glycemic Control in Persons with Type 2 Diabetes Improves Beta-Cell Actions of Endogenous Glucose-Dependent Insulinotropic Polypeptide
Meeting Abstracts

214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

EMILIE E. CHRISTENSEN, KATRINE D. GALSGAARD, CHRISTIAN D. JOHANSEN, SAMUEL TRAMMELL, ANNA B. BOMHOLT, JENNA HUNT, THOMAS KRUSE, JESPER F. LAU, TRISHA GREVENGOED, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):214-LB
DOI: https://doi.org/10.2337/db22-214-LB
Published: 01 June 2022
View article titled, 214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth
Journal Articles

Glucagon Clearance Is Preserved in Type 2 Diabetes

Magnus F.G. Grøndahl, Asger B. Lund, Jonatan I. Bagger, Tonny S. Petersen, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Tina Vilsbøll, Mikkel B. Christensen, Filip K. Knop
Journal: Diabetes
Diabetes 2022;71(1):73–82
DOI: https://doi.org/10.2337/db21-0024
Published: 26 October 2021
View article titled, Glucagon Clearance Is Preserved in Type 2 Diabetes
Click here to open pdf in another window PDF for Glucagon Clearance Is Preserved in Type 2 Diabetes
Meeting Abstracts

10-OR: In Women with Prior Gestational Diabetes Mellitus, the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Improves Glucose Tolerance Irrespective of Body Weight Loss after Five Years of Treatment, but Effects Are Lost after Wash-Out

EMILIE S. ANDERSEN, SIGNE FOGHSGAARD, LOUISE VEDTOFTE, MARIE H. PEDERSEN, JULIE FORMAN, ELISABETH R. MATHIESEN, JENS SVARE, JENS J. HOLST, TINE D. CLAUSEN, PETER DAMM, FILIP K. KNOP, TINA VILSBØLL
Journal: Diabetes
Diabetes 2021;70(Supplement_1):10-OR
DOI: https://doi.org/10.2337/db21-10-OR
Published: 01 June 2021
View article titled, 10-OR: In Women with Prior Gestational Diabetes Mellitus, the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Improves Glucose Tolerance Irrespective of Body Weight Loss after Five Years of Treatment, but Effects Are Lost after Wash-Out
Meeting Abstracts

47-OR: Acute Fluctuations in Plasma Glucose Affect Echocardiographic-Derived Measures of Systolic Function in Patients with Type 1 Diabetes

CHRISTINE R. ANDREASEN, ANDREAS ANDERSEN, PER G. HAGELQVIST, KIRSTEN U. ABELIN, JULIUS V. LAURITSEN, PETER G. JØRGENSEN, SUSANNE ENGBERG, JENS J. HOLST, ULRIK PEDERSEN-BJERGAARD, FILIP K. KNOP, TINA VILSBØLL
Journal: Diabetes
Diabetes 2021;70(Supplement_1):47-OR
DOI: https://doi.org/10.2337/db21-47-OR
Published: 01 June 2021
View article titled, 47-OR: Acute Fluctuations in Plasma Glucose Affect Echocardiographic-Derived Measures of Systolic Function in Patients with Type 1 Diabetes
Meeting Abstracts

36-LB: The Effect of Dietary Carbohydrate Restriction on Health-Related Quality of Life and Cognition: A Randomized Trial

NICOLE J. JENSEN, HELENA Z. WODSCHOW, MADS J. SKYTTE, AMIRSALAR SAMKANI, ARNE ASTRUP, JAN FRYSTYK, BOLETTE HARTMANN, JENS J. HOLST, THOMAS M. LARSEN, STEN MADSBAD, FAIDON MAGKOS, KAMILLA MISKOWIAK, JOERGEN RUNGBY, STEEN B. HAUGAARD, THURE KRARUP, MADS N. THOMSEN
Journal: Diabetes
Diabetes 2021;70(Supplement_1):36-LB
DOI: https://doi.org/10.2337/db21-36-LB
Published: 01 June 2021
View article titled, 36-LB: The Effect of Dietary Carbohydrate Restriction on Health-Related Quality of Life and Cognition: A Randomized Trial
Meeting Abstracts

216-LB: Development and Evaluation of a Glucagon Sensitivity Test in Humans

SASHA KJELDSEN, NICOLE J. JENSEN, MALIN NILSSON, JANUS D. NYBING, FREDERIK H. LINDEN, ERIK HØGH-SCHMIDT, MIKAEL P. BOESEN, STEN MADSBAD, HENDRIK VILSTRUP, SR., ELIAS B. RASHU, LISE GLUUD, STEEN B. HAUGAARD, JENS J. HOLST, JOERGEN RUNGBY, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2021;70(Supplement_1):216-LB
DOI: https://doi.org/10.2337/db21-216-LB
Published: 01 June 2021
View article titled, 216-LB: Development and Evaluation of a Glucagon Sensitivity Test in Humans