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Journal Articles

Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis

Magnus F.G. Grøndahl, Andreas H. Lange, Malte P. Suppli, Jonatan I. Bagger, Mira Thing, Lise L. Gluud, Dea H. Kofod, Mads Hornum, Gerrit van Hall, Samuel A.J. Trammell, Trisha J. Grevengoed, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Mikkel B. Christensen, Asger B. Lund, Filip K. Knop

Diabetes 2024;73(10):1641–1647

https://doi.org/10.2337/db24-0305

Published: 25 July 2024

View articletitled, Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis

Journal Articles

Glucagon Resistance in Individuals With Obesity and Hepatic Steatosis Can Be Measured Using the GLUSENTIC Test and Index

Diabetes 2024;73(10):1716–1727

https://doi.org/10.2337/db23-0858

Published: 08 July 2024

View articletitled, Glucagon Resistance in Individuals With Obesity and Hepatic Steatosis Can Be Measured Using the GLUSENTIC Test and Index

Meeting Abstracts

108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

GIANFRANCO DI GIUSEPPE, LAURA SOLDOVIERI, GEA CICCARELLI, MICHELA BRUNETTI, FRANCESCA CINTI, SIMONA MOFFA, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):108-OR

https://doi.org/10.2337/db24-108-OR

Published: 14 June 2024

View articletitled, 108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

Meeting Abstracts

1620-P: Vagus Nerve Integrity Is Critical for GLP-1 (7-36) Safeness against Hypoglycemia

CAROLINA B. LOBATO, JENS J. HOLST

Diabetes 2024;73(Supplement_1):1620-P

https://doi.org/10.2337/db24-1620-P

Published: 14 June 2024

View articletitled, 1620-P: Vagus Nerve Integrity Is Critical for GLP-1 (7-36) Safeness against Hypoglycemia

Meeting Abstracts

1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

GIANFRANCO DI GIUSEPPE, SARA L. JEPSEN, JON VERGARA UCIN, BOLETTE HARTMANN, ANDREA GIACCARI, JENS J. HOLST, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1619-P

https://doi.org/10.2337/db24-1619-P

Published: 14 June 2024

View articletitled, 1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

Journal Articles

In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

Mark M. Smits, Katrine D. Galsgaard, Sara Lind Jepsen, Nicolai Wewer Albrechtsen, Bolette Hartmann, Jens J. Holst

Diabetes 2024;73(5):671–681

https://doi.org/10.2337/db23-0848

Published: 31 January 2024

View articletitled, In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

Meeting Abstracts

1651-P: Elevated FGF21 Levels after Total Pancreatectomy and in Response to Single-Dose Glucagon Receptor Antagonism in Humans

MAGNUS F.G. GRØNDAHL, CAROLINE T. JUEL, ASGER LUND, SOFIE HAEDERSDAL, MARIA M. ANDERSEN, JENS S. SVENNINGSEN, MATTHEW GILLUM, BOLETTE HARTMANN, JENS J. HOLST, TINA VILSBØLL, FILIP K. KNOP

Diabetes 2023;72(Supplement_1):1651-P

https://doi.org/10.2337/db23-1651-P

Published: 20 June 2023

View articletitled, 1651-P: Elevated FGF21 Levels after Total Pancreatectomy and in Response to Single-Dose Glucagon Receptor Antagonism in Humans

Meeting Abstracts

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, SIMONA MOFFA, GEA CICCARELLI, LAURA SOLDOVIERI, FRANCESCA CINTI, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2023;72(Supplement_1):1754-P

https://doi.org/10.2337/db23-1754-P

Published: 20 June 2023

View articletitled, 1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

Meeting Abstracts

244-OR: Signs of Glucagon Resistance after a Two-Week Hypercaloric Diet Intervention

MALTE P. SUPPLI, JONATAN I. BAGGER, SR., JENS J. HOLST, FILIP K. KNOP

Diabetes 2023;72(Supplement_1):244-OR

https://doi.org/10.2337/db23-244-OR

Published: 20 June 2023

View articletitled, 244-OR: Signs of Glucagon Resistance after a Two-Week Hypercaloric Diet Intervention

Meeting Abstracts

1378-P: Habitual High Sodium Intake Is Associated with Alterations in Glucose Homeostasis Including GLP-1 Secretion

ANNA DONKERS, HANNA HUBER, ALINA SCHIEREN, AAKASH MANTRI, WALDEMAR SEEL, BIRGIT STOFFEL-WAGNER, MARTIN COENEN, PETER KRAWITZ, JENS J. HOLST, PETER STEHLE, MARIE-CHRISTINE SIMON

Diabetes 2023;72(Supplement_1):1378-P

https://doi.org/10.2337/db23-1378-P

Published: 20 June 2023

View articletitled, 1378-P: Habitual High Sodium Intake Is Associated with Alterations in Glucose Homeostasis Including GLP-1 Secretion

Journal Articles

The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

Morten Hindsø, Nora Hedbäck, Maria S. Svane, Andreas Møller, Christoffer Martinussen, Nils B. Jørgensen, Carsten Dirksen, Lærke S. Gasbjerg, Viggo B. Kristiansen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller

Diabetes 2023;72(3):336–347

https://doi.org/10.2337/db22-0568

Published: 07 December 2022

View articletitled, The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

Journal Articles

Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes

Signe Stensen, Lærke S. Gasbjerg, Mette M. Rosenkilde, Tina Vilsbøll, Jens J. Holst, Bolette Hartmann, Mikkel B. Christensen, Filip K. Knop

Diabetes 2022;71(10):2209–2221

https://doi.org/10.2337/db22-0059

Published: 07 July 2022

View articletitled, Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes

Journal Articles

The Liver–α-Cell Axis in Health and in Disease

Michael M. Richter, Katrine D. Galsgaard, Emilie Elmelund, Filip K. Knop, Malte P. Suppli, Jens J. Holst, Marie Winther-Sørensen, Sasha A.S. Kjeldsen, Nicolai J. Wewer Albrechtsen

Diabetes 2022;71(9):1852–1861

https://doi.org/10.2337/dbi22-0004

Published: 03 June 2022

View articletitled, The Liver–α-Cell Axis in Health and in Disease

Meeting Abstracts

321-OR: Empagliflozin Improves Beta-Cell Function Independently of Glucose Toxicity in Patients with Type 2 Diabetes

ROOPAMEERA THIRUMATHYAM, ERIK A. RICHTER, JENS PETER GOETZE, PER L. MADSEN, JENS J. HOLST, STEN MADSBAD, SR., NILS B. JØRGENSEN

Diabetes 2022;71(Supplement_1):321-OR

https://doi.org/10.2337/db22-321-OR

Published: 01 June 2022

View articletitled, 321-OR: Empagliflozin Improves Beta-Cell Function Independently of Glucose Toxicity in Patients with Type 2 Diabetes

Meeting Abstracts

214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

EMILIE E. CHRISTENSEN, KATRINE D. GALSGAARD, CHRISTIAN D. JOHANSEN, SAMUEL TRAMMELL, ANNA B. BOMHOLT, JENNA HUNT, THOMAS KRUSE, JESPER F. LAU, TRISHA GREVENGOED, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2022;71(Supplement_1):214-LB

https://doi.org/10.2337/db22-214-LB

Published: 01 June 2022

View articletitled, 214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

Meeting Abstracts

271-OR: Hepatic Glucagon Resistance in Mice with Nonalcoholic Fatty Liver Disease

FREDERIK R. CEUTZ, EMILIE E. CHRISTENSEN, MARIE WINTHER-SOERENSEN, HENDRIK VILSTRUP, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2022;71(Supplement_1):271-OR

https://doi.org/10.2337/db22-271-OR

Published: 01 June 2022

View articletitled, 271-OR: Hepatic Glucagon Resistance in Mice with Nonalcoholic Fatty Liver Disease

Meeting Abstracts

235-OR: Sustained QTc Prolongation during Recovery from Hypoglycemia in Patients with Type 1 Diabetes

CHRISTINE R. ANDREASEN, ANDREAS ANDERSEN, PER G. HAGELQVIST, JULIUS V. LAURITSEN, SUSANNE ENGBERG, JENS J. HOLST, ULRIK PEDERSEN-BJERGAARD, FILIP K. KNOP, TINA VILSBØLL

Diabetes 2022;71(Supplement_1):235-OR

https://doi.org/10.2337/db22-235-OR

Published: 01 June 2022

View articletitled, 235-OR: Sustained QTc Prolongation during Recovery from Hypoglycemia in Patients with Type 1 Diabetes

Meeting Abstracts

876-P: Empagliflozin-Induced Metabolic Changes and Cardiac Function in Patients with Type 2 Diabetes: A Randomized Crossover MRI Study with Insulin as Comparator

ROOPAMEERA THIRUMATHYAM, JENS PETER GOETZE, JENS J. HOLST, NIELS VEJLSTRUP, STEN MADSBAD, SR., PER L. MADSEN, NILS B. JØRGENSEN

Diabetes 2022;71(Supplement_1):876-P

https://doi.org/10.2337/db22-876-P

Published: 01 June 2022

View articletitled, 876-P: Empagliflozin-Induced Metabolic Changes and Cardiac Function in Patients with Type 2 Diabetes: A Randomized Crossover MRI Study with Insulin as Comparator

Meeting Abstracts

1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes

LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, LIVA S.L. KROGH, ALEXANDER H. SPARRE-ULRICH, BOLETTE HARTMANN, TINA VILSBØLL, MIKKEL B. CHRISTENSEN, JENS J. HOLST, CHRISTINA CHRISTOFFERSEN, FILIP K. KNOP, METTE M. ROSENKILDE

Diabetes 2022;71(Supplement_1):1362-P

https://doi.org/10.2337/db22-1362-P

Published: 01 June 2022

View articletitled, 1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes

Meeting Abstracts

1343-P: The Acute Effects of Glucagon on Glucose Dynamics Are Not Impaired in Individuals with Nonalcoholic Fatty Liver Disease

SASHA KJELDSEN, NICOLE J. JENSEN, MALIN NILSSON, NIKLAS HEINZ, JANUS D. NYBING, FREDERIK H. LINDEN, ERIK HØGH-SCHMIDT, MIKAEL P. BOESEN, STEN MADSBAD, HENDRIK VILSTRUP, SR., FRANK V. SCHIØDT, ANDREAS MØLLER, ELIAS B. RASHU, LISE GLUUD, STEEN B. HAUGAARD, JENS J. HOLST, JOERGEN RUNGBY, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2022;71(Supplement_1):1343-P

https://doi.org/10.2337/db22-1343-P

Published: 01 June 2022

View articletitled, 1343-P: The Acute Effects of Glucagon on Glucose Dynamics Are Not Impaired in Individuals with Nonalcoholic Fatty Liver Disease

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Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis

Glucagon Resistance in Individuals With Obesity and Hepatic Steatosis Can Be Measured Using the GLUSENTIC Test and Index

108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

1620-P: Vagus Nerve Integrity Is Critical for GLP-1 (7-36) Safeness against Hypoglycemia

1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

1651-P: Elevated FGF21 Levels after Total Pancreatectomy and in Response to Single-Dose Glucagon Receptor Antagonism in Humans

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

244-OR: Signs of Glucagon Resistance after a Two-Week Hypercaloric Diet Intervention

1378-P: Habitual High Sodium Intake Is Associated with Alterations in Glucose Homeostasis Including GLP-1 Secretion

The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes

The Liver–α-Cell Axis in Health and in Disease

321-OR: Empagliflozin Improves Beta-Cell Function Independently of Glucose Toxicity in Patients with Type 2 Diabetes

214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

271-OR: Hepatic Glucagon Resistance in Mice with Nonalcoholic Fatty Liver Disease

235-OR: Sustained QTc Prolongation during Recovery from Hypoglycemia in Patients with Type 1 Diabetes

876-P: Empagliflozin-Induced Metabolic Changes and Cardiac Function in Patients with Type 2 Diabetes: A Randomized Crossover MRI Study with Insulin as Comparator

1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes

1343-P: The Acute Effects of Glucagon on Glucose Dynamics Are Not Impaired in Individuals with Nonalcoholic Fatty Liver Disease

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