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Meeting Abstracts

2032-LB: In Vivo Chain Splitting of Human Insulin

JEPPE STURIS, CHRISTIAN CRAMER, CHRISTIAN L. BRAND, HANS HELLEBERG, PETER KURTZHALS, FRANTISEK HUBALEK

Diabetes 2024;73(Supplement_1):2032-LB

https://doi.org/10.2337/db24-2032-LB

Published: 14 June 2024

View article titled, 2032-LB: In Vivo Chain Splitting of Human Insulin

Meeting Abstracts

815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec

FRANTISEK HUBALEK, CHRISTIAN CRAMER, HANS HELLEBERG, EVA JOHANSSON, GERD SCHLUCKEBIER, DORTE B. STEENSGAARD, JEPPE STURIS, THOMAS KJELDSEN

Diabetes 2023;72(Supplement_1):815-P

https://doi.org/10.2337/db23-815-P

Published: 20 June 2023

View article titled, 815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec

Meeting Abstracts

381-P: Recurrent Hypoglycemia Alters Endocrine Counterregulation during Insulin-Induced Hypoglycemia in Healthy and Diabetic Göttingen Minipigs

MILLE KRONBORG LYHNE, KATHRIN HINZ, ANDREAS VEGGE, JEPPE STURIS, JONAS KILDEGAARD, ULRIK PEDERSEN-BJERGAARD, LISBETH HØIER OLSEN

Diabetes 2022;71(Supplement_1):381-P

https://doi.org/10.2337/db22-381-P

Published: 01 June 2022

View article titled, 381-P: Recurrent Hypoglycemia Alters Endocrine Counterregulation during Insulin-Induced Hypoglycemia in Healthy and Diabetic Göttingen Minipigs

Journal Articles

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca²⁺ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K⁺ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A. Zuellig, Giatgen A. Spinas, Per O.G. Arkhammar, Thomas Mandrup-Poulsen, Marc Y. Donath

Diabetes 2004;53(7):1706–1713

https://doi.org/10.2337/diabetes.53.7.1706

Published: 01 July 2004

View article titled, Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Journal Articles

One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

Kristine B. Degn, Claus B. Juhl, Jeppe Sturis, Grethe Jakobsen, Birgitte Brock, Visvanathan Chandramouli, Joergen Rungby, Bernard R. Landau, Ole Schmitz

Diabetes 2004;53(5):1187–1194

https://doi.org/10.2337/diabetes.53.5.1187

Published: 01 May 2004

View article titled, One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

Journal Articles

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K_ATP Channel Opener

Kresten Skak, Carsten F. Gotfredsen, Dorthe Lundsgaard, John Bondo Hansen, Jeppe Sturis, Helle Markholst

Diabetes 2004;53(4):1089–1095

https://doi.org/10.2337/diabetes.53.4.1089

Published: 01 April 2004

View article titled, Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener

Journal Articles

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Richard D. Carr, Christian L. Brand, Thora B. Bodvarsdottir, John B. Hansen, Jeppe Sturis

Diabetes 2003;52(10):2513–2518

https://doi.org/10.2337/diabetes.52.10.2513

Published: 01 October 2003

View article titled, NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Journal Articles

The GLP-1 Derivative NN2211 Restores β-Cell Sensitivity to Glucose in Type 2 Diabetic Patients After a Single Dose

Annette M. Chang, Grethe Jakobsen, Jeppe Sturis, Marla J. Smith, Cathie J. Bloem, Bob An, Andrzej Galecki, Jeffrey B. Halter

Diabetes 2003;52(7):1786–1791

https://doi.org/10.2337/diabetes.52.7.1786

Published: 01 July 2003

View article titled, The GLP-1 Derivative NN2211 Restores β-Cell Sensitivity to Glucose in Type 2 Diabetic Patients After a Single Dose

Journal Articles

Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Claus B. Juhl, Malene Hollingdal, Jeppe Sturis, Grethe Jakobsen, Henrik Agersø, Johannes Veldhuis, Niels Pørksen, Ole Schmitz

Diabetes 2002;51(2):424–429

https://doi.org/10.2337/diabetes.51.2.424

Published: 01 February 2002

View article titled, Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Journal Articles

Changes in Pancreatic Islet Glucokinase and Hexokinase Activities With Increasing Age, Obesity, and the Onset of Diabetes

Brian N Cockburn, Diane M Ostrega, Jeppe Sturis, Christian Kubstrup, Kenneth S Polonsky, Graeme I Bell

Diabetes 1997;46(9):1434–1439

https://doi.org/10.2337/diab.46.9.1434

Published: 01 September 1997

View article titled, Changes in Pancreatic Islet Glucokinase and Hexokinase Activities With Increasing Age, Obesity, and the Onset of Diabetes

Journal Articles

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Maria M Byrne, Jeppe Sturis, Stephan Menzel, Kazuya Yamagata, Stefan S Fajans, Mark J Dronsfield, Stephen C Bain, Andrew T Hattersley, Gilberto Velho, Phillipe Froguel, Graeme I Bell, Kenneth S Polonsky

Diabetes 1996;45(11):1503–1510

https://doi.org/10.2337/diab.45.11.1503

Published: 01 November 1996

View article titled, Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Journal Articles

Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNA^Leu(UUR) Gene Mutation

Gilberto Velho, Maria M Byrne, Karine Clément, Jeppe Sturis, Maria E. Pueyo, Helène Blanché, Nathalie Vionnet, Jean Fiet, Philippe Passa, Jean-Jacques Robert, Kenneth S Polonsky, Philippe Froguel

Diabetes 1996;45(4):478–487

https://doi.org/10.2337/diab.45.4.478

Published: 01 April 1996

View article titled, Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation

Journal Articles

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

Yoshiharu Tokuyama, Jeppe Sturis, Alex M DePaoli, Jun Takeda, Markus Stoffel, Jiping Tang, Xiaohong Sun, Kenneth S Polonsky, Graeme I Bell

Diabetes 1995;44(12):1447–1457

https://doi.org/10.2337/diab.44.12.1447

Published: 01 December 1995

View article titled, Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

Journal Articles

Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20

Maria M Byrne, Jeppe Sturis, Stefan S Fajans, F Javier Ortiz, Anjanette Stoltz, Markus Stoffel, Marla J Smith, Graeme I Bell, Jeffrey B Halter, Kenneth S Polonsky

Diabetes 1995;44(6):699–704

https://doi.org/10.2337/diab.44.6.699

Published: 01 June 1995

View article titled, Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20

Journal Articles

Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes

Edmond A Ryan, Sharleen Imes Imes, Dating Liu, Ruth McManus, Diane T Finegood, Kenneth S Polonsky, Jeppe Sturis

Diabetes 1995;44(5):506–512

https://doi.org/10.2337/diab.44.5.506

Published: 01 May 1995

View article titled, Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes

Journal Articles

Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

Jeppe Sturis, Irwin J Kurland, Marie M Byrne, Erik Mosekilde, Philippe Froguel, Simon J Pilkis, Graeme I Bell, Kenneth S Polonsky

Diabetes 1994;43(5):718–723

https://doi.org/10.2337/diab.43.5.718

Published: 01 May 1994

View article titled, Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

Journal Articles

Abnormal Insulin Secretion, Not Insulin Resistance, Is the Genetic or Primary Defect of MODY in the RW Pedigree

William H Herman, Stefan S Fajans, Francisco J Ortiz, Marla J Smith, Jeppe Sturis, Graeme I Bell, Kenneth S Polonsky, Jeffrey B Halter

Diabetes 1994;43(1):40–46

https://doi.org/10.2337/diab.43.1.40

Published: 01 January 1994

View article titled, Abnormal Insulin Secretion, Not Insulin Resistance, Is the Genetic or Primary Defect of MODY in the RW Pedigree

Journal Articles

Oscillatory Insulin Secretion After Pancreas Transplant

Niall M O′Meara, Jeppe Sturis, John D Blackman, Maria M Byrne, Jonathan B Jaspan, Dianne C Roland, J Richard Thistlethwaite, Kenneth S Polonsky

Diabetes 1993;42(6):855–861

https://doi.org/10.2337/diab.42.6.855

Published: 01 June 1993

View article titled, Oscillatory Insulin Secretion After Pancreas Transplant

Journal Articles

Insulin Secretory Profiles and C-Peptide Clearance Kinetics at 6 Months and 2 Years After Kidney-Pancreas Transplantation

John D Blackman, Kenneth S Polonsky, Jonathan B Jaspan, Jeppe Sturis, Eve Van Cauter, J Richard Thistlethwaite

Diabetes 1992;41(10):1346–1354

https://doi.org/10.2337/diab.41.10.1346

Published: 01 October 1992

View article titled, Insulin Secretory Profiles and C-Peptide Clearance Kinetics at 6 Months and 2 Years After Kidney-Pancreas Transplantation

Journal Articles

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

Eve Van Cauter, Fabienne Mestrez, Jeppe Sturis, Kenneth S Polonsky

Diabetes 1992;41(3):368–377

https://doi.org/10.2337/diab.41.3.368

Published: 01 March 1992

View article titled, Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

NARROW

2032-LB: In Vivo Chain Splitting of Human Insulin

815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec

381-P: Recurrent Hypoglycemia Alters Endocrine Counterregulation during Insulin-Induced Hypoglycemia in Healthy and Diabetic Göttingen Minipigs

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca²⁺ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K⁺ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K_ATP Channel Opener

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

The GLP-1 Derivative NN2211 Restores β-Cell Sensitivity to Glucose in Type 2 Diabetic Patients After a Single Dose

Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Changes in Pancreatic Islet Glucokinase and Hexokinase Activities With Increasing Age, Obesity, and the Onset of Diabetes

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNA^Leu(UUR) Gene Mutation

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

Altered Insulin Secretory Responses to Glucose in Subjects with a Mutation in the MODY1 Gene on Chromosome 20

Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes

Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations

Abnormal Insulin Secretion, Not Insulin Resistance, Is the Genetic or Primary Defect of MODY in the RW Pedigree

Oscillatory Insulin Secretion After Pancreas Transplant

Insulin Secretory Profiles and C-Peptide Clearance Kinetics at 6 Months and 2 Years After Kidney-Pancreas Transplantation

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

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