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Meeting Abstracts

2-OR: Exosomes from Adipose Tissue Macrophages Can Mediate Insulin-Sensitizing Effects of Rosiglitazone

THERESA V. ROHM, FELIPE C.G. REIS, ROI ISAAC, MILES PASZEK, GAUTAM BANDYOPADHYAY, JERROLD M. OLEFSKY

Diabetes 2022;71(Supplement_1):2-OR

DOI: https://doi.org/10.2337/db22-2-OR

Published: 01 June 2022

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Meeting Abstracts

140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects

ALEX DEPAOLI, VAN PHUNG, MUSTAFA R. BASHIR, LINDA MORROW, CARINE BEYSEN, ANDREW YAN, LEI LING, BRYAN BAXTER, KENNETH L. LUSKEY, JERROLD M. OLEFSKY

Diabetes 2019;68(Supplement_1):140-LB

DOI: https://doi.org/10.2337/db19-140-LB

Published: 01 June 2019

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Journal Articles

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance

Joshua Wollam, Matthew Riopel, Yong-Jiang Xu, Andrew M.F. Johnson, Jachelle M. Ofrecio, Wei Ying, Dalila El Ouarrat, Luisa S. Chan, Andrew W. Han, Nadir A. Mahmood, Caitlin N. Ryan, Yun Sok Lee, Jeramie D. Watrous, Mahendra D. Chordia, Dongfeng Pan, Mohit Jain, Jerrold M. Olefsky

Diabetes 2019;68(7):1415–1426

DOI: https://doi.org/10.2337/db18-1307

Published: 22 April 2019

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Includes: Supplementary data

Journal Articles

GPR43 Potentiates β-Cell Function in Obesity

Joanne C. McNelis, Yun Sok Lee, Rafael Mayoral, Rik van der Kant, Andrew M.F. Johnson, Joshua Wollam, Jerrold M. Olefsky

Diabetes 2015;64(9):3203–3217

DOI: https://doi.org/10.2337/db14-1938

Published: 28 May 2015

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Journal Articles

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

Hidetaka Morinaga, Rafael Mayoral, Jan Heinrichsdorff, Olivia Osborn, Niclas Franck, Nasun Hah, Evelyn Walenta, Gautam Bandyopadhyay, Ariane R. Pessentheiner, Tyler J. Chi, Heekyung Chung, Juliane G. Bogner-Strauss, Ronald M. Evans, Jerrold M. Olefsky, Da Young Oh

Diabetes 2015;64(4):1120–1130

DOI: https://doi.org/10.2337/db14-1238

Published: 14 October 2014

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Includes: Supplementary data

Journal Articles

Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats

Jian Jiao, Eun Ju Bae, Gautam Bandyopadhyay, Jason Oliver, Chaitra Marathe, Michael Chen, Jer-Yuan Hsu, Yu Chen, Hui Tian, Jerrold M. Olefsky, Maziyar Saberi

Diabetes 2013;62(4):1074–1083

DOI: https://doi.org/10.2337/db12-0681

Published: 14 March 2013

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Includes: Supplementary data

Journal Articles

Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients

Mohammed Qatanani, Yejun Tan, Radu Dobrin, Danielle M. Greenawalt, Guanghui Hu, Wenqing Zhao, Jerrold M. Olefsky, Dorothy D. Sears, Lee M. Kaplan, Daniel M. Kemp

Diabetes 2013;62(3):855–863

DOI: https://doi.org/10.2337/db12-0399

Published: 14 February 2013

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Includes: Supplementary data

Journal Articles

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

Da Young Oh, Hidetaka Morinaga, Saswata Talukdar, Eun Ju Bae, Jerrold M. Olefsky

Diabetes 2012;61(2):346–354

DOI: https://doi.org/10.2337/db11-0860

Published: 17 January 2012

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Journal Articles

SirT1 Regulates Adipose Tissue Inflammation

Matthew P. Gillum, Maya E. Kotas, Derek M. Erion, Romy Kursawe, Paula Chatterjee, Kevin T. Nead, Eric S. Muise, Jennifer J. Hsiao, David W. Frederick, Shin Yonemitsu, Alexander S. Banks, Li Qiang, Sanjay Bhanot, Jerrold M. Olefsky, Dorothy D. Sears, Sonia Caprio, Gerald I. Shulman

Diabetes 2011;60(12):3235–3245

DOI: https://doi.org/10.2337/db11-0616

Published: 13 November 2011

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Includes: Supplementary data

Journal Articles

FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue

Jane J. Kim, Pingping Li, Jessica Huntley, Jeffrey P. Chang, Karen C. Arden, Jerrold M. Olefsky

Diabetes 2009;58(6):1275–1282

DOI: https://doi.org/10.2337/db08-1001

Published: 16 March 2009

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Includes: Supplementary data

Journal Articles

Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity

Chloé C. Féral, Jaap G. Neels, Christiane Kummer, Marina Slepak, Jerrold M. Olefsky, Mark H. Ginsberg

Diabetes 2008;57(7):1842–1851

DOI: https://doi.org/10.2337/db07-1751

Published: 01 July 2008

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Includes: Supplementary data

Journal Articles

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Gautam K. Bandyopadhyay, Joseph G. Yu, Jachelle Ofrecio, Jerrold M. Olefsky

Diabetes 2006;55(8):2277–2285

DOI: https://doi.org/10.2337/db06-0062

Published: 01 August 2006

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Journal Articles

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

Hiroaki Satoh, M.T. Audrey Nguyen, Maria Trujillo, Takeshi Imamura, Isao Usui, Philipp E. Scherer, Jerrold M. Olefsky

Diabetes 2005;54(5):1304–1313

DOI: https://doi.org/10.2337/diabetes.54.5.1304

Published: 01 May 2005

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Journal Articles

Inhibition of Mitochondrial Na⁺-Ca²⁺ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Bumsup Lee, Philip D. Miles, Leonardo Vargas, Peng Luan, Susan Glasco, Yulia Kushnareva, Elisabeth S. Kornbrust, Kathryn A. Grako, Claes B. Wollheim, Pierre Maechler, Jerrold M. Olefsky, Christen M. Anderson

Diabetes 2003;52(4):965–973

DOI: https://doi.org/10.2337/diabetes.52.4.965

Published: 01 April 2003

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Journal Articles

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance

Hong Ruan, Philip D. G. Miles, Christine M. Ladd, Kenneth Ross, Todd R. Golub, Jerrold M. Olefsky, Harvey F. Lodish

Diabetes 2002;51(11):3176–3188

DOI: https://doi.org/10.2337/diabetes.51.11.3176

Published: 01 November 2002

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Includes: Supplementary data

Journal Articles

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

Joseph G. Yu, Sandrine Javorschi, Andrea L. Hevener, Yolanta T. Kruszynska, Rodney A. Norman, Madhur Sinha, Jerrold M. Olefsky

Diabetes 2002;51(10):2968–2974

DOI: https://doi.org/10.2337/diabetes.51.10.2968

Published: 01 October 2002

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Journal Articles

Decreased Susceptibility to Fatty Acid–Induced Peripheral Tissue Insulin Resistance in Women

Juan P. Frias, Gina B. Macaraeg, Jachelle Ofrecio, Joseph G. Yu, Jerrold M. Olefsky, Yolanta T. Kruszynska

Diabetes 2001;50(6):1344–1350

DOI: https://doi.org/10.2337/diabetes.50.6.1344

Published: 01 June 2001

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Journal Articles

Exercise-Stimulated Glucose Turnover in the Rat Is Impaired by Glucosamine Infusion

Philip D.G. Miles, Katsuya Higo, Jerrold M. Olefsky

Diabetes 2001;50(1):139–142

DOI: https://doi.org/10.2337/diabetes.50.1.139

Published: 01 January 2001

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Journal Articles

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

Philip D G Miles, Oreste M Romeo, Katsuya Higo, Aaron Cohen, Karim Rafaat, Jerrold M Olefsky

Diabetes 1997;46(11):1678–1683

DOI: https://doi.org/10.2337/diab.46.11.1678

Published: 01 November 1997

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Journal Articles

Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion

Yolanta T Kruszynska, Mim I Mulford, Joseph G Yu, Debra A Armstrong, Jerrold M Olefsky

Diabetes 1997;46(10):1586–1593

DOI: https://doi.org/10.2337/diacare.46.10.1586

Published: 01 October 1997

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2 3 4

NARROW

2-OR: Exosomes from Adipose Tissue Macrophages Can Mediate Insulin-Sensitizing Effects of Rosiglitazone

140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance

GPR43 Potentiates β-Cell Function in Obesity

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats

Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

SirT1 Regulates Adipose Tissue Inflammation

FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue

Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

Inhibition of Mitochondrial Na⁺-Ca²⁺ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

Decreased Susceptibility to Fatty Acid–Induced Peripheral Tissue Insulin Resistance in Women

Exercise-Stimulated Glucose Turnover in the Rat Is Impaired by Glucosamine Infusion

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion

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