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Jessica Tyrrell
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Meeting Abstracts

190-LB: Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects

SUSAN MARTIN, JESSICA TYRRELL, ELIZABETH L. THOMAS, MATTHEW BOWN, JAMES T. ELDER, CHRISTOPHER KABRHEL, NIKOS PAPADIMITRIOU, MARC GUNTER, EMMA E. VINCENT, JIMMY D. BELL, TIMOTHY M. FRAYLING, HANIEH YAGHOOTKAR
Journal: Diabetes
Diabetes 2021;70(Supplement_1):190-LB
https://doi.org/10.2337/db21-190-LB
Published: 01 June 2021
View articletitled, 190-LB: Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects
Journal Articles

Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease

Susan Martin, Madeleine Cule, Nicolas Basty, Jessica Tyrrell, Robin N. Beaumont, Andrew R. Wood, Timothy M. Frayling, Elena Sorokin, Brandon Whitcher, Yi Liu, Jimmy D. Bell, E. Louise Thomas, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2021;70(8):1843–1856
https://doi.org/10.2337/db21-0129
Published: 12 May 2021
View articletitled, Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease
Open the PDF for Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease in another window
Journal Articles

A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function

Francesco Casanova, Andrew R. Wood, Hanieh Yaghootkar, Robert N. Beaumont, Samuel E. Jones, Kim M. Gooding, Kunihiko Aizawa, W. David Strain, Andrew T. Hattersley, Faisel Khan, Angela C. Shore, Timothy M. Frayling, Jessica Tyrrell
Journal: Diabetes
Diabetes 2020;69(5):1072–1082
https://doi.org/10.2337/db19-0862
Published: 08 January 2020
View articletitled, A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Open the PDF for A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function in another window
Includes: Supplementary data
Journal Articles

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Yingjie Ji, Andrianos M. Yiorkas, Francesca Frau, Dennis Mook-Kanamori, Harald Staiger, E. Louise Thomas, Naeimeh Atabaki-Pasdar, Archie Campbell, Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont, Andrew R. Wood, Marcus A. Tuke, Katherine S. Ruth, Anubha Mahajan, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Andrew T. Hattersley, Caroline Hayward, Jürgen Machann, Hans-Ulrich Häring, Paul Franks, Renée de Mutsert, Ewan Pearson, Norbert Stefan, Timothy M. Frayling, Karla V. Allebrandt, Jimmy D. Bell, Alexandra I. Blakemore, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2019;68(1):207–219
https://doi.org/10.2337/db18-0708
Published: 23 October 2018
View articletitled, Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Open the PDF for Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension in another window
Includes: Supplementary data
Meeting Abstracts

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes

HANIEH YAGHOOTKAR, YINGJIE JI, ANDRIANOS M. YIORKAS, FRANCESCA FRAU, DENNIS MOOK-KANAMORI, RENÉE DE MUTSERT, JESSICA TYRRELL, SAMUEL E. JONES, ROBERT BEAUMONT, ANDREW R. WOOD, LOUISE THOMAS, KARLA V. ALLEBRANDT, NORBERT STEFAN, HARALD STAIGER, EWAN PEARSON, ALEX I. BLAKEMORE, JIMMY D. BELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):20-OR
https://doi.org/10.2337/db18-20-OR
Published: 01 July 2018
View articletitled, Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes
Meeting Abstracts

Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity

ANDREW R. WOOD, SAMUEL E. JONES, REBECCA RICHMOND, SHAFQAT AHMAD, HANIEH YAGHOOTKAR, ROBERT BEAUMONT, KATHERINE S. RUTH, MARCUS TUKE, ANNA MURRAY, RACHEL M. FREATHY, GEORGE DAVEY SMITH, I-MIN LEE, NIC TIMPSON, DANIEL CHASMAN, ZOLTAN KUTALIK, MICHAEL N. WEEDON, JESSICA TYRRELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):23-OR
https://doi.org/10.2337/db18-23-OR
Published: 01 July 2018
View articletitled, Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity
Journal Articles

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

Hanieh Yaghootkar, Luca A. Lotta, Jessica Tyrrell, Roelof A.J. Smit, Sam E. Jones, Louise Donnelly, Robin Beaumont, Archie Campbell, Marcus A. Tuke, Caroline Hayward, Katherine S. Ruth, Sandosh Padmanabhan, J. Wouter Jukema, Colin C. Palmer, Andrew Hattersley, Rachel M. Freathy, Claudia Langenberg, Nicholas J. Wareham, Andrew R. Wood, Anna Murray, Michael N. Weedon, Naveed Sattar, Ewan Pearson, Robert A. Scott, Timothy M. Frayling
Journal: Diabetes
Diabetes 2016;65(8):2448–2460
https://doi.org/10.2337/db15-1671
Published: 26 April 2016
View articletitled, Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Open the PDF for Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease in another window
Includes: Supplementary data