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Meeting Abstracts

88-LB: Safety, PK, PD, and Efficacy of Weekly Dosing Supaglutide in Patients with T2D

YUE ZHOU, XIN JIANG, YAN-RU LOU, ANRAN MA, JIA LI, YING ZHAO, GERALD J. PRUD’HOMME, QINGHUA WANG

Diabetes 2022;71(Supplement_1):88-LB

DOI: https://doi.org/10.2337/db22-88-LB

Published: 01 June 2022

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Meeting Abstracts

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

ANRAN MA, YUE ZHOU, YAN-RU LOU, YIJING LIAO, ANNA SHAO, ZHIHONG WANG, YAOJING JIANG, QIAOLI CUI, YING ZHAO, JIA LI, GERALD J. PRUD’HOMME, DALONG ZHU, QINGHUA WANG

Diabetes 2022;71(Supplement_1):93-LB

DOI: https://doi.org/10.2337/db22-93-LB

Published: 01 June 2022

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Journal Articles

DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

Lin Shuai, Bo-Han Li, Hao-Wen Jiang, Lin Yang, Jia Li, Jing-Ya Li

Diabetes 2021;70(6):1317–1333

DOI: https://doi.org/10.2337/db20-1110

Published: 01 April 2021

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Meeting Abstracts

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

JIA LI, MADHAVI JAGDISH RANE, LU CAI, YI TAN

Diabetes 2020;69(Supplement_1):473-P

DOI: https://doi.org/10.2337/db20-473-P

Published: 01 June 2020

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Meeting Abstracts

1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

QIAN LIN, GENXIANG CAI, ZHENGSHUAI LIU, JINGYA LI, JIA LI, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YU LI, YI TAN

Diabetes 2020;69(Supplement_1):1831-P

DOI: https://doi.org/10.2337/db20-1831-P

Published: 01 June 2020

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Meeting Abstracts

1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

HAOWEN JIANG, JIA LI

Diabetes 2020;69(Supplement_1):1849-P

DOI: https://doi.org/10.2337/db20-1849-P

Published: 01 June 2020

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Journal Articles

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li

Diabetes 2019;68(12):2197–2209

DOI: https://doi.org/10.2337/db19-0589

Published: 30 August 2019

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Includes: Supplementary data

Meeting Abstracts

2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis

LIN SHUAI, JIA LI, JINGYA LI

Diabetes 2019;68(Supplement_1):2044-P

DOI: https://doi.org/10.2337/db19-2044-P

Published: 01 June 2019

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Meeting Abstracts

32-OR: Coordination of Mitochondrial Uncoupling with Pyruvate Dehydrogenase Activation Safely Ameliorates Hyperglycemia through Preferential Glucose Oxidation

HAOWEN JIANG, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):32-OR

DOI: https://doi.org/10.2337/db19-32-OR

Published: 01 June 2019

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Meeting Abstracts

2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

YUTING LU, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):2129-P

DOI: https://doi.org/10.2337/db19-2129-P

Published: 01 June 2019

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Meeting Abstracts

1776-P: Gut Microbiota Remodeling and Intestinal FXR Inhibition Mediate the Antimetabolic Syndrome Properties of Gynostemma Pentaphyllum

ZHIFU XIE, LIHONG HU, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):1776-P

DOI: https://doi.org/10.2337/db19-1776-P

Published: 01 June 2019

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Meeting Abstracts

1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion

YILI SUN, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):1788-P

DOI: https://doi.org/10.2337/db19-1788-P

Published: 01 June 2019

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Journal Articles

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

Lin Shuai, Li-Na Zhang, Bo-Han Li, Chun-Lan Tang, Ling-Yan Wu, Jia Li, Jing-Ya Li

Diabetes 2019;68(7):1449–1461

DOI: https://doi.org/10.2337/db18-1103

Published: 22 April 2019

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Includes: Supplementary data

Journal Articles

Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Peng-Fei Ma, Jie Jiang, Chang Gao, Pan-Pan Cheng, Jia-Li Li, Xin Huang, Ying-Ying Lin, Qing Li, Yuan-Zheng Peng, Mei-Chun Cai, Wei Shao, Qi Zhu, Sai Han, Qing Qin, Jun-Jie Xia, Zhong-Quan Qi

Diabetes 2014;63(10):3458–3469

DOI: https://doi.org/10.2337/db14-0012

Published: 15 September 2014

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Journal Articles

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Li-Na Zhang, Hua-Yong Zhou, Yan-Yun Fu, Yuan-Yuan Li, Fang Wu, Min Gu, Ling-Yan Wu, Chun-Mei Xia, Tian-Cheng Dong, Jing-Ya Li, Jing-Kang Shen, Jia Li

Diabetes 2013;62(4):1297–1307

DOI: https://doi.org/10.2337/db12-0703

Published: 14 March 2013

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Includes: Supplementary data

Journal Articles

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

Fei Xiao, Zhiying Huang, Houkai Li, Junjie Yu, Chunxia Wang, Shanghai Chen, Qingshu Meng, Ying Cheng, Xiang Gao, Jia Li, Yong Liu, Feifan Guo

Diabetes 2011;60(3):746–756

DOI: https://doi.org/10.2337/db10-1246

Published: 21 February 2011

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Includes: Supplementary data

Journal Articles

High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

Bei-Ying Qiu, Nigel Turner, Yuan-Yuan Li, Min Gu, Meng-Wei Huang, Fang Wu, Tao Pang, Fa-Jun Nan, Ji-Ming Ye, Jing-Ya Li, Jia Li

Diabetes 2010;59(1):256–265

DOI: https://doi.org/10.2337/db09-0223

Published: 15 October 2009

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Includes: Supplementary data

Journal Articles

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W.C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, Ji-Ming Ye

Diabetes 2008;57(5):1414–1418

DOI: https://doi.org/10.2337/db07-1552

Published: 01 May 2008

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Includes: Supplementary data

Journal Articles

Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis

Adam Kretowski, Kim McFann, John E. Hokanson, David Maahs, Gregory Kinney, Janet K. Snell-Bergeon, R. Paul Wadwa, Robert H. Eckel, Lorraine Ogden, Satish Garg, Jia Li, Suzanne Cheng, Henry A. Erlich, Marian Rewers

Diabetes 2007;56(3):863–871

DOI: https://doi.org/10.2337/db06-1321

Published: 01 March 2007

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Includes: Supplementary data

NARROW

88-LB: Safety, PK, PD, and Efficacy of Weekly Dosing Supaglutide in Patients with T2D

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis

32-OR: Coordination of Mitochondrial Uncoupling with Pyruvate Dehydrogenase Activation Safely Ameliorates Hyperglycemia through Preferential Glucose Oxidation

2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

1776-P: Gut Microbiota Remodeling and Intestinal FXR Inhibition Mediate the Antimetabolic Syndrome Properties of Gynostemma Pentaphyllum

1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis

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