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Meeting Abstracts

1640-P: Targeting Cathepsin L for Liver Fibrosis—Mechanistic Insights and Therapeutic Potential in a Diabetic Mouse Model

MING-JIA LI, MIAOMIAO ZHAO, JIN-KUI YANG

Diabetes 2024;74(Supplement_1):1640-P

https://doi.org/10.2337/db25-1640-P

Published: 20 June 2025

View articletitled, 1640-P: Targeting Cathepsin L for Liver Fibrosis—Mechanistic Insights and Therapeutic Potential in a Diabetic Mouse Model

Meeting Abstracts

1782-LB: Treatment Efficacy of Diabetic Kidney Disease with a Novel Specific Cathepsin L Inhibitor

MIAOMIAO ZHAO, MING-JIA LI, XIAO-YA LI, JIN-KUI YANG

Diabetes 2024;73(Supplement_1):1782-LB

https://doi.org/10.2337/db24-1782-LB

Published: 14 June 2024

View articletitled, 1782-LB: Treatment Efficacy of Diabetic Kidney Disease with a Novel Specific Cathepsin L Inhibitor

Meeting Abstracts

842-P: Development of Long-Acting GLP-1 Receptor Antagonist for the Treatment of Congenital Hyperinsulinism

YUE YUAN, HAOWEN JIANG, SHI MENG, DONGNA HAN, QIUSHA ZHU, MANCHEN WANG, HUSHAN LI, JIA LI, CHANGHONG LI

Diabetes 2023;72(Supplement_1):842-P

https://doi.org/10.2337/db23-842-P

Published: 20 June 2023

View articletitled, 842-P: Development of Long-Acting GLP-1 Receptor Antagonist for the Treatment of Congenital Hyperinsulinism

Meeting Abstracts

1351-P: Caffeine Intake Is Associated with a Lower Risk of Nonalcoholic Fatty Liver Disease–Related Fibrosis in Patients with Type 2 Diabetes

JIAHAO HAN, CHUAN LIU, HUANHUAN YANG, RUIXIA GAO, ZHIHUI LI, JIA LI, XIAOLONG QI

Diabetes 2023;72(Supplement_1):1351-P

https://doi.org/10.2337/db23-1351-P

Published: 20 June 2023

View articletitled, 1351-P: Caffeine Intake Is Associated with a Lower Risk of Nonalcoholic Fatty Liver Disease–Related Fibrosis in Patients with Type 2 Diabetes

Meeting Abstracts

1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

CHANG SU, DONGNA HAN, SHI MENG, QIUSHA ZHU, XUE ZHOU, HAOWEN JIANG, JIA LI, CHUNXIU GONG, CHANGHONG LI

Diabetes 2023;72(Supplement_1):1581-P

https://doi.org/10.2337/db23-1581-P

Published: 20 June 2023

View articletitled, 1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

Meeting Abstracts

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

ANRAN MA, YUE ZHOU, YAN-RU LOU, YIJING LIAO, ANNA SHAO, ZHIHONG WANG, YAOJING JIANG, QIAOLI CUI, YING ZHAO, JIA LI, GERALD J. PRUD’HOMME, DALONG ZHU, QINGHUA WANG

Diabetes 2022;71(Supplement_1):93-LB

https://doi.org/10.2337/db22-93-LB

Published: 01 June 2022

View articletitled, 93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

Meeting Abstracts

88-LB: Safety, PK, PD, and Efficacy of Weekly Dosing Supaglutide in Patients with T2D

YUE ZHOU, XIN JIANG, YAN-RU LOU, ANRAN MA, JIA LI, YING ZHAO, GERALD J. PRUD’HOMME, QINGHUA WANG

Diabetes 2022;71(Supplement_1):88-LB

https://doi.org/10.2337/db22-88-LB

Published: 01 June 2022

View articletitled, 88-LB: Safety, PK, PD, and Efficacy of Weekly Dosing Supaglutide in Patients with T2D

Journal Articles

DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

Lin Shuai, Bo-Han Li, Hao-Wen Jiang, Lin Yang, Jia Li, Jing-Ya Li

Diabetes 2021;70(6):1317–1333

https://doi.org/10.2337/db20-1110

Published: 01 April 2021

View articletitled, DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

Meeting Abstracts

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

JIA LI, MADHAVI JAGDISH RANE, LU CAI, YI TAN

Diabetes 2020;69(Supplement_1):473-P

https://doi.org/10.2337/db20-473-P

Published: 01 June 2020

View articletitled, 473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

Meeting Abstracts

1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

QIAN LIN, GENXIANG CAI, ZHENGSHUAI LIU, JINGYA LI, JIA LI, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YU LI, YI TAN

Diabetes 2020;69(Supplement_1):1831-P

https://doi.org/10.2337/db20-1831-P

Published: 01 June 2020

View articletitled, 1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

Meeting Abstracts

1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

HAOWEN JIANG, JIA LI

Diabetes 2020;69(Supplement_1):1849-P

https://doi.org/10.2337/db20-1849-P

Published: 01 June 2020

View articletitled, 1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

Journal Articles

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li

Diabetes 2019;68(12):2197–2209

https://doi.org/10.2337/db19-0589

Published: 30 August 2019

View articletitled, Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

Includes: Supplementary data

Meeting Abstracts

32-OR: Coordination of Mitochondrial Uncoupling with Pyruvate Dehydrogenase Activation Safely Ameliorates Hyperglycemia through Preferential Glucose Oxidation

HAOWEN JIANG, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):32-OR

https://doi.org/10.2337/db19-32-OR

Published: 01 June 2019

View articletitled, 32-OR: Coordination of Mitochondrial Uncoupling with Pyruvate Dehydrogenase Activation Safely Ameliorates Hyperglycemia through Preferential Glucose Oxidation

Meeting Abstracts

2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

YUTING LU, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):2129-P

https://doi.org/10.2337/db19-2129-P

Published: 01 June 2019

View articletitled, 2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

Meeting Abstracts

1776-P: Gut Microbiota Remodeling and Intestinal FXR Inhibition Mediate the Antimetabolic Syndrome Properties of Gynostemma Pentaphyllum

ZHIFU XIE, LIHONG HU, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):1776-P

https://doi.org/10.2337/db19-1776-P

Published: 01 June 2019

View articletitled, 1776-P: Gut Microbiota Remodeling and Intestinal FXR Inhibition Mediate the Antimetabolic Syndrome Properties of Gynostemma Pentaphyllum

Meeting Abstracts

1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion

YILI SUN, JINGYA LI, JIA LI

Diabetes 2019;68(Supplement_1):1788-P

https://doi.org/10.2337/db19-1788-P

Published: 01 June 2019

View articletitled, 1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion

Meeting Abstracts

2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis

LIN SHUAI, JIA LI, JINGYA LI

Diabetes 2019;68(Supplement_1):2044-P

https://doi.org/10.2337/db19-2044-P

Published: 01 June 2019

View articletitled, 2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis

Journal Articles

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

Lin Shuai, Li-Na Zhang, Bo-Han Li, Chun-Lan Tang, Ling-Yan Wu, Jia Li, Jing-Ya Li

Diabetes 2019;68(7):1449–1461

https://doi.org/10.2337/db18-1103

Published: 22 April 2019

View articletitled, SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

Includes: Supplementary data

Journal Articles

Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Peng-Fei Ma, Jie Jiang, Chang Gao, Pan-Pan Cheng, Jia-Li Li, Xin Huang, Ying-Ying Lin, Qing Li, Yuan-Zheng Peng, Mei-Chun Cai, Wei Shao, Qi Zhu, Sai Han, Qing Qin, Jun-Jie Xia, Zhong-Quan Qi

Diabetes 2014;63(10):3458–3469

https://doi.org/10.2337/db14-0012

Published: 15 September 2014

View articletitled, Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Journal Articles

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Li-Na Zhang, Hua-Yong Zhou, Yan-Yun Fu, Yuan-Yuan Li, Fang Wu, Min Gu, Ling-Yan Wu, Chun-Mei Xia, Tian-Cheng Dong, Jing-Ya Li, Jing-Kang Shen, Jia Li

Diabetes 2013;62(4):1297–1307

https://doi.org/10.2337/db12-0703

Published: 14 March 2013

View articletitled, Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Includes: Supplementary data

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1640-P: Targeting Cathepsin L for Liver Fibrosis—Mechanistic Insights and Therapeutic Potential in a Diabetic Mouse Model

1782-LB: Treatment Efficacy of Diabetic Kidney Disease with a Novel Specific Cathepsin L Inhibitor

842-P: Development of Long-Acting GLP-1 Receptor Antagonist for the Treatment of Congenital Hyperinsulinism

1351-P: Caffeine Intake Is Associated with a Lower Risk of Nonalcoholic Fatty Liver Disease–Related Fibrosis in Patients with Type 2 Diabetes

1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects

88-LB: Safety, PK, PD, and Efficacy of Weekly Dosing Supaglutide in Patients with T2D

DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

1849-P: Fructose Induces Hepatic Steatosis via ME1-Mediated Cytosolic Redox Status

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

32-OR: Coordination of Mitochondrial Uncoupling with Pyruvate Dehydrogenase Activation Safely Ameliorates Hyperglycemia through Preferential Glucose Oxidation

2129-P: DAP-Related Apoptosis-Inducing Kinase-2 Negatively Regulate Islet Beta-Cell Function by Autophagy Repression

1776-P: Gut Microbiota Remodeling and Intestinal FXR Inhibition Mediate the Antimetabolic Syndrome Properties of Gynostemma Pentaphyllum

1788-P: The Natural Product ZYM01 Exerts Antidiabetic and Islet-Protective Effects in Diabetic Mice and Promotes Glucagon-Like Peptide-1 Secretion

2044-P: Histone Methyltransferase DOT1L Regulates Brown Adipocyte Differentiation and Thermogenesis

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue

Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

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