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Meeting Abstracts

2492-PUB: KCNK16 Deficiency Protects Mice against High-Fat Diet-Induced Weight Gain

Free
SEBASTIAN BRACHS, UWE SCHWAHN, KLAUS STEINMEYER, MATTHIAS SCHÄFER, JOHANN GASSENHUBER, JOACHIM SPRANGER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2492-PUB
https://doi.org/10.2337/db19-2492-PUB
Published: 01 June 2019
View articletitled, 2492-PUB: KCNK16 Deficiency Protects Mice against High-Fat Diet-Induced Weight Gain
Journal Articles

Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance

Free
Sebastian Brachs, James Polack, Maria Brachs, Kerstin Jahn-Hofmann, Ralf Elvert, Anja Pfenninger, Felix Bärenz, Daniel Margerie, Knut Mai, Joachim Spranger, Aimo Kannt
Journal: Diabetes
Diabetes 2019;68(3):527–542
https://doi.org/10.2337/db18-0780
Published: 14 December 2018
View articletitled, Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance
Open the PDF for Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance in another window
Includes: Supplementary data
Journal Articles

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

Free
Knut Mai, Linna Li, Susanna Wiegand, Maria Brachs, Verena Leupelt, Andrea Ernert, Peter Kühnen, Norbert Hübner, Peter Robinson, Wei Chen, Heiko Krude, Joachim Spranger
Journal: Diabetes
Diabetes 2019;68(1):57–65
https://doi.org/10.2337/db18-0440
Published: 02 November 2018
View articletitled, An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance
Open the PDF for An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance in another window
Includes: Supplementary data
Meeting Abstracts

Genetic Nicotinamide N-Methyltransferase Deficiency Improves Insulin Sensitivity in DIO Mice

Free
SEBASTIAN BRACHS, JAMES POLACK, MARIA BRACHS, KERSTIN JAHN-HOFMANN, RALF ELVERT, ANJA PFENNINGER, FELIX BÄRENZ, DANIEL MARGERIE, SR., KNUT MAI, AIMO KANNT, JOACHIM SPRANGER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2030-P
https://doi.org/10.2337/db18-2030-P
Published: 01 July 2018
View articletitled, Genetic Nicotinamide N-Methyltransferase Deficiency Improves Insulin Sensitivity in DIO Mice
Journal Articles

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Open Access
Antigone S. Dimas, Vasiliki Lagou, Adam Barker, Joshua W. Knowles, Reedik Mägi, Marie-France Hivert, Andrea Benazzo, Denis Rybin, Anne U. Jackson, Heather M. Stringham, Ci Song, Antje Fischer-Rosinsky, Trine Welløv Boesgaard, Niels Grarup, Fahim A. Abbasi, Themistocles L. Assimes, Ke Hao, Xia Yang, Cécile Lecoeur, Inês Barroso, Lori L. Bonnycastle, Yvonne Böttcher, Suzannah Bumpstead, Peter S. Chines, Michael R. Erdos, Jurgen Graessler, Peter Kovacs, Mario A. Morken, Narisu Narisu, Felicity Payne, Alena Stancakova, Amy J. Swift, Anke Tönjes, Stefan R. Bornstein, Stéphane Cauchi, Philippe Froguel, David Meyre, Peter E.H. Schwarz, Hans-Ulrich Häring, Ulf Smith, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Thomas Quertemous, Lars Lind, Torben Hansen, Oluf Pedersen, Mark Walker, Andreas F.H. Pfeiffer, Joachim Spranger, Michael Stumvoll, James B. Meigs, Nicholas J. Wareham, Johanna Kuusisto, Markku Laakso, Claudia Langenberg, Josée Dupuis, Richard M. Watanabe, Jose C. Florez, Erik Ingelsson, Mark I. McCarthy, Inga Prokopenko, on behalf of the MAGIC Investigators
Journal: Diabetes
Diabetes 2014;63(6):2158–2171
https://doi.org/10.2337/db13-0949
Published: 15 May 2014
View articletitled, Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
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Includes: Supplementary data
Journal Articles

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Open Access
Kirk M. Habegger, Kerstin Stemmer, Christine Cheng, Timo D. Müller, Kristy M. Heppner, Nickki Ottaway, Jenna Holland, Jazzminn L. Hembree, David Smiley, Vasily Gelfanov, Radha Krishna, Ayman M. Arafat, Anish Konkar, Sara Belli, Martin Kapps, Stephen C. Woods, Susanna M. Hofmann, David D’Alessio, Paul T. Pfluger, Diego Perez-Tilve, Randy J. Seeley, Morichika Konishi, Nobuyujki Itoh, Alexei Kharitonenkov, Joachim Spranger, Richard D. DiMarchi, Matthias H. Tschöp
Journal: Diabetes
Diabetes 2013;62(5):1453–1463
https://doi.org/10.2337/db12-1116
Published: 16 April 2013
View articletitled, Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
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Includes: Supplementary data
Journal Articles

Caloric Restriction Chronically Impairs Metabolic Programming in Mice

Open Access
Henriette Kirchner, Susanna M. Hofmann, Antje Fischer-Rosinský, Jazzminn Hembree, William Abplanalp, Nickki Ottaway, Elizabeth Donelan, Radha Krishna, Stephen C. Woods, Timo D. Müller, Joachim Spranger, Diego Perez-Tilve, Paul T. Pfluger, Matthias H. Tschöp, Kirk M. Habegger
Journal: Diabetes
Diabetes 2012;61(11):2734–2742
https://doi.org/10.2337/db11-1621
Published: 16 October 2012
View articletitled, Caloric Restriction Chronically Impairs Metabolic Programming in Mice
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Includes: Supplementary data
Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

Open Access
Özlem Gögebakan, Janin Andres, Katrin Biedasek, Knut Mai, Peter Kühnen, Heiko Krude, Frank Isken, Natalia Rudovich, Martin A. Osterhoff, Ulrich Kintscher, Michael Nauck, Andreas F.H. Pfeiffer, Joachim Spranger
Journal: Diabetes
Diabetes 2012;61(2):292–300
https://doi.org/10.2337/db10-0902
Published: 17 January 2012
View articletitled, Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Open the PDF for Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids in another window
Includes: Supplementary data
Journal Articles

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

Open Access
Robin Winkler, Verena Benz, Markus Clemenz, Mandy Bloch, Anna Foryst-Ludwig, Sami Wardat, Nicole Witte, Manuela Trappiel, Pawel Namsolleck, Knut Mai, Joachim Spranger, Gabriele Matthias, Tim Roloff, Oliver Truee, Kai Kappert, Michael Schupp, Patrick Matthias, Ulrich Kintscher
Journal: Diabetes
Diabetes 2012;61(2):513–523
https://doi.org/10.2337/db11-0313
Published: 17 January 2012
View articletitled, Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
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Journal Articles

Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21

Open Access
Knut Mai, Janin Andres, Katrin Biedasek, Jessica Weicht, Thomas Bobbert, Markus Sabath, Sabine Meinus, Franziska Reinecke, Matthias Möhlig, Martin O. Weickert, Markus Clemenz, Andreas F.H. Pfeiffer, Ulrich Kintscher, Simone Spuler, Joachim Spranger
Journal: Diabetes
Diabetes 2009;58(7):1532–1538
https://doi.org/10.2337/db08-1775
Published: 28 April 2009
View articletitled, Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
Open the PDF for Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21 in another window
Journal Articles

Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels

Free
Andrea Henze, Simone K. Frey, Jens Raila, Martin Tepel, Alexandra Scholze, Andreas F. H. Pfeiffer, Martin O. Weickert, Joachim Spranger, Florian J. Schweigert
Journal: Diabetes
Diabetes 2008;57(12):3323–3326
https://doi.org/10.2337/db08-0866
Published: 01 December 2008
View articletitled, Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
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Journal Articles

IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies

Free
Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, Johanna K. Wolford, Birgit Langer, Barbara Thorand, Norman Klopp, Yasmin H. Hamid, Oluf Pedersen, Torben Hansen, Valeriya Lyssenko, Leif Groop, Christa Meisinger, Angela Döring, Hannelore Löwel, Wolfgang Lieb, Christian Hengstenberg, Wolfgang Rathmann, Stephan Martin, Jeffrey W. Stephens, Helen Ireland, Hugh Mather, George J. Miller, Heather M. Stringham, Michael Boehnke, Jaakko Tuomilehto, Heiner Boeing, Matthias Möhlig, Joachim Spranger, Andreas Pfeiffer, Ingrid Wernstedt, Anders Niklason, Abel López-Bermejo, José-Manuel Fernández-Real, Robert L. Hanson, Luis Gallart, Joan Vendrell, Anastasia Tsiavou, Erifili Hatziagelaki, Steve E. Humphries, H.-Erich Wichmann, Christian Herder, Thomas Illig
Journal: Diabetes
Diabetes 2006;55(10):2915–2921
https://doi.org/10.2337/db06-0600
Published: 01 October 2006
View articletitled, IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies
Open the PDF for IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies in another window
Includes: Supplementary data
Journal Articles

Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells

Free
Joachim Spranger, Sulekha Verma, Isabel Göhring, Thomas Bobbert, Joseph Seifert, Amy L. Sindler, Andreas Pfeiffer, Stanley M. Hileman, Matthias Tschöp, William A. Banks
Journal: Diabetes
Diabetes 2006;55(1):141–147
https://doi.org/10.2337/diabetes.55.01.06.db05-1077
Published: 01 January 2006
View articletitled, Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells
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Journal Articles

Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction

Free
Thomas Bobbert, Helmut Rochlitz, Uta Wegewitz, Suzan Akpulat, Knut Mai, Martin O. Weickert, Matthias Möhlig, Andreas F.H. Pfeiffer, Joachim Spranger
Journal: Diabetes
Diabetes 2005;54(9):2712–2719
https://doi.org/10.2337/diabetes.54.9.2712
Published: 01 September 2005
View articletitled, Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
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Journal Articles

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

Free
Joachim Spranger, Anja Kroke, Matthias Möhlig, Kurt Hoffmann, Manuela M. Bergmann, Michael Ristow, Heiner Boeing, Andreas F.H. Pfeiffer
Journal: Diabetes
Diabetes 2003;52(3):812–817
https://doi.org/10.2337/diabetes.52.3.812
Published: 01 March 2003
View articletitled, Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Open the PDF for Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study in another window
Journal Articles

Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease

Free
Joachim Spranger, Martin Osterhoff, Manja Reimann, Matthias Möhlig, Michael Ristow, Mary Kay Francis, Vincent Cristofalo, Hans-Peter Hammes, Gillian Smith, Michael Boulton, Andreas F.H. Pfeiffer
Journal: Diabetes
Diabetes 2001;50(12):2641–2645
https://doi.org/10.2337/diabetes.50.12.2641
Published: 01 December 2001
View articletitled, Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease
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Journal Articles

Growth Factor Alterations in Advanced Diabetic Retinopathy: A Possible Role of Blood Retina Barrier Breakdown

Free
Andreas Pfeiffer, Joachim Spranger, Rolf Meyer-Schwickerath, Helmut Schatz
Journal: Diabetes
Diabetes 1997;46(Supplement_2):S26–S30
https://doi.org/10.2337/diab.46.2.S26
Published: 01 September 1997
View articletitled, Growth Factor Alterations in Advanced Diabetic Retinopathy: A Possible Role of Blood Retina Barrier Breakdown
Open the PDF for Growth Factor Alterations in Advanced Diabetic Retinopathy: A Possible Role of Blood Retina Barrier Breakdown in another window