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Jocelyn E. Manning Fox
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Meeting Abstracts

135-OR: Mapping Cis-Regulatory Programs Affecting Diabetes Risk in Pancreatic Islet Cell Types Using Single-Cell Multimodal Profiling

HANNAH MUMMEY, WESTON ELISON, KATHA KORGAONKAR, YUN S. LEE, JACKLYN M. NEWSOME ASHMUS, PAOLA BENAGLIO, MICHAEL T. MILLER, JOCELYN E. MANNING FOX, ANNA L. GLOYN, PATRICK MACDONALD, SEBASTIAN PREISSL, KYLE J. GAULTON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):135-OR
https://doi.org/10.2337/db23-135-OR
Published: 20 June 2023
View article titled, 135-OR: Mapping Cis-Regulatory Programs Affecting Diabetes Risk in Pancreatic Islet Cell Types Using Single-Cell Multimodal Profiling
Journal Articles

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Haopeng Lin, Nancy Smith, Aliya F. Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A. Alghamdi, Sophie L. Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E. Manning Fox, Matthew J. Merrins, Jean Buteau, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2021;70(11):2626–2638
https://doi.org/10.2337/db20-1235
Published: 30 August 2021
View article titled, β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice
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Journal Articles

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2017;66(7):1890–1900
https://doi.org/10.2337/db16-1170
Published: 15 June 2017
View article titled, Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction
Open the PDF for Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction in another window
Includes: Supplementary data
Journal Articles

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

Richard Yan-Do, Eric Duong, Jocelyn E. Manning Fox, Xiaoqing Dai, Kunimasa Suzuki, Shara Khan, Austin Bautista, Mourad Ferdaoussi, James Lyon, Xichen Wu, Stephen Cheley, Patrick E. MacDonald, Matthias Braun
Journal: Diabetes
Diabetes 2016;65(8):2311–2321
https://doi.org/10.2337/db15-1272
Published: 03 May 2016
View article titled, A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

Boris L. Gala-Lopez, Andrew R. Pepper, Rena L. Pawlick, Doug O’Gorman, Tatsuya Kin, Antonio Bruni, Nasser Abualhassan, Mariusz Bral, Austin Bautista, Jocelyn E. Manning Fox, Lachlan G. Young, Patrick E. MacDonald, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(2):451–462
https://doi.org/10.2337/db15-0764
Published: 18 November 2015
View article titled, Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice
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Journal Articles

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Janine K. Kruit, Nadeeja Wijesekara, Jocelyn E. Manning Fox, Xiao-Qing Dai, Liam R. Brunham, Gavin J. Searle, Garry P. Morgan, Adam J. Costin, Renmei Tang, Alpana Bhattacharjee, James D. Johnson, Peter E. Light, Brad J. Marsh, Patrick E. MacDonald, C. Bruce Verchere, Michael R. Hayden
Journal: Diabetes
Diabetes 2011;60(12):3186–3196
https://doi.org/10.2337/db11-0081
Published: 13 November 2011
View article titled, Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
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Includes: Supplementary data
Journal Articles

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Xiao-Qing Dai, Greg Plummer, Marina Casimir, Youhou Kang, Catherine Hajmrle, Herbert Y. Gaisano, Jocelyn E. Manning Fox, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2011;60(3):838–847
https://doi.org/10.2337/db10-0440
Published: 21 February 2011
View article titled, SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
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Journal Articles

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Gary M. Pigeau, Jelena Kolic, Brandon J. Ball, Michael B. Hoppa, Ying W. Wang, Thomas Rückle, Minna Woo, Jocelyn E. Manning Fox, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2009;58(9):2084–2092
https://doi.org/10.2337/db08-1371
Published: 23 June 2009
View article titled, Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells
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