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John C. Hutton
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Journal Articles

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes

Caroline A. Brorsson, Suna Onengut, Wei-Min Chen, Janet Wenzlau, Liping Yu, Peter Baker, Alistair J.K. Williams, Polly J. Bingley, John C. Hutton, George S. Eisenbarth, Patrick Concannon, Stephen S. Rich, Flemming Pociot, for the Type 1 Diabetes Genetics Consortium
Journal: Diabetes
Diabetes 2015;64(8):3017–3027
https://doi.org/10.2337/db14-1730
Published: 31 March 2015
View article titled, Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion

Lynley D. Pound, James K. Oeser, Tracy P. O’Brien, Yingda Wang, Chandler J. Faulman, Prasanna K. Dadi, David A. Jacobson, John C. Hutton, Owen P. McGuinness, Masakazu Shiota, Richard M. O’Brien
Journal: Diabetes
Diabetes 2013;62(5):1547–1556
https://doi.org/10.2337/db12-1067
Published: 16 April 2013
View article titled, G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
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Journal Articles

HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients

Eric Mbunwe, Bart J. Van der Auwera, Ilse Vermeulen, Simke Demeester, Annelien Van Dalem, Eric V. Balti, Sara Van Aken, Luc Derdelinckx, Harry Dorchy, Jean De Schepper, Chris van Schravendijk, Janet M. Wenzlau, John C. Hutton, Daniël Pipeleers, Ilse Weets, Frans K. Gorus, and the Belgian Diabetes Registry
Journal: Diabetes
Diabetes 2013;62(4):1345–1350
https://doi.org/10.2337/db12-0747
Published: 14 March 2013
View article titled, <em>HLA-A*24</em> Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients
Open the PDF for <em>HLA-A*24</em> Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients in another window
Includes: Supplementary data
Journal Articles

Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes: A Twin and Population Study

Huriya Beyan, Harriette Riese, Mohammed I. Hawa, Guisi Beretta, Howard W. Davidson, John C. Hutton, Huibert Burger, Michael Schlosser, Harold Snieder, Bernhard O. Boehm, R. David Leslie
Journal: Diabetes
Diabetes 2012;61(5):1192–1198
https://doi.org/10.2337/db11-0971
Published: 13 April 2012
View article titled, Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes: <subtitle>A Twin and Population Study</subtitle>
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Journal Articles

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice

James K. Oeser, Vrajesh V. Parekh, Yingda Wang, Naresh K. Jegadeesh, Suparna A. Sarkar, Randall Wong, Catherine E. Lee, Lynley D. Pound, John C. Hutton, Luc Van Kaer, Richard M. O’Brien
Journal: Diabetes
Diabetes 2011;60(11):2922–2927
https://doi.org/10.2337/db11-0220
Published: 17 October 2011
View article titled, Deletion of the <em>G6pc2</em> Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
Open the PDF for Deletion of the <em>G6pc2</em> Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice in another window
Includes: Supplementary data
Journal Articles

Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)

Lars C. Stene, Sami Oikarinen, Heikki Hyöty, Katherine J. Barriga, Jill M. Norris, Georgeanna Klingensmith, John C. Hutton, Henry A. Erlich, George S. Eisenbarth, Marian Rewers
Journal: Diabetes
Diabetes 2010;59(12):3174–3180
https://doi.org/10.2337/db10-0866
Published: 21 September 2010
View article titled, Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: <subtitle>The Diabetes and Autoimmunity Study in the Young (DAISY)</subtitle>
Open the PDF for Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: <subtitle>The Diabetes and Autoimmunity Study in the Young (DAISY)</subtitle> in another window
Includes: Supplementary data
Journal Articles

Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes

John C. Hutton, Howard W. Davidson
Journal: Diabetes
Diabetes 2010;59(2):335–336
https://doi.org/10.2337/db09-1767
Published: 01 February 2010
View article titled, Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes
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Journal Articles

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

Janet M. Wenzlau, Yu Liu, Liping Yu, Ong Moua, Kimberly T. Fowler, Sampathkumar Rangasamy, Jay Walters, George S. Eisenbarth, Howard W. Davidson, John C. Hutton
Journal: Diabetes
Diabetes 2008;57(10):2693–2697
https://doi.org/10.2337/db08-0522
Published: 01 October 2008
View article titled, A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

Kirstine Juhl, Suparna A. Sarkar, Randall Wong, Jan Jensen, John C. Hutton
Journal: Diabetes
Diabetes 2008;57(10):2755–2761
https://doi.org/10.2337/db07-1126
Published: 01 October 2008
View article titled, Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic <em>Ngn3</em>-Null Mouse
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Includes: Supplementary data
Journal Articles

Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Yingda Wang, Brian P. Flemming, Cyrus C. Martin, Shelley R. Allen, Jay Walters, James K. Oeser, John C. Hutton, Richard M. O'Brien
Journal: Diabetes
Diabetes 2008;57(1):133–141
https://doi.org/10.2337/db07-0092
Published: 01 January 2008
View article titled, Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo
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Includes: Supplementary data
Journal Articles

Induction of Indoleamine 2,3-Dioxygenase by Interferon-γ in Human Islets

Suparna A. Sarkar, Randall Wong, Seija I. Hackl, Ong Moua, Ronald G. Gill, Alexander Wiseman, Howard W. Davidson, John C. Hutton
Journal: Diabetes
Diabetes 2007;56(1):72–79
https://doi.org/10.2337/db06-0617
Published: 01 January 2007
View article titled, Induction of Indoleamine 2,3-Dioxygenase by Interferon-γ in Human Islets
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Journal Articles

The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo

Claudia Frigeri, Cyrus C. Martin, Christina A. Svitek, James K. Oeser, John C. Hutton, Maureen Gannon, Richard M. O’Brien
Journal: Diabetes
Diabetes 2004;53(7):1754–1764
https://doi.org/10.2337/diabetes.53.7.1754
Published: 01 July 2004
View article titled, The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo
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Journal Articles

T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse

Katalin Kelemen, Dale R. Wegmann, John C. Hutton
Journal: Diabetes
Diabetes 2001;50(8):1729–1734
https://doi.org/10.2337/diabetes.50.8.1729
Published: 01 August 2001
View article titled, T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse
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Journal Articles

Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines

Larry J. Bischof, Cyrus C. Martin, Christina A. Svitek, Beth T. Stadelmaier, Lauri A. Hornbuckle, Joshua K. Goldman, James K. Oeser, John C. Hutton, Richard M. O’Brien
Journal: Diabetes
Diabetes 2001;50(3):502–514
https://doi.org/10.2337/diabetes.50.3.502
Published: 01 March 2001
View article titled, Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: <subtitle>Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines</subtitle>
Open the PDF for Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: <subtitle>Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines</subtitle> in another window
Journal Articles

Characterization of the Unusual Insulin of Psammomys obesus, a Rodent With Nutrition-Induced NIDDM-Like Syndrome

Nurit Kaiser, Elaine M Bailyes, Bruce S Schneider, Erol Cerasi, Donald F Steiner, John C Hutton, David J Gross
Journal: Diabetes
Diabetes 1997;46(6):953–957
https://doi.org/10.2337/diab.46.6.953
Published: 01 June 1997
View article titled, Characterization of the Unusual Insulin of <em>Psammomys obesus</em>, a Rodent With Nutrition-Induced NIDDM-Like Syndrome
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Journal Articles

Autoantibodies to Protein Tyrosine Phosphatase-Like Proteins In Type I Diabetes: Overlapping Specificities To Phogrin And ICA512/IA-2

Eiji Kawasaki, George S Eisenbarth, Christina Wasmeier, John C Hutton
Journal: Diabetes
Diabetes 1996;45(10):1344–1349
https://doi.org/10.2337/diab.45.10.1344
Published: 01 October 1996
View article titled, Autoantibodies to Protein Tyrosine Phosphatase-Like Proteins In Type I Diabetes: Overlapping Specificities To Phogrin And ICA512/IA-2
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Journal Articles

Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2

Charlotte J Hawkes, Christina Wasmeier, Michael R Christie, John C Hutton
Journal: Diabetes
Diabetes 1996;45(9):1187–1192
https://doi.org/10.2337/diab.45.9.1187
Published: 01 September 1996
View article titled, Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2
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Journal Articles

T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM

Bart O Roep, Aram A Kallan, Gaby Duinkerken, Susan D Arden, John C Hutton, G Jan Bruining, René R P De Vries
Journal: Diabetes
Diabetes 1995;44(3):278–283
https://doi.org/10.2337/diab.44.3.278
Published: 01 March 1995
View article titled, T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM
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Journal Articles

The Stimulus-secretion Coupling of Amino Acid-induced Insulin Release: Metabolism and Cationic Effects of Leucine

Willy J Malaisse, John C Hutton, Angelo R Carpinelli, André Herchuelz, Abdullah Sener
Journal: Diabetes
Diabetes 1980;29(6):431–437
https://doi.org/10.2337/diab.29.6.431
Published: 01 June 1980
View article titled, The Stimulus-secretion Coupling of Amino Acid-induced Insulin Release: Metabolism and Cationic Effects of Leucine
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