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Journal Articles

The Relationship Between Cardiac Energy Metabolism and Cardiac Function in Obesity and Type 2 Diabetes: Revisiting a 2003 Diabetes Classic by Aasum et al.

John R. Ussher, Ellen Aasum

Diabetes 2024;73(9):1373–1376

https://doi.org/10.2337/dbi24-0029

Published: 20 August 2024

View article titled, The Relationship Between Cardiac Energy Metabolism and Cardiac Function in Obesity and Type 2 Diabetes: Revisiting a 2003 Diabetes Classic by Aasum et al.

Journal Articles

Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology

Lisa C. Heather, Keshav Gopal, Nikola Srnic, John R. Ussher

Diabetes 2024;73(5):659–670

https://doi.org/10.2337/dbi23-0019

Published: 22 February 2024

View article titled, Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology

Journal Articles

The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

Seyed Amirhossein Tabatabaei Dakhili, Amanda A. Greenwell, Kunyan Yang, Rabih Abou Farraj, Christina T. Saed, Keshav Gopal, Jordan S.F. Chan, Jadin J. Chahade, Farah Eaton, Crystal Lee, Carlos A. Velázquez-Martínez, Peter A. Crawford, J.N. Mark Glover, Rami Al Batran, John R. Ussher

Diabetes 2023;72(1):126–134

https://doi.org/10.2337/db22-0221

Published: 18 October 2022

View article titled, The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

Meeting Abstracts

233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

CHRISTINA T. SAED, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, AMANDA A. GREENWELL, JORDAN S.F. CHAN, KUNYAN YANG, KESHAV GOPAL, FARAH EATON, JOHN R. USSHER

Diabetes 2022;71(Supplement_1):233-LB

https://doi.org/10.2337/db22-233-LB

Published: 01 June 2022

View article titled, 233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

Meeting Abstracts

1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

AMANDA A. GREENWELL, CHRISTINA T. SAED, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, KIM HO, KESHAV GOPAL, JORDAN S.F. CHAN, OKSANA KACZMAR, SCOTT A. DYER, FARAH EATON, GARY LOPASCHUK, RAMI A. BATRAN, JOHN R. USSHER

Diabetes 2022;71(Supplement_1):1397-P

https://doi.org/10.2337/db22-1397-P

Published: 01 June 2022

View article titled, 1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

Meeting Abstracts

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

QUTUBA G. KARWI, KESHAV GOPAL, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, LIYAN ZHANG, QIUYU SUN, CHRISTINA T. SAED, SAI PANIDARAPU, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK

Diabetes 2022;71(Supplement_1):207-LB

https://doi.org/10.2337/db22-207-LB

Published: 01 June 2022

View article titled, 207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

Meeting Abstracts

118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

SEYED AMIRHOSSEIN TABATABAEI DAKHILI, RABIH ABOU FARRAJ, AMANDA A. GREENWELL, CHRISTINA T. SAED, KUNYAN YANG, KESHAV GOPAL, JORDAN S.F. CHAN, CRYSTAL LEE, FARAH EATON, CARLOS A. VELAZQUEZ, PETER A. CRAWFORD, MARK GLOVER, RAMI AL BATRAN, JOHN R. USSHER

Diabetes 2022;71(Supplement_1):118-LB

https://doi.org/10.2337/db22-118-LB

Published: 01 June 2022

View article titled, 118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

Journal Articles

GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Jonathan E. Campbell, Jacqueline L. Beaudry, Berit Svendsen, Laurie L. Baggio, Andrew N. Gordon, John R. Ussher, Chi Kin Wong, Fiona M. Gribble, David A. D’Alessio, Frank Reimann, Daniel J. Drucker

Diabetes 2022;71(5):1115–1127

https://doi.org/10.2337/db21-1166

Published: 22 February 2022

View article titled, GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Journal Articles

Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials

John R. Ussher, Amanda A. Greenwell, My-Anh Nguyen, Erin E. Mulvihill

Diabetes 2022;71(2):173–183

https://doi.org/10.2337/dbi20-0049

Published: 11 January 2022

View article titled, Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials

Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK

Diabetes 2021;70(Supplement_1):379-P

https://doi.org/10.2337/db21-379-P

Published: 01 June 2021

View article titled, 379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

Meeting Abstracts

34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity

RAMI AL BATRAN, KESHAV GOPAL, JADIN J. CHAHADE, JOHN R. USSHER

Diabetes 2019;68(Supplement_1):34-OR

https://doi.org/10.2337/db19-34-OR

Published: 01 June 2019

View article titled, 34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity

Journal Articles

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice

John R. Ussher, Natasha Fillmore, Wendy Keung, Liyan Zhang, Jun Mori, Vaninder K. Sidhu, Arata Fukushima, Keshav Gopal, David G. Lopaschuk, Cory S. Wagg, Jagdip S. Jaswal, Jason R.B. Dyck, Gary D. Lopaschuk

Diabetes 2016;65(7):1883–1891

https://doi.org/10.2337/db15-1145

Published: 13 May 2016

View article titled, Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice

Includes: Supplementary data

Journal Articles

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice

Erin E. Mulvihill, Elodie M. Varin, John R. Ussher, Jonathan E. Campbell, K.W. Annie Bang, Tahmid Abdullah, Laurie L. Baggio, Daniel J. Drucker

Diabetes 2016;65(3):742–754

https://doi.org/10.2337/db15-1224

Published: 15 December 2015

View article titled, Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice

Includes: Supplementary data

Journal Articles

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

Wendy Keung, John R. Ussher, Jagdip S. Jaswal, Monique Raubenheimer, Victoria H.M. Lam, Cory S. Wagg, Gary D. Lopaschuk

Diabetes 2013;62(3):711–720

https://doi.org/10.2337/db12-0259

Published: 14 February 2013

View article titled, Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

Includes: Supplementary data

Journal Articles

Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr^−/− Mice

Holly E. Bates, Jonathan E. Campbell, John R. Ussher, Laurie L. Baggio, Adriano Maida, Yutaka Seino, Daniel J. Drucker

Diabetes 2012;61(1):40–48

https://doi.org/10.2337/db11-1060

Published: 12 December 2011

View article titled, Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr−/− Mice

Includes: Supplementary data

Journal Articles

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

John R. Ussher, Timothy R. Koves, Virgilio J.J. Cadete, Liyan Zhang, Jagdip S. Jaswal, Suzanne J. Swyrd, David G. Lopaschuk, Spencer D. Proctor, Wendy Keung, Deborah M. Muoio, Gary D. Lopaschuk

Diabetes 2010;59(10):2453–2464

https://doi.org/10.2337/db09-1293

Published: 03 June 2010

View article titled, Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Includes: Supplementary data

Journal Articles

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

John R. Ussher, Timothy R. Koves, Jagdip S. Jaswal, Liyan Zhang, Olga Ilkayeva, Jason R.B. Dyck, Deborah M. Muoio, Gary D. Lopaschuk

Diabetes 2009;58(8):1766–1775

https://doi.org/10.2337/db09-0011

Published: 28 May 2009

View article titled, Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

Includes: Supplementary data

NARROW

The Relationship Between Cardiac Energy Metabolism and Cardiac Function in Obesity and Type 2 Diabetes: Revisiting a 2003 Diabetes Classic by Aasum et al.

Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology

The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice

Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr^−/− Mice

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase

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